Lettuce is one of the vegetable plants that contain water, energy, protein, and fat; rich in carbohydrates, fiber, sugar, calcium, iron, magnesium, phosphorus, potassium, sodium, zinc, copper, manganese, selenium, vitamin C, and several other vitamins. Solids are the waste from the by-products of fresh fruit bunch (FFB) processing in palm oil mills. Inorganic fertilizers are fertilizers from chemical, physical, and biological engineering processes resulting from an industry or fertilizer manufacturing plant. The provision of solid compost with urea fertilizer is expected to complement each other's nutrient needs. In contrast, lettuce plants need nitrogen nutrients in the vegetative phase and protein formation in their tissues. This research aimed to evaluate the effect of several doses of solid compost treatment with urea fertilizer and get the best combination of solid compost with urea fertilizer on the growth and production of lettuce plants (Lactuca sativa L.). The research was conducted experimentally using a completely randomized design (CRD) with six fertilizer treatments. The treatments included: 30 ton/ha solid compost + 0 kg/ha urea fertilizer, 30 ton/ha solid compost + 100 kg/ha urea fertilizer, 30 ton/ha solid compost + 200 kg/ha urea fertilizer, 20 ton/ha solid compost + 0 kg/ha urea fertilizer, 20 ton/ha solid compost + 100 kg/ha urea fertilizer, 20 ton/ha solid compost + 200 kg/ha Urea fertilizer. The results were analyzed using variance analysis and continued with Duncan's multiple range test at the 5% level. Applying 20 - 30 tons/ha of solid compost with 200 kg/ha of urea fertilizer gave the best results on the growth and yield of lettuce plants.