Mol Syst Biol. 8: 612 Thirty years ago, it was relatively easy to protect one's privacy and remain anonymous. Few computerized systems existed to store our personal information, the internet was so primitive that most were not even aware it existed, and only a few thousand individuals were privileged enough to own a handheld cellular phone. Fast forward to our current day and life—everything has changed. Rapid electronic transactions among individuals and between individuals and entire communities occur on an unprecedented scale, our life stream is continuously digitized and archived—GPS positioning information, cell phone calls, text messages, credit card purchases, e‐mails, online social network chatter and even our electronic medical records (Figure 1). In fact, today the marketing department of your neighborhood Target can know before you that your own daughter is pregnant, given changes in purchase patterns (Duhigg, 2012). Long gone are the days of anonymity and privacy. Figure 1. Big data are all around us, enabled by technological advances in micro‐ and nano‐electronics, nano materials, interconnectivity provided by sophisticated telecommunication infrastructure, massive network‐attached storage capabilities, and commodity‐based high‐performance computing infrastructures. The ability to store all credit card transactions, all cell phone traffic, all e‐mail traffic, video and images from extensive networks of surveillance devices, satellite and ground sensing data informing on all aspects of the weather and overall climate, and now to generate and store massive data informing on our personal health including whole genome sequencing data and extensive imaging data, is driving a revolution in high‐end data analytics to make sense of the big data, drive more accurate descriptive and predictive models that inform decision making on every level, whether identifying the next big security threat or making the best diagnosis and treatment choice for a given patient. The life and biomedical sciences have not been shielded from—and …