Biocompatibility Of Cement Research Articles

Influence of chlorhexidine digluconate on biocompatibility of cements: Morphological and immunohistochemistry analysis.

In this study, the in vivo biocompatibility was evaluated by using conventional ionomer cements modified with Chlorhexidine (CHX) in different time intervals. In total, 105 male Wistar rats were randomized into seven groups: control, groups M, M10, M18 and groups RL, RL10, RL18 (M-Meron and RL-RivaLuting, and added CHX-10% and CHX-18%, respectively). Histological analyses of inflammatory infiltrate and collagen fibers, and immunohistochemistry of CD68+ for macrophages (MOs) and multinucleated giant cells (MGCs) were performed. Data were analyzed using the Kruskal-Wallis and Dunn (p< .05) tests. Intense inflammatory infiltrate was demonstrated in Group Riva CHX-18% within 7 and 15 days (p< .05), without differences after 30 days. For collagenization, healing of the groups was compatible with that of control in 15 and 30 days (p> .05). Immunomarking of CD68+ was more significant in the groups with higher concentration of CHX. There was significant difference in quantity of MGCs in groups with 18% CHX, Meron (p= .001) in 7 days, and in Riva at 30 days (p= .001). Significant difference was also found in quantities of MOs in Groups Meron and Riva in 7 days (p= .001), and only in Riva at 15 and 30 days (p= .001). The cements with addition of CHX demonstrated biocompatibility with tissues. Riva CHX-18% had the most effect on cells of the inflammatory process but showed satisfactory tissue repair. RESEARCH HIGHLIGHTS: The concentration of 18% chlorhexidine was shown to be biocompatible with tissues; the slow release of chlorhexidine by the cements could significantly prolong its antibacterial effect on the oral medium.

Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis.

Objective The focus of this study was to evaluate the biocompatibility of ionomer cements modified with ethanolic extracts of propolis (EEP) in different concentrations and time intervals. Materials and Methods In total, one hundred and thirty-five male Wistar rats were randomized into nine groups: Control, Groups Meron, and Groups Ketac (conventional, and added with 10, 25, 50% EEP, respectively). Histological analyses of inflammatory infiltrate and collagen fibers, and immunohistochemistry of CD68+ for macrophages (MOs) and multinucleated giant cells (MGCs) were performed. Statistical Analysis Data were analyzed using the Kruskal—Wallis and Dunn ( p < 0.05) tests. Results Intense inflammatory infiltrate was demonstrated in the cements with 10% EEP at 7 days and 15 days ( p < 0.05), only Group Ketac 10% EEP ( p = 0.01) at 30 days. A smaller quantity of collagen fibers was observed in the cements with 10% EEP ( p = 0.01) at 7 days, and Group Meron 10% EEP ( p = 0.04) at 15 days. MOs and MGCs showed significant difference for the cements with 10% EEP ( p = 0.01) at 7 and 15 days. At 30 days, MOs persisted in the Groups with 10% EEP. Conclusions The concentration of 10% EEP had the greatest influence on the inflammatory and tissue repair processes. The concentrations of 25 and 50% EEP demonstrated biocompatibility similar to that of cements that did not receive EEP.

Dual-Curing Polylactide for Resorbable Bone Cement

Polymeric cement based on poly (methyl methacrylate) (PMMA) has been known as a common material for fixation of prostheses with the advantages of mechanical properties. However, one of drawbacks of PMMA cement is heat produced during polymerization. The elevating temperature during polymerization resulting from exothermic polymerization of MMA can cause bone cellular necrosis. Additionally, the residual MMA monomer after polymerization is an issue regarding the biocompatibility of cement. In this study, a resorbable cement based on polylactide (PLA) has been developed. Its physical, mechanical and biological properties were investigated as an alternative biocompatible bone cement. The dual-cured polylactide cements prepared by combining spherical powder of star-shaped and linear PLA blends with triethylene glycol dimethacrylate liquid were radically polymerized by UV-VIS light and self-curing methods. Flexural strength, maximum temperature during polymerization and biocompatibility via the percentages of cell viability using MTT assay of the dual-cured polylactide were determined to meet requirements for bone cement. The best flexural strength of 108 MPa was achieved from the cement composed of 80%-wt of star-shaped PLA with molecular weight (Mw) of 10770. The preparation of cement using paste/liquid mixing, in which the powder was allowed to wet in the liquid before mixing, significantly encouraged mechanical properties compared to powder/liquid mixing due to satisfactory solubility of PLA prior to polymerization. The amount of initiator/activator was studied to fine-tune the maximum temperature during polymerization. The maximum temperature during polymerization of the PLA cement was in the range of 80-90 degree Celsius and the percentage of osteogenic cell viability immediately after cement setting was 83 indicating a non-toxic material. Therefore, this PLA cement polymerized with a dual curing mode is promising for a resorbable bone cement.

Cement Selection for Cement-Retained Implant-Supported Prostheses: A Literature Review.

Cement-retained implant-supported prostheses are widely used for restoring missing teeth; however, they show some complications in comparison to screw-retained restorations, such as difficulty in retrieving the restoration and biocompatibility of cement. Therefore, the practitioner should consider several important aspects when using this type of restoration. In this regard, one major concern is appropriate cement selection, with considerations including cement biologic compatibility, methods for limiting the excess cement, ease of removing the excess cement, radiographic view of the cement, and also the possibility of future retrieval of the prosthesis. The aim of this review article was to address most aspects related to this type of prosthesis in terms of cementation.