Benign Tumor Of Adipose Tissue Research Articles

A Novel Approach for Treating Lipomas: Percutaneous Microwave Ablation Combined with Liposuction.

Lipomas, benign adipose tissue tumors, are a common occurrence but currently, the options for their treatment are limited, with surgical excision being the most frequently used management pathway. This scenario can often lead to unsatisfactory cosmetic results and significant patient discomfort. This paper introduces a novel technique, percutaneous microwave ablation with liposuction, to address these challenges. The innovative procedure aims to enhance patient satisfaction, minimize post-operative discomfort, and improve aesthetic outcomes. The technique involves two key steps: (1) the application of percutaneous microwave ablation to selectively disrupt the lipoma cells, followed by (2) a targeted liposuction procedure to remove the ablated lipoma tissue. Our approach optimizes the removal of the lipoma and preserves the surrounding healthy tissue, reducing the risk of local recurrence and improving the cosmetic result. The use of preoperative ultrasound imaging allows for precise localization and delineation of the lipoma, aiding in the planning and execution of the procedure. This novel approach to lipoma treatment is reliable, associated with minimal morbidity, and consistently yields effective results. Additionally, it provides a new perspective on lipoma management, potentially changing the paradigm of current treatment approaches.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Imaging diagnosis: CT characteristics of a retrobulbar hibernoma in a dog.

A 12-year-old female spayed Beagle was referred for investigation of exophthalmos. CT revealed a well-defined, retrobulbar mass causing rostro-dorsal displacement of the left globe. The mass had a mildly heterogeneous precontrast soft tissue attenuation with mild heterogeneous enhancement following iohexol administration. The mass was surgically removed en bloc with an orbital exenteration. Histopathology confirmed the mass to be a hibernoma, a benign tumor of brown adipose tissue. Hibernomas have CT characteristics consistent with both benign and malignant adipose tumors and may be underrecognized by radiologists.

Symptomatic Preperitoneal Lipoma Resected via Preperitoneal Approach: A Case Report and Review of the Literature

Introduction: Lipomas are benign adipose tissue tumors that can vary in size and location. Magnetic resonance images should be obtained for all soft-tissue masses that are deep to fascia or those >5 cm in subcutaneous tissue. In this case report, we present a minimal invasive technique to resect a large preperitoneal lipoma. Case Presentation: A 36-year-old woman presenting with left fossa pain caused by a large mass. MRI-imaging shows a large preperitoneal lipomatous lesion (61 × 58 × 40 mm) which compresses the bladder, tuba and surrounding vessels. We did a minimally invasive preperitoneal laparoscopic surgical resection. Postoperative follow-up was uneventful. The pathology report confirmed benign lipoma without signs of malignancy. Discussion: Preperitoneal lipomas should be considered in the diagnosis of lower abdominal pain and can be minimally invasive resected via preperitoneal laparoscopic approach in day clinic.

ЛИПОМА КАК СЛУЧАЙНАЯ НАХОДКА В АБДОМИНАЛЬНОЙ ХИРУРГИИ

Primary neoplasms of the abdominal cavity are rare and usually have a mesenchymal origin. Lipoma is a benign mature tumor of adipose tissue, it occurs more often in women aged 30 to 50 years. Retroperitoneal lipoma is a rare variant of lipoma, manifested by various signs and symptoms that can mislead specialists. Lipomas are more common in abdominal surgery in the gastrointestinal tract. In this localization, the main pathognomonic complication is intestinal intussusception. Diagnosis is difficult, due to the relatively slow growth of education, characteristic clinical manifestations may be absent for a long time. X-ray imaging is the preferred diagnostic method. To date, surgical resection is the priority method of treatment of this pathology. The analysis of scientific literature on the occurrence of abdominal lipomas is carried out. The diagnostic significance in assessing the condition and complications of lipomas has been studied. Clinical cases from personal practice on the basis of the State Clinical Hospital named after him are presented. Yudina. Patients with diagnoses of giant retroperitoneal lipoma and complicated small intestine lipoma by female intussusception aged 62 and 78 years, respectively. The first clinical case demonstrates the randomness of the determination of lipoma in a patient admitted to the clinic with a closed craniocerebral injury and a wound of the soft tissues of the head. Ultrasound of the abdominal cavity showed the presence of a large retroperitoneal formation of an inhomogeneous consistency. During laparotomy, a giant fatty tumor with clear boundaries was revealed, closely adjacent to the adipose tissue of the retroperitoneal space. Lipoma was removed, drainage of the abdominal cavity and retroperitoneal space was performed. Histopathological examination confirmed the diagnosis of retroperitoneal lipoma. The weight of the lipoma was 10.610 kg. The postoperative period proceeded without complications. The second clinical case shows how a long-term undiagnosed lipoma of the gastrointestinal tract leads to a complicated course, namely intussusception. Patient A. 78 years old with discomfort and abdominal pain during the last few weeks, small intestine invagination was detected using ultrasound. Diagnosis upon admission: acute pancreatitis. A resection of the altered section of the small intestine was performed. The postoperative period was favorable. The patient was discharged on the 10th day. The presented clinical cases of this disease once again confirm the importance of timely dispensary diagnosis of abdominal tumors.

Large soft-tissue mass in the extremity is not necessarily a sarcoma: A case report of a giant lipoma of the thigh

Lipoma is the most common benign adipose tissue tumor. Giant lipomas are those that measure more than 10 cm in length or more than 1000 g in weight. There is a possibility of sarcomatous change in them but it is not always the rule. Lipoma and liposarcoma can be differentiated on the magnetic resonance imaging features of tumor size, stranding, nodularity, T2 signal, and contrast enhancement. The existence of thin septa helps identify lipomas and distinguishes them from well-differentiated liposarcomas, which have thick and irregular septa and fat necrosis at times. The open surgical approach is the best for the complete excision of giant lipomas without any recurrence.

Comparative Study of Outcome of Wedge Excision of Perforation Site and Trimming of Perforation Margin Followed by Primary Repair in the Management of Ileal Perforation

Lipomas are benign tumors of adipose tissue consisting of soft, lobulated masses held together with connective tissue and sometimes encapsulated in a thin, fibrous capsule. Lipomas are the most common soft tissue tumor, occurring in 1% of the population. The objective of our study is to present the epidemiological aspects of lipomas in the population of the region of Tangier-Tetouan-Al Hoceima, to determine the etiopathogenic aspects, and to describe the modalities of surgical treatment and especially to make a comparison between the lipectomy and liposuction. This study was carried out retrospectively, by collecting, the sex, and the reason for consultation and the location of the lipomas in the patients admitted to our service, over a period of 12 months from April 2021 to May 2022. The age of our patients ranged from 21 to 46 years. The mean age was 35 years and 3 months. We had 20 (74%) women and 7 (26%) men. The sex-ratio men/women were 0, 35. It must be said that many of our patients consulted because they had noticed an abnormal swelling on one part or another of their bodies. Regarding the management of our patients, only 5 benefited from liposuction while 22 patients benefited from a lipectomy. In all patients, the postoperative follow-up was simple with no early complications.

Lipectomy vs Liposuction

Lipomas are benign tumors of adipose tissue consisting of soft, lobulated masses held together with connective tissue and sometimes encapsulated in a thin, fibrous capsule. Lipomas are the most common soft tissue tumor, occurring in 1% of the population. The objective of our study is to present the epidemiological aspects of lipomas in the population of the region of Tangier-Tetouan-Al Hoceima, to determine the etiopathogenic aspects, and to describe the modalities of surgical treatment and especially to make a comparison between the lipectomy and liposuction. This study was carried out retrospectively, by collecting, the sex, and the reason for consultation and the location of the lipomas in the patients admitted to our service, over a period of 12 months from April 2021 to May 2022. The age of our patients ranged from 21 to 46 years. The mean age was 35 years and 3 months. We had 20 (74%) women and 7 (26%) men. The sex-ratio men/women were 0, 35. It must be said that many of our patients consulted because they had noticed an abnormal swelling on one part or another of their bodies. Regarding the management of our patients, only 5 benefited from liposuction while 22 patients benefited from a lipectomy. In all patients, the postoperative follow-up was simple with no early complications.

SUBMANDIBULAR LIPOMA EXCISION: A CASE REPORT

The aim of this study is to report the excision of a benign tumor of adipose tissue in the submandibular region. A 57-year-old dark-skinned male patient reported increased volume on the left side of his face, with approximately 10 years of evolution. The physical exam showed increased submandibular volume on the left side: a nodule measuring about 10 cm, with a soft and mobile consistency and painless. Fine needle aspiration puncture exam, contrast computed tomography, and ultrasound of the affected site were performed and the result was suggestive of benign tumor of adipose tissue. The patient underwent surgery by submandibular approach and excisional biopsy of the lesion was performed. The tumor presented a yellowish color, measuring 7 cm in its largest diameter. The material was sent for histopathologic examination, which confirmed the diagnosis of lipoma, a benign tumor of adipose tissue. Twelve months of follow-up showed no recurrence or complications.

Fibrolipoma of Neck - A Case Report

Introduction: Lipoma is the most common benign mesenchymal tumor of adipose tissue. Their occurrence in the head and neck is relatively rare. Lipomas in the neck region are rare tumors that usually present as slowly growing painless masses, found in the lateral portions of the neck. Case Report: Here, we report a case of lipoma lying over the right nape of the neck in a 26-year-old female. A pedunculated overgrowth was gradually progressive in size with no other complaints. It was soft, mobile and non-tender. It was clinically diagnosed as a fibroepithelial polyp and later on, a histopathological examination was performed which revealed benign lipoma. Surgical excision is an elective treatment. However, an accurate differential diagnosis, postsurgical histological examination and careful follow-up are required. The purpose of this case report is to recognize rare lipomas that occur in unusual locations in the head and neck in order to identify them when they cause diagnostic problems. Conclusion: Lipomas can occur in any site of the body, However, rare variants in unusual sites should not be ignored by clinicians and should be sent for histopathological diagnosis for a confirmed diagnosis.

Intermuscular Lipoma in the Pelvic Limb of an Aged Shih Tzu-Terrier Dog

A ten and half-year-old spayed female Shih Tzu-terrier dog was presented with swollen mass in the right pelvic limb. The mass was first noticed by the owner three months prior to the presentation but it had enlarged significantly during the past seven days before presentation resulting in pain and lameness. Clinical examination revealed the presence of a large fluctuant mass with soft tissue consistency in the caudal region of the right stifle joint with pain elicited during joint flexion. A well circumscribed large fatty tumor situated between the semimembranosus and semitendinosus muscles was encountered during surgical exploration of the affected area under general anesthesia which was completely removed. Diagnosis of intermuscular lipoma was confirmed based on clinical findings, the gross appearance of the tumor, and the presence of mature adipocytes in histological sections. This report describes clinical signs, physical examination, and diagnostic imaging findings along with surgical treatment of canine intermuscular lipoma, a rare form of lipoma, and benign mesenchymal tumor of adipose tissue situated between muscle bellies which is not locally invasive and does not metastasize. To the best of our knowledge, this type of canine tumor has not been previously reported in Iran.

Subgaleal Lipoma: Imaging Findings

Subgaleal lipoma is a benign tumor of adipose tissue. It should be suspected when a semi-spherical avascular mass with well-defined margins, iso- or hyperechoic in most cases, with thin internal echogenic lines parallel to the long axis of the tumor, is observed between the galea aponeurosis and periosteum of the cranial bone. We report a series of cases of three patients who underwent surgical lesion excision and whose histopathological examination findings confirmed the diagnosis of lipoma.Main Teaching Point:The presence of long continuous echogenic lines within a lens-shaped soft tissue mass located beneath the galea aponeurosis may suggest the diagnosis of subgaleal lipoma.

Giant lipoma of breast-a diagnostic dilemma

Lipoma is the most common benign tumor of adipose tissue. Giant lipoma of breast is very rare.Majority of them are small in size, slow growing and asymptomatic until they reach large size. Most patients seek medical advice due to asymmetry in the breast and due to fear of malignancy. Breast lipomas pose a diagnostic challenge due to similarity of their texture to normal breast parenchyma and make it difficult to distinguish from other common breast lesions. The clinical and radiographic identification of breast lipoma remains challenging. Complete surgical excision with the capsule is essential to prevent recurrence. Breast reconstruction may require, to prevent asymmetry following surgical excision of giant breast lipoma. High degree of clinical suspicion and histolopathological correlation will help in preopertaive diagnosis of this clinical condition. Here, we report a case 50- year -old woman with left breast lump which clinically, radiologically and on fine needle aspiration cytology was diagnosed as phyllodes tumor, but after surgical excision it was reported as breast lipoma on final histopathology.

Computed tomographic findings, surgical management and postoperative outcomes of large intermuscular lipomas in the hindlimb of 11 dogs.

Lipomas are benign adipose tissue tumours of mesenchymal origin and can originate in various locations. Intermuscular lipomas in the thigh can cause substantial hindlimb expansion in the dog. We describe the computed tomography findings, surgical management and the outcomes of 11 dogs with large intermuscular lipomas of the hindlimb. Retrospective case series. Medical records between 2009 and 2019 of dogs presenting to The Animal Hospital at Murdoch University were reviewed. Inclusion criteria included dogs with a histologically confirmed, large hindlimb lipoma that was surgically excised following preoperative computed tomography (CT) imaging. CT with intravenous contrast revealed a well-defined, smoothly marginated, fat attenuating mass with minimal vascularity, separating the muscle bellies of the caudal hindlimb. The mass was often in close proximity to the femoral artery and vein. All lipomas were marginally excised. At surgery, some lipomas were intimately associated with the sciatic nerve and some showed infiltration of, or attachment to, neighbouring muscle that could be excised en bloc with the lipoma. Postoperative closed-suction wound drainage was used in 6 of 11 dogs. One dog required revision surgery due to partial wound dehiscence. Long-term follow-up with owners reported good postoperative function of the affected hindlimb in all dogs. One dog developed an infiltrative lipoma in the same location 22 months post-excision. Preoperative CT allowed a presumptive diagnosis of intermuscular lipoma and facilitated surgical planning for marginal excision. Large intermuscular lipomas of the hindlimb can be safely excised with minimal short-term complications, good long-term functional outcome and low likelihood of recurrence.

Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma

Lipoblastoma is a rare benign adipose tissue tumor that occurs mostly in infants and children. Histological diagnosis of lipoblastoma is sometimes difficult because it closely resembles other lipomatous tumors. The detection of PLAG1 gene rearrangement is useful for the diagnosis of lipoblastoma. Four PLAG1 fusion partner genes are known in lipoblastoma: HAS2 at 8q24.1, COL1A2 at 7q22, COL3A1 at 2q32, and RAB2A at 8q12. Herein, we describe a novel fusion gene in a case of lipoblastoma of left back origin. We identified a potential PLAG1 fusion partner using 5′ rapid amplification of cDNA ends, and sequence analysis revealed the novel fusion gene, BOC-PLAG1. The BOC-PLAG1 fusion transcript consists of the first exon of the BOC gene fused to exon 2 or exon 3 of the PLAG1 gene. PLAG1 expression was found to be 35.7 ± 2.1 times higher in the tumor specimen than in human adipocytes by qRT-PCR. As a result of the translocation, the constitutively active promoter of BOC leads to PLAG1 overexpression. The identification of the BOC-PLAG1 fusion gene will lead to more accurate diagnosis of lipoblastoma.

A Giant Oral Lipoma with Possible Post-Traumatic Origin: A Rare Entity at the University Teaching Hospital Center of Yaounde

Lipomas are benign tumors of adipose tissue with pathogenesis and a controversial etiology. An explicit link between soft tissue trauma and the occurrence of lipomas is difficult to establish. However, some cases have been described. These soft tissue tumors have been called post-traumatic lipomas. Clinically oral lipomas appear as yellowish nodular masses less than 3 cm in diameter. Yet the oral lipoma can increase in size from 5 to 11 cm over several years. The reported case is the first referred in our service. It was a mass located on the inside of the left cheek painless, nodular, yellowish about 8 cm in diameter, secondary to trauma. The treatment was surgical under local anesthesia. In the presence of mature fat cells very similar in appearance to the surrounding normal fat associated with a detachment of the superficial layers of the oral epithelium, the suggested diagnosis was a posttraumatic intraoral lipoma.

Stem Cells Derived from Lipoma and Adipose Tissue-Similar Mesenchymal Phenotype but Different Differentiation Capacity Governed by Distinct Molecular Signature.

Lipomas are benign adipose tissue tumors of unknown etiology, which can vary in size, number, body localization and cell populations within the tissue. Lipoma-derived stem cells (LDSCs) are proposed as a potential tool in regenerative medicine and tissue engineering due to their similar characteristics with adipose-derived stem cells (ADSCs) reported so far. Our study is among the first giving detailed insights into the molecular signature and differences in the differentiation capacity of LDSCs in vitro compared to ADSCs. Mesenchymal stem cell phenotype was analyzed by gene expression and flow cytometric analysis of stem cell markers. Adipogenesis and osteogenesis were analyzed by microscopic analysis, cytochemical and immunocytochemical staining, gene and protein expression analyses. We showed that both LDSCs and ADSCs were mesenchymal stem cells with similar phenotype and stemness state but different molecular basis for potential differentiation. Adipogenesis-related genes expression pattern and presence of more mature adipocytes in ADSCs than in LDSCs after 21 days of adipogenic differentiation, indicated that differentiation capacity of LDSCs was significantly lower compared to ADSCs. Analysis of osteogenesis-related markers after 16 days of osteogenic differentiation revealed that both types of cells had characteristic osteoblast-like phenotype, but were at different stages of osteogenesis. Differences observed between LDSCs and ADSCs are probably due to the distinct molecular signature and their commitment in the tissue that governs their different capacity and fate during adipogenic and osteogenic induction in vitro despite their similar mesenchymal phenotype.

A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

Background: Hibernoma or lipoma of brown fat is a rare benign tumor, representing 1.6% of the neoplasms of this tissue. Because of its histological characteristics can be wrongly classified as liposarcoma, therefore a correct differential diagnosis is necessary to provide appropriate treatment.Case presentation: The patient on which this case study is based is a 44-year-old male with a painless soft mass in his axilla located by his 4th and 5th ribs. The resected specimen did not have the classic macroscopic features of lipoma or fibrolipoma. Microscopically, the report described a proliferation of unilocular adipocytes with eccentric nucleus and, in less frequency, multilocular adipocytes with central nucleus. He had no recurrence after excision.Conclusions: Despite radiology studies and other technologies such as magnetic resonance imaging, computerized axial tomography (CAT), etc., the clinical diagnosis of hibernoma could be difficult. Lipoma-like hibernoma only have a few multilocular cells and can be wrongly classified as liposarcoma. Well-differentiated liposarcoma resembles it on low-power examination. Due to this it is especially important to perform a differential diagnosis with lipoma, fibroma, and even with liposarcoma. In this study we describe the histological features, the molecular markers and cytogenetic aspects that contribute to differentiate hibernoma from others tumors.

Intramuscular Hibernoma of the Scapular Region Misdiagnosed on Cytology as a Malignant Lesion: A Report of a Rare Case

Hibernomas are extremely rare benign tumors of adipose tissue characterized by an admixture of brown fat cells with granular, multivacuolated cytoplasm and white fat cells. Hibernomas account for 1.6% of benign adipose tissue tumors and approximately 1.1% of all adipocytic tumors. Around 10% of these cases are intramuscular. It was initially described in the early 1900s as being composed of brown fat. Hibernomas usually occur in third to fourth decades of life and the most frequent sites being thigh, trunk, shoulder, back etc. Cytological differential diagnoses of hibernoma include well differentiated liposarcoma, myxoid/round cell liposarcoma, chondroid lipoma and benign granular cell tumor. Due to its abundant vascularity evident on angiography, it can sometimes mimic a malignant lesion, from which it needs to be distinguished as complete surgical excision is the only treatment required for a hibernoma. Moreover, it has no malignant or metastatic potential. We presented a rare case of intramuscular hibernoma of the scapular region in a 34-year-old male, in which cytology was reported as pleomorphic fibrolipomatous malignant lesion.

A Rare Case of Refractory Hematemesis Caused by a Gastric Lipoma

Lipomas in the stomach are a rare finding representing less than 1% of all stomach tumors. These are usually asymptomatic and rarely cause significant bleeding or obstructive symptoms. We report an unusual case of a gastric lipoma presenting as massive refractory hematemesis. A 76 year old female taking NSAIDs for a recent hip fracture repair presented with multiple episodes of large volume hematemesis leading to weakness and fatigue. She was initially unstable with hypotension and tachycardia. Her abdominal examination was benign. The patient was intubated for airway protection and resuscitated with blood and intravenous fluids. She had no prior history of gastrointestinal bleeding. The patient underwent an EGD which showed a 3 cm polypoid mass in the posterior gastric body that was actively bleeding. This was cauterized and injected with epinephrine but the patient became hypotensive requiring the case to be stopped. Another EGD was attempted after the patient was transferred to the ICU for stabilization. Endoscopy again showed active bleeding at the mass site and several endoclips were applied and ethanolamine injected for hemostasis. However, bleeding continued with a drop in her hemoglobin and hematocrit to a nadir of 5.9/16.9. Interventional radiology was consulted for embolization. Angiography indicated the bleeding was localized to a branch of the left gastric artery but the vessel could not be accessed due to its tortuosity. The patient was subsequently taken to the operating room given her continued hematemesis. She underwent an open partial gastrectomy removing the stomach body and antrum with retrocolic gastrojejunostomy. Post-surgery, the patient was stable with cessation of bleeding. Anatomical specimens collected from the partial gastrectomy showed a submucosal lipoma measuring 4.5 cm in its greatest dimension with fat necrosis extending into the submucosa and muscularis propria layers. Gastric lipomas are benign tumors of adipose tissue arising from the submucosal layer and rarely present with bleeding or obstructive symptoms. In cases with bleeding the blood loss is usually slow and chronic. Only a few cases of massive bleeding have previously been reported. Endoscopic techniques such as submucosal dissection or unroofing have been employed successfully for treatment of smaller lipomas or those with relatively mild symptoms. However, in the case of larger tumors and those with large volume bleeding surgical resection is usually required.Figure: Initial EGD showing an approximately 3 cm polypoid mass in the posterior gastric body.Figure: The mass seen with EGD shows evidence of active bleeding and an ulcerated tip.Figure: Endoscopic measures failed to achieve hemostasis at the lipoma site.

Co-existence of multiple pyogenic granuloma and intra oral lipoma in a 52 year old female patient- a rare entity

Pyogenic granuloma is a reactive hyperplasia usually arises in the oral cavity secondary to low grade local irritation, traumatic injury, hormonal factors or certain kind of drugs. Lipoma is a benign tumor of adipose tissue, which constitutes 1-4% of all benign lesions. This paper presents the co-existence of pyogenic granuloma and intra oral lipoma on right buccal mucosa, both were managed by surgical intervention.