To further improve the load-bearing capability and anti-impact properties of the auxetic structure, a novel enhanced auxetic honeycomb core (NEH) was introduced, and the bending resistance and crashworthiness of this sandwich beam (NEH-SWB) were analyzed through numerical simulation. First, bending tests on sandwich beams under different loading situations revealed that NEH-SWB was more susceptible to impact damage in three-point bending situations than those under four-point bending, and the influence of structural parameters were more pronounced. In addition, the impact of load position and structural parameters on the bending response and deformation pattern of NEH-SWB were investigated. NEH-SWB exhibited superior bending resistance when the punch was located in the S position. Furthermore, increasing the panel thickness and altering the panel thickness configuration both contributed to improving the flexural resistance of NEH-SWBs. At a certain mass, the configuration with T f / T b > 1 exhibited better bending resistance. Meanwhile, increasing both the cell angle (θ) and wall thickness-to-length ratio (t/l) enhanced load-carrying capability and energy absorption of NEH-SWB. Subsequently, further analysis showed that NEH had better bending performance compared to cell structures with reentrant (RH), star-shaped (SSH), and reentrant-star (RSH) honeycombs. Finally, the complex proportion assessment method was employed to examine the significance of structural parameters regarding the flexural behavior of the NEH-SWB. It was concluded that increasing the t/l value could be the best solution to enhance the bending performance of the NEH-SWB.