Retrograde type A dissection (RTAD) and stent graft-induced new entry (SINE) is one of the most common post-TEVAR complications, and is defined as a new tear caused by the stent-graft itself (Dong Z.H. et al., 2009). Presumably, the mechanical action and potential damage of stent-graft to the aorta is related to the stent-graft and the anchoring position, mainly from two aspects: (1) The metal skeleton functions to fix the whole support to the wall of the aorta because it is self-inflating and strong in radial force. (2) After implantation, the stent-graft is bent into the arch like a bent spring, with a tendency to be straight. This may result in elastic recoil force to the aortic wall. This study investigated the occurring reasons of new lesions from the biomechanical and mechanobiological view when stent-grafts were implanted into the true lumen to treat an aortic dissection.