Background: Thyroid swelling is one of the concerned health issues in middle age female patients. Though majority of the thyroid lesion were benign in nature but its cost-effective preliminary diagnosis is a big challenge. Fine Needle Aspiration Cytology (FNAC) is a simple, cost-effective, highly sensitive and specific test for preliminary diagnosis of thyroid swelling. FNAC accompanying with the thyroid function tests (TFT) may be helpful in the proper assessment and management of thyroid swellings. We aimed to evaluate the thyroid swellings by FNAC and correlate FNAC findings with the TFT. Material & Methods: This study was performed in the Sampurna Sodani Diagnostic Clinic, Khandwa (M.P) for the period of one year from July 2019 to July 2020. Total 50 patients with thyroid swelling enrolled in the current study. Assessment of cytomorphological features of thyroid swelling by using FNAC and also the thyroid function test (TFT) by using chemiluminescence immunoassay (CLIA) method. Results: Most of the cases belong to age range 41 - 50 years with female predominance.1:4.6 was male to female ratio. Cytological diagnosis comprised benign thyroid lesion was 88% amongst them colloid goiter (30%) was predominant.