Benign Cystic Teratoma Research Articles

MRI features of ovarian teratomas with somatic-type malignancy and mature cystic teratomas.

We evaluated the magnetic resonance imaging (MRI) features of ovarian teratomas with somatic-type malignancy (TSMs) and benign ovarian mature cystic teratomas (MCTs) to determine the diagnostic contribution of the MRI findings for differentiating these two teratomas. We compared the MRI findings between ovarian TSMs (n = 10) and MCTs (n = 193), and we conducted a receiver operating characteristic (ROC) analysis to determine the MRI findings' contribution to the differentiation of TSMs from MCTs. The maximum diameters of whole lesion and the largest solid component in the TSMs were larger than those of the MCTs (p = 0.0001 and p < 0.0001, respectively). Fat tissue in solid components was seen in 73/116 (62.9%) MCTs but in none of the TSMs (p = 0.0001). Ring-like enhancement in solid components was seen in 60/116 (51.7%) MCTs and none of the TSMs (p = 0.0031). On dynamic contrast-enhanced MRI (DCE MRI), all of the solid components in the TSMs showed a high- or intermediate-risk time intensity curve (TIC), and those in 113 of the 116 (97.4%) MCTs showed a low-risk TIC (p < 0.0001). The area under the curve of the ROC analysis using the high-/intermediate-risk TIC on DCE MRI was the highest (0.99) for differentiating TSMs from MCTs: sensitivity 100%, specificity 97.4%, positive predictive value 75.0%, negative predictive value 100%, and accuracy, 97.6%. Compared to ovarian MCTs, ovarian TSMs are larger and have larger solid components with high- or intermediate-risk TICs on DCE MRI. Ovarian MCTs frequently show small solid components with fat tissue, ring-like enhancement, and a low-risk TIC on DCE MRI.

Ovarian masses and pregnancy: About 2 cases and literature review (experience of Gyneco-obstetrics service 2 Fez)

Management of adnexal masses during pregnancy can be challenging for the patient and clinician. The specter of a possible malignant tumor may influence the decision to intervene rather than the expected management. The etiologies of ovarian masses vary depending on the age of the parturient, and therefore, benign entities such as functional ovarian cysts, benign cystic teratomas, and serous cystadenomas predominate. In cases of malignancy, these are generally germ cell tumors and borderline, low-grade ovarian tumors. Ultrasound is the primary modality used to detect ovarian masses and assess the risk of malignancy. Morphological criteria identify benign cysts more precisely than malignant tumors. Tumor markers are mainly used to monitor disease status after treatment rather than to establish the diagnosis of ovarian tumor due to lack of specificity, as several markers can be elevated by pregnancy itself (e.g. , CA-125, β-hCG). We report the cases of 2 patients who consulted the emergency room in a context of pelvic pain during pregnancy whose clinical examination aimed first to eliminate an emergency, notably a torsion of the adnexa, then to explore using ultrasound the etiology and characterize the objectified ovarian mass. The care is specific during pregnancy. Expectant management is recommended for most pregnant patients with asymptomatic, unsuspicious cystic ovarian masses. Surgical intervention during pregnancy is indicated for large and/or symptomatic tumors and those that appear highly suspicious for malignancy on imaging tests. The extent of surgery depends on the intraoperative diagnosis of a benign or malignant tumor. Conservative surgery is most often performed. More aggressive surgery is indicated for ovarian malignancies, including surgical staging. Although rarely necessary, chemotherapy has been used during pregnancy with minimal fetal toxicity in patients with advanced ovarian cancer, in which the risk of maternal mortality outweighs fetal consequences.

MRI findings of malignant transformation arising from mature cystic teratoma of the ovary: comparison with benign mature cystic teratoma.

This study aimed to evaluate the efficacy of MRI findings to differentiate malignant transformation arising from mature cystic teratoma (MT-MCT) of the ovary from benign mature cystic teratoma (BMCT). This study included 11 patients with histopathologically proven MT-MCT and 50 with BMCT. Overall, 7 patients with MT-MCT and all 50 with BMCT underwent unenhanced and contrast-enhanced MRIs and 4 with MT-MCT only underwent unenhanced MRIs. The MRI findings were evaluated and compared between the two diseases. The median age (55 vs. 38years, p < 0.01) and maximum diameter (109 vs. 65mm, p < 0.01) were higher in MT-MCT than in BMCT. Fat component occupancy was lower in MT-MCT than in BMCT (median, 5% vs. 63%, p < 0.01). Only MT-MCT exhibited irregular tumor margins (64%), peritoneal dissemination (18%), and abnormal ascites (27%). The solid components were more commonly observed in MT-MCT than in BMCT (100% vs. 32%, p < 0.01) on contrast-enhanced images. The maximum diameter of solid components in MT-MCT was larger than that in BMCT (median, 61mm vs. 14mm, p < 0.01). In MT-MCT, the common configuration of solid components was endophytic or exophytic sessile (85%), whereas in BMCT, it was endophytic papillary (88%). Compared with BMCT, MT-MCT demonstrated a larger maximum diameter, lower occupancy rate of fat components, and sessile solid components. The characteristic configuration of solid components was endophytic or exophytic sessile in MT-MCT and endophytic papillary in BMCT.

Case Report of Endometrial Polyp with Bilateral Cystic Teratoma Ovary

Benign ovarian teratomas or dermoid cysts are the commonest germ cell tumour of ovaries, accounting for 10 to 15% of all ovarian tumours. The common age of presentation includes women's reproductive age group and post-menopausal age. These lesions can be benign, like mature teratoma or malignant, like immature teratoma, yolk sac tumour, and mixed germ cell neoplasm. These lesions are usually asymptomatic, or they can present with varying symptoms and signs. Diagnosis includes imaging and measurement of levels of tumour markers. Here we report a case of a 48-year-old woman who presented with menorrhagia for four years. The patient initially underwent dilation and curettage for similar complaints in the past, following which her cycles regularized. Later the patient was started on medications for the recurrence of symptoms. Examination revealed no abnormalities. The patient was further investigated with ultrasound and MRI pelvis and proceeded with bilateral salpingo-oopherectomy. Biopsy revealed features suggestive of benign ovarian teratoma. The patient has managed accordingly and is in regular follow-up. Benign ovarian tumours are mostly asymptomatic or present with nonspecific symptoms, of which abdominal pain and mass are seen in many cases. The commonest of these tumours is a benign mature cystic teratoma or dermoid cyst, which is bilateral. Though only one per cent contain a secondary malignancy arising from one of their components, early recognition and timely intervention are necessary to avoid untoward complications. Therefore, we recommend follow-up of such cases with radiological and blood investigations.

Large benign cystic teratoma of the ovary: a case report

Cystic teratoma is the most common ovarian germ cell tumour. It is made up of ectoderm, mesoderm, and endoderm that eventually become hair, muscle, teeth, or bone. These tumors are usually benign. A 30-year-old para 6+0 with 2 living children, presented to the gynaecological clinic of the Federal Medical Centre, Yenagoa with complaints of abdominal swelling of four-year duration. Physical examination revealed a young woman, in no obvious distress. Her abdomen was uniformly enlarged, moved with respiration and non-tender, smooth, firm, mobile in two planes and not attached to underlying structures or overlying skin. It was dull to percussion, and there was ascites demonstrable by fluid thrill. Report of abdominopelvic ultrasound scan revealed a huge cystic mass arising from the right adnexae, and extending into the abdomen. She subsequently had right ovarian cystectomy, and was discharged home on the 3rd day post-operation. Histopathology report revealed a diagnosis of benign cystic teratoma. She is presently on follow-up. Ovarian cyst is commoner among the women of reproductive age-group. Routine pelvic examination is advised to enable early detection and prompt management of this condition. Prognosis is usually good when the cyst is benign.

Primary Adrenal Teratoma- An Unusual Extragonadal Site

Among mesenchymal neoplasms of Adrenal cortex, Myelolipoma constitutes the most common neoplasm that often diagnosed in patients in their fifth to seventh decade of life. Whereas Teratoma in retroperitoneal location, in Adrenal gland is rare. We present a case of 27year old woman who presented with pain abdomen, found to have a left adrenal mass. On imaging left adrenal mass had defined boundaries and fat predominant component with likely diagnosis of Myelolipoma. She underwent laparoscopic Adrenalectomy with histopathological diagnosis of Benign cystic teratoma. Primary adrenal teratomas are rare neoplasms, more commonly involving left adrenal gland. They are generally amenable to laparoscopic resection and have favorable prognosis.

Clinicopathological Study of Ovarian Germ Cell Tumours in Tertiary Care Hospital, Tamil Nadu, India: A cross-sectional Study

Introduction: Ovarian germ cell tumours are a heterogeneous group of neoplasms derived from primitive germ cells of the embryonic gonad, either directly or indirectly. They can be classified as benign and malignant, with slow and rapid growth and spread, respectively. Benign ovarian germ cell tumours are common, while malignant tumours are rare and account for about 2.6% of all ovarian malignancies. They are more common in the second and third decades of life and typically present with abdominal mass, pain, and elevated serum tumour markers, which aid in primary diagnosis and follow-up. Aim: To analyse the distribution of germ cell tumours in the ovary in relation to age, parity, mode of presentation, biochemical markers, histomorphological patterns, and immunohistochemical markers. Materials and Methods: This cross-sectional study was conducted at Department of Pathology, Sree Balaji Medical College, Hospital and Research Institute, Chromepet, Chennai, Tamil Nadu, India. The study involved 86 ovarian specimens, of which 25 were germ cell tumours. Complete clinical history, radiological findings, and pre-operative laboratory test values were recorded. The ovarian specimens were carefully examined for gross appearances, fixed in 10% neutral buffered formalin for 24-48 hours, and subjected to histopathological processing, routine and special staining, and immunohistochemical study after observing the different morphological patterns of the ovarian specimens received. Results: The age range of presentation was between 14 years and 58 years. Seventeen patients were parous (14 benign and 3 malignant), and eight (5 benign and 3 malignant) were nulliparous. Abdominal mass and abdominal pain were the most common modes of presentation. Out of 25 germ cell tumours, 19 were benign cystic mature teratomas, 2 were immature teratomas, 1 was a yolk sac tumour, 2 were dysgerminomas, and 1 was a carcinoid tumour, with 6 being malignant and 19 being benign tumours. Among the 6 malignant ovarian tumours, 5 cases had raised serum tumour markers {cancer antigen-125 (CA-125), Alpha-Fetoprotein (AFP)} pre-operatively, and the levels reduced and became normal after surgery. Among the 2 cases of immature teratoma, one was Grade-II and the other was Grade-III. For one case with mixed tumour components, CD-30 and α-fetoprotein immunohistochemical markers were performed, showing negative and positive results, respectively. Conclusion: Among the histopathological subtypes, benign cystic teratomas were the most common ovarian germ cell tumours in this study. Both benign and malignant tumours presented with abdominal pain and abdominal mass. Most of the tumours were diagnosed between the ages of 21 and 40 years. In this study, α-fetoprotein immunohistochemical marker s

A curious case of ovarian cysts.

Benign mature cystic teratomas are a form of ovarian germ cell tumor that originates from primordial germ cells in the ovaries. Of the three types of teratoma neoplasms, benign mature cystic teratomas (also called dermoid cysts) are the most common. Patients may present with intermittent abdominal or pelvic pain, abdominal enlargement, dysmenorrhea, dyspareunia, or may be asymptomatic. Clinicians should have a high suspicion for benign mature cystic teratomas, which account for more than 20% of all ovarian neoplasms. This article focuses on the clinical symptoms, ovarian growth characteristics, pathophysiology, potential complications, management options, and recurrence of benign mature cystic teratomas.

LBODP097 Malignant Struma Ovarii: Long Term Successful Treatment. Outcome

Abstract 18 year old African American female saw her GYN in 9/2008 for abdominal pain. CT: bilateral adnexal masses (10×8 cm left; 6.3×3.1 cm right). Surgical pathology reported a left benign cystic teratoma and right corpus luteum cyst. Pain recurred in 2010. MRI showed: 9×7.5×4 cm right adnexal mass. Repeat surgery was done. Pathology: benign cystic teratoma with focal thyroid tissue - "Struma Ovarii". Abdominal pain recurred yet again in 2012. Sonography revealed a mixed solid/cystic pelvic mass measuring 10.6×7.9×7.6 cm. Exploratory laparotomy 9/2012 revealed a right adnexal mass and widespread peritoneal nodules. Pathology reported follicular tissue with colloid in the nodules - "Peritoneal Strumatosis" suggesting benignity. Upon further review was reclassified as metastatic well differentiated follicular thyroid cancer of ovarian origin with follicular thyroid tissue identified in peritoneal lymph nodes, spleen, bladder and rectal wall. The patient was then referred to endocrinology at our facility. On exam she was clinically euthyroid without thyromegaly or nodularity. Thyroid hormone levels were normal. Antithyroid antibodies were absent. Serum Thyroglobulin (Tg): elevated (229; normal 2-35 ng/ml) as was CA125 (64; normal &amp;lt;21 U/ml). Immunohistochemistry: positive for Tg and Thyroid transcription factor-1. Molecular markers: no mutations in BRAF, RAS, or TP53. In preparation for radioactive iodine (RAI) therapy, total thyroidectomy was performed 4/13/2013 and reported as normal thyroid tissue. Dosimetry findings: very iodine avid tissue with prolonged retention (33% at 6 days). Maximum tolerated dose: 200 mCi. A 62.8 mCi RAI was administered 7/13/2013. Post RAI whole body scan (WBS): numerous focal areas of increased uptake in abdomen and pelvis consistent with metastatic disease. Treatment with L-thyroxine was given to suppress TSH. Follow up WBS 12/26/2013 showed persistent increased uptake in abdomen and pelvis. Serum Tg was high (198. 0). A second RAI dose of 104.8 mCi was given. Post RAI WBS confirmed multiple areas of metastatic disease in abdomen and pelvis. Subsequent serum Tg levels down trended. WBS 11/12/2014: only two residual abnormal foci in the lower neck and one inferior to the liver without abdominal or pelvic foci. Given the dosimetry issue and the reassuring serum Tg levels, surveillance was continued. WBS 9/25/2015: unchanged. Now age 27, WBS 1/26/2022: only residual faint lower neck uptake, resolution of the focus inferior to the liver and no distant foci. Stimulated Tg was normal at 2.2 ng/ml with stimulated TSH &amp;gt;110. 0 uIU/ml. Presentation: No date and time listed

Dermoid cyst of ovary: A common pathology with an uncommon presentation

Mature cystic teratoma of ovary is the most common germ cell tumour and also the most common tumour of the ovary. It accounts for more than 20% of all the ovarian neoplams. In spite of it being so common, the cut section of such a tumour containing multiple sebaceous balls of varying sizes is quite a rare presentation. Extensive literature search has revealed only few such cases reported in the practice of gynaecology. Here, we present a case of benign cystic teratoma of ovary in a 30-year-old lady with similar presentation.

An Unusual Case of Bilateral Ovarian Dermoid Cyst in an Infertile Woman - A Case Report

Dermoid ovarian cysts or benign cystic teratomas are benign germ cell tumours which make up to 10 to 25 % of all ovarian tumours. These are usually found in women of reproductive age group with peak age between 25 and 45 years. Of all cystic tumours of the ovary, 5 to 10 % are dermoid cysts. These are bilateral in 12 to 15 % of cases.&#x0D; Mature cystic teratomas account for 10–20 % of all ovarian neoplasms and are the most common neoplasms in patients younger than 20 years of age. Mature teratomas are usually benign, but in 0.1-0.2 % of cases, they may undergo malignant transformation.[1]&#x0D; The word “teratoma,” initially coined by Virchow in 1863, originates from the Greek word teraton, meaning monster. The term “dermoid cyst” used much earlier for the same entity was coined by Leblanc, in 1831.[2] These are initially asymptomatic but can become symptomatic and present with symptoms like pain in the abdomen, anorexia, bloating, and an increase in size. Other complications are torsion, rupture, and infection. They are usually unilocular with smooth surfaces containing sebaceous material with hair, lined by squamous epithelium. Tissues like cartilage, bone, teeth, bronchial mucosa and thyroid tissue can be found in the wall. They have tissues from all three germ layers but ectodermal structures predominate. Diagnosis is usually made by ultrasound scan. Dermoid cysts have a characteristic appearance on ultrasound. Ultrasound findings include the presence of a Rokitansky nodule, fat fluid levels, dermoid mesh, and the “tip of the iceberg sign”.[3] CT scan and MRI can also be used. Management includes surgical excision by laparotomy or laparoscopy.

Benign ovarian tumours in a tertiary care hospital

Objectives: To find out frequency of types and subtypes of Benign Ovarian Neoplasms and to compare it with other studies. Methodology: A 10 year retrospective study of Benign ovarian tumours ,specimens of that were received and diagnosed in the Department of Pathology, R.N.T. Medical College, Udaipur Rajasthan . This study was conducted for a period of 10 years from Jan 2004 to Dec 2013 Results: The study was carried out on 472 specimens , for the period from January 2004 to December 2013 (only retrospective) of ovarian neoplasm that were received in the Histopathological section of Pathology department, R.N.T. Medical College, Udaipur. Total of 472 ovarian tumors were analysed out of which 355 (75.21%) were Benign. In the benign tumors of the ovary, number of serous cystadenoma was maximum, accounting to 151(42.55%) cases followed by benign cystic teratoma 125 (35.21%) cases and 67 (18.87%) cases Mucinous cystadenoma, 4 cases(1.12%)Benign Brenner tumor), 6 cases (1.69%) Fibroma and 2 (0.56%)cases were of Fibrothecoma . Conclusion:In the benign tumors of the ovary, number of serous cystadenoma was maximum, accounting to 151(42.55%) cases followed by benign cystic teratoma 125 (35.21%) cases and 67 (18.87%) cases were Mucinous cystadenoma.

Ovarian Dermoid Cyst- Management by Laparoscopy Versus Laparotomy

Background: Benign cystic teratoma or dermoid cysts are germ cell tumour of the ovary which accounts for 20-25% of all ovarian tumour and are bilateral in 10-15% of cases. These tumour have a low incidence of malignancy, reported as 1-3%. The aim of the study is to determine the safety and efficacy of the laparoscopic management of ovarian dermoid cyst over laparotomy.&#x0D; Methods: This prospective study was conducted in the Department of Obstetrics and Gynaecology, BIRDEM-II General Hospital, from January 2013-December 2018. During the study period, a total of sixty subjects were included for comparison. Thirty patients were selected for laparoscopic ovarian cystectomy and another thirty patients were selected for laparotomy. They were randomly selected for the procedures.&#x0D; Result: Thirty patients with ovarian dermoid cyst undergoing laparospic surgery were compared with thirty patients with ovarian dermoid cyst undergoing laparotomy in respect to selection criteria, surgical procedures, operation time, blood loss, hospital stay and outcome of operation. Although the operation time for ovarian cystectomy performed by laparoscopic surgery was slightly longer (62.15 ± 16.3 min, mean ± SD) than by laparotomy (50 ± 16.20 min, p &lt; 0.52), blood loss is smaller and hospital stay is shorter in laparoscopic group than laparotomy.&#x0D; Conclusion: The laparoscopic approach is generally considered to be the gold standard for the management of dermoid cyst. We believe that laparoscopic management of dermoid cyst may be a safe and beneficial procedure when performed by experienced surgeon.&#x0D; Bangladesh J Obstet Gynaecol, 2020; Vol. 35(2): 107-111

A rare case of intrapulmonary teratoma

Benign cystic teratomas of the lung are extremely rare. We diagnosed such case in 22 years old male suffering from heaviness in left side of chest for 2 years with occasional cough with expectoration for 1 year. Patient suffered typical symptom of white hair in expectoration. Diagnosis was confirmed on computed tomography thorax and Fine needle aspiration cytology. Teratoma was located in anterior segment of left upper lobe and was treated with left upper lobectomy. Histopathology was done and was implicational mature teratoma.

Laparoscopic management of large ovarian dermoid cyst and the safety of controlled spillage of dermoid content. case report

The safety and efficacy of laparoscopic management of benign cystic teratoma, and tips to improve results of surgery complications that may result from cyst spillage The patient is placed in a trendelenburg position, the bladder was emptied. Clorhexidine was applied to the abdominal area and vagina. Umbilical port 10 mm was inserted by an open technique (Hasson technique), creation of pneumoperitoneum, intra- abdominal pressure 12 mmHg, two 5mm ancillary trocars were placed under direct endoscopic control at both quadrant sites. A 10 mm, 30-degree laparoscope was used and we identified the left adnexal mass, and incision was made on the wall cyst with the bipolar forceps, we developed a plane between the ovarian wall and cyst by traction and countertraction. And inadvertent rupture of the dermoid cyst was presented so we drained all the material to an endobag. We roll out the ovarian capsule and the bleeding from the ovary was controlled with the bipolar forceps. The resected tissue were removed through the 10 mm laparoscopic port. And finally with applied the rule of jet-wash irrigation with copious amounts of fluid, removing up to microscopic particles of cyst contents. We conclude that laparoscopic management of dermoid cysts is a safe and valuable method in selected cases. Review of 15 studies in the literature, revealed only 0.2% incidence of chemical peritonitis following laparoscopic removal of dermoid cysts. The unnecessary fear of dermoid cyst content spillage was championed by the fact that spillage never affects patient morbidity or prognosis in benign cystic teratoma, as shown in the literature. In case of spillage it seems satisfactory to contain all spilled material in the endobag and vigorous jet-wash suction irrigation.

Benign germ cell tumour and epithelial carcinoma – Rare synchronous presentation in unilateral ovary on background of endometriosis

Ovarian carcimomas are the second most common gynecological malignancy of which more than 90% arise from surface epithelial cells. Endometriosis-related ovarian neoplasms (ERONs) are described as a group of tumors which include clear cell carcinoma, endometrioid carcinoma, and seromucinous borderline tumor. Benign cystic teratomas are commonest benign ovarian neoplasms derived from germ cells. Coexistence of benign cystic teratoma, endometrioid adenocarcinoma and clear cell carcinoma in the same ovary is very unusual. Our case presented with well differentiated endometrioid adenocarcinoma grade 2 with squamous metaplasia and a nodule of clear cell carcinoma on the background of endometriosis and benign cystic teratoma in the same ovary. To the best of our knowledge, this is the first case with such an unusual combination to be reported in the medical English literature.

Neck Dermoid Cyst with Rare Imaging Appearance on Ultrasound, Elastography, and Computed Tomography

Dermoid cyst is a type of inclusion cyst and a benign cystic teratoma containing two or more germ cell layers. It can show variable appearance on ultrasound and Computed Tomography (CT) as it is derived from squamous cell epithelium (ectoderm) and contains dermal-derived elements such as skin appendages, hair follicles, sebaceous and sweat glands. It is uncommon for a dermoid cyst to occur in the neck region during old age. The present case report highlights a rare imaging appearance of a dermoid cyst, presenting in a 65-year-old elderly male as a midline neck swelling, displaying a rare “coin in sack” appearance on ultrasound, “sack of marbles sign” on Contrast-Enhanced CT (CECT). On strain elastography, it showed characteristics of a hard mass. Diagnosing this type of large dermoid cyst with its radiological appearance is challenging. Multimodality imaging is often needed for early intervention, to prevent its rupture and transformation into malignancy. The dermoid cyst was surgically excised, and the patient was symptomatically normal on follow-up.

Ovarian teratomas in bimodal age groups- Case report

Ovarian teratomas are the most common germ cell tumors and are classified as mature, immature and malignant.Mature cystic teratomas, also called dermoid cysts, are the most common germ cell tumour, accounting for upto 70% of benign ovarian masses in the reproductive years and 20% in postmenopausal women.Immature ovarian teratoma affects primarily younger patients and mature cystic teratomas seen in reproductive age groups. This case report provides a brief summary of the clinicopathological features of the ovarian teratomas such as, the immature teratoma which being a rare tumour was diagnosed in a 15 year old adolescent girl, managed surgically by laparotomy followed by chemotherapy, and the other case of a benign mature cystic teratoma in an elderly 52 year old postmenopausal woman, managed surgically although benign cystic teratomas are rare in the postmenopausal age group.

Rare case of BRAF V600E mutant anaplastic pleomorphic xanthroastrocytoma in a 5-year survivor of acute lymphoblastic leukaemia

A 20-year-old woman with a history of acute lymphoblastic leukaemia treated at 13 years old with radiation and chemotherapy and a benign cystic mature ovarian teratoma diagnosed at 18 years...

Histopathological study of ovarian lesions at a tertiary care hospital

Background: Ovary is the commonest site of neoplastic and non-neoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aims & Objectives: (1) To know about various histopathological types of ovarian lesions presented and diagnosed. (2) To study the incidence of ovarian lesions with respect to patient’s age. (3) To study the frequency of ovarian lesions in terms of non-neoplastic or neoplastic, benign or malignant, unilateral or bilateral, etc.Materials and Method: This is a descriptive study which was carried out at B.J. Medical College, Ahmedabad for a period of three years from 1st January 2018 to 31st December 2020. A Total of 225 cases of ovarian lesions were received and processed in the Pathology Department. Hematoxylin and Eosin stained slides were examined. We have included parameters like Age wise incidence, Nature of Lesion, Frequency & Laterality in this study.Results: Out of 225 cases, 197 cases (87.56%) were unilateral and 28cases (12.44%) were bilateral, 98 cases (43.56%) were non neoplastic & 127 cases (56.44%) were neoplastic. Majority of cases 112(49.78%) belong to age group of 20-39 years. The most common non-neoplastic lesion seen was Follicular Cyst followed by simple and corpus luteal cyst. Among neoplastic lesions, 120 cases (94.49%) were benign & 1 case (0.78%) was borderline & 6 cases (4.73%) were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cyst adenoma followed by benign cystic teratoma and mucinous cyst adenoma. In malignant cases, maximum were of serous cyst adenocarcinoma and endometrioid carcinoma. Conclusion: Ovarian Lesions both non-neoplastic and neoplastic include a variety of morphological features and show a particular age wise incidence. Role of histopathological evaluation remains always important in both diagnosis & management of such cases, particularly in cases of Malignant Lesions in order to save the patient’s life.