In reinforced concrete building structures, the slab is the component with the largest volume of concrete of all the superstructure components. Various innovations were carried out. Currently, the use of Hollow Core Slab (HCS) to reduce the load on building superstructures is widely used in Indonesia. Another type of slab is Biaxial Hollow Slab (BHS) as an alternative to reduce slab concrete volume. BHS is considered capable of reducing concrete consumption by up to 30% -50% of conventional concrete without reducing the performance of the slab itself. It could be reducing the load on the working superstructure can reduce the influence of seismic loads on the foundation. Indonesia is a country with an earthquake zone, so the use of BHS must be considered with seismic design categories that are appropriate to the earthquake zones in Indonesia. This research is focused on giving information about the numerical study of application BHS in 10th story building with design seismic category D. The thickness used in this study is equivalent thickness of BHS to solid slab. The absence of beams in weak axis and the present of perimeter beam by utilization BHS, gives the result BHS has sufficient capacity to carry the workload.