We identify robust predictors of global systemic risk proxied by conditional capital shortfall (SRISK) among a comprehensive set of commodity prices for the period between January 2004 and December 2021. The search is based on a battery of ML variable selection algorithms which apply both to price levels and price shocks in the presence of control variables, including the first lag of SRISK, world industrial production, global economic policy uncertainty, geopolitical risk as well as the global stance of monetary and macroprudential policies. We find that these controls outweigh commodity prices as the predictors of global systemic risk. Of the commodities themselves, the prices for agricultural commodities, including food, e.g. chicken, bananas, beef, tea, cocoa, are more important predictors of global systemic risk than the prices for energy commodities, e.g. natural gas and oil prices. The financialization of agricultural commodities, bio-energy expansion as well as commodity-specific dependence of the major economies contributing to global systemic risk, e.g. China, account for our main finding. We also document the positive linkage between commodity prices and systemic risk for the majority of commodities. Thus, monitoring commodity prices to avoid their unbalanced growth is of vast importance to curb global systemic financial risk.