<h3>Purpose/Objective(s)</h3> The prognostic value of total disease burden FDG-PET metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in cervical cancer has previously been demonstrated. These parameters in the independent analysis of primary cervical tumor (PT), pelvic nodal disease (PND), and para-aortic nodal disease (PAND) sub-volumes are not known. We evaluated PET characteristics of these sub-volumes as a potential predictor of patient outcomes. <h3>Materials/Methods</h3> This retrospective study included cervical cancer patients who received definitive chemoradiation (CRT). Lesions in pre- and post-treatment FDG-PET scans were segmented with a fixed SUVmax threshold of 2.5 to calculate MTV and TLG for PT, PND, and PAND sub-volumes. SUV, MTV, and TLG were treated as continuous variables for analysis. <h3>Results</h3> Between 2015-2021, 100 patients treated with definitive CRT had PET scans available for analysis. Median age was 50 years and 72% had squamous cell carcinomas. 33% had localized disease (FIGO I, II), 15% were locally advanced (IIIA, IIIB, IVA), and 52% had lymph node positive disease (IIIC1, IIIC2). Most (85%) received 4 or more cycles of weekly concurrent chemotherapy. One- and five-year OS were 89.5% and 70.2%, respectively. Age, histology, HPV status, grade, stage, and receipt of chemotherapy were not associated with DFS. Bilateral parametrial involvement was statistically significant for DFS (HR 3.1, p = 0.01). On pre-treatment PET, the SUVmax of the PT, PND, and PAND was not significant predictors for DFS. Higher PT TLG and MTV were associated with poorer DFS (p = 0.007 and <0.001, respectively). Higher PND MTV was associated with poorer DFS (p = 0.022) but TLG did not reach significance (p = 0.058). Higher PAND TLG and MTV were not associated with DFS. Characteristics associated with worse OS included age >50 years, negative HPV status, stage, bilateral parametrial involvement, radiation treatment time >49 days, and lack of concurrent chemotherapy (all p < 0.05). Pre-treatment SUVmax of the PT, PND, and PAND were not significant predictors for OS. Higher PT TLG and MTV were associated with poorer OS (p = 0.023 and <0.01, respectively). Higher PND MTV was associated with poorer OS (p = 0.047) but not TLG (p = 0.129). Higher PAND TLG and MTV were not associated with OS. Among 28 pts with recurrence, 82% had distant metastases, 7% had out-of-field nodal relapse, and 11% relapsed within the radiation field. The percent change in pre- to post-treatment PT SUVmax was associated with development of distant metastases (p = 0.034). Percent change of TLG or MTV were not predictive of recurrence. <h3>Conclusion</h3> Pre-treatment FDG-PET PT TLG and MTV and PND MTV were predictive of DFS and OS in patients undergoing CRT for cervical cancer. Percent change in pre- to post-treatment PT SUVmax was predictive of distant metastases. Further study is needed to characterize the utility of these variables in informing treatment paradigms for cervical cancer.