It has become increasingly prevalent in the foot and ankle surgical literature to evaluate outcomes and trends obtained from large databases. The objective of this investigation was to provide a broad descriptive analysis and compare basic demographic characteristics relating to foot and ankle surgery within the American College of Surgeons National Surgical Quality Improvement Program database. The 16 Current Procedural Terminology® (CPT) codes available within this database pertaining to foot and ankle surgery were studied. Several CPT codes were observed to be more frequently associated with male gender: 27650 (Achilles tendon repair), 27698 (Lateral ankle reconstruction), 27702 (Total ankle arthroplasty), 27766 (ORIF medial malleolus fracture), 27792 (ORIF lateral malleolus fracture), and 28805 (Metatarsal amputation). Several other CPT codes were observed to be more frequently associated with female gender: 27658 (Primary peroneal tendon repair), 27814 (ORIF bimalleolar fracture), 27822 (ORIF trimalleolar ankle fracture without posterior lip fracture), and 27823 (ORIF trimalleolar ankle fracture with posterior lip fracture). The elective case designation was observed to be more frequently associated with male gender (65.4 vs 58.7%; p < .001). These data have potential use in the development and interpretation of quality improvement/performance improvement protocols at individual health care delivery centers, as well as the interpretation of other published investigations utilizing this database.