Infusion Of Beta-hydroxybutyrate Research Articles

RENAL RETENTION OF URIC ACID INDUCED BY INFUSION OF BETA-HYDROXYBUTYRATE AND ACETOACETATE.

HYPERURICEMIA has been observed in conjunction with a variety of metabolic aberrations, including starvation,1 2 3 4 obesity4 5 6 7 and diabetic ketoacidosis.8 The possibility that ketosis facilitates an increase in serum urate concentration by promoting renal retention of uric acid has been suggested in a number of reports.4,9 10 11 12 13 14 15 The purpose of the present study was to compare the influence of intravenously administered beta-hydroxybutyrate, acetoacetate and acetone on the renal clearance of uric acid in normal human subjects. Methods and Materials Sodium acetoacetate was prepared by hydrolysis of freshly redistilled ethyl acetoacetate¶ with a 5 per cent excess of 1 N sodium hydroxide under . . .