To reduce traffic congestion, air pollution, and lost revenue due to wasted driving around looking for parking spaces, effective parking management has become a crucial issue in urban areas. Previous studies have shown that parking demand is related to the location of parking spaces/lots, parking fees, time spent looking for spaces, and various driver and environmental characteristics. However, there have been more studies of on-street rather than off-street parking. Also, the spatio-temporal variance between variables and turnover rate (such as the hours of operation for various types of Points of Interest (POIs) as well as the causes of bias estimators has been largely overlooked.To solve the above problems, the Geographical and Temporal Weighted Regression (GTWR) model was utilized in this study to predict the hourly parking turnover rate in off-street parking lots. The flexible coefficient setting of this model can be used to capture the spatial and temporal variance. In addition to this model, the Geographically Weighted Regression (GWR) and the Ordinary Least Squares (OLS) models were used as a basis for comparison. The study included 346 public off-street parking lots in Taipei and 10 types of nearby POIs. The study period was for 24 h on August 31, 2021. Due to the dissimilar trend of the turnover rate, the researchers separated all parking lots into three groups for regression analysis: those that experience a daytime decrease, remain stable, and those with an increase during the day.Our results show the following: (1) For the types of parking lots that experienced increases and decreases, the GTWR model performed best for the prediction of hourly turnover rate, while all models performed similarly for the prediction of the stable type parking lot. (2) With regard to related factors (the type 1 parking lot for example), parking lots in areas with more traditional markets, MRT stations, and with fewer schools, supermarkets, hotel bus stops, and lower parking fees tended to have higher turnover rates. (3) Incorporating a more precise POI dataset (the number and types of POIs as well as their business hours) and applying a suitable spatial temporal model improved the parking demand model’s performance. However, the GTWR model’s limitations may hamper its performance, especially with regard to analysis of the time-stable parking lots or variables. Future studies might include other datasets, such as nearby private parking lots or holiday data to improve the model fit.