The present case report shows an uncommon entity (a rhino-orbito-cerebral mucormycosis in a non-diabetic no intravenous-drug-user HIV patient with an extended cerebral affection, probably due to bilateral cavernous sinus thrombosis). As interesting aspects of the case, the onset of the illness in an HIV patient (which it is actually very rare [1]) in a context of non-ketosic metabolic acidosis may support that any kind of acidosis (and not only diabetic ketoacidosis) can behave as a contributing risk factor for zygomycosis in HIV patients. Neuroimages of the case are also of great interest.