Purpose The purpose of this study is to examine the state of the literature related to the psychophysiological effects of travel, to identify gaps in the literature and to propose a vision to guide research between now and 2050. Design/methodology/approach The study was guided by a systematic literature review which started with more than 2,100 papers. The extant review and its findings are written in a conceptual nature with the concluding propositions, for the year 2050, guided by the systematic review and the authors’ personal knowledge. Findings It was found that research related to the psychophysiological effects of travel has greatly progressed over the past two decades. Findings include evidence that travel reduces both perceived and actual stresses and that taking more vacations has the ability to make people healthier. The study also revealed that travel can have negative effects on physiological health. The overall results led to a call for research on the psychophysiological benefits of travel between now and 2050. Research limitations/implications The systematic review of literature was limited to studies conducted in English and to studies that included the words “travel” or “tourism” and “benefits”, stress, “health” and “wellness”. Results provide a discussion of theories that should guide the research agenda. Practical implications The review and proposed vision for research provide a detailed guide for researchers to follow. Should the proposed research come to fruition, tourism practitioners globally will have results to aid in engineering tourism experiences that could provide health benefits to visitors. Social implications The proposed vision could have profound social implications, as the understanding of the positive and negative effects of travel should make travel experiences healthier for all. The study also proposes a call for research to determine ways to make the benefits of travel available to both the “haves” and “have nots” so that the benefits of travel can be more inclusive. Originality/value The main contribution of this manuscript is that it proposes 11 propositions for research between now and 2050 based on a thorough review of gaps related to the psychophysiological benefits of travel. The resultant propositions provide a clear and unique call for research in this area of inquiry.