Bilateral Ovarian Tumors Research Articles

Endocrine and morphological study of a case of ovarian sex-cord tumor with annular tubules in a woman with Peutz-Jeghers syndrome

A bilateral ovarian sex-cord tumor with annular tubules (SCTAT) was incidentally discovered in an amenorrheic patient with Peutz-Jeghers syndrome during conservative surgery in which a small non-capsulated mass was removed from each ovary. Ovulation was then induced over two consecutive cycles with urinary gonadotropins; the couple did not conceive because of a male infertility factor. Hysterectomy and bilateral oophorectomy were performed to prevent recurrence and avoid the possibility of a cervical malignant adenoma. Immunohistochemistry of the SCTAT showed positivity for estradiol and testosterone similar to that of Sertoli and granulosa cell tumors; progesterone was not detected in any cellular component of the neoplasia. Electron microscopy showed that the neoplasm consisted of numerous solid cords of cells surrounded by fibrillary layers of basal lamina, as well as central hyaline bodies. Two types of cells, clear and dark, were noted; clear cells were predominant and intermixed with scattered dark cells. No crystalloids or Charchot-Bottcher filaments were detectable in the tumors.

Malignant lymphoma presenting as an ovarian tumour: a clinicopathological analysis of 34 cases.

The clinicopathological features of 34 patients with malignant lymphoma or leukaemia where the initial presentation was as an ovarian tumour are described. Nineteen patients died, usually within 1 year of diagnosis, whilst 15 survived, some for long periods. Factors indicating a poor prognosis were rapid onset of abdominal symptoms, the presence of systemic symptoms, bilateral ovarian tumours, advanced stage and a histological pattern other than that of a B-cell lymphoma. For staging purposes the Ann Arbor method appeared a more sensitive prognostic indicator than did the FIGO staging system. It is suggested that primary malignant lymphomas of the ovary are extremely rare and that for therapeutic purposes all lymphomas of the ovary should be regarded as local manifestations of systemic disease.

Bilateral ovarian involvement as the only manifestation of malignant lymphoma

A 16-year-old girl presented with a large pelvic mass. At laparotomy, bilateral ovarian tumors were disclosed and bilateral salpingo-oophorectomy was performed. No evidence of extra-ovarian disease was found. Histopathological examination and histochemical immunoperoxidase studies demonstrated the tumors to be malignant lymphoma of the lymphoblastic type. The patient had radiotherapy and systemic chemotherapy and more than 10 years later she is alive with no evidence of recurrent disease. The rarity of ovarian involvement as the initial manifestation of malignant lymphoma is discussed. The question of whether this patient represents a case of a primary ovarian malignant lymphoma or merely represents a case of ovarian initial manifestation of an occult generalized disease cannot be answered.

Female genital tract tumors in Peutz-Jeghers syndrome

Multiple genital tract tumors, including bilateral ovarian sex cord tumors with annular tubules, adenoma malignum of the cervix, and bilateral ovarian mucinous tumors, developed in a female patient with Peutz-Jeghers syndrome. Although each of these tumor types has been reported to occur in this syndrome, the present case appears to be the first in which the syndrome was complicated by tumors of all three types.

Carcinoma of the colon presenting as bilateral ovarian tumors during pregnancy

A case of adenocarcinoma of the descending colon during pregnancy is reported. The patient presented with bilateral large ovarian tumors in pregnancy, and surgery was performed for a presumed ovarian cancer. Only a small, 1 × 1-cm primary focus of adenocarcinoma was found in the resected descending colon. The association of pregnancy and colon cancer above the peritoneal reflection is rare, and only 20 such patients have previously been reported.

Bilateral Sertoli-Leydig cell tumor with heterologous elements: Report of an unusual case and review of the literature

A case of bilateral ovarian Sertoli-Leydig cell tumor with heterologous elements is reported in an 18-yr-old girl with marked virilization. Panhysterectomy was performed, yet the tumor recurred shortly after the intervention. The microscopic picture was one of intermediate to poor differentiation. Despite chemotherapy, the postoperative course was rapidly malignant, and the patient died 4 wk later.

Clinical and pathologic evaluation of 342 benign ovarian tumors

A series of 289 patients who were diagnosed with 342 benign ovarian tumors (BOT) at laparotomy have been reviewed. Mean age was 36.7 years (S.D. ± 13.9), mean parity was 1.5 (S.D. ± 1.6); 236 (81.7%) patients had a single unilateral ovarian tumor; 29 (10%) patients had bilateral ovarian tumors. Benign cyst teratoma was diagnosed in 89 (26%) tumors, and it was the most frequent histological type. In eight patients (2.8%) the post-operative pathologic report was compatible with malignancy, despite the lack of suspicion at laparotomy. Mean maximal diameter of BOT was 9.1 cm, and almost 60% of the mucinous cystoadenomas were larger than 16 cm. Benign cyst teratoma and serous cytoadenoma had a medium size, about 6–10 cm. Lower abdominal-pelvic pain was the symptom most frequently reported by patients with BOT. Calcifications were most frequently seen in benign cyst teratoma. Tumors of 11–15 cm in size were the tumors most frequently torsioned. Twenty four (8.3%) patients had their surgical operation done during pregnancy; benign cyst teratoma was the tumor most frequently associated with pregnancy.

Peutz-Jeghers syndrome with “adenoma malignum” of the cervix: A report of two cases

Two cases of the Peutz-Jeghers syndrome associated with cervical adenocarcinoma of the “adenoma malignum” type are reported with a review of four similar cases, three of which have been reported elsewhere. One of our two patients also had bilateral ovarian sex cord tumors with annular tubules and the other had bilateral ovarian mucinous cystadenomas of borderline malignancy. The relatively frequent occurrence of “adenoma malignum” of the cervix, an otherwise rare form of cervical cancer, in women with the Peutz-Jeghers syndrome, warrants close supervision of these patients by a gynecologist to assure early detection and treatment of this highly malignant tumor.

Malignant lymphoma involving the ovaries

From a review of the literature pertaining to ovarian malignant lymphoma, 4 cases of so-called primary and 24 cases of obviously secondary or “metastatic” disease are cited. In addition, 6 personally studied cases are presented in which clinical features pointed to ovarian participation in a more generalized lymphoblastomatous process.The grim prognosis associated with unilateral or bilateral ovarian tumors of this type, regardless of size, raises questions regarding the validity of the notion that malignant lymphoma is ever a primary process in these organs.

FERTILITY AND DYSGERMINOMA OVARII

PREGNANCIES have occurred in the presence of or after the removal of dysgerminomata. The harborers of these rare ovarian tumors, which are usually on the right side, are not necessarily sterile. These patients may be grouped into those with normal pelvic organs and secondary sex characteristics; and those who have coincidentally undeveloped genitalia or pseudohermaphroditism. All of the pregnancies reviewed have been in the former group. The incidence is 1 in 43,822 deliveries at the Woman's Clinic of the New York Hospital. Most unusual are some of the circumstances in which the pregnancies have occurred. Lorber (1) reported a patient whose tumor was diagnosed in the third month of gestation. A corpus luteum of pregnancy was found in the capsule of the tumor. Cunningham (2) delivered a healthy infant by cesarean section from a patient with large, bilateral ovarian tumors and widespread metastases. This patient succumbed fourteen months later. Von Szathmary (3) reported a case with a fist-sized cold absces...

FERTILITY AND DYSGERMINOMA OVARII

PREGNANCIES have occurred in the presence of or after the removal of dysgerminomata. The harborers of these rare ovarian tumors, which are usually on the right side, are not necessarily sterile. These patients may be grouped into those with normal pelvic organs and secondary sex characteristics; and those who have coincidentally undeveloped genitalia or pseudohermaphroditism. All of the pregnancies reviewed have been in the former group. The incidence is 1 in 43,822 deliveries at the Woman's Clinic of the New York Hospital. Most unusual are some of the circumstances in which the pregnancies have occurred. Lorber (1) reported a patient whose tumor was diagnosed in the third month of gestation. A corpus luteum of pregnancy was found in the capsule of the tumor. Cunningham (2) delivered a healthy infant by cesarean section from a patient with large, bilateral ovarian tumors and widespread metastases. This patient succumbed fourteen months later. Von Szathmary (3) reported a case with a fist-sized cold absces...

An Observation of Primary Tumors of the Pituitary, Ovaries, and Mammary Glands in a Mouse

Though mammary tumors frequently occur in certain strains of mice, the incidence of primary tumors of other organs is much lower. One reference has been found in the literature to a pituitary tumor in a mouse. Slye, Holmes, and Wells (1931) have reported a pituitary tumor observed in one animal among more than 11,000 examined at autopsy. In this instance a small tumor was observed in a fixed specimen. The incidence of ovarian tumors in mice also appears to be quite low. Slye (1916) reports observing 18 in 11,000 autopsied mice. The writers know of no reports of evidence of physiological activity of ovarian tumors in mice. Simple follicular cysts, usually associated with atrophic genital organs, have occasionally been observed in the ovaries of old mice of our colony. The bilateral ovarian tumors to be reported here were apparently actively secreting female sex hormone. Numerous recent experiments with hormones which induce specific growth-stimulating reactions have been attempted to associate hormonal factors with atypical growths or tumors. In view of this the present observation of primary tumors of three glands in one animal, two endocrine and one exocrine, as functionally associated as the pituitary, ovary, and mammary glands, merits recording.

Report of a case of bilateral ovarian tumors of the brenner type

Report of a case of bilateral ovarian tumors of the brenner type

Bilateral Ovarian Dermoid Tumours, One of Which Obstructed Labour on Two Occasions

Bilateral Ovarian Dermoid Tumours, One of Which Obstructed Labour on Two Occasions