Binder Jet 3D Printing Research Articles

Binder jetting 3D printing of challenging medicines: From low dose tablets to hydrophobic molecules

Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ) technology. The approach is demonstrated using two model APIs: hydrophilic quinapril hydrochloride (QHCl, logP = 1.4) and hydrophobic clotrimazole (CLO, logP = 5.4). The proposed printing method uses inexpensive, well known, and easily available FDA approved pharmaceutical excipients. The obtained model tablets had uniform content of the drug, excellent mechanical properties, and highly porous structure resulting in short disintegration time and fast dissolution rate. The tablets could be scaled and obtained in predesigned shapes and sizes. The proposed method may find its application in the early stages of drug development where high flexibility of the formulation is required and the amount of available API is limited.

Microstructure evolution for isothermal sintering of binder jet 3D printed alloy 625 above and below the solidus temperature

When compared to beam-based melting methods, binder jet 3D printing is less time consuming, and the printed material is less prone to residual stresses. However, binder jet printing often contains remnant porosity that survives pressureless sintering and limits the mechanical properties of metals including fatigue strength and ductility. In this work, gas atomized nickel-based superalloy 625 powders with three different particle size distributions are binder jet printed and subsequently isothermally sintered at subsolidus and supersolidus temperatures. Individual feature measurements were conducted on two-dimensional sections and pore size distribution frequencies were plotted to reveal the difference in microstructural evolution between subsolidus and supersolidus sintering. Supersolidus liquid phase sintering is thought to have facilitated particle rearrangement under the surface tension of the liquid phase, resulting in a homogeneous microstructure that favored subsequent densification and higher final density. Additionally, printed powder with a wide particle size distribution not only reached high green density of ~52%, but also achieved final densities above 99%.

Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures.

Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyridoxine hydrochloride (LEV-PN) multicompartmental structure dispersible tablets. PN was dissolved in printing ink directly and accurately jetted into the middle, nested layer of the tablet, and precise control of the drug dose was achieved through the design of printing layers. With modification of the drying method, the “coffee ring” effect caused by drug migration during the curing and molding of the tablets was overcome. Furthermore, 3D topography showed that the tablets have a promising surface morphology. Scanning electron microscopy and porosity results indicated that the tablets have a loose interior and tight exterior, which would ensure good mechanical properties while enabling the tablet to disintegrate quickly in the mouth and achieve rapid release of the two drugs. This study used BJ-3DP technology to prepare personalized multicompartmental structures of drug systems and provides a basis for the development of complex preparations.

Pharmaceutical applications of powder-based binder jet 3D printing process - A review.

Pharmaceutical applications of the 3D printing process have recently matured, followed by the FDA approval of Spritam, the first commercial 3D printed dosage form. Due to being a new technology in the conventional dosage formulation field, there is still a dearth of understanding in the 3D printing process regarding the effect of the raw materials on the printed dosage forms and the plausibility of using this technology in dosage development beyond the conventional ways. In this review, the powder-based binder jet 3D printing (BJ3DP) process and its pharmaceutical applications have been discussed, along with a perspective of the formulation development step. The recent applications of BJ3DP in pharmaceutical dosage development, the advantages, and limitations have further been discussed here. A discussion of the critical formulation parameters that need to be explored for the preformulation study of the solid oral dosage development using the BJ3DP process is also presented.

Effect of binder saturation and drying time on microstructure and resulting properties of sinter-HIP binder-jet 3D-printed WC-Co composites

Binder-jet 3D-printing, a non-beam-based additive manufacturing method, is a process of selectively joining layers of powder using a polymeric binder. In this study, the effects of print processing parameters such as binder saturation (60–250%) and drying time (30–45 s) on 3D-printed WC-Co composite powder is studied. Densification is attained by sintering under a vacuum atmosphere to reach the maximum temperature of 1435 ℃ followed by hot isostatic pressing under a pressure of 6.1 MPa. Although the green density of the 3D printed samples was ~21–23%, solid volume fraction of 97% to nearly 100% and near theoretical densities of 14.10–14.35 g/cm3 were achieved depending on the print processing parameters. Microstructural characterization of the final parts reveals potential spreading defects appearing as remnant pores formed during printing at a higher binder saturation level. Additionally, Co-rich pools also appear in the final parts. X-ray diffraction shows WC and Co as the main phases and a potential η-phase formation depending on the binder saturation level. Parts with WC grain size of 1.6 ± 0.7 µm, average Vickers hardness of 1270–1320 HV60 and fracture toughness of 17–22 MPa m1/2 are attained, similar to conventionally produced WC-Co with medium grain size. Here, binder-jet 3D-printing is used to fabricate WC-Co parts with uniform microstructure and mechanical properties.

The effects of sintering temperature and hold time on densification, mechanical properties and microstructural characteristics of binder jet 3D printed 17-4 PH stainless steel

In this study, the influence of sintering temperature and hold time on densification, mechanical properties, and microstructural characteristics of 17–4 PH stainless steel samples produced by binder jet 3D printing (BJ3DP) was investigated. An ultimate tensile strength (UTS) of 1050 MPa, an elongation at break (A) of >4% and a hardness of ≥330 HV10 through sintering at 1300 °C for 90 min were achieved. The tensile properties are predominantly influenced by porosity as opposed to the grain size or the volume fraction of δ-ferrite. A layered porosity appears in the sintered parts, which is attributed to the layer-wise BJ3DP process. Shrinkage in z-direction is about 2% higher than in x- and y-direction and is therefore anisotropic. Fluctuations in green density of up to 1.2% affect sintered density throughout the study and are compensated best by extended hold times. Microstructural analyses show the expected grain growth and increase in δ-ferrite fraction by increasing sintering temperature and more extensive hold times, while the comparison of fringe and core microstructures reveals little differences of the grain size but significant differences of the fraction of δ-ferrite and porosity.

Binder Jetting of Custom Silicone Powder for Direct Three-Dimensional Printing of Maxillofacial Prostheses.

Recent advances in digital workflow have transformed clinician's ability to offer patient-specific devices for medical and dental applications. However, the digital workflow of patient-specific maxillofacial prostheses (MFP) remains incomplete, and several steps in the manufacturing process are still labor-intensive and are costly in both time and resources. Despite the high demand for direct digital MFP manufacturing, three-dimensional (3D) printing of colored silicone MFP is limited by the processing routes of medical-grade silicones and biocompatible elastomers. In this study, a binder jetting 3D printing process with polyvinyl butyral (PVB)-coated silicone powder was developed for direct 3D printing of MFP. Nanosilica-treated silicone powder was spray dried with PVB by controlling the Ohnesorge number and processing parameters. After printing, the interconnected pores were infused with silicone and hexamethyldisiloxane (HMDS) by pressure-vacuum sequential infiltration to produce the final parts. Particle size, coating composition, surface treatment, and infusion conditions influenced the mechanical properties of the 3D-printed preform, and of the final infiltrated structure. In addition to demonstrating the feasibility of using silicone powder-based 3D printing for MFP, these results can be used to inform the modifications required to accommodate the manufacturing of other biocompatible elastomeric materials.

Alumina‐based filters made via binder jet 3D printing of alumina powder, colloidal silica infiltration, and sintering

AbstractAlumina‐based, porous filter media was made via a binder jet 3D printing process consisting of an alumina powder printing step with subsequent heating, colloidal silica infiltration, drying, and sintering to consolidate particles yet retain a net open porous microstructure. The composites made were alumina‐silica or alumina‐mullite, where the silica sintering aid was used to densify and join the alumina particles. The resulting composite structures had open porosities in the 25–31 vol% range as measured by Archimedes density. Pressure drops were measured across the filter media at constant flow rates to compare disc shapes and complex, 3D printed filters based on the N95 design requirements. Complex, 3D‐printed alumina composites were produced with acceptable pressure drops for N95 implementation.

Cast Iron Parts Obtained in Ceramic Molds Produced by Binder Jetting 3D Printing-Morphological and Mechanical Characterization.

Mechanical behavior and characteristics of two different types of materials: cast iron with lamellar graphite EN-GJL-250 and cast iron with spheroidal graphite EN-GJS-400-15 which were cast in ceramic molds using gravitational casting method has considered in this research. The ceramic molds were obtained by 3D printing method. First, a finite element analysis was developed to determine Tresca and von Mises stresses and the deformations of the ceramic molds under an applied pressure of 25 MPa. Samples were produced by gravitational casting using two types of cast iron materials. Mechanical tests were made using samples produced from these two types of materials and microstructure analysis evaluation of fractured zones was realized by scanning electron microscopy. Obtained results were finally used for designing, developing, and producing of one ‘hydraulic block’ of a railway installation by the Benninger Guss company of Switzerland.

Predicting sintering window during supersolidus liquid phase sintering of steels using feedstock analysis and CALPHAD

Binder jet 3D printing results in carbon pickup from the binder at the inter-particle regions during binder burnout. The excess carbon lowers the solidus temperature of the green part locally during supersolidus liquid phase sintering (SLPS). Currently, thermodynamic calculations rely on the use of bulk powder compositions to predict the sintering window. This can overestimate the sintering temperature since the local increase in carbon on powder surfaces is not accounted for, that can locally lower the solidus temperature during SLPS. Here we show that using the inputs from feedstock and binder analysis, the excess carbon and hence the sintering window for the alloy can be predicted using CALPHAD. We present a case study on applying the proposed approach for pressureless sintering of binder jet additive manufactured (BJAM) of H13 steel via SLPS.

Proposal for enhancing the compressive strength of alkali-activated materials-based binder jetting 3D printed outputs

Additive manufacturing (AM), also known as 3D printing, is a fabrication method used to create geometric 3D objects. Particularly, binder jetting 3D printing (BJ3DP) can be used to produce complex geometries. In this study, we have enhanced the compressive strength of alkali-activated materials (AAM)-based BJ3DP outputs by optimizing the powder mixture, post-processing machine, and post-processing storage solution. These optimization measures present a compressive strength of 22.56 MPa at 7 days (20 mm ×20 mm ×20 mm sized printed output). Consequently, we have confirmed the possibility of the application to construction by enhancing the compressive strength of BJ3DP.

Binder jetting 3D printing process optimization for rapid casting of green parts with high tensile strength

Binder jetting 3D printing is a rapid, cost effective, and efficient moulding/core making process, which can be applied to a large variety of materials. However, it exhibits a relatively low green-part strength. This may cause the collapse of the printed parts during de-caking and the pick-up procedure, especially in the case of small-scale structures, such as thin walls, tips, and channels. In this work, polyvinyl alcohol (PVA) was used as the additive in coated sand powder. By exploiting the binding effect between the two composites (thermoplastic phenolic resin and PVA) triggered by the binder, bonding necks firmly form among the sand particles, improving the green-part strength of the coated sand printed parts. Experiments based on the Taguchi method were used to investigate the relationship between the process parameters and the green-part tensile strength. The following set of optimal process parameters was identified: 50wt.% alcoholicity of the binder, 75% binder saturation, 0.36 mm layer thickness and 4.5wt.% PVA content. Further, the effect of such parameters on the green-part tensile strength was determined via statistical analysis. The green part of an engine cylinder head sand pattern with complex cavity structures was printed, and the green-part tensile strength reached 2.31 MPa. Moreover, the ZL301 aluminum alloy impeller shape casting was prepared using sand molds printed with the optimal process parameters. The results confirm that the proposed binder jetting 3D printing process can guarantee the integrity of the printed green parts and of small-size structures during decaking and the pick-up procedure. Furthermore, the casting made from the printed sand molds exhibits a relatively high quality.

Properties of SiC‐Si made via binder jet 3D printing of SiC powder, carbon addition, and silicon melt infiltration

AbstractWe report the physical and mechanical properties of ceramic composite materials fabricated by binder jet 3D printing (BJ3DP) with silicon carbide (SiC) powders, followed by phenolic resin infiltration and pyrolysis (IP) to generate carbon, and a final reactive silicon melt infiltration step. After two phenolic resin infiltration and pyrolysis cycles; porosity was less than 2%, Young's modulus was close to 300 GPa, and the flexural strength was 517.6 ± 24.8 MPa. However, diminishing returns were obtained after more than two phenolic resin infiltration and pyrolysis cycles as surface pores in carbon were closed upon the formation of SiC, resulting in reaction choking and residual‐free carbon and porosity. The instantaneous coefficient of thermal expansion of the composite was found to be independent of the number of phenolic IP cycles and had values of between 4.2 and 5.0 ppm/°C between 300 and 1000℃, whereas the thermal conductivity was found to have a weak dependence on the number of phenolic IP cycles. While the manufacturing procedures described here yielded highly dense, gas impermeable, siliconized SiC composites with properties comparable to those of bulk siliconized silicon carbide processed according to conventional techniques, BJ3DP enables the manufacture of objects with complex shape, unlike conventional techniques.

Printability and Setting Time of CSA Cement with Na2SiO3 and Gypsum for Binder Jetting 3D Printing.

The purpose of this study is to optimize the composition of CSA (calcium sulfoaluminate) cement with sodium silicate (Na2SiO3) and gypsum for binder jetting 3D printing. The preliminary test was carried out with an applicator to decide the proper thickness of one layer before using the 3D printer. A liquid binder was then selected to maintain the shape of the particles. Based on the results, the optimal mixture of dry materials and a liquid activator was derived through various parametric studies. For dry materials, the optimum composition of CSA cement, gypsum, and sand was suggested, and the liquid activator made with sodium silicate solution and VMA (viscosity modified agent) were selected. The setting time with gypsum and sodium silicate was controlled within 30 s. In case of the delayed setting time and the rapid setting mixture, the jetting line was printed thicker or thinner and the accuracy of the printout was degraded. In order to adjust the viscosity of the liquid activator, 10% of the VMA was used in 35% of sodium silicate solution and the viscosity of 200–400 cP was suitable to be sprayed from the nozzle. With this optimal mixture, a prototype of atypical decorative wall was printed, and the compressive strength was measured at about 7 MPa.

3D printing of fine alumina powders by binder jetting

Additive manufacturing of ceramics is still at an early-development stage; however, the huge interest in custom production of these materials has led to the development of different techniques that could provide highly performing devices. In this work, alumina (α-Al2O3) components were produced by binder jetting 3D printing (BJ), a powder-based technique that enables the ex-situ thermal treatment of the printed parts. The employment of fine particles has led to high green relative density values (>60 %), as predicted by Lubachevsky-Stillinger algorithm and DEM modelling. Then, extended sintering has been observed on samples treated at 1750 °C that have reached a final density of 75.4 %. Finally, the mechanical properties of the sintered material have been assessed through bending test for flexural resistance and micro-indentation for Vickers hardness evaluation.

Synergistic application of twin-screw granulation and selective laser sintering 3D printing for the development of pharmaceutical dosage forms with enhanced dissolution rates and physical properties

This study demonstrated the first case of combining a novel continuous granulation technique with powder-bed fusion-based selective laser sintering (SLS) process to enhance the dissolution rate and physical properties of a poorly water-soluble drug. Selective laser sintering and binder jetting 3D printing processes have gained much attention in pharmaceutical dosage form manufacturing in recent times. These powder bed-based 3D printing platforms have been known to face printing and uniformity problems due to the inherent poor flow properties of the pharmaceutical physical mixtures. To address this issue a hot-melt extrusion-based versatile granulation process equipped with a process analytical technology (PAT) tool for the in-line monitoring of critical quality attributes (i.e., solid-state) of indomethacin was developed. The collected granules with enhanced flow properties were mixed with Kollidon® VA64 and a conductive excipient for efficient sintering. These mixtures were further characterized for their bulk properties observing an excellent flow and later subjected to an SLS-3D printing process. The physical mixtures, processed granules, and printed tablets were characterized using conventional as well as advanced solid-state characterizations. These characterizations revealed the amorphous nature of the drug in the processed granules and printed tablets. Further, the in vitro release testing of the tablets with produced granules as a reference standard depicted a notable dissolution advantage (100% drug released in 5 min at >pH 6.8) over the pure drug and the physical mixture. Our developed system known as DosePlus combines innovative continuous granulation and SLS-3D printing process which can potentially improve the physical properties of the bulk drug and formulations in comparison to when used in isolation. This process can further find application in continuous manufacturing of granules and additive manufacturing of pharmaceuticals to produce dosage forms with excellent uniformity and solubility advantage.

Numerical Simulation of Particle Size Influence on the Sintering Behavior of 316L Stainless Steel Powders Fabricated by Binder Jet 3D Printing

Binder jet 3D printing (BJ3DP) is one of the most promising 3D printing technologies, due to its ability of printing large-scale complex parts with high efficiency and low cost. The powder particle size is crucial for the sintering quality of BJ3DP. In this work, on the basis of the constitutive model of viscoplastic theory, the shape evolution (shrinkage and relative density) of cubes produced by BJ3DP using 316L stainless steel powders (normal distribution of powder sizes) with different mean particle sizes (i.e., 20, 30, 40, 50, 60, and 70 μm) was studied via finite element numerical simulation during sintering. It revealed that the volumetric shrinkage, relative density, and maximum sintering stress decreased with increasing the mean particle size. The maximum sintering stress of the sample with mean particle size of 70 μm was 0.0492 MPa, with the volumetric shrinkage of ~40% and the relative density of ~89%. In the meantime, the maximum sintering stress of the sample with mean particle size of 20 μm was 0.1789 MPa, with the volumetric shrinkage of ~48% and the relative density of ~97%. In addition, the simulated results of the relative density of assumed samples agreed well with the experimental results from the literature.

Impact of powder-binder interactions on 3D printability of pharmaceutical tablets using drop test methodology

In this study, a pre-screening test has been developed for the binder-jet 3D printing process (BJ3DP) which has been validated using statistical analysis. The pre-screening test or drop test has been adapted from the wet granulation field and modified later on to be used for tablet manufacturing in BJ3DP. Initially, a total of eight powders and ten water-based binder solutions have been introduced in the preliminary test to understand the powder-binder interactions. Afterward, based on the preliminary test results, three blends were developed which had undergone the same drop test. All these powder and binder combinations were then used for 3D printing. The key parameters such as mechanical strength and shape factors of the drop test agglomerates and 3D printed tablets were then compared using multiple linear regressions. Few dimensionless parameters were introduced in this study such as binding capacity and binding index to capture the printability properties of the powders used in this study.Significant relations (p<0.05) were found between the drop test and the BJ3DP process. Application of drop test was carried out to establish a prescreening test, ii) to develop new blend formulations as well as iii) to develop a fundamental understanding of powder-binder interaction during BJ3DP process

A review on the progress and challenges of binder jet 3D printing of sand moulds for advanced casting

Abstract 3D sand mould printing using binder jet technology can enable many technical improvements in casting practice, including part consolidation, design of parts to optimise the consumption of materials and hazardous chemicals, and on-demand and flexible size part manufacturing near the customer. Incorporating artificial intelligence in optimising the design of moulds, printing process parameters, and solidification processes may help automate a production facility and reduce labour time. Elimination of hazardous chemicals from industrial use may be a challenge. Therefore, an alternative technology to fuse the sand particles during printing or an environmentally friendlier alternative option for the binders and other consumables should be utilised with the 3D sand printing process. Properties of parts produced using 3D printed sand moulds have the potential to be better than the properties of parts produced using traditional casting due to this technology's benefits. This technology is an enabling technology for traditional casting processes rather than a competing technology. It is causing a paradigm shift in casting design because of the mould geometries achievable by using additive manufacturing to produce the sand mould. This paper reviews the first twenty years of research and challenges in developing 3D sand printing processes as an innovation for sustainable manufacturing.

DEM based investigation of powder packing in 3D printing of pharmaceutical tablets

3D printing is emerging as one of the most promising methods to manufacture Pharmaceutical dosage forms as it offers multiple advantages such as personalization of dosage forms, polypill, fabrication of complex dosage forms etc. 3D printing came into existence in 1980s but its use was extended recently to pharmaceutical industry along with the approval of first 3D printed tablet Spritam by FDA in 2015. Spritam was manufactured by Aprecia pharmaceuticals using binder jetting technology. Binder jet 3D printing involves a hopper for powder discharge and printheads for ink jetting. The properties of tablets are highly dependent upon the discharge quality of powder mixture from the hopper and jetting of the ink/binder solution from the printhead nozzle. In this study, numerical models were developed using Discrete element method (DEM) to gain better understanding of the binder jet 3D printing process. The DEM modeling of hopper discharge was performed using in-house DEM code to study the effect of raw material attributes such as powder bed packing density (i.e. particle size, particle density etc) on the printing process, especially during powder bed preparation. This DEM model was further validated experimentally, and the model demonstrated good agreement with experimental results.