Introduction: Limited information is available about the skeletal frame size of urban-dwelling adolescent female West African children. Aim and Objective: This study assessed variations in skeletal frame-size as estimated from the truncal breadths of adolescent female Nigerian children from two different socioeconomic backgrounds in Lagos. Materials and Methods: Anthropometric measurements of biacromial, bi-iliocristal, bitrochanteric, and chest breadths were taken from 320 adolescent female school children aged 10-17 years selected from public and private schools in Lagos using a systematic random method. The socioeconomic status (SES) of the subjects was classified on the basis of attendance at either fee-paying private or non-fee-paying public schools. Results: The range of skeletal breadth measurements were as follows: Biacromial breadth 32.24 ± 2.01 cm to 34.23 ± 1.35 cm; bi-iliocristal breadth 22.46 ± 1.07 cm to 23.75 ± 1.47 cm; bitrochanteric breadth 24.47 ± 2.22 cm to 28.29 ± 2.10 cm; and chest breadth 18.43 ± 2.14 cm to 19.71 ± 0.75 cm. Statistically significant differences were observed in the mean biacromial, bi-iliocristal, bitrochanteric, and chest breadths between age-matched private school girls (PRG) and public school girls (PUG). Conclusion: The observed variations in skeletal frame size among female adolescents may reflect a complex interaction between lifestyle and biological variables existing in this population, suggesting a morphologic uniqueness among the adolescent females of Lagos that calls for further systematic investigation.