Binaural Processing Research Articles

The lateral superior olive in the mouse: Two systems of projecting neurons.

The lateral superior olive (LSO) is a key structure in the central auditory system of mammals that exerts efferent control on cochlear sensitivity and is involved in the processing of binaural level differences for sound localization. Understanding how the LSO contributes to these processes requires knowledge about the resident cells and their connections with other auditory structures. We used standard histological stains and retrograde tracer injections into the inferior colliculus (IC) and cochlea in order to characterize two basic groups of neurons: (1) Principal and periolivary (PO) neurons have projections to the IC as part of the ascending auditory pathway; and (2) lateral olivocochlear (LOC) intrinsic and shell efferents have descending projections to the cochlea. Principal and intrinsic neurons are intermixed within the LSO, exhibit fusiform somata, and have disk-shaped dendritic arborizations. The principal neurons have bilateral, symmetric, and tonotopic projections to the IC. The intrinsic efferents have strictly ipsilateral projections, known to be tonotopic from previous publications. PO and shell neurons represent much smaller populations (<10% of principal and intrinsic neurons, respectively), have multipolar somata, reside outside the LSO, and have non-topographic, bilateral projections. PO and shell neurons appear to have widespread projections to their targets that imply a more diffuse modulatory function. The somata and dendrites of principal and intrinsic neurons form a laminar matrix within the LSO and share quantifiably similar alignment to the tonotopic axis. Their restricted projections emphasize the importance of frequency in binaural processing and efferent control for auditory perception. This study addressed and expanded on previous findings of cell types, circuit laterality, and projection tonotopy in the LSO of the mouse.

Convergence of bilateral auditory midbrain inputs on neurons in the auditory thalamus of chicken.

In the avian ascending auditory pathway, the nucleus mesencephalicus lateralis pars dorsalis (MLd; the auditory midbrain center) receives inputs from virtually all lower brainstem auditory nuclei and sends outputs bilaterally to the nucleus ovoidalis (Ov; the auditory thalamic nucleus). Axons from part of the MLd terminate in a particular domain of Ov, thereby suggesting a formation of segregated pathways point-to-point from lower brainstem nuclei via MLd to the thalamus. However, it has not yet been demonstrated whether any spatial clustering of thalamic neurons that receive inputs from specific domains of MLd exists. Ov neurons receive input from bilateral MLds; however, the degree of laterality has not been reported yet. In this study, we injected a recombinant avian adeno-associated virus, a transsynaptic anterograde vector into the MLd of the chick, and analyzed the distribution of labeled postsynaptic neurons on both sides of the Ov. We found that fluorescent protein-labeled neurons on both sides of the Ov were clustered in domains corresponding to subregions of the MLd. The laterality of projections was calculated as the ratio of neurons labeled by comparing ipsilateral to contralateral projections from the MLd, and it was 1.86 on average, thereby indicating a slight ipsilateral projection dominance. Bilateral inputs from different subdomains of the MLd converged on several single Ov neurons, thereby implying a possibility of a de novo binaural processing of the auditory information in the Ov.

Neuroethology of sound localization in anurans.

Albert Feng pioneered the study of neuroethology of sound localization in anurans by combining behavioral experiments on phonotaxis with detailed investigations of neural processing of sound direction from the periphery to the central nervous system. The main advantage of these studies is that many species of female frogs readily perform phonotaxis towards loudspeakers emitting the species-specific advertisement call. Behavioral studies using synthetic calls can identify which parameters are important for phonotaxis and also quantify localization accuracy. Feng was the first to investigate binaural processing using single-unit recordings in the first two auditory nuclei in the central auditory pathway and later investigated the directional properties of auditory nerve fibers with free-field stimulation. These studies showed not only that the frog ear is inherently directional by virtue of acoustical coupling or crosstalk between the two eardrums, but also confirmed that there are extratympanic pathways that affect directionality in the low-frequency region of the frog's hearing range. Feng's recordings in the midbrain also showed that directional information is enhanced by cross-midline inhibition. An important contribution toward the end of his career involved his participation in neuroethological research with a team of scientists working with frogs that produce ultrasonic calls.

Binaural Integration of Spectrally Degraded Speech in Adult Cochlear Implant Recipients with Single-Sided Deafness

Introduction: Our purpose was to investigate binaural integration for spectrally degraded speech in normal-hearing (NH) subjects, single-sided deafness (SSD) cochlear implant (CI) recipients, and bilateral deaf bilateral CI recipients. Methods: We tested ten adult subjects in each group with a modified version of the binaural fusion test according to Matzker. Speech recognition was assessed for monotic listening with the better-hearing ear or CI, monotic listening with the poorer-hearing ear or CI, and dichotic listening. We employed two presentation modes: (1) low pass (LP)-filtered speech to the better ear or CI and high pass (HP)-filtered speech to the poorer ear or CI, and (2) LP-filtered speech to the poorer ear or CI and HP-filtered speech to the better ear or CI. Five magnitudes of LP and HP filtering, i.e., spectral degradation, for each presentation mode were applied yielding two spectrally overlapping and three nonoverlapping presentation conditions. Sentences from the Oldenburg Children’s sentence test were applied to assess speech recognition. Results: NH subjects, SSD CI recipients, and bilateral CI recipients were able to understand spectrally degraded speech under both monotic and dichotic listening conditions for both the presentation modes. Speech performance decreased with the increasing loss of spectral information in all the three subject groups. In the NH subjects, speech recognition scores significantly improved for dichotic compared with each monotic listening type under two spectrally nonoverlapping conditions. The SSD CI subjects showed a significant improvement in speech scores for dichotic listening compared with monotic listening with the NH ear under one nonoverlapping condition, i.e., a dichotic benefit in speech recognition with CI. We saw a dichotic benefit in the bilateral CI recipients who achieved significantly better speech scores for dichotic compared with monotic listening with the better CI in three nonoverlapping conditions. Conclusions: All the three groups (NH subjects, SSD CI recipients, and BiCI recipients) showed binaural integration for the side-separated presentation of spectrally degraded speech. Use of strictly side-separated dichotic stimulus presentation avoided the possible occurrence of physical effects such as the head shadow effect and therefore, confirmed the binaural benefit attributable to central binaural processing.

Age-Related Changes in Interaural-Level-Difference-Based Across-Frequency Binaural Interference.

Low-frequency interaural time differences and high-frequency interaural level differences (ILDs) are used to localize sounds in the horizontal plane. Older listeners appear to be worse at horizontal-plane sound localization to compared younger listeners, but little is understood about age-related changes to across-frequency binaural processing. This study investigated if the frequency dependence of across-frequency ILD processing is altered for older compared to younger listeners, which was done by using an across-frequency binaural interference task (when the interaural difference sensitivity for a target sound is decreased by a spectrally remote interfering sound with zero interaural differences). It was hypothesized that as listeners experience advancing age and age-related high-frequency hearing loss (i.e., presbycusis), they will demonstrate worse binaural performance and experience more across-channel binaural interference (because of age-related temporal processing deficits), and will increasingly be affected by interferers at lower frequencies (because of age-related hearing loss) when compared to younger listeners. There were 11 older (>65 yrs) and 20 younger (<30 yrs) listeners with normal to near-normal audiometric thresholds up to 2 kHz. They were tested using a left-right ILD lateralization discrimination task. Single-tone ILD discrimination thresholds and across-frequency binaural interference were measured at 0.5, 1, 2, 4, and 8 kHz. ILD thresholds and interference were about twice as large for older compared to younger listeners. Interferers ≤1 kHz produced 2–3 times as much across-frequency binaural interference for older compared to younger listeners. Hearing thresholds were significant predictors of single-tone ILD thresholds; in addition, both target and interferer hearing thresholds were significant predictors of binaural interference. The results suggest a reweighting of binaural information that occurs with advancing age and age-related high-frequency hearing loss. This evidence of plasticity may help explain some of the age-related changes in spatial-hearing abilities.

Computed-Tomography Estimates of Interaural Mismatch in Insertion Depth and Scalar Location in Bilateral Cochlear-Implant Users.

Bilateral cochlear-implant (BI-CI) users will have a range of interaural insertion-depth mismatch because of different array placement or characteristics. Mismatch will be larger for electrodes located near the apex or outside scala tympani, or for arrays that are a mix of precurved and straight types. Brainstem superior olivary-complex neurons are exquisitely sensitive to interaural-difference cues for sound localization. Because these neurons rely on interaurally place-of-stimulation-matched inputs, interaural insertion-depth or scalar-location differences for BI-CI users could cause interaural place-of-stimulation mismatch that impairs binaural abilities. Insertion depths and scalar locations were calculated from temporal-bone computed-tomography scans for 107 BI-CI users (27 Advanced Bionics, 62 Cochlear, 18 MED-EL). Median interaural insertion-depth mismatch was 23.4 degrees or 1.3 mm. Mismatch in the estimated clinically relevant range expected to impair binaural processing (>75 degrees or 3 mm) occurred for 13 to 19% of electrode pairs overall, and for at least three electrode pairs for 23 to 37% of subjects. There was a significant three-way interaction between insertion depth, scalar location, and array type. Interaural insertion-depth mismatch was largest for apical electrodes, for electrode pairs in two different scala, and for arrays that were both-precurved. Average BI-CI interaural insertion-depth mismatch was small; however, large interaural insertion-depth mismatch-with the potential to degrade spatial hearing-occurred frequently enough to warrant attention. For new BICI users, improved surgical techniques to avoid interaural insertion-depth and scalar mismatch are recommended. For existing BI-CI users with interaural insertion-depth mismatch, interaural alignment of clinical frequency tables might reduce negative spatial-hearing consequences.

Validity and Reliability of theArabicVersion of Children’s Auditory Performance Scale

Background and Aim: Central auditory processing disorder (CAPD) is seen in a wide array of populations, including children and adults. CAPD is characterized by deficits in one or more auditory abilities, causes difficulties in auditory discrimination, temporal and binaural processing although hearing thresholds are in the normal range. Children’s auditory performance scale (CHAPS) is a screening instrument. This study examined the reliability and validity of the Arabic version of children’s auditory performance scale.&#x0D; Methods: In this cross-sectional study, 50 healthy children were included. The children’s ages ranged from seven to nine years, and they passed the screening test using distortion product otoacoustic emissions before administering the scale in the translation process, the back- translation method was used, in addition to the face validity procedure. Teachers fulfilled the questionnaire in the presence of an audiologist. After two weeks, the scale was re-administrated, and then the statistical analysis was done to examine the reliability and validity of Arabic version of CHAPS (CHAPS-AR).&#x0D; Results: The internal consistency was examined with Cronbach’s α (α=0.997), for test- retest reliability, Pearson›s (r) was examined (r=0.994) and when executing the face validity, five experts agreed that the CHAPS-AR has a clear structure, syntax and it is easy to understand and use.&#x0D; Conclusion: The Arabic version of CHAPS can be considered a reliable and valid screening instrument for clinical and research use&#x0D; &#x0D; Keywords: Central auditory processing disorder; screening; children; auditory; Arabic; validity

New Multi-Center Clinical Trial to Address Cochlear Implantation of Children with Asymmetric Hearing Loss or Single-Sided Deafness

New Multi-Center Clinical Trial to Address Cochlear Implantation of Children with Asymmetric Hearing Loss or Single-Sided Deafness

The electrophysiological masking level difference: effects of age and mediation of hearing and cognition

Objective Evaluate the conceptual framework that age effects on the electrophysiological binaural masking level difference (MLD) are partially mediated by age-related hearing loss and/or global cognitive function via mediation analysis. Design Participants underwent a series of audiometric tests. The MLD was measured via cortical auditory evoked potentials using a speech stimulus (/ɑ/) in speech-weighted background noise. We used mediation analyses to determine the total effect, natural direct effects, and natural indirect effects, which are displayed as regression coefficients ([95% CI]; p value). Study sample Twenty-eight individuals aged 19–87 years (mean [SD]: 53.3 [25.2]), recruited from the community. Results Older age had a significant total effect on the MLD (-0.69 [95% CI: −0.96, −0.45]; p < 0.01). Neither pure tone average (-0.11 [95% CI: −0.43, 0.24; p = 0.54] nor global cognitive function (-0.02 [95% CI: −0.13, 0.02]; p = 0.55) mediated the relationship of age and the MLD and effect sizes were small. Results were insensitive to use of alternative hearing measures or inclusion of interaction terms. Conclusions The electrophysiological MLD may be an age-sensitive measure of binaural temporal processing that is minimally affected by age-related hearing loss and global cognitive function.

Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing.

The inferior colliculus (IC) is a critical centre for the binaural processing of auditory information. However, previous studies have mainly focused on the central nucleus of the inferior colliculus (ICC), and less is known about the dorsal nucleus of the inferior colliculus (ICD). Here, we first examined the characteristics of the neuronal responses in the mouse ICD and compared them with those in the inferior colliculus under binaural and monaural conditions using in vivo loose-patch recordings. ICD neurons exhibited stronger responses to ipsilateral sound stimulation and better binaural summation than those of ICC neurons, which indicated a role for the ICD in binaural hearing integration. According to the abundant interactions between bilateral ICDs detected using retrograde virus tracing, we further studied the effect of unilateral ICD silencing on the contralateral ICD. After lidocaine was applied, the responses of some ICD neurons (13/26), especially those to ipsilateral auditory stimuli, decreased. Using whole-cell recording and optogenetic methods, we investigated the underlying neuronal circuits and synaptic mechanisms of binaural auditory information processing in the ICD. The unilateral ICD provides both excitatory and inhibitory projections to the opposite ICD, and the advantaged excitatory inputs may be responsible for the enhanced ipsilateral responses and binaural summation of ICD neurons. Based on these results, the contralateral ICD might modulate the ipsilateral responses of the neurons and binaural hearing.

Binaural Processing Deficits Due to Synaptopathy and Myelin Defects.

Hidden hearing loss (HHL) is a deficit in auditory perception and speech intelligibility that occurs despite normal audiometric thresholds and results from noise exposure, aging, or myelin defects. While mechanisms causing perceptual deficits in HHL patients are still unknown, results from animal models indicate a role for peripheral auditory neuropathies in HHL. In humans, sound localization is particularly important for comprehending speech, especially in noisy environments, and its disruption may contribute to HHL. In this study, we hypothesized that neuropathies of cochlear spiral ganglion neurons (SGNs) that are observed in animal models of HHL disrupt the activity of neurons in the medial superior olive (MSO), a nucleus in the brainstem responsible for locating low-frequency sound in the horizontal plane using binaural temporal cues, leading to sound localization deficits. To test our hypothesis, we constructed a network model of the auditory processing system that simulates peripheral responses to sound stimuli and propagation of responses via SGNs to cochlear nuclei and MSO populations. To simulate peripheral auditory neuropathies, we used a previously developed biophysical SGN model with myelin defects at SGN heminodes (myelinopathy) and with loss of inner hair cell-SGN synapses (synaptopathy). Model results indicate that myelinopathy and synaptopathy in SGNs give rise to decreased interaural time difference (ITD) sensitivity of MSO cells, suggesting a possible mechanism for perceptual deficits in HHL patients. This model may be useful to understand downstream impacts of SGN-mediated disruptions on auditory processing and to eventually discover possible treatments for various mechanisms of HHL.

Modelling speech reception thresholds and their improvements due to spatial noise reduction algorithms in bimodal cochlear implant users

Spatial noise reduction algorithms (“beamformers”) can considerably improve speech reception thresholds (SRTs) for bimodal cochlear implant (CI) users. The goal of this study was to model SRTs and SRT-benefit due to beamformers for bimodal CI users. Two existing model approaches varying in computational complexity and binaural processing assumption were compared: (i) the framework of auditory discrimination experiments (FADE) and (ii) the binaural speech intelligibility model (BSIM), both with CI and aided hearing-impaired front-ends. The exact same acoustic scenarios, and open-access beamformers as in the comparison clinical study Zedan et al. (2021) were used to quantify goodness of prediction. FADE was capable of modeling SRTs ab-initio, i.e., no calibration of the model was necessary to achieve high correlations and low root-mean square errors (RMSE) to both, measured SRTs (r = 0.85, RMSE = 2.8 dB) and to measured SRT-benefits (r = 0.96). BSIM achieved somewhat poorer predictions to both, measured SRTs (r = 0.78, RMSE = 6.7 dB) and to measured SRT-benefits (r = 0.91) and needs to be calibrated for matching average SRTs in one condition. Greatest deviations in predictions of BSIM were observed in diffuse multi-talker babble noise, which were not found with FADE. SRT-benefit predictions of both models were similar to instrumental signal-to-noise ratio (iSNR) improvements due to the beamformers. This indicates that FADE is preferrable for modeling absolute SRTs. However, for prediction of SRT-benefit due to spatial noise reduction algorithms in bimodal CI users, the average iSNR is a much simpler approach with similar performance.

Aging effects on binaural listening and other auditory system assessments

Older listeners are known to have decreased sound localization and hearing in noise abilities compared to young listeners, even when exhibiting clinically normal hearing. We hypothesize that these deficits may be related to decreased temporal precision of neural activity in the sound localization processing pathway, and/or other central auditory system deficits involving more complex functions such as speech recognition. Presented here are preliminary results from a study underway on the impact of aging on auditory functioning, and in particular, binaural processing. Subjects range from 21 to 89 years of age, have normal or near normal-hearing sensitivity, and are being evaluated on assessments of auditory system integrity and behavioral performance. Primary outcome measures include speech understanding in noise, auditory brainstem responses (ABRs) and the calculated ABR binaural interaction component, behavioral measures of spatial acuity, and a subjective questionnaire of hearing handicap. Secondary measures include temporal fine structure and spectro-temporal modulation sensitivity tests, otoacoustic emissions, and electrocochleography. In addition, extended-high-frequency hearing thresholds are measured and working memory assessed. Early results show an aging effect across decades of life on several of these measures. Greatest aging effects are seen in the more adverse listening conditions from behavioral testing. [Support: R01-DC017924.]

Large group differences in binaural sensitivity are represented in preattentive responses from auditory cortex.

Correlated sounds presented to two ears are perceived as compact and centrally lateralized, whereas decorrelation between ears leads to intracranial image widening. Though most listeners have fine resolution for perceptual changes in interaural correlation (IAC), some investigators have reported large variability in IAC thresholds, and some normal-hearing listeners even exhibit seemingly debilitating IAC thresholds. It is unknown whether or not this variability across individuals and outlier manifestations are a product of task difficulty, poor training, or a neural deficit in the binaural auditory system. The purpose of this study was first to identify listeners with normal and abnormal IAC resolution, second to evaluate the neural responses elicited by IAC changes, and third to use a well-established model of binaural processing to determine a potential explanation for observed individual variability. Nineteen subjects were enrolled in the study, eight of whom were identified as poor performers in the IAC-threshold task. Global scalp responses (N1 and P2 amplitudes of an auditory change complex) in the individuals with poor IAC behavioral thresholds were significantly smaller than for listeners with better IAC resolution. Source-localized evoked responses confirmed this group effect in multiple subdivisions of the auditory cortex, including Heschl's gyrus, planum temporale, and the temporal sulcus. In combination with binaural modeling results, this study provides objective electrophysiological evidence of a binaural processing deficit linked to internal noise, that corresponds to very poor IAC thresholds in listeners that otherwise have normal audiometric profiles and lack spatial hearing complaints.NEW & NOTEWORTHY Group differences in the perception of interaural correlation (IAC) were observed in human adults with normal audiometric sensitivity. These differences were reflected in cortical-evoked activity measured via electroencephalography (EEG). For some participants, weak representation of the binaural cue at the cortical level in preattentive N1-P2 cortical responses may be indicative of a potential processing deficit. Such a deficit may be related to a poorly understood condition known as hidden hearing loss.

Field assessment of acute auditory responses to environmental exposures in close quarters tactics training

Objective The purpose of this study was to evaluate auditory performance of military instructors as part of a training course involving noise and blast exposure. Boothless audiometry was used to estimate the test-retest reliability of the auditory measures under realistic field conditions and to determine risk of acute auditory injury during standard training practices. Design and study sample Thirteen U.S. Marine instructors participated in study activities. An audiologic testing suite embedded in a noise-attenuating headset was used to test various tone detection tasks on subjects after exposure. Acoustic exposures were captured with sound level meters. Results Boothless audiometry provide highly repeatable results for various tests of auditory performance in the field environment. In this test population, changes in auditory performance pre- and post-noise exposure were minimal for most measures. The notable exception was binaural (NoSπ) tone detection, which showed significant degradations both as a function of pre- and post-noise exposure on the same day and as a result of cumulative noise exposure over the period of the study. Conclusions Study outcomes are consistent with prior laboratory and epidemiological work and suggest a link between the binaural processes required for NoSπ detection and the hearing-related issues reported by blast-exposed service members.

Towards a simplified and generalized monaural and binaural auditory model for psychoacoustics and speech intelligibility

Auditory perception involves cues in the monaural auditory pathways, as well as binaural cues based on interaural differences. So far, auditory models have often focused on either monaural or binaural experiments in isolation. Although binaural models typically build upon stages of (existing) monaural models, only a few attempts have been made to extend a monaural model by a binaural stage using a unified decision stage for monaural and binaural cues. A typical prototype of binaural processing has been the classical equalization-cancelation mechanism, which either involves signal-adaptive delays and provides a single channel output, or can be implemented with tapped delays providing a high-dimensional multichannel output. This contribution extends the (monaural) generalized envelope power spectrum model by a non-adaptive binaural stage with only a few, fixed output channels. The binaural stage resembles features of physiologically motivated hemispheric binaural processing, as simplified signal-processing stages, yielding a 5-channel monaural and binaural matrix feature “decoder” (BMFD). The back end of the existing monaural model is applied to the BMFD output and calculates short-time envelope power and power features. The resulting model accounts for several published psychoacoustic and speech-intelligibility experiments and achieves a prediction performance comparable to existing state-of-the-art models with more complex binaural processing.

Using a blind EC mechanism for modelling the interaction between binaural and temporal speech processing

We reanalyzed a study that investigated binaural and temporal integration of speech reflections with different amplitudes, delays, and interaural phase differences. We used a blind binaural speech intelligibility model (bBSIM), applying an equalization-cancellation process for modeling binaural release from masking. bBSIM is blind, as it requires only the mixed binaural speech and noise signals and no auxiliary information about the listening conditions. bBSIM was combined with two non-blind back-ends: The speech intelligibility index (SII) and the speech transmission index (STI) resulting in hybrid-models. Furthermore, bBSIM was combined with the non-intrusive short-time objective intelligibility (NI-STOI) resulting in a fully blind model. The fully non-blind reference model used in the previous study achieved the best prediction accuracy (R2 = 0.91 and RMSE = 1 dB). The fully blind model yielded a coefficient of determination (R2 = 0.87) similar to that of the reference model but also the highest root mean square error of the models tested in this study (RMSE = 4.4 dB). By adjusting the binaural processing errors of bBSIM as done in the reference model, the RMSE could be decreased to 1.9 dB. Furthermore, in this study, the dynamic range of the SII had to be adjusted to predict the low SRTs of the speech material used.

Cortical Processing of Binaural Cues as Shown by EEG Responses to Random-Chord Stereograms

Spatial hearing facilitates the perceptual organization of complex soundscapes into accurate mental representations of sound sources in the environment. Yet, the role of binaural cues in auditory scene analysis (ASA) has received relatively little attention in recent neuroscientific studies employing novel, spectro-temporally complex stimuli. This may be because a stimulation paradigm that provides binaurally derived grouping cues of sufficient spectro-temporal complexity has not yet been established for neuroscientific ASA experiments. Random-chord stereograms (RCS) are a class of auditory stimuli that exploit spectro-temporal variations in the interaural envelope correlation of noise-like sounds with interaurally coherent fine structure; they evoke salient auditory percepts that emerge only under binaural listening. Here, our aim was to assess the usability of the RCS paradigm for indexing binaural processing in the human brain. To this end, we recorded EEG responses to RCS stimuli from 12 normal-hearing subjects. The stimuli consisted of an initial 3-s noise segment with interaurally uncorrelated envelopes, followed by another 3-s segment, where envelope correlation was modulated periodically according to the RCS paradigm. Modulations were applied either across the entire stimulus bandwidth (wideband stimuli) or in temporally shifting frequency bands (ripple stimulus). Event-related potentials and inter-trial phase coherence analyses of the EEG responses showed that the introduction of the 3- or 5-Hz wideband modulations produced a prominent change-onset complex and ongoing synchronized responses to the RCS modulations. In contrast, the ripple stimulus elicited a change-onset response but no response to ongoing RCS modulation. Frequency-domain analyses revealed increased spectral power at the fundamental frequency and the first harmonic of wideband RCS modulations. RCS stimulation yields robust EEG measures of binaurally driven auditory reorganization and has potential to provide a flexible stimulation paradigm suitable for isolating binaural effects in ASA experiments.

Monaural and binaural phase sensitivity in school-age children with early-childhood otitis media

Objective Previous research has linked recurrent otitis media (OM) during early childhood to reduced binaural masking level differences (BMLDs) in school-age children. How this finding relates to monaural processing abilities and the individual otologic history has not been investigated systematically. The current study, therefore, addressed these issues. Design Sensitivity to monaural and binaural phase information was assessed using a common test paradigm. To evaluate the influence of the otologic history, overall OM duration, OM onset age, and the time since the last OM episode were considered in the analyses. Study sample Children aged 6–13 years with a history of recurrent OM (N = 42) or without any previous ear diseases (N = 20). Results Compared to the controls, the OM children showed smaller BMLDs (p < 0.05) whereas their monaural and binaural detection thresholds were comparable (p > 0.05). After controlling for age, the otologic history factors failed to predict the BMLDs of the OM children. Their monaural detection thresholds were correlated with the binaural detection thresholds (r = ∼0.5, p < 0.05) but not the BMLDs. Conclusions The current study suggests that early-childhood OM can impair binaural processing abilities in school-age children.

Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex.

Binaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural processing of AI neurons is affected by reversible unilateral conductive hearing loss (RUCHL), are not fully elucidated. Here, we determined the binaural processing of AI neurons in four groups of rats: postnatal day (P) 14–18 rats, P19–30 rats, P57–70 adult rats, and RUCHL rats (P57–70) with RUCHL during P14–30. We recorded the responses of AI neurons to both monaural and binaural stimuli with variations in interaural level differences (ILDs) and average binaural levels. We found that the monaural response types, the binaural interaction types, and the distributions of the best ILDs of AI neurons in P14–18 rats are already adult-like. However, after hearing onset, there exist developmental refinements in the binaural processing of AI neurons, which are exhibited by the increase in the degree of binaural interaction, and the increase in the sensitivity and selectivity to ILDs. RUCHL during early hearing development affects monaural response types, decreases the degree of binaural interactions, and decreases both the selectivity and sensitivity to ILDs of AI neurons in adulthood. These new evidences help us to understand the refinements and plasticity in the binaural processing of AI neurons during hearing development, and might enhance our understanding in the neuronal mechanism of developmental changes in auditory spatial perception.