Objectives: The study was aimed at examining the risk factors for pre-eclampsia in the multiparous women in Lagos, Nigeria.Methods: This is a cross-sectional case-control study designed to examine the risk factors for pre-eclampsia in the multiparous women in Lagos, Nigeria. Structured questionnaires were administered to eligible participants (pre-eclamptic and normotensive) who delivered at the two teaching hospitals in Lagos during the study period. Information obtained were entered into computer and analysis was done using Epi-Info 2008 version 3.5.1 statistical software package.Results: A total of 350 multiparous women participated in the study. 150 of them were preeclamptic while the remaining 200 who were normotensive were used as control. Monogamous relationship, change of spouse, age of 40 years and above, previous pre-eclampsia, chronic hypertension, diabetes, family history of hypertension and unbooked status were the risk factors found to be associated with pre-eclampsia in multiparous women in the study (P?0.05).Conclusion: Identified risk factors were not different from previously identified factors in other studies. A call for early antenatal booking, good control of hypertension and diabetes cannot be overemphasized in the prevention of preeclampsia/eclampsia.