Benefits Of Aerobic Exercise Research Articles

Cardiorespiratory Benefit of Aerobic Exercise for Patients With Asthma.

Cardiorespiratory Benefit of Aerobic Exercise for Patients With Asthma.

Does Aerobic Exercise Increase 24-Hour Ambulatory Blood Pressure Among Workers With High Occupational Physical Activity?-A RCT.

OBJECTIVEHigh occupational physical activity (OPA) increases cardiovascular risk and aerobic exercise has been recommended for reducing this risk. This paper investigates the effects of an aerobic exercise intervention on 24-hour ambulatory blood pressure (ABP) among cleaners with high OPA.METHODSHundred and sixteen cleaners between 18 and 65 years were randomized. During the 4-month intervention period, the aerobic exercise group (AE) (n = 57) performed worksite aerobic exercise (2 × 30 minutes/week), while the reference group (REF) (n = 59) attended lectures. Between-group differences in 4-month ABP changes were evaluated by intention-to-treat analysis using a repeated-measure 2 × 2 multiadjusted mixed-models design.RESULTSRelative to REF, 24-hour ABP significantly increased in AE: systolic 3.6 mm Hg (95% confidence interval (CI) 1.6–5.7) and diastolic 2.3 mm Hg (95% CI 0.9–3.8). Cleaners with high aerobic workload exhibited particularly high 24-hour ABP increases: systolic 6.0 mm Hg (95% CI 2.4–9.6), and diastolic 3.8 mm Hg (95% CI 1.3–6.4).CONCLUSIONAerobic exercise increased 24-hour ABP among cleaners. This adverse effect raises questions about the safety and intended benefits of aerobic exercise, especially among workers with high OPA and a demanding aerobic workload. http://www.controlled-trials.com/ISRCTN86682076. Unique identifier ISRCTN86682076.CLINICAL TRIAL REGISTRATIONTrial Number ISRCTN86682076.

Efecto del ejercicio aeróbico en la rigidez vascular en una población sana

IntroductionA healthy lifestyle is key for cardiovascular health. There is controversy about beneficial vascular effects of physical exercise. MotivationTo assess the behaviour of vascular stiffness parametres in a healthy population group that practices routine aerobic exercise in comparison with another group of healthy population with a sedentary lifestyle. MethodsStudy of 32 healthy individuals, paired according to age and gender: 12 men and 20 women (46.3±9.7 years old); the study assessed and compared arterial stiffness parametres (brachial systolic and diastolic blood pressure, brachial and central augmentation index, pulse wave velocity, central systolic and diastolic blood pressure and brachial and central pulse pressure). Measurements were conducted using the noninvasive oscillometric method Arteriograph® (TensioMed Budapest Hungary, Ltd.). ResultsArterial stiffness parametres were compared between both groups (16 active individuals vs. 16 sedentary ones), and the following significant differences were found: heart rate 53.25±8.0 bpm vs. 59.75±8.6 bpm (p=0.034), brachial diastolic blood pressure of 70.0 (4.5) mmHg vs. 77.5 (8.3) mmHg (p=0.043), central diastolic blood pressure of 70.0 (4.5) mmHg vs. 77.5 (8.1) mmHg (p=0.043) and pulse wave velocity of 6.70 (1.1) m/s vs. 7.75 (1.1) m/s (p=0.001). ConclusionsRoutine aerobic exercise has a beneficial effect on vascular stiffness in a healthy population group, at the expense of a significant decrease in pulse wave velocity, heart rate and diastolic blood pressure (both brachial and central). These findings help explain the benefits of aerobic exercise on the cardiovascular system.

Interventions in Parkinson rsquo s disease Role of executive function

The cortico-striatal network plays a major role in executive functions (EF), and is believed to play a role in the pathophysiology of Parkinson's disease (PD). However, the tools to assess EF are limited. This review assesses the impact of all PD interventions, namely, pharmacotherapy, physical exercise and Deep Brain Stimulation (DBS) surgery on EF. The effect of PD pharmacotherapy varies with the drug class, neuropsychological test used and the affected dopamine receptor family. There appears to be a benefit of aerobic exercise on EF, including judgment and attention. The effect of Deep Brain Stimulation on EF might vary with site of brain stimulation, the neuropsychological test performed and the pre-operative cognitive state. The effect of EF on underlying manifestations and as a factor in the pathway to the motor benefit needs to be better assessed with more accurate tests that focus on motor component of EF.

Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions.

Cancer and cardiovascular disease are major causes of morbidity and mortality worldwide. Older cancer patients often wrestle with underlying heart disease during cancer therapy, whereas childhood cancer survivors are living long enough to face long-term unintended cardiac consequences of cancer therapies, including anthracyclines. Although effective and widely used, particularly in the pediatric population, anthracycline-related side effects including dose-dependent association with cardiac dysfunction limit their usage. Currently, there is only one United States Food and Drug Administration-approved drug, dexrazoxane, available for the prevention and mitigation of cardiotoxicity related to anthracycline therapy. While aerobic exercise has been shown to reduce cardiovascular complications in multiple diseases, its role as a therapeutic approach to mitigate cardiovascular consequences of cancer therapy is in its infancy. This systematic review aims to summarize how aerobic exercise can help to alleviate unintended cardiotoxic side effects and identify gaps in need of further research. While published work supports the benefits of aerobic exercise, additional clinical investigations are warranted to determine the effects of different exercise modalities, timing, and duration to identify optimal aerobic training regimens for reducing cardiovascular complications, particularly late cardiac effects, in cancer survivors exposed to anthracyclines.

Chronic effect of aerobic exercise on anthropometric, biochemical and hemodynamic variables in individuals with type 2 diabetes mellitus: A systematic review

ObjectiveThe aim of this study was to analyze the effects of aerobic exercise on biochemical, anthropometric and hemodynamic profiles of patients with type 2 diabetes mellitus, in randomized clinical trials and case–control studies. MethodThe databases used in the study were: MEDLINE, BVS (LiLacs), IBECS (Spain), MED Caribbean and Central Controlled Clinical Trial Registry. We included studies published from 2004 to 2014. Were analyzed anthropometric (body mass index, waist circumference and percentage of body fat), hemodynamic (blood pressure and heart rate) and biochemical parameters (glycemia, glycated hemoglobin, insulin, cholesterol-HDL, cholesterol-LDL and triglycerides). ResultsThe results showed that, aerobic exercise of moderate intensity and often three or more times a week, promoted a significant reduction in waist circumference, blood glucose and diastolic blood pressure. ConclusionIt is concluded that there are benefits of aerobic exercise of moderate intensity practiced regularly often more than three times a week on waist circumference, glycemia and diastolic blood pressure in diabetes mellitus type 2.

Aerobic Exercises for Cognition Rehabilitation following Stroke: A Systematic Review

Cognitive impairments are highly prevalent in stroke survivors and can substantially affect their physical rehabilitation and quality of life. The management of these impairments currently remains limited, but increasing studies reported the effect of aerobic exercise on cognitive performance in patients suffering from stroke. The purpose of this review was to assess the effects of aerobic exercise on cognitive function following stroke. Seven electronic databases (China National Knowledge Infrastructure [CNKI], Chinese Science and Technology Periodical Database [VIP], Wanfang, China Biology Medicine disc [CBM], Science Citation Index [SCI], EMBASE, and PubMed) were searched from their inception to May 31, 2015, for the effects of aerobic exercise on cognitive ability compared to usual physical activity in stroke survivors. RevMan V5.3 (The Nordic Cochrane Centre) was used to analyze the data and to evaluate the methodological quality of the included studies. Ten eligible studies including 394 participants were identified. Six studies showed that aerobic exercise significantly improved global cognitive ability in stroke survivors. Four studies reported aerobic exercise to be beneficial in improving memory, but only one showed statistical significance. Two studies investigated the effects of aerobic exercise on attention, and one showed a significant improvement. One study reported a significant benefit of aerobic exercise on visuospatial ability in stroke survivors. No adverse events were reported in the included studies. Aerobic exercise may have a positive effect on improving global cognitive ability and a potential benefit on memory, attention, and the visuospatial domain of cognition in stroke survivors. However, further large, rigorously designed trials are needed to confirm these findings.

Potential Social and Neurocognitive Benefits of Aerobic Exercise as Adjunct Treatment for Patients With ADHD

Objective: The aim of the article is to review the evidence that aerobic exercise may be a useful adjunct treatment for ADHD. Method: Studies on physical, cognitive, and psychosocial aspects of aerobic exercise that are relevant to ADHD are reviewed and evaluated. Results: Stimulant medication, the main pharmacotherapy for ADHD, and aerobic exercise both act on catecholamine pathways. Aerobic exercise has been shown to be beneficial in preclinical studies on spontaneous hypertensive rats, an animal model of ADHD, and in clinical trials of children with ADHD, as an adjunct treatment to medication. Social and neurocognitive function in children and adults seem to be positively affected by exercise as well. Nevertheless, no controlled clinical trials in adults with ADHD have been conducted. Conclusion: Aerobic exercise may be a useful non-medication adjunct therapy for ADHD. The clinical effectiveness of aerobic exercise for ADHD in children and adults warrants further clinical studies.

Aerobic Exercise for Older Adults

Older adults move less, making them prone to deconditioning and a host of other consequences including stiffness, weakness, cardiovascular changes, decreased balance, cognitive disorders, insomnia, mood changes, and adverse effects on appetite, to name a few. Because the benefits of aerobic exercise...

The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease.

In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence-based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of nonmotor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include nonmotor outcomes in exercise trials with the goal of developing evidence-based exercise interventions as a safe, broad-spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.

Aerobic exercise to improve cognitive function in older people without known cognitive impairment.

There is increasing evidence that physical activity supports healthy ageing. Exercise is helpful for cardiovascular, respiratory and musculoskeletal systems, among others. Aerobic activity, in particular, improves cardiovascular fitness and, based on recently reported findings, may also have beneficial effects on cognition among older people. To assess the effect of aerobic physical activity, aimed at improving cardiorespiratory fitness, on cognitive function in older people without known cognitive impairment. We searched ALOIS - the Cochrane Dementia and Cognitive Improvement Group's Specialized Register, the Cochrane Controlled Trials Register (CENTRAL) (all years to Issue 2 of 4, 2013), MEDLINE (Ovid SP 1946 to August 2013), EMBASE (Ovid SP 1974 to August 2013), PEDro, SPORTDiscus, Web of Science, PsycINFO (Ovid SP 1806 to August 2013), CINAHL (all dates to August 2013), LILACS (all dates to August 2013), World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (http://apps.who.int/trialsearch), ClinicalTrials.gov (https://clinicaltrials.gov) and Dissertation Abstracts International (DAI) up to 24 August 2013, with no language restrictions. We included all published randomised controlled trials (RCTs) comparing the effect on cognitive function of aerobic physical activity programmes with any other active intervention, or no intervention, in cognitively healthy participants aged over 55 years. Two review authors independently extracted the data from included trials. We grouped cognitive outcome measures into eleven categories covering attention, memory, perception, executive functions, cognitive inhibition, cognitive speed and motor function. We used the mean difference (or standardised mean difference) between groups as the measure of the treatment effect and synthesised data using a random-effects model. We conducted separate analyses to compare aerobic exercise interventions with no intervention and with other exercise, social or cognitive interventions. Also, we performed analyses including only trials in which an increase in the cardiovascular fitness of participants had been demonstrated. Twelve trials including 754 participants met our inclusion criteria. Trials were from eight to 26 weeks in duration.We judged all trials to be at moderate or high risk of bias in at least some domains. Reporting of some risk of bias domains was poor.Our analyses comparing aerobic exercise to any active intervention showed no evidence of benefit from aerobic exercise in any cognitive domain. This was also true of our analyses comparing aerobic exercise to no intervention. Analysing only the subgroup of trials in which cardiorespiratory fitness improved in the aerobic exercise group showed that this improvement did not coincide with improvements in any cognitive domains assessed. Our subgroup analyses of aerobic exercise versus flexibility or balance interventions also showed no benefit of aerobic exercise in any cognitive domain.Dropout rates did not differ between aerobic exercise and control groups. No trial reported on adverse effects.Overall none of our analyses showed a cognitive benefit from aerobic exercise even when the intervention was shown to lead to improved cardiorespiratory fitness. We found no evidence in the available data from RCTs that aerobic physical activities, including those which successfully improve cardiorespiratory fitness, have any cognitive benefit in cognitively healthy older adults. Larger studies examining possible moderators are needed to confirm whether or not aerobic training improves cognition.

Swimming exercise enhances the hippocampal antioxidant status of female Wistar rats

ObjectivesModerate exercise is known to have health benefits, while both sedentarism and strenuous exercise have pro-oxidant effects. In this study, we assessed the effect of moderate exercise on the antioxidant homeostasis of rats’ hippocampi.MethodsFemale Wistar rats were submitted to a 30-minute swimming protocol on 5 days a week, for 4 weeks. Control rats were immersed in water and carefully dried. Production of hippocampal reactive species, activity of antioxidant enzymes, and glutathione levels in these animals were determined up to 30 days after completion of the 4-week protocol.ResultsProduction of reactive species and hippocampal glutathione levels were increased 1 day after completion of the 4-week protocol, and returned to control levels after 7 days. Antioxidant enzyme activities were increased both 1 day (catalase) and 7 days (superoxide dismutase and glutathione peroxidase) after completion of the protocol. Thirty days after completion of the protocol, none of the antioxidant parameters evaluated differed from those of controls.DiscussionOur results reinforce the benefits of aerobic exercise, which include positive modulation of antioxidant homeostasis in the hippocampi. The effects of exercise are not permanent; rather, an exercise regimen must be continued in order to maintain the neurometabolic adaptations.

Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise

Alzheimer disease (AD) and cerebrovascular disease often coexist with advanced age. Mounting evidence indicates that the presence of vascular disease and its risk factors increase the risk of AD, suggesting a potential overlap of the underlying pathophysiological mechanisms. In particular, atherosclerosis, endothelial dysfunction, and stiffening of central elastic arteries have been shown to associate with AD. Currently, there are no effective treatments for the cure and prevention of AD. Vascular risk factors are modifiable via either pharmacological or lifestyle intervention. In this regard, habitual aerobic exercise is increasingly recognized for its benefits on brain structure and cognitive function. Considering the well-established benefits of regular aerobic exercise on vascular health, exercise-related improvements in brain structure and cognitive function may be mediated by vascular adaptations. In this review, we will present the current evidence for the physiological mechanisms by which vascular health alters the structural and functional integrity of the aging brain and how improvements in vascular health, via regular aerobic exercise, potentially benefits cognitive function.

Cognitive Behavioral Therapy and Aerobic Exercise for Survivors of Sexual Violence with Posttraumatic Stress Disorder: A Feasibility Study

Cognitive Behavioral Therapy and Aerobic Exercise for Survivors of Sexual Violence with Posttraumatic Stress Disorder: A Feasibility Study Sexual violence is a significant and pervasive public health issue impacting women. Due to the high prevalence rate of posttraumatic stress disorder (PTSD) among this population, women who have experienced sexual assault may constitute the largest group of individuals suffering from PTSD in the United States. Although effective treatments for PTSD have been developed, survivors of sexual violence may be reluctant to seek formal treatment such as psychotherapy or pharmacotherapy and remission may be difficult to obtain using these interventions. Given that research supports the psychological benefits of aerobic exercise for reducing symptoms of depression and anxiety, which commonly co-occur with PTSD, aerobic exercise may also reduce symptoms of PTSD. We discuss a strategy to examine the impact and feasibility of incorporating an adjunct aerobic exercise intervention as a treatment for PTSD among women who experienced sexual violence. Fourteen participants received cognitive behavioral therapy (CBT) or CBT plus group aerobic exercise sessions (CBT+E). Feasibility was measured by participant retention and adherence. Acceptability was assessed using a questionnaire. The findings support that it is feasible to conduct a study to evaluate a package of interventions that include an evidence-based treatment for PTSD and aerobic exercise. The high rates of participant retention and satisfaction suggest that exercise is an acceptable intervention among this population. Our results indicate that a large, randomized controlled trial to explore the efficacy of aerobic exercise for the treatment of PTSD among adult women survivors of sexual violence would be safe and feasible. Methodological challenges in conducting this research as well as suggestions for further examination of exercise interventions with adult survivors of sexual violence are discussed.

Aerobic exercise as an adjunct therapy for improving cognitive function in heart failure.

Persons with heart failure (HF) are typically older and are at a much higher risk for developing cognitive impairment (CI) than persons without HF. Increasingly, CI is recognized as a significant, independent predictor of worse clinical outcomes, more frequent hospital readmissions, and higher mortality rates in persons with HF. CI can have devastating effects on ability to carry out HF effective self-care behaviors. If CI occurs, however, there are currently no evidence based guidelines on how to manage or improve cognitive function in this population. Improvement in cognition has been reported following some therapies in HF and is thought to be the consequence of enhanced cerebral perfusion and oxygenation, suggesting that CI may be amenable to intervention. Because there is substantial neuronal loss with dementia and no effective restorative therapies, interventions that slow, reverse, or prevent cognitive decline are essential. Aerobic exercise is documented to increase cerebral perfusion and oxygenation by promoting neuroplasticity and neurogenesis and, in turn, cognitive functioning. Few studies have examined exercise as a potential adjunct therapy for attenuating or alleviating cognitive decline in HF. In this review, the potential benefit of aerobic exercise on cognitive functioning in HF is presented along with future research directions.

Aerobic Exercise Prescription for Older Population: A Short Review

Aerobic exercise can lower the susceptibility to certain preventable chronic diseases, decrease mortality and improve health in the older adults. The health benefits of aerobic exercise include prevention of cardiovascular and coronary heart diseases; lowering blood pressure and blood lipids; lowering the risk of type 2 diabetes mellitus, back pain, osteoarthritis, osteoporosis, falls and, to some extent, sarcopenia; and improving quality of life and independent living in older adults. Aerobic training should be continued in order to be beneficial. If it is professionally prescribed by a physiotherapist or clinical exercise specialist using the most current research evidence, aerobic exercise can be enjoyable and safe. Professional and medical supervision during aerobic training may be needed for the older population and those who are at a higher risk for cardiovascular disease, stroke, hypertension or who have diabetes mellitus, obesity, osteoarthritis, and osteoporosis. More research is still needed to identify the physiological and cellular mechanisms that show exercise can slow the aging process. This review article presents aerobic exercise-induced cardiovascular benefits and optimal exercise prescription for promoting cardiovascular-pulmonary-muscular health and preventing age-related diseases and mortality

Aerobic exercise improves gastrointestinal motility in psychiatric inpatients.

To evaluate the benefit of aerobic exercise on colonic transit time (CTT) for psychiatric inpatients in a closed ward. Sixty consecutive adult inpatients of the Somang Hospital Psychiatry Unit (Eumsung-gun, South Korea), without CTT-related diseases or drug therapies, were recruited for study from March to June of 2012. Upon enrollment, the patients were randomly assigned to partake in a 12-wk instructor-led group aerobic exercise program (exercise group; n = 30) or to maintain their ordinary daily activities (control group; n = 30). The exercise program was structured as 10 min warm-up (stretching), 40 min exercise, and 10 min cool-down (stretching) for three days each week. The exercise sessions consisted of walking only in week one and aerobics from weeks two to 12, with increasing intensity (50% heart rate reserve (HRR) for weeks one to four, 60% HRR for weeks five to eight, and 70% HRR for weeks nine to 12). CTT was measured before (baseline) and after (week 12) the exercise program, in duplicate (on days four and seven), using abdominal radiography and the multiple radio-opaque marker technique. Changes in the exercising patients' CTT and weight-, cardiovascular- and fitness-related parameters were statistically assessed. The study dropout rate was 30.0%, with 23 patients in the exercise group and 19 patients in the control group completing the study. At week 12, the exercise group showed decreases in body weight (mean ± SE) baseline: 69.4 ± 2.8 vs study-end: 67.6 ± 2.7; P < 0.635) and body mass index (BMI) (25.2 ± 1.1 vs 24.9 ± 0.8; P < 0.810), but the extent of change was not significantly different from that experienced by the control group (body weight: 68.8 ± 4.0 vs 68.8 ± 3.9; BMI: 24.3 ± 1.1 vs 24.4 ± 1.2). However, the exercise group showed significant improvements in leg muscle strength (baseline: 41.7 ± 4.3 vs study-end: 64.1 ± 5.0; P < 0.001), cardio-respiratory endurance (120.5 ± 4.5 vs 105.4 ± 2.8; P < 0.004), and leg muscle elasticity and power output (21.5 ± 2.6 vs 30.6 ± 2.8; P < 0.001). The exercise group showed an exercise-induced reduction in total CTT (baseline: 54.2 ± 8.0 vs 30.3 ± 6.1), which was significantly different from that experienced by the control group over the 12-wk period (48.6 ± 9.3 vs 48.3 ± 12.3; P = 0.027); however, the exercise-induced decreases in CTT involving the three colonic segments examined (right, left and recto-sigmoid) showed no significant differences from the control group. A 12-wk aerobic exercise program can benefit psychiatric inpatients by increasing intestinal motility, possibly decreasing risk of metabolic- and cardiovascular-related disease.

Trade-Offs Between Anti-Aging Dietary Supplementation and Exercise

In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements increasing longevity in humans is lacking. On the contrary, transient hormetic increases in reactive oxygen species (ROS), for example, associated with exercise, are actually associated with increased mammalian health span and life span. Recent studies in humans suggest that anti-oxidants such as vitamins C, E, resveratrol, and acetyl-N-cysteine blunt the beneficial effects of exercise on glucose sensitivity and blood sugar regulation, likely through direct inhibition of ROS signaling. Alternately, other studies suggest that vitamin C has beneficial effects on exercise-associated dysfunction, inhibiting exercise-induced bronchioconstriction. These data suggest that there are tradeoffs between potential benefits and harm from anti-oxidant dietary supplementation. Specific biomolecular interactions for each antioxidant also will be important. Omega-3 (n-3) polyunsaturated fattty acids (PUFAs) have anti-inflammatory activity that is not mediated through direct ROS inhibition. Although data are limited in humans, n-3 PUFAs do not seem to blunt blood sugar regulatory benefits of aerobic exercise and actually increase anabolic activity in skeletal muscle. However, another kind of tradeoff may exist with PUFAs, at least for men. A recent large clinical trial demonstrates an association of omega-3 fatty acids blood levels with increased incidence of prostate cancer, especially aggressive prostate cancer. Together these results suggest that there are significant tradeoffs in the use of dietary supplementation for prevention and treatment of diseases associated with aging. Such tradeoffs may result from underlying intertwined homeostatic mechanisms. For most individuals, moderate exercise is of significant benefit. Careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise.

Efeitos de curto prazo de um programa de atividade física moderada em pacientes com síndrome metabólica

ABSTRACTObjectives:To evaluate whether a short-term moderate intensity exercise program could change inflammatory parameters, and improve different components of metabolic syndrome in sedentary patients.Methods:Sixteen patients completed the 12-week program of supervised exercise, which consisted of a 40 to 50 minutes of walking, 3 times a week, reaching 50 to 60% of the heart rate reserve. The parameters evaluated before and after intervention were waist circumference, systolic and diastolic blood pressure, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, C-reactive protein and interleukin 8.Results:There was a significant reduction in waist circumference (102.1±7.5cm to 100.8±7.4cm; p=0.03) and in body mass index (29.7±3.2kg/m2 versus 29.3±3.5kg/m2; p=0.03). Systolic blood pressure dropped from 141±18 to 129±13mmHg and diastolic from 79±12 to 71±10mmHg (with p<0.05 for both). No changes were observed on total cholesterol, LDL cholesterol and triglycerides, although HDL cholesterol levels improved, from 45.5±6.0 to 49.5±9.8mg/dL (p=0.02). There was a trend toward reduction of C-reactive protein (8.3%; p=0.07) and interleukin 8 levels (17.4%; p=0.058). The improvement in cardiovascular capacity was demonstrated by an increase of 13% in estimated volume of oxygen (p<0.001).Conclusion:Benefits of aerobic exercise of moderate intensity were seen within only 12 weeks of training in sedentary patients with metabolic syndrome. Considering the easy self-applicability and proven metabolic effects, an exercise program could be a first approach to sedentary patients with metabolic syndrome.

Resistance exercise interventions during and following cancer treatment: a systematic review

Findings from prior systematic reviews suggest that exercise results in meaningful improvements in many clinically relevant physiologic and quality of life (QOL) outcomes during and following cancer treatment. However, the majority of exercise-cancer studies have focused upon the benefits of aerobic exercise (AE) and knowledge of the efficacy of resistance exercise (RE) alone as a supportive care intervention for cancer patients and survivors remains limited. Consequently, the purpose of this review was to provide the first systematic evaluation of the effects of RE alone upon clinically relevant physiologic and QOL outcomes during and following cancer treatment. Literature searches were conducted to identify studies examining RE interventions in cancer patients and survivors. Data were extracted on physiologic (fitness, physical function, and body composition) and QOL (fatigue, psychological well-being, and cancer-specific and global QOL outcomes. Cohen's d effect sizes were calculated for each outcome. A total of 15 studies (6 in samples undergoing active cancer treatment and 9 in samples having completed cancer treatment) involving 1,077 participants met the inclusion criteria. Findings revealed that, on average, RE resulted in large effect-size improvements in muscular strength (d = 0.86), moderate effect-size improvements in physical function (d = 0.66), and small effect-size improvements in body composition (d = 0.28) and QOL (d = 0.25) outcomes. The effect sizes observed following RE are comparable in magnitude to the effects of exercise interventions reported in prior comprehensive reviews of the exercise-cancer literature which primarily focused upon AE. Additionally, the methodologic quality of the studies was generally strong. Taken collectively, results of this systematic review suggest that RE is a promising supportive care intervention that results in meaningful improvements in clinically relevant physiologic and QOL outcomes during and following cancer treatment.