Bentham Science Research Articles

Withdrawn: Acceptability and Concerns Towards Covid -19 Vaccination among Parents; A Cross-Sectional Survey in Ras Al-Khaimah, United Arab Emirates

The article has been withdrawn from the website of The New Emirates Medical Journal at the request of the authors. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/journal/186/editorialpolicy Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Withdrawal Notice: Cluster-based Sampling for Fake News on Healthcare During COVID-19 Infodemic

This article has been withdrawn from the journal Recent Advances in Electrical and Electronic Engineering. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: Mechanism and Research Progress of Agarwood in Improving Recurrent Oral Aphthous Ulcer and Ulcerative Colitis

The article has been withdrawn at the request of the corresponding author of the journal The Natural Products Journal. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham editorial policy on article withdrawal can be found at https://benthamscience.com/pages/editorialpolicies-main BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Withdrawal Notice: Design and Synthesis of Circular Antenna Array for Low Side Lobe Level and High Directivity Using Artificial Hummingbird Optimization Algorithm

The article has been withdrawn at the request of the authors of the journal Recent Advances in Electrical and Electronic Engineering. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policiesmain. php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Pumpkin Seeds (Cucurbita spp.) as a Nutraceutical Used In Various Lifestyle Disorders

Background: The pumpkin, a very well-edible plant that is a member of the Cucurbitaceae family, has long been utilised as a functional food and an herbal remedy. Pumpkins include a wealth of phytoestrogens, unsaturated fatty acids, and vitamin E in their seeds that may have medicinal, nutritional, and cosmetic benefits. In recent years, knowledge of the nutritional benefits and medicinal uses of pumpkin seeds has grown significantly. An abundant source of nutrients and a well-known multipurpose food, pumpkin has recently given scientists fresh insights. Primary and secondary metabolites, such as carbohydrates, proteins, monounsaturated fatty acids, poly saturated fatty acids, carotenoids, tocopherols, tryptophan, delta-7-sterols, & numerous other phytochemicals, are abundant in the pumpkin fruit, including the meat, seed, and peel. Objective: In this review, the nutraceutical importance of pumpkin's seed anti-diabetic, hypoglycemic, cardiovascular preventive and anti-cancer effects are explored along with the nutraceutical effects of anti-depressants, anti-helminthic and anti-oxidants effects are involved. Methods: A comprehensive analysis of the literature search was conducted. A number of databases have been searched using the common terms "pumpkin,", "pumpkin seeds", "cucurbita,", "functional food", "phenolic compounds", "minerals,", and "phytochemicals" using PubMed and Google Scholar as search engines. The content was based on information from publications like Bentham Science, Elsevier, Taylor & Francis, Nature, Plos One, etc. We have focused on the review and research papers published between 2000 and 2023. Result: Meanwhile, some research gaps on the biological activities of pumpkin seeds and their potential as a functional food element have been discovered in the current literature. The pharmacokinetics of Pumpkin seeds bioactives and the characterization and identification of functional molecules have received very little attention in the literature. It is necessary to conduct more studies to connect the pharmacodynamics and pharmacokinetics of Pumpkin seeds. Conclusion: The therapeutic benefits of pumpkin seeds & the potential disease-preventing mechanisms are updated in this review article, also on the chemical make-up, nutritional value, phytochemical research, pharmacological characteristics, bioavailability, food use, & industrial applications of pumpkin.

OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment

Cancer is a wide-spreading disease. Its count goes on increasing and became the second leading cause of death in respect of diseases. New cancer-targeting molecules are explored. In this study, we tried to collect information about one such molecule, OTX015. Articles were searched across reputed search engines and publishers such as Cochrane, EMBASE, The Lancet, PubMed, GoogleScholar, ScienceDirect, Wiley Online, Springer and Bentham Science by using different keywords: “OTX015”, “Cancer”, “Small molecule PROTACs”, “BRD/BET” and “BET inhibitors”. The quality papers were retrieved, studied, categorized into different sections, analyzed, and used for article writing.OTX015 is a novel molecule in clinical trials. It showed some promising results in various cancers as well as other diseases like latent-HIV with the least side-effects.This article will give an insight into Small Molecules as PROTACs, their advantages and disadvantages, OTX015 and its PROTAC ARV- 825. It is advised that more research/studies are required to be carried out to know more about OTX015 and other PROTACs, their advancements, receptors, and mechanism/ mode of action to know their abilities to work against proteins involving diseases.

Development of a Comprehensive Regulatory Model for Medical Devices

Abstract Background: The development of a comprehensive regulatory model for medical devices is essential to ensure the safety, efficacy, and quality of medical devices throughout their lifecycle, from design and development to post-market surveillance. This paper outlines a robust framework for such a regulatory model, detailing key components and processes necessary for effective regulation. Methods: The data and literature were collected from various databases including Springer, Science Direct, Taylor and Francis, Wiley, Bentham Science, and websites of different regulatory agencies. The collected data were utilized in the research work to formulate the new regulatory model. Results: Different guidelines represent acceptable regulatory practices for all medical items. There are four risk classification levels of the medical devices (class I–IV, based on the risk level). For every country, the regulatory requirements are different. Global regulations for medical device approval are essential to guaranteeing their quality, safety, efficacy, and performance before they can be put on the market to safeguard, prevent, enhance, and maintain public health. Different classes have different regulatory steps for approval of the devices, which varies from region to region. The World Health Organization’s Department of Essential Health Technologies’ Diagnostic Imaging and Medical Devices team has developed and implemented the Baseline Country Survey on Medical Devices. The proposed model includes the establishment of a clear legislative and regulatory framework, featuring a risk-based classification system aligned with international standards. It emphasizes rigorous pre-market requirements, including design controls, clinical evaluation, quality management systems, and technical documentation. Market authorization processes are described, highlighting pathways such as Premarket Notification (510(k)), Premarket Approval (PMA), and De Novo Classification, supported by thorough scientific review and expert advisory panels. The present study is all about the global requirements of the regulation of the medical devices and it was concluded that overall, a global comprehensive regulatory model for medical devices aims to strike a balance between ensuring patient safety, facilitating innovation, and enabling timely access to life-saving medical technologies around the world. Conclusion: The model advocates for international harmonization and collaboration, promoting regulatory convergence and the adoption of global standards. It also supports innovation through accelerated approval pathways and regulatory sandboxes, alongside continuous improvement driven by regulatory science research and stakeholder engagement. By integrating these elements, the comprehensive regulatory model aims to protect public health while fostering medical device innovation and ensuring global regulatory compatibility.

A Detailed Analysis of the Carotenoids and their Derivatives, including their Multiple Health Advantages

Background: The majority of foods, vegetation, plankton, and photosynthetic bacteria all include carotenoids, which are pigments that naturally exist. Since humans are unable to produce carotenoids, they must be consumed through food or supplements. There are many roles for carotenoids in ensuring human health. They generally act as antioxidants, but different carotenoids may also have other functions. For instance, β-carotene functions as pro-vitamin A, while lutein and zeaxanthin make up the macular pigmentation in the eyes. Objective: The primary goal of this review article is to emphasise the numerous health advantages of the various carotenoids and their derivatives, including neuro, cardio, bone, immune, and cancer protection. Methods: The information for this review article was acquired by using Google Scholar and PubMed as search engines, as well as a number of publishers, including Springer Nature, Bentham Science, Taylor & Francis, and Elsevier. Results: Carotenoids are biologically active antioxidants, and their anti-inflammatory and antioxidant properties may help to lessen cardiovascular events such as adiposity, insulin sensitivity, hyperlipidemia, and inflammatory markers. Evidence shows they enhance eyesight, cognitive ability, and cardiovascular health. They could also reduce the risk of a number of malignancies. Carotenoids' diverse properties and therapeutic capacity to prevent neurodegeneration in conditions including Alzheimer's, Parkinson's, stroke, and others are reviewed. Conclusion: Despite the data supporting the health advantages of carotenoids, extensive population-based supplement research on several carotenoids has yielded conflicting results. Further study, especially clinical studies, is required to demonstrate and validate the medical benefits of the various carotenoids.

WITHDRAWN: A Review on the Role of Nanotechnology for Sustainable Agriculture to Increase Crop Productivity

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the website of the journal Nanoscience & Nanotechnology-Asia. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorialpolicies-main.php. ENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Withdrawal Notice: Fusion of Signal Processing Techniques to Design an Algorithm for Determination of Single Stage and Multiple Power Quality Events

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies- main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit- ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Role of Nutraceuticals and Physical Activity in Parkinson's Disease Risk and Lifestyle Management.

Parkinson's disease is a complicated, gradually progressive neurological illness characterized by locomotor and non-motor symptomatology that impedes daily activities. Despite significant advances in symptomatic therapies with various extents of negative effects, there are currently no disease-modifying medicinal alternatives. Symptoms worsen, creating an additional strain that reduces living quality and creates the perception that prescription drugs are no longer productive. Adopting healthy lifestyle habits can help patients feel more empowered, promote wellness, relieve symptoms, and potentially slow neurodegeneration. Nutrition, intellectual stimulation, physical exercise, and stress reduction are all examples of lifestyle habits that improve cognitive health and life satisfaction. We discuss how changes in lifestyle, nutrition, yoga, exercise, and acupuncture can help with managing the disease's symptoms. We searched Google Scholar for various research papers and review articles from publishers, such as Bentham Science, Elsevier, Taylor and Francis, Springer Nature, and others for gathering the data for the study. Pesticide exposure, environmental hazards, dietary choices, stress, and anxiety all have an indirect or immediate influence on the commencement of Parkinson's disease. Naturopathic remedies, such as nutraceuticals, yoga, exercise, and acupuncture, have been shown to help with Parkinson's disease management. Various preclinical and clinical studies have shown that the various factors mentioned are beneficial in the management of the disease, but more research is needed to validate the extent to which such factors are beneficial.

WITHDRAWN: In Vitro and In Vivo Models Used for Drug Discovery and Drug Screening on Atherosclerotic Research: A Review

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: Tunable Biological Characteristics of Nanobiomaterials for Bone Tissue Engineering

The article has been withdrawn at the request of the authors of the journal Current Mechanics and Advanced Materials. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: COVID-19: Mortality Rate (In Time) An Analysis of Publicly Available Data from 11 Countries to Calculate the Mortality Rate of COVID-19

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the website of the journal Coronaviruses. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham editorial policy on article withdrawl can be found at https://benthamscience.com/editorialpolicies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: A Novel Sine Cosine Optimization with Stacked Long Short-term Memory-enabled Stock Price Prediction

Since the authors are not responding to the editor’s requests to fulfil the editorial requirement, therefore, the article has been withdrawn from the journal Recent Advances in Computer Science and Communications. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: Ectopic Kidney as a Clinical Manifestation of Type II MRKH Syndrome Patient: A Case Report

The article has been withdrawn at the request of the author. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Retraction note to: Analytical Method Development and Validation for Determination of Assay of Antibacterial Drugs Besifloxacin Hydrochloride and Phenoxyethanol in Gel Formulation

<p>The article entitled “Analytical Method Development and Validation for Determination of Assay of Antibacterial Drugs Besifloxacin Hydrochloride and Phenoxyethanol in Gel Formulation”, by Pradeep Kundu, Neelam Pawar, Neha Minocha and Asha Poonia, published in Anti-Infective Agents 2023; 21(4): e310323215342. https://dx.doi.org/10.2174/2211352521666230331111623. <p> The corresponding author of this article submitted it simultaneously to the journal “Biochemistry & Analytical Biochemistry of Walsh Medical Media publishers and to the journal of “Anti-Infective Agents” of Bentham Science Publishers. Therefore, the article has been retracted due to the unethical practice of the author and during plagiarism checking with a previously published article titled: “Analytical Method Development and Validation for the Determination of Assay of Antibacterial Drugs Besifloxacin Hydrochloride and Phenoxyethanol in Gel Formulation. Biochem Anal Biochem. 11:426. doi: 10.35248/2161-1009.22.11.426 <p> The authors were informed of this submission and were suggested to give justification on the matter in their defense. Instead of sending justification, the corresponding author Dr. Neelam Pawar suggested Bentham Science Publishers to retract this article. <p> Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. <p> The Editorial Policy of Bentham Science Publishers on Article Retraction can be found at the link https://benthamscience.com/editorial-policies-main.php. <p> BENTHAM SCIENCE DISCLAIMER: <p> It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: Natural Phytochemicals, Phenformin, and Docosahexaenoic Acid (DHA) as Novel Inhibitors of Leukotriene B4 and ACE2 Receptors, a Therapeutic Strategy for Targeting COVID-19 Cell Entry and Cytokine Storm (An In-silico Approach)

This article has been withdrawn from the journal Letters in Drug Design & Discovery due to a conflict of interest among the authors. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/pages/editorial-policies-main BENTHAM SCIENCE DISCLAIMER: It is a prerequisite for publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

WITHDRAWN: Exploring the Nutritional, Biochemical, and Phytoceutical Attributes of Pumpkin and its Utilization in Ready-to-Serve and Ready-to-Eat Products

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Treatment of Parkinson's Disease: Current Treatments and Recent Therapeutic Developments.

Parkinson's disease (PD) is a neurodegenerative syndrome defined by a variety of motor, cognitive, and psychomotor dysfunctions. The current pharmaceutical treatment focuses on treating the condition's symptoms. They are primarily concerned with reducing illness symptoms or avoiding dopamine metabolism. As our understanding of disease pathogenesis improves, new therapeutic approaches emerge. This article aims to describe the standard Parkinson's medications based on symptoms and requirements. It emphasizes recent advancements in symptomatic therapy for motor indications and achievements in the research and clinical testing of medicines that promise to enable disease modification in patients with already-manifest PD. Information for this paper was found by looking through Google Scholar and reading several research and review articles from Bentham Science, Science Direct, Elsevier, Frontiers, Taylor & Francis, and other publishers. Parkinson's disease therapeutic interventions are now limited to symptomatic therapy, mostly in dopaminergic medications and deep brain stimulation (DBS). They have the potential to deliver great therapeutic progress, yet they can also have serious drawbacks that decrease a patient's quality of life. The progress of pluripotent stem cell therapies and genome engineering procedures has sparked renewed hope for the treatment of a wide range of human illnesses, particularly genetic abnormalities. The current Parkinson's therapy trends are successful and continually evolving, with several drugs currently undergoing clinical trials. As these new therapies constantly coming out and can be used together, they will likely change how Parkinson's disease is treated in the coming years.