In order to increase energy security and improve environmental quality, the Indonesian Goverment set a target of 23% renewable energy mix in 2025, one of which is the Mandatory Bioediesel Program. A higher biodiesel blending ratio will affect the performance and emissions of diesel engines because biodiesel is chemically different from diesel oil. Research related to the prediction of diesel engine performance and emissions using Artificial Neural Network (ANN) has been conducted, but the author sees a research opportunity for the implementation of the ANN Resilient Backpropagation (Rprop) algorithm. The data used to create the ANN model prediction was secondary data from previous research. The model designed multi input and multi output (MIMO) with 4 input variables and 7 output variables. Model building done by varying the number of neurons and hidden layers. Model evaluation selected based on the largest coefficient of determination parameter R2 and the smallest RMSE or MAPE. The results showed that the ANN single layer 4-20-7 network architecture is the best model for predicting diesel engine performance and emissions with test data R2 , RMSE and MAPE of 0.962532, 6.699428 and 6.0% respectively, while for overall data testing has a performance of 0.982869, 3.908542 and 4.3%. The results also show that based on the ANN prediction results, the increasing biodiesel ratio can increase NOx emissions and decrease HC, CO and CO emissions2 . In terms of performance, the addition of biodiesel can increase BSFC and BP and decrease BTE. The results also show that the addition of ZnO concentration can reduce emissions while in terms of performance it will increase BTE and reduce BSFC and BP.