Faced with increasing climate challenges, this pioneering study introduces groundbreaking approaches to ensure the resilience of potato crops in east-central Poland. Our research was aimed at developing an innovative, cost-effective system tailored to the diverse local conditions of this region. Conducted between 2018 and 2020, the study analyzed integrated and organic production systems across different soil types and potato varieties. The experiment was conducted using a randomized block design with three replications in two locations. Integrated production systems involve the strategic use of mineral fertilization and chemical protection to optimize crop growth and health, whereas organic production systems rely solely on natural inputs and biological pest control methods. Integrated practices, enhanced by mineral fertilization and chemical protection, notably delayed the onset of late blight by 16 days and extended the critical infection period by 17% compared to their organic counterparts. Remarkably, the integrated systems resulted in a 49% increase in total production and a 52% increase in commercial yields, demonstrating their effectiveness in enhancing crop resilience. Different potato varieties exhibit varied responses to cultivation systems, influencing both yield and disease resistance. Further investigation into these varietal responses can help optimize cultivation practices, leading to improved efficiency and sustainability in potato farming. Location and soil conditions have a significant impact on potato yield and the spread of potato blight. Specific soil properties such as pH levels, organic matter content, soil texture (clay, silt, and sand composition), moisture retention capacity, and nutrient availability are crucial in determining potato productivity and disease dynamics. Further research into these soil properties and the adaptation of varieties to local conditions can contribute to increased productivity and stability in potato production. This study not only paves the way toward sustainable agriculture but also highlights the crucial role of soil diversity in shaping resilient farming practices. Potato producers in the eastern-central region of Poland should implement integrated production systems using mineral fertilization and chemical plant protection, adapted to local soil conditions and potato varieties. These practices can delay the appearance of late blight and increase the total and marketable potato yield. Further research on soil properties and variety adaptation may increase production stability and efficiency. Promoting soil diversity and modern technologies will ensure resilient and sustainable agricultural production in the face of climate change.