By comparing several cloud computing of big data network center during COVID-19, this paper proposes a new topology model, which realizes two functions of cloud computing big data center caching and big data real-time distribution. In addition, cloud computing network requires higher performance than traditional application big data center, which makes the consideration of network platform construction performance different from the traditional understanding. During COVID-19, we deeply understood the underlying attributes of cloud, combined with the topology model, we can realize the decoupling of cloud computing big data system, change the situation of direct connection between upstream and downstream, and have more reliable and efficient transmission of message and command big data.