The use of polycarbonates in the biomedical application has been largely studied, owing to appropriate biodegradation reaction, without producing any by-products [1, 2]. Generally, the synthesis of the polycarbonates is via ring opening polymerization, which requires several steps and high purity of the reagents. Step growth polymerization can be an easy method to design polycarbonates with molar masses around 20,000 g mol-1 [3]. The protocol of organocatalytic polycondensation consists of a two-step reaction, which involves an initial condensation and the subsequent chain propagation based on transesterification. The reaction will be catalyzed by organic based catalyst, N,N’-dimethyl-4-aminopyridine (DMAP). From Scheme 1, the possibility of tuning the polycarbonate structure can be deduced; the diol is a key reagent of designing the final homopolymer or copolymer structure. This methodology gives us an opportunity to obtain linear or cross-linked polymer. In our work, we have incorporated a mono-ether functionality for biocompatibility as well as a double bond for formation of a cross-linked network. Scheme 1. The polycondensation approach for new polycarbonate-based biocompatible gels. [1] K. Fukushima, Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials, Biomaterials Science, 4 (2016) 9-24. [2] K. Fukushima, Y. Inoue, Y. Haga, T. Ota, K. Honda, C. Sato, M. Tanaka, Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents, Biomacromolecules, 18 (2017) 3834-3843. [3] L. Meabe, N. Lago, L. Rubatat, C. Li, A.J. Müller, H. Sardon, M. Armand, D. Mecerreyes, Polycondensation as a Versatile Synthetic Route to Aliphatic Polycarbonates for Solid Polymer Electrolytes, Electrochimica Acta, 237 (2017) 259-266. Figure 1