The benefits of medicinal plants may not be without some biochemical impediments. Anti-plasmodial activity of Hippocratea africana has been studied; its effects on some biochemical parameters were examined in rats in this study. It was observed that in the female test groups, there was no significant (p > 0.05) changes in urea concentration but there was significant (p 0.05). The male treatment groups however recorded significant (p 0.05) decrease. The result generally does not suggest any biochemical imbalance and therefore the herb may be safe for use for its anti-plasmodial property. Key words: Hippocratea africana, biochemical imbalance, glucose, total protein, urea, albumin, bilirubin, anti-plasmodial property, health benefit.