Upping the anti: Asymmetric anti-selective hydrogenation of α-amino-β-keto esters through dynamic kinetic resolution has been achieved for the first time by using the Ru–binap catalyst. The reaction affords important anti-β-hydroxy-α-amino acids with 74–98 % ee and high diastereomeric ratio in excellent yields (see scheme; binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl).