Bilateral Internal Thoracic Artery Harvesting Research Articles

Subcostal bilateral internal thoracic artery harvesting with the da Vinci Single Port system: an experimental feasibility study.

We evaluated the feasibility of harvesting bilateral internal thoracic arteries with the da Vinci Single Port system (SP)through a single left-sided subcostal incision. Complete bilateral mobilization with sufficiently long conduits for multivessel grafting was possible in 2 human cadavers and 2 live porcine. Creating the subcostal access and docking the SP system took between 14 and 21 min and the total harvest time ranged from 65 to 125 min in all models. No major bleeding was observed in the live porcine and hemostasis was managed with the available instrumentation. One porcine deceased during surgery due to ventricular fibrillation followed by cardiac arrest. The robotic harvesting was technically easily reproduced by the surgeons and required no additional rib-spreading. Further studies will be required to assess if this subcostal approach with the da Vinci SP system yields true clinical benefits in patients.

Robot-Assisted MIDCAB Using Bilateral Internal Thoracic Artery: A Propensity Score-Matched Study With OPCAB Patients.

Robot-assisted minimally invasive direct coronary artery bypass (RA-MIDCAB) is an attractive strategy for coronary revascularization. Growing evidence supports the use of total arterial grafting in coronary surgery. We evaluated total arterial left-sided coronary revascularization with bilateral internal thoracic artery (BITA) using RA-MIDCAB and compared it with a propensity score-matched (PSM) off-pump CAB (OPCAB) surgery population. We retrospectively included all isolated OPCAB and RA-MIDCAB surgery using BITA without saphenous vein graft from January 1, 2015, to October 31, 2022. We analyzed all our RA-MIDCAB patients and performed PSM to compare them with our OPCAB population. Primary outcomes were major adverse cardiovascular and cerebrovascular events (MACCE) and mortality. Secondary outcomes were surgical parameters, length of hospital stay, and learning curve. We included 601 OPCAB and 77 RA-MIDCAB procedures, which resulted in 2 cohorts of 54 patients after PSM. Mortality and MACCE survival analysis showed no significant difference. There was less blood transfusion in the RA-MIDCAB (16.7%) compared with the OPCAB group (38.9%; P = 0.02). We observed fewer intensive care unit (ICU) admissions (24.1% vs 96.6%), shorter ICU stay (0.78 ± 1.7 vs 1.91 ± 1.01 days), and shorter hospital stay (6.78 ± 2.4 vs 8.01 ± 2.5 days) in the RA-MIDCAB versus OPCAB group (P < 0.01). Surgery time decreased from 400.0 ± 70.8 to 325.0 ± 38.0 min with more experience in RA-MIDCAB BITA harvesting (P < 0.01). This is a first publication of 77 consecutive RA-MIDCAB BITA harvesting for left coronary artery system revascularization. This technique is safe in terms of MACCE and mortality. Additional advantages are shorter length of hospital stay, fewer ICU admissions, and less blood transfusion.

Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply.

There is controversy regarding which internal thoracic artery (ITA) should be anastomosed to the left anterior descending artery (LAD). Here, we propose an optimal graft design based on measurement of blood flow in the ITA. Sixty-one patients (53 men, median age 68 [62-75] years) undergoing first elective coronary artery bypass grafting were enrolled. Fifty-seven left ITAs (LITAs) and 28 right ITAs (RITAs) were harvested in either a semi-skeletonized manner using a harmonic scalpel covered with papaverine-soaked gauze (group-A, n = 45) or a fully skeletonized manner using electrocautery with intraluminal papaverine injection (group-B, n = 41). Free flow of 33 ITAs was measured after pharmacological dilatation and in situ ITA-LAD flow was measured in 59 patients by transit-time flowmetry. RITA and LITA free flow were 147.0 [87.8-213.0] mL/min and 108.0 [90.0-144.0] mL/min, respectively (P = 0.199). The group-B had significantly higher ITA free flow (135.0 [102.0-171.0] mL/min) than group-A (63.0 [36.0-96.0] mL/min, P = 0.009). In 13 patients with bilateral ITA harvesting, free flow of the RITA (138.0 [79.5-204.0] mL/min) was also significantly higher than the LITA (102.0 [81.0-138.0] mL/min, P = 0.046). There was no significant difference between RITA and LITA flow anastomosed to the LAD. The group-B had significantly higher ITA-LAD flow (56.5 [32.3-73.6] mL/min) than group-A (40.9 [20.1-53.7] mL/min, P = 0.023). RITA provides significantly higher free flow than LITA but similar blood flow to the LAD. Full skeletonization with intraluminal papaverine injection maximizes both free flow and ITA-LAD flow.

First-in-Human µCAB™ Coronary Revascularization Surgery.

Less invasive coronary artery bypass grafting surgery is underused despite more than 25 years of interest from surgeons and growing patient demands for less pain and rapid full recovery. New approaches may offer surgeons additional options to provide enhanced clinical results through reliable subxiphoid bilateral internal thoracic artery harvesting and the creation of durable anastomoses through very small thoracotomy incisions. This first-in-human case report describes 2 patients who received surgical coronary revascularization using the µCAB™ technology and techniques. The encouraging early results indicate that the µCAB™ approach may offer a new ergonomic, affordable method for coronary revascularization with less surgical trauma.

Chest wall infarction following bilateral internal thoracic harvesting for coronary revascularization in a patient with previous aortic abdominal aneurysm surgery: A rare complication

A 75 years old man with previous aortic abdominal aneurysm surgery through a transverse laparotomy underwent bilateral internal thoracic artery to coronary artery bypass grafting. He immediately thereafter developed a severe chest and upper abdominal walls ischemia with metabolic acidosis, and finally deep sternum wound infection and upper abdominal wall necrosis. He benefitted from sternal reconstruction and vaccum assisted treatment, with delayed pectus major flap reconstruction. Chest and abdominal wall infarction following bilateral internal thoracic artery (BITA) harvesting is a very rare but life-threatening complication. Caution use of BIMA should be in order in patients with inferior epigastric artery flow impairment.

A Novel Subxiphoid Approach for Bilateral Internal Thoracic Artery Harvesting.

Bilateral internal thoracic artery (BITA) bypass can enable more complete arterial revascularization procedures. Minimally invasive cardiac surgery (MICS) can offer significant patient benefits. New minimally invasive technology for sternal retraction and tissue manipulation is needed to enable ergonomic and reliable minimally invasive ITA harvesting. The goal of this research was to develop technology and techniques, along with experimental testing and training models, for a sternal-sparing approach to in situ BITA harvesting through a small subxiphoid access site. This study focused on optimizing custom equipment and methods for subxiphoid BITA harvesting initially in a porcine model (19 pig carcasses, 36 ITAs) and subsequently in 7 cadavers (14 ITAs). Fifty consecutive ITAs were successfully harvested using this remote access approach. The last 20 ITA specimens harvested from the porcine model were explanted and measured; the average length of the free ITA grafts was 12.8 ± 0.9 cm (range 10.8 to 14.2 cm) with a mean time of 23.3 ± 5.2 minutes (range 13 to 25 minutes) for each harvest. Early results demonstrate that both ITAs can be reliably harvested in a skeletonized fashion in situ through sternal-sparing, small subxiphoid access in 2 experimental models. This innovative approach warrants further exploration toward facilitating complete arterial revascularization and the further adoption of minimally invasive coronary artery bypass graft surgery.

Coronary Artery Bypass Grafting with Arterial Conduits in the Elderly.

Although improved long-term outcomes obtained with the use of arterial grafts for coronary revascularization in comparison with the traditional association of a single arterial and saphenous vein grafts have been demonstrated in the overall population, the efficacy of this newer technique in the elderly is difficult to prove because their shorter life expectancy due to advanced heart disease, associated with severe comorbidities. Moreover, more widespread use of this technique is limited by the concerns on the potential morbidity, particularly the longer time required to perform the operation and the possibility of deep sternal wound infection in case of bilateral internal thoracic artery harvesting due to the decreased blood supply to the sternum and surrounding tissues.The review of the recent literature indicates that the use of bilateral internal thoracic arteries in very elderly patients should not be considered routinely. It seems reasonable to avoid it in octogenarians in the presence of well-known predictors of sternal complications such as diabetes, morbid obesity, and severe chronic lung disease.There is also still controversy about the superiority of the radial artery over the saphenous vein graft as a second or third conduit for surgical myocardial revascularization, although the majority of recent studies seem to support more liberal use of the radial artery as second arterial conduit in the elderly. Although a clinical benefit of arterial graft revascularization cannot be formally excluded for elderly patients, the increased complexity of this technique suggests that careful clinical judgment is necessary to select grafts for individual patients.

Assessment of the Impact of Skeletonization on Pleuropulmonary Changes after Bilateral Internal Thoracic Artery Harvest for Coronary Artery Bypass Grafting.

Skeletonization has been proposed as a technique to minimize the risk of sternal devascularization during bilateral internal thoracic artery harvest for coronary artery bypass grafting. The impact of this strategy on late radiologic pleuropulmonary changes has not been addressed. Post-operative chest radiographs from patients (n = 253 per group) undergoing bilateral internal thoracic artery harvest using skeletonized and non-skeletonized techniques were reviewed by blinded radiologists. The primary outcome was the incidence of atelectasis and pleural effusion. Multivariable linear regression models were derived to assess the relationship of radiologic pleuropulmonary outcomes to patients and operative variables. Patients in the skeletonized group were older (p < 0.0001), had a lower preoperative hematocrit (p = 0.014), had higher prevalence of peripheral vascular disease (p = 0.001), were of female gender (p = 0.015), underwent off-pump surgery (p < 0.001), had urgent/emergent status (p = 0.024), and had chronic obstructive pulmonary disease (p = 0.019). There was no difference in the incidence of post-operative complications, ventilation time, or intensive care unit stay. There was no difference in the severity of post-operative atelectasis in both groups. More patients in the non-skeletonized group had a grade 2/3 left pleural effusion on the late post-operative chest X-ray (p = 0.007). The independent effect of skeletonization on the development of a late left pleural effusion was significant (odds ratio = 0.558, 95% confidence interval = 0.359-0.866, p = 0.009). Skeletonization results in a decreased incidence of late post-operative left pleural effusion with no difference in early or late atelectasis. Further studies are warranted to assess the mechanism of these pleuropulmonary changes and the impact of other factors such as pleural violation during surgery.

Invited Commentary

The authors of this study [1Rubens F.D. Chen L. Bourke M. Assessment of the association of bilateral internal thoracic artery skeletonization and sternal wound infection after coronary artery bypass grafting.Ann Thorac Surg. 2016; 101: 1677-1683Abstract Full Text Full Text PDF Scopus (25) Google Scholar] have again verified the safety of bilateral internal thoracic arterial (BITA) grafting in patients requiring coronary revascularization. Their sizeable experience involving a large cohort of patients comparing skeletonized pedicle harvesting with traditional pedicle harvesting techniques demonstrated equivalent rates of sternal infections and other related complications. Over time, arterial conduit use has become the standard of care, relegated to hallowed evidence-based acceptance in appropriately selected patients. However, despite the universal acceptance of single arterial grafting, ElBardissi and colleagues [2ElBardissi A.W. Aranki S.F. Sheng S. O’Brien S.M. Greenberg C.C. Gammie J.S. Trends in isolated coronary artery bypass grafting: an analysis of the Society of Thoracic Surgeons adult cardiac surgery database.J Thorac Cardiovasc Surg. 2012; 143: 273-281Abstract Full Text Full Text PDF PubMed Scopus (345) Google Scholar] revealed that only 4% to 12% of surgical revascularization procedures use BITA; clearly, evidence-based practice is rarely translated into routine clinical practice outside of reporting centers. Previous guidelines supporting arterial grafting with BITA conduits were often dependent on the severity of the native vessel disease; these studies often discouraged the use of BITA when the stenosis was not critical (<90%) [3Hillis L.D. Smith P.K. Anderson J.L. et al.American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines2011 ACCF/AHA guideline for coronary artery bypass graft surgery: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.J Thorac Cardiovasc Surg. 2012; 143: 4-34Abstract Full Text Full Text PDF PubMed Scopus (186) Google Scholar]. In regards to sternal complications, Dorman and coworkers [4Dorman M.J. Kurlansky P.A. Traad E.A. Galbut D.L. Zucker M. Ebra G. Bilateral internal mammary artery grafting enhances survival in diabetic patients a 30-year follow-up of propensity score–matched cohorts.Circulation. 2012; 126: 2935-2942Crossref PubMed Scopus (123) Google Scholar] addressed the effects of diabetes in a high-volume center with extensive BITA use. An even earlier large-scale, multicenter randomized arterial revascularization trial (ART) compared revascularization using BITA for the two most important left-sided target arteries with single internal thoracic artery (ITA) coupled with a combination of radial arteries or venous conduits for the remaining graft sites. This study demonstrated equivalent low 30-day (1%) and 1-year (2.5%) mortality rates, as well as similar rates of stroke and myocardial infarction, and the need for repeat revascularization for BITA grafting compared with the more traditional single ITA grafting strategy. Of note in this study was the increased incidence of sternal wound healing complications requiring reconstruction (1.9% versus 0.6%) in BITA patients compared with single ITA use, especially in diabetic patients. Although this randomized trial used a variety of ITA harvesting techniques, the results suggested that skeletonization of the ITA during harvesting may yield fewer sternal complications [5Taggart D.P. Altman D.G. Gray A.M. et al.ART InvestigatorsRandomized trial to compare bilateral vs. single internal mammary coronary artery bypass grafting: 1-year results of the Arterial Revascularisation Trial (ART).Eur Heart J. 2010; 31: 2470-2481Crossref PubMed Scopus (303) Google Scholar]. It is clear that skeletonization affords the surgeon increased arterial conduit length, creating the potential for multiple grafts of the left coronary circulation with a longer left ITA, as well as improving the distal reach of the right coronary arterial target sites with a skeletonized right ITA. Importantly, the known risk factors for suspected increased sternal complications from BITA use (increased body mass index, diabetes, peripheral vascular disease, female sex, and preoperative anemia) are more related to full sternotomy itself, instead of ITA harvesting, and were not significantly different in this report. Bilateral ITA utilization strategies for complex coronary revascularization has clearly demonstrated safety, diminished future interventions, improved graft longevity, and increased patient survival rates. The current report provides further evidence that harvesting techniques matter; hopefully studies like these will prevail over the continued reluctance to commit to more arterial grafting among the cardiac surgery community. The authors are to be congratulated for their excellent results, as well as advancing our understanding of this important topic. Assessment of the Association of Bilateral Internal Thoracic Artery Skeletonization and Sternal Wound Infection After Coronary Artery Bypass GraftingThe Annals of Thoracic SurgeryVol. 101Issue 5PreviewSkeletonization is a technique of bilateral internal thoracic artery (BITA) harvest that preserves sternal blood flow. We sought to identify the relationship of skeletonization and sternal wound infection in a population undergoing BITA harvest. Full-Text PDF

The Effect of Bilateral versus Single Internal Thoracic Artery Harvesting on Superficial and Deep Sternal Wound Infection

Objectives: Many studies have shown that the use of both internal thoracic arteries (BITA) increases long-term survival relative to the use of the single internal thoracic artery (SITA) and saphenous vein grafts (SVG). But on the other side the use of BITA potentially increases the incidence of sternal wound infections.

Clinical Correlation of Early Atelectasis after Bilateral Internal Thoracic Artery Harvest for Coronary Artery Bypass Grafting

Atelectasis is a significant complication after cardiac surgery. The current study was designed to assess the significance of atelectasis after bilateral internal thoracic artery (BITA) harvest. The ICU admission chest x-ray of 565 patients undergoing BITA was reviewed. Linear regression modelling was used to assess the relationship between atelectasis and oxygenation as well as patient variables to length of ventilation and length of stay in the Intensive Care Unit (ICU). Eighty-nine patients (15.8%) had Grade 2/3 atelectasis which was significantly more common on the left as compared to the right (left 0.149 95% CI [0.119-0.178], right 0.027 95% CI [0.013-0.040], p<0.001). Grade 2/3 atelectasis on the right was associated with a significant drop in the pO2 (p=0.001) and the per cent O2-fractional O2 (PF) ratio (p=0.002). Factors associated with increased ventilation time included presence of Grade 2/3 atelectasis (p=0.001) and peripheral vascular disease (PVD) (p<0.001), both of which were predictors of prolonged ICU length of stay (p=0.002 and p<0.001 respectively). Early atelectasis is related to impaired oxygenation, prolonged ventilation and prolonged ICU stay. Future research should focus on strategies to minimise atelectasis and to determine if these changes translate into better patient outcomes.

Risk Factors for Sternal Wound Infection After Open Heart Operations Vary According to Type of Operation

This study evaluated whether risk factors for sternal wound infections vary with the type of surgical procedure in cardiac operations. This was a university hospital surveillance study of 3,249 consecutive patients (28% women) from 2006 to 2010 (median age, 69 years [interquartile range, 60 to 76]; median additive European System for Cardiac Operative Risk Evaluation score, 5 [interquartile range, 3 to 8]) after (1) isolated coronary artery bypass grafting (CABG), (2) isolated valve repair or replacement, or (3) combined valve procedures and CABG. All other operations were excluded. Univariate and multivariate binary logistic regression were conducted to identify independent predictors for development of sternal wound infections. We detected 122 sternal wound infections (3.8%) in 3,249 patients: 74 of 1,857 patients (4.0%) after CABG, 19 of 799 (2.4%) after valve operations, and 29 of 593 (4.9%) after combined procedures. In CABG patients, bilateral internal thoracic artery harvest, procedural duration exceeding 300 minutes, diabetes, obesity, chronic obstructive pulmonary disease, and female sex (model 1) were independent predictors for sternal wound infection. A second model (model 2), using the European System for Cardiac Operative Risk Evaluation, revealed bilateral internal thoracic artery harvest, diabetes, obesity, and the second and third quartiles of the European System for Cardiac Operative Risk Evaluation were independent predictors. In valve patients, model 1 showed only revision for bleeding as an independent predictor for sternal infection, and model 2 yielded both revision for bleeding and diabetes. For combined valve and CABG operations, both regression models demonstrated revision for bleeding and duration of operation exceeding 300 minutes were independent predictors for sternal infection. Risk factors for sternal wound infections after cardiac operations vary with the type of surgical procedure. In patients undergoing valve operations or combined operations, procedure-related risk factors (revision for bleeding, duration of operation) independently predict infection. In patients undergoing CABG, not only procedure-related risk factors but also bilateral internal thoracic artery harvest and patient characteristics (diabetes, chronic obstructive pulmonary disease, obesity, female sex) are predictive of sternal wound infection. Preventive interventions may be justified according to the type of operation.

Assessment of the Association of Bilateral Internal Thoracic Artery Skeletonization and Sternal Wound Infection After Coronary Artery Bypass Grafting

Skeletonization is a technique of bilateral internal thoracic artery (BITA) harvest that preserves sternal blood flow. We sought to identify the relationship of skeletonization and sternal wound infection in a population undergoing BITA harvest. Demographics and outcomes were recorded from patients undergoing coronary artery bypass graft surgery with BITA using either skeletonized (n= 531) or nonskeletonized (n= 970) techniques. The primary outcome was total infection. Propensity scores analysis as well as univariable and multivariable analysis was performed to determine the effect of skeletonization in the total cohort and in each sex. Although patients undergoing skeletonized BITA had a lower body mass index, they were significantly older, with a higher proportion of women, diabetes mellitus, urgent or emergent surgery, renal failure, vascular and lung disease, and lower preoperative hemoglobin. There was a significant effect of skeletonization in decreasing total infection incidence (odds ratio [OR] 0.606, 95% confidence interval [CI]: 0.383 to 0.959, p= 0.032). The effect of skeletonization on total infection in men was more prominent (OR 0.466, 95% CI: 0.290 to 0.870), whereas there was no effect in women (OR 0.887, 95% CI: 0.441 to 1.786). Multivariable analysis confirmed that skeletonization was protective (OR 0.606, 95% CI: 0.383 to 0.957, p= 0.032). Other factors associated included being female (OR 3.327, 95% CI: 2.080 to 5.322, p < 0.001), insulin-dependent diabetes mellitus (OR 2.638, 95% CI: 1.506 to 4.624, p= 0.001), peripheral vascular disease (OR 2.101, 95% CI: 1.247 to 3.539, p= 0.005), increased body mass index (OR 1.100, 95% CI: 1.054 to 1.149, p < 0.001), and decreased preoperative hemoglobin (OR 0.984, 95% CI: 0.972 to 0.997, p= 0.013). Skeletonization is associated with a significant protective effect with regard to sternal infection after coronary artery bypass graft surgery with BITA. Being female is a major risk factor for infection, and the risk is not modified significantly with a strategy of skeletonization in women.

Bilateral Internal Thoracic Artery Harvest and Deep Sternal Wound Infection in Diabetic Patients

Coronary artery bypass graft surgery is superior to percutaneous intervention in diabetic patients with multivessel disease. The use of bilateral internal thoracic arteries (BITA) may provide better long-term graft patency, but the risk of postoperative deep sternal wound infection has limited its use in diabetic patients. However, studies have reported conflicting results, and require systematic evaluation. MEDLINE, EMBASE, World of Science, and the Cochrane library were searched for randomized controlled trials and observational studies comparing the incidence of deep sternal wound infection in diabetic patients undergoing either left internal thoracic artery (LITA) or BITA harvest. We used random effect models to compare risk ratios within groups. One randomized controlled trial and 10 observational studies (126,235 diabetic patients: 122,465 LITA, 3,770 BITA) met inclusion criteria. Deep sternal wound infection occurred in 3.1% and 1.6% for the BITA and LITA cohorts, respectively. The risk ratio for deep sternal wound infection development was 1.71 (1.37 to 2.14) for BITA compared with LITA. Patients who underwent skeletonized BITA harvest had a similar risk of deep sternal wound infection compared with LITA (0.9 [0.42 to 2.09]), although pedicled harvest demonstrated increased risk (1.77 [1.4 to 2.23]). Early mortality was comparable in the LITA cohort (2.5%) and the BITA cohort (2.3%; p = 0.8). The risk of deep sternal wound infection can be minimized in diabetic patients undergoing coronary artery bypass graft surgery by performing ITA harvested in a skeletonized manner with meticulous attention to preserving sternal blood flow. Pedicled harvest is to be discouraged when utilizing both ITA owing to a significant increase in the risk of postoperative deep sternal wound infection.

Reduction of sternal wound infections in diabetic patients undergoing off-pump coronary artery bypass surgery and using modified pedicle bilateral internal thoracic artery harvest technique

We compared sternal wound infections between diabetic patients undergoing off-pump coronary artery bypass surgery using bilateral internal thoracic artery grafting or single internal thoracic artery grafting and nondiabetic patients receiving bilateral internal thoracic artery or single internal thoracic artery grafting using a modified pedicled harvest technique of internal thoracic artery. This retrospective study was conducted to analyze the data from 3072 patients who underwent primary coronary artery bypass surgery using an off-pump technique from August 2004 to October 2010. Of the 1211 diabetic patients, 181 received bilateral internal thoracic artery grafts (group 1) and 1030 received single internal thoracic artery grafts (group 2). Of the 1861 nondiabetic patients, 161 received bilateral internal thoracic artery grafts (group 3) and 1700 received single internal thoracic artery grafts (group 4). The incidence of postoperative sternal wound infections in diabetic patients who received bilateral internal thoracic artery grafting was compared with the incidence in other groups (group 2, 3, and 4). A modified technique of pedicled harvesting of the internal thoracic artery was done in patients receiving bilateral internal thoracic artery grafting, and a standard pedicled harvest was used in patients receiving single internal thoracic artery grafts. No significant differences were present in the preoperative variables among the groups. The observed rate of superficial sternal wound infections in groups 1, 2, 3, and 4 was 1.1% (2 patients), 1.65% (17 patients), 1.86% (3 patients), and 1.65% (28 patients), respectively (P=.9941). Deep sternal infections were observed in 1 (0.55%), 5 (0.48%), 1 (0.62%), and 14 patients (0.82%) in groups 1 through 4, respectively (P=.8380). Multivariate analysis showed that bilateral internal thoracic artery harvesting (P=.889), diabetes mellitus (P=.96), and patient age were not predictors of sternal wound infection. The results of the present study show that there is no increase in the incidence of sternal wound infections in diabetic patients undergoing coronary artery bypass surgery with bilateral internal thoracic artery grafting by using a modified pedicle bilateral internal thoracic artery harvesting technique with sparing of the communicating bifurcation of internal thoracic artery to the chest wall and preservation of pericardiacophrenic artery branch.

Is It True Bilateral Internal Thoracic Artery Harvest for Coronary Artery Bypass Grafting Increase the Risk of Mediastinitis?

Summary: The single internal thoracic artery (SITA) has been used almost exclusively as a pedicled graft. Many publications report that bilateral pedicled internal thoracic artery (ITA) grafting increases the risk of mediastinitis. Recently in order to gain the additional length, increase the number of arterial anastomoses and decrease the occurrence of deep sternal infections, there has been an increasing popularity of bilateral use of the skeletonized internal thoracic artery (ITA) for CABG. The aim of this article is to review English literature from multicenter and different cardiac surgeon's experiences regarding this fact. We used terms bilateral mammary harvesting, harvesting of bilateral mammary, mediastinitis and related keywords to search MEDLINE, other literature databases and article reference lists for English-language single versus bilateral internal mammary artery for coronary artery bypass grafting that were published from 1990 – December, 2007. Current available evidence shows that skeletonized BITA grafting carries an acceptable risk of deep sternal infection but is not recommended for repeat CABG or for patients with chronic obstructive pulmonary disease (COPD). Skeletonized BITA grafting can be safely applied in almost every patient. All cardiac surgeons should be trained efficiently in using skeletonized BITA.

A novel internal thoracic artery harvesting technique via subxiphoid approach – for the least invasive coronary artery bypass grafting

We have performed 12 cases of robotically assisted coronary artery bypass grafting (CABG) to accomplish less invasive revascularization. In this report, we describe a new method of robotically assisted internal thoracic artery (ITA) harvesting via subxiphoid approach, using the da Vinci surgical system. A 22-year-old man with three-vessel coronary artery disease due to Kawasaki disease was referred to our institution for coronary artery revascularization. A small subxiphoid incision was made, and the xiphoid process at the lower end of the sternum was excised. A U-shaped hook was inserted into the retrosternal space, and the lower sternum was lifted. A 30 degrees angle-up camera was inserted under the U-shaped hook, bilateral ITAs were harvested in a totally skeletonized fashion endoscopically. The required time for right ITA harvesting was 50 min, and that for the left was 20 min. After bilateral ITAs were harvested, composite grafts were made, and then the distal anastomoses were made. The patient was discharged six days after the operation. We performed a new robotically assisted bilateral ITA harvesting technique via sub-xiphoid safely and with excellent results. This method might be an evolutionary step of minimally invasive direct coronary artery bypass (MIDCAB) using the da Vinci surgical system.

Sternal Stabilization by Interlocking Wires: An Alternative Simple Technique for High-Risk Patients

Sternal dehiscence following midline sternotomy is associated with significant morbidity and mortality in high-risk patients. A novel simple technique of sternal stabilization after midline sternotomy by interlocking wires was introduced in high-risk patients with morbid obesity, diabetes, osteoporosis, chronic obstructive pulmonary disease, bilateral internal thoracic artery harvesting, or various combinations of the above. A sternal stabilization by interlocking wires was performed in 25 consecutive high-risk patients. Stable sternum was achieved in all patients despite multiple risk factors. We describe a simple technique of interlocking wires that provides excellent stabilization of the sternum after midline stenotomy in high-risk patients. This technique utilizes the benefit of figure-eight wires, provides the continuity of the weave and effectively prevents cutting of the wires through the sternum without compromising its blood supply.

Does Bilateral Pedicle Internal Thoracic Artery Harvest Increase the Risk of Mediastinitis?

PurposeBilateral in situ internal thoracic artery (ITA) bypassing may result in excellent myocardial revascularization without increasing the risk of deep sternal wound infection. Although there have been concerns with the use of pedicled bilateral ITA, the risk of infection may not be greater than the use of skeletonized ITA.Materials and MethodsThe present study was retrospectively undertaken to determine if pedicled BITA grafts are associated with a higher risk of sternal wound complications. A total of 207 patients who underwent bilateral ITA bypasses with or without existing diabetes mellitus, and 162 patients of those received bilateral pedicled ITA and 98 patients received unilateral ITA bypass grafts.ResultsNo sternal wound complications were noted in either the bilateral ITA or unilateral left ITA groups.ConclusionBilateral pedicled ITA harvesting was not associated with a greater incidence of infectious sternal complications compared to patients receiving unilateral ITA bypass grafts.

Bilateral internal thoracic artery harvesting; anatomical variations to be considered

Predictable intrathoracic course, anatomical proximity to heart and long-term patency has made Internal thoracic artery (ITA) a conduit of choice in coronary artery bypass grafting (CABG). Its frequent bilateral use has necessitated the need to have a comparative knowledge of surgical anatomy of ITA on both sides. A random study was conducted on 100 adult human cadavers. Sternocostal wall was removed and fixed in 10% formalin and dissected for detailed anatomy of ITA. All observations were expressed as mean ± 2SD and appropriate statistical analysis conducted. ITA originated in common trunk with other branches of subclavian artery in 12% on right side and 4% on left. Mean length of right ITA was 20.15 ± 1.22 cm, left 19.83 ± 1.66 cm in 28% of cases where bilateral ITA terminated in 6th Intercostal space (ICS). On pattern of origin of sternal branches from ITA 3 groups were observed. Group-I-some sternal branches arising from common trunk of ITA on both sides (24%), Group-II-some sternal branches arising from common branch of ITA on one side only (54%), Group-III-all sternal branches arising directly from ITA on both sides (22%). Phrenic nerve crossed anterior to ITA on both sides in 52%, posteriorly in 14% and in remaining it crossed anteriorly on one side and posteriorly on other. Variations as described in our study in relations to phrenic nerve, level of bifurcation and sternal blood supply must be kept in mind while harvesting bilateral ITA to reduce risk of sternal dehiscence by preserving the sternal blood supply from common trunk and to prevent post operative phrenic nerve palsy.