Benchtop Setup Research Articles

Wearable inertial energy harvester with sputtered bimorph lead zirconate titanate (PZT) thin-film beams

Energy harvesting from human motion addresses the growing need for self-powered wearable health monitoring systems which require 24/7 operation. Human motion is characterized by low and irregular frequencies, large amplitudes, and multi-axial motion, all of which limit the performance of conventional translational energy harvesters. An eccentric rotor-based rotational approach originally used in self-winding watches has been adopted to address the challenge. This paper presents a three-dimensional generalized rotational harvester model that considers both linear and rotational excitations. A hypothetical power upper bound for such architectures derived using this generalized model demonstrated the possibility for harvesting significantly more energy compared to existing devices. A wrist-worn piezoelectric rotational energy harvester was designed and fabricated attempting to narrow this gap between existing devices and the theoretical upper bound. The harvester utilizes sputtered bimorph PZT/nickel/PZT thin-film beams to accommodate the need for both flexibility and high piezoelectric figure of merit in order to realize a multi-beam wearable harvester. The prototype was characterized using a bench-top swing arm set-up to validate the system-level model, which provides many degrees of freedom for optimization.

Synthesis of Azolo[1,3,5]triazines via Rhodium(III)-Catalyzed Annulation of N-Azolo Imines and Dioxazolones.

A wide range of azolo[1,3,5]triazines were obtained by Rh(III)-catalyzed annulation of N-azolo imines and dioxazolones. The reaction proceeds by the first catalytic C-H amidation of an imidoyl C-H bond followed by cyclodehydration. Good yields were obtained for N-azolo imines derived from aminoazoles and aromatic and heteroaromatic aldehydes. A range of dioxazolone amidating reagents were employed to introduce aryl, heteroaryl, and alkyl substituents. The reaction was also performed with a benchtop setup at 1 mmol scale using microwave heating.

Athermal planar-waveguide Fourier-transform spectrometer for methane detection

We demonstrate a passively thermally-stabilized planar waveguide Fourier-transform spectrometer for remote detection of atmospheric methane. The device is implemented as a spatial heterodyne spectrometer using an array of 100 Mach-Zehnder interferometers (MZIs) on an integrated photonic chip. The spectrometer is buffered against temperature fluctuations by using waveguides with a carefully engineered, athermal geometry. The achieved waveguide thermooptic optic coefficient is 3.5×10−6K−1. Effective entrance aperture is increased over dispersive element spectrometers, without sacrificing spectral resolution, by coupling light independently to each of the 100 MZIs. The output of each MZI is sampled in quadrature, to compensate for non-uniform illumination across the MZI input apertures. The spectrometer is validated using a methane reference cell in a benchtop setup: an interferogram is inverted via least-squares spectral analysis (LSSA) to retrieve multiple absorption lines at a spectral resolution of 50 pm over a 1 nm free spectral range (FSR) centered at λ0 = 1666.5 nm. The retrieved spectrum is compared against the Beer-Lambert absorption law and is found to provide a correct measurement of the volume mixing ratio (VMR) in the optical path.

Dynamic Light Scattering Microrheology Reveals Multiscale Viscoelasticity of Polymer Gels and Precious Biological Materials.

The development of experimental techniques capable of probing the viscoelasticity of soft materials over a broad range of time scales is essential to uncovering the physics that governs their behavior. In this work, we develop a microrheology technique that requires only 12 μL of sample and is capable of resolving dynamic behavior ranging in time scales from 10–6 to 10 s. Our approach, based on dynamic light scattering in the single-scattering limit, enables the study of polymer gels and other soft materials over a vastly larger hierarchy of time scales than macrorheology measurements. Our technique captures the viscoelastic modulus of polymer hydrogels with a broad range of stiffnesses from 10 to 104 Pa. We harness these capabilities to capture hierarchical molecular relaxations in DNA and to study the rheology of precious biological materials that are impractical for macrorheology measurements, including decellularized extracellular matrices and intestinal mucus. The use of a commercially available benchtop setup that is already available to a variety of soft matter researchers renders microrheology measurements accessible to a broader range of users than existing techniques, with the potential to reveal the physics that underlies complex polymer hydrogels and biological materials.

Model-based Bayesian signal extraction algorithm for peripheral nerves

Objective. Multi-channel cuff electrodes have recently been investigated for extracting fascicular-level motor commands from mixed neural recordings. Such signals could provide volitional, intuitive control over a robotic prosthesis for amputee patients. Recent work has demonstrated success in extracting these signals in acute and chronic preparations using spatial filtering techniques. These extracted signals, however, had low signal-to-noise ratios and thus limited their utility to binary classification. In this work a new algorithm is proposed which combines previous source localization approaches to create a model based method which operates in real time. Approach. To validate this algorithm, a saline benchtop setup was created to allow the precise placement of artificial sources within a cuff and interference sources outside the cuff. The artificial source was taken from five seconds of chronic neural activity to replicate realistic recordings. The proposed algorithm, hybrid Bayesian signal extraction (HBSE), is then compared to previous algorithms, beamforming and a Bayesian spatial filtering method, on this test data. An example chronic neural recording is also analyzed with all three algorithms. Main results. The proposed algorithm improved the signal to noise and signal to interference ratio of extracted test signals two to three fold, as well as increased the correlation coefficient between the original and recovered signals by 10–20%. These improvements translated to the chronic recording example and increased the calculated bit rate between the recovered signals and the recorded motor activity. Significance. HBSE significantly outperforms previous algorithms in extracting realistic neural signals, even in the presence of external noise sources. These results demonstrate the feasibility of extracting dynamic motor signals from a multi-fascicled intact nerve trunk, which in turn could extract motor command signals from an amputee for the end goal of controlling a prosthetic limb.

Silicon Micropore-Based Parallel Plate Membrane Oxygenator.

Extracorporeal membrane oxygenation (ECMO) is a life support system that circulates the blood through an oxygenating system to temporarily (days to months) support heart or lung function during cardiopulmonary failure until organ recovery or replacement. Currently, the need for high levels of systemic anticoagulation and the risk for bleeding are main drawbacks of ECMO that can be addressed with a redesigned ECMO system. Our lab has developed an approach using microelectromechanical systems (MEMS) fabrication techniques to create novel gas exchange membranes consisting of a rigid silicon micropore membrane (SμM) support structure bonded to a thin film of gas-permeable polydimethylsiloxane (PDMS). This study details the fabrication process to create silicon membranes with highly uniform micropores that have a high level of pattern fidelity. The oxygen transport across these membranes was tested in a simple water-based bench-top set-up as well in a porcine in vivo model. It was determined that the mass transfer coefficient for the system using SµM-PDMS membranes was 3.03 ± 0.42 mL O2 min-1 m-2 cm Hg-1 with pure water and 1.71 ± 1.03 mL O2 min-1 m-2 cm Hg-1 with blood. An analytic model to predict gas transport was developed using data from the bench-top experiments and validated with in vivo testing. This was a proof of concept study showing adequate oxygen transport across a parallel plate SµM-PDMS membrane when used as a membrane oxygenator. This work establishes the tools and the equipoise to develop future generations of silicon micropore membrane oxygenators.

Spatially-localized bench-top X-ray scattering reveals tissue-specific microfibril orientation in Moso bamboo

Background Biological materials have a complex, hierarchical structure, with vital structural features present at all size scales, from the nanoscale to the macroscale. A method that can connect information at multiple length scales has great potential to reveal novel information. This article presents one such method with an application to the bamboo culm wall. Moso (Phyllostachys edulis) bamboo is a commercially important bamboo species. At the cellular level, bamboo culm wall consists of vascular bundles embedded in a parenchyma cell tissue matrix. The microfibril angle (MFA) in the bamboo cell wall is related to its macroscopic longitudinal stiffness and strength and can be determined at the nanoscale with wide-angle X-ray scattering (WAXS). Combining WAXS with X-ray microtomography (XMT) allows tissue-specific study of the bamboo culm without invasive chemical treatment.Results The scattering contribution of the fiber and parenchyma cells were separated with spatially-localized WAXS. The fiber component was dominated by a high degree of orientation corresponding to small MFAs (mean MFA 11°). The parenchyma component showed significantly lower degree of orientation with a maximum at larger angles (mean MFA 65°). The fiber ratio, the volume of cell wall in the fibers relative to the overall volume of cell wall, was determined by fitting the scattering intensities with these two components. The fiber ratio was also determined from the XMT data and similar fiber ratios were obtained from the two methods, one connected to the cellular level and one to the nanoscale. X-ray diffraction tomography was also done to study the differences in microfibril orientation between fibers and the parenchyma and further connect the microscale to the nanoscale.Conclusions The spatially-localized WAXS yields biologically relevant, tissue-specific information. With the custom-made bench-top set-up presented, diffraction contrast information can be obtained from plant tissue (1) from regions-of-interest, (2) as a function of distance (line scan), or (3) with two-dimensional or three-dimensional tomography. This nanoscale information is connected to the cellular level features.

A novel portable energy dispersive X-ray fluorescence spectrometer with triaxial geometry

The X-ray fluorescence technique is a powerful analytical tool with a broad range of applications such as quality control, environmental contamination by heavy metals, cultural heritage, among others. For the first time, a portable energy dispersive X-ray fluorescence spectrometer was assembled, with orthogonal triaxial geometry between the X-ray tube, the secondary target, the sample and the detector. This geometry reduces the background of the measured spectra by reducing significantly the Bremsstrahlung produced in the tube through polarization in the secondary target and in the sample. Consequently, a practically monochromatic excitation energy is obtained. In this way, a better peak-background ratio is obtained compared to similar devices, improving the detection limits and leading to superior sensitivity. The performance of this setup is compared with the one of a benchtop setup with triaxial geometry and a portable setup with planar geometry. Two case studies are presented concerning the analysis of a 18th century paper document, and the bone remains of an individual buried in the early 19th century.

Design and evaluation of a miniature laser speckle imaging device to assess gingival health.

Current methods used to assess gingivitis are qualitative and subjective. We hypothesized that gingival perfusion measurements could provide a quantitative metric of disease severity. We constructed a compact laser speckle imaging (LSI) system that could be mounted in custom-made oral molds. Rigid fixation of the LSI system in the oral cavity enabled measurement of blood flow in the gingiva. In vitro validation performed in controlled flow phantoms demonstrated that the compact LSI system had comparable accuracy and linearity compared to a conventional bench-top LSI setup. In vivo validation demonstrated that the compact LSI system was capable of measuring expected blood flow dynamics during a standard postocclusive reactive hyperemia and that the compact LSI system could be used to measure gingival blood flow repeatedly without significant variation in measured blood flow values (p<0.05). Finally, compact LSI system measurements were collected from the interdental papilla of nine subjects and compared to a clinical assessment of gingival bleeding on probing. A statistically significant correlation (?=0.53; p<0.005) was found between these variables, indicating that quantitative gingival perfusion measurements performed using our system may aid in the diagnosis and prognosis of periodontal disease.

The Evolution of Pd0/PdII-Catalyzed Aromatic Fluorination.

ConspectusAromatic fluorides are prevalent in both agrochemical and pharmaceutical agents. However, methods for their rapid and general preparation from widely available starting materials are limited. Traditional approaches such as the Balz–Schiemann and Halex reactions require harsh conditions that limit functional group tolerance and substrate scope. The use of transition metals to affect C–F bond formation has provided some useful alternatives, but a broadly applicable method remains elusive. In contrast to the widespread use of Pd0/PdII catalysis for aryl–Z bond formation (Z = C, N, O), the analogous C–F cross-coupling process was unknown until fairly recently. In large part, this is due to the challenging Ar–F reductive elimination from Pd(II) intermediates. We have discovered that certain biaryl monophosphine ligands are uniquely capable of promoting this transformation. In this Account, we describe the discovery and development of a Pd-catalyzed C–F cross-coupling process and the systematic developments that made this once hypothetical reaction possible.Key to these developments was the discovery of an unusual in situ ligand modification process in which a molecule of substrate is incorporated into the ligand scaffold and the identity of the modifying group is crucial to the outcome of the reaction. This prompted the synthesis of a variety of “premodified” ligands and the identification of one that led to an expanded substrate scope, including (hetero)aryl triflates and bromides. Contemporaneously, a new Pd(0) precatalyst was also discovered that avoids the need to reduce Pd(II) in situ, a process that was often inefficient and led to the formation of byproducts.The use of inexpensive but hygroscopic sources of fluoride necessitates a reaction setup inside of a N2-filled glovebox, limiting the practicality of the method. Thus, a preformed wax capsule was designed to isolate the catalyst and reagents from the atmosphere and permit benchtop storage and setup. This new technology thus removes the requirement to employ a glovebox for the aromatic fluorination process and other air-sensitive protocols.In every catalyst system that we have studied to date, we observed the formation of regioisomeric fluoride side products. Through deuterium labeling studies it was found that they likely arise from a deprotonation event resulting in the formation of HF and a Pd–benzyne intermediate. Through an investigation of the mechanism of this undesired pathway, a new ligand was designed that substantially reduces the formation of the aryl fluoride regioisomer and even allows room-temperature Ar–F reductive elimination from a Pd(II) intermediate.

Experimental Generation of Riemann Waves in Optics: A Route to Shock Wave Control

We report the first observation of Riemann (simple) waves, which play a crucial role for understanding the dynamics of any shock-bearing system. This was achieved by properly tailoring the phase of an ultrashort light pulse injected into a highly nonlinear fiber. Optical Riemann waves are found to evolve in excellent quantitative agreement with the remarkably simple inviscid Burgers equation, whose applicability in physical systems is often challenged by viscous or dissipative effects. Our method allows us to further demonstrate a viable novel route to efficiently control the shock formation by the proper shaping of a laser pulse phase. Our results pave the way towards the experimental study, in a convenient benchtop setup, of complex physical phenomena otherwise difficult to access.

Gaussian beam propagation in anisotropic turbulence along horizontal links: theory, simulation, and laboratory implementation.

Experimental and theoretical work has shown that atmospheric turbulence can exhibit "non-Kolmogorov" behavior including anisotropy and modifications of the classically accepted spatial power spectral slope, -11/3. In typical horizontal scenarios, atmospheric anisotropy implies that the variations in the refractive index are more spatially correlated in both horizontal directions than in the vertical. In this work, we extend Gaussian beam theory for propagation through Kolmogorov turbulence to the case of anisotropic turbulence along the horizontal direction. We also study the effects of different spatial power spectral slopes on the beam propagation. A description is developed for the average beam intensity profile, and the results for a range of scenarios are demonstrated for the first time with a wave optics simulation and a spatial light modulator-based laboratory benchtop counterpart. The theoretical, simulation, and benchtop intensity profiles show good agreement and illustrate that an elliptically shaped beam profile can develop upon propagation. For stronger turbulent fluctuation regimes and larger anisotropies, the theory predicts a slightly more elliptical form of the beam than is generated by the simulation or benchtop setup. The theory also predicts that without an outer scale limit, the beam width becomes unbounded as the power spectral slope index α approaches a maximum value of 4. This behavior is not seen in the simulation or benchtop results because the numerical phase screens used for these studies do not model the unbounded wavefront tilt component implied in the analytic theory.

Evaluation of the tip-bending response in clinically used endoscopes.

Background and study aims: Endoscopic interventions require accurate and precise control of the endoscope tip. The endoscope tip response depends on a cable pulling system, which is known to deliver a significantly nonlinear response that eventually reduces control. It is unknown whether the current technique of endoscope tip control is adequate for a future of high precision procedures, steerable accessories, and add-on robotics. The aim of this study was to determine the status of the tip response of endoscopes used in clinical practice. Materials and methods: We evaluated 20 flexible colonoscopes and five gastroscopes, used in the endoscopy departments of a Dutch university hospital and two Dutch teaching hospitals, in a bench top setup. First, maximal tip bending was determined manually. Next, the endoscope navigation wheels were rotated individually in a motor setup. Tip angulation was recorded with a USB camera. Cable slackness was derived from the resulting hysteresis plot. Results: Only two of the 20 colonoscopes (10 %) and none of the five gastroscopes reached the maximal tip angulation specified by the manufacturer. Four colonoscopes (20 %) and none of the gastroscopes demonstrated the recommended cable tension. Eight colonoscopes (40 %) had undergone a maintenance check 1 month before the measurements were made. The tip responses of these eight colonoscopies did not differ significantly from the tip responses of the other colonoscopes. Conclusion: This study suggests that the majority of clinically used endoscopes are not optimally tuned to reach maximal bending angles and demonstrate adequate tip responses. We suggest a brief check before procedures to predict difficulties with bending angles and tip responses.

An experimental approach to determining fatigue crack size in polyethylene tibial inserts

A major limiting factor to the longevity of prosthetic knee joints is fatigue crack damage of the polyethylene tibial insert. Existing methods to quantify fatigue crack damage have several shortcomings, including limited resolution, destructive testing approach, and high cost. We propose an alternative fatigue crack damage visualization and measurement method that addresses the shortcomings of existing methods. This new method is based on trans-illumination and differs from previously described methods in its ability to non-destructively measure subsurface fatigue crack damage while using a simple and cost-effective bench-top set-up. We have evaluated this method to measure fatigue crack damage in two tibial inserts. This new method improves on existing image-based techniques due to its usability for subsurface damage measurement and its decreased reliance on subjective damage identification and measurement.

Flow Synthesis of 2-Methylpyridines via α-Methylation.

A series of simple 2-methylpyridines were synthesized in an expedited and convenient manner using a simplified bench-top continuous flow setup. The reactions proceeded with a high degree of selectivity, producing α-methylated pyridines in a much greener fashion than is possible using conventional batch reaction protocols. Eight 2-methylated pyridines were produced by progressing starting material through a column packed with Raney® nickel using a low boiling point alcohol (1-propanol) at high temperature. Simple collection and removal of the solvent gave products in very good yields that were suitable for further use without additional work-up or purification. Overall, this continuous flow method represents a synthetically useful protocol that is superior to batch processes in terms of shorter reaction times, increased safety, avoidance of work-up procedures, and reduced waste. A brief discussion of the possible mechanism(s) of the reaction is also presented which involves heterogeneous catalysis and/or a Ladenberg rearrangement, with the proposed methyl source as C1 of the primary alcohol.

Ex vivo catheter-based imaging of coronary atherosclerosis using multimodality OCT and NIRAF excited at 633 nm.

While optical coherence tomography (OCT) has been shown to be capable of imaging coronary plaque microstructure, additional chemical/molecular information may be needed in order to determine which lesions are at risk of causing an acute coronary event. In this study, we used a recently developed imaging system and double-clad fiber (DCF) catheter capable of simultaneously acquiring both OCT and red excited near-infrared autofluorescence (NIRAF) images (excitation: 633 nm, emission: 680nm to 900nm). We found that NIRAF is elevated in lesions that contain necrotic core - a feature that is critical for vulnerable plaque diagnosis and that is not readily discriminated by OCT alone. We first utilized a DCF ball lens probe and a bench top setup to acquire en face NIRAF images of aortic plaques ex vivo (n = 20). In addition, we used the OCT-NIRAF system and fully assembled catheters to acquire multimodality images from human coronary arteries (n = 15) prosected from human cadaver hearts (n = 5). Comparison of these images with corresponding histology demonstrated that necrotic core plaques exhibited significantly higher NIRAF intensity than other plaque types. These results suggest that multimodality intracoronary OCT-NIRAF imaging technology may be used in the future to provide improved characterization of coronary artery disease in human patients.

Granular structure determined by terahertz scattering

Light scattering from particles reveals static and dynamical information about the particles and their correlations. Such methods are particularly powerful when the wavelength of the light is chosen similar to the sizes and distances of the particles. To apply scattering to investigate granular matter in particular —or other objects of similar submillimeter size— light of suitable wavelength in the terahertz regime needs to be chosen. By using a quantum cascade laser in a benchtop setup we determine the angle-dependent scattering of spherical particles as well as coffee powder and sugar grains. The scattering from single particles can be interpreted by form factors derived within the Mie theory. In addition, collective correlations can be extracted as static structure factors and compared to recent computer simulations.

Rapid sealing and cutting of porcine blood vessels,ex vivo, using a high-power, 1470-nm diode laser

Suture ligation with subsequent cutting of blood vessels to maintain hemostasis during surgery is time consuming and skill intensive. Energy-based electrosurgical and ultrasonic devices are often used to replace sutures and mechanical clips to provide rapid hemostasis and decrease surgery time. Some of these devices may create undesirably large collateral zones of thermal damage and tissue necrosis, or require separate mechanical blades for cutting. Infrared lasers are currently being explored as alternative energy sources for vessel sealing applications. In a previous study, a 1470-nm laser was used to seal vessels 1 to 6 mm in diameter in 5 s, yielding burst pressures of ∼500 mmHg. The purpose of this study was to provide vessel sealing times comparable with current energy-based devices, incorporate transection of sealed vessels, and demonstrate high vessel burst pressures to provide a safety margin for future clinical use. A 110-W, 1470-nm laser beam was transmitted through a fiber and beam shaping optics, producing a 90-W linear beam 3.0 by 9.5 mm for sealing (400 W/cm2), and 1.1 by 9.6 mm for cutting (1080 W/cm2). A two-step process sealed and then transected ex vivo porcine renal vessels (1.5 to 8.5 mm diameter) in a bench top setup. Seal and cut times were 1.0 s each. A burst pressure system measured seal strength, and histologic measurements of lateral thermal spread were also recorded. All blood vessels tested (n=55 seal samples) were sealed and cut, with total irradiation times of 2.0 s and mean burst pressures of 1305±783 mmHg. Additional unburst vessels were processed for histological analysis, showing a lateral thermal spread of 0.94±0.48 mm (n=14 seal samples). This study demonstrated that an optical-based system is capable of precisely sealing and cutting a wide range of porcine renal vessel sizes and, with further development, may provide an alternative to radiofrequency- and ultrasonic-based vessel sealing devices.

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Introduction: While multifactorial, VAP etiology remains largely accepted to be secondary to micro-aspiration. Recent developments in endotracheal tube (ETT) cuffs have focused on improved cuff shapes and/or materials. However, to date, the only option for critical care physicians to adopt these improved tubes in previously intubated patients is extubation and re-intubation. In order to provide a tool to reduce micro-aspiration without the risk of extubation and re-intubation, we have developed a novel independent cuff that can be added on to any current standard ETT. One of the first steps in development was to assess in-vitro sealing efficacy of our novel balloon cuff (Bronchoguard, Ciel Medical, CA) in comparison to both standard and improved ETT cuffs. The aim of this study was thus to determine the ex-vivo sealing efficacy of the novel silicone balloon cuff in comparison to current ETT cuffs. We hypothesize that the novel silicone cuff will be more effective at sealing the simulated trachea than existing ETT cuffs given the thin, compliant material and the lack of folds in the cuff upon inflation. Methods: A bench-top model was set up in order to simulate 2 different trachea sizes (18 mm and 20 mm diameter PVC tubes). A minimum of 1-hour leakage of water around cuff was measured for 4 common ETT cuffs and the novel silicone cuff. Tested cuffs were Mallinckrodt Hi-Lo and Taperguard, Teleflex ISIS, Rüsch and Mallinckrodt TaperGuard and compared individually to the novel cuff, using standard T test. Leak rates were measure in cc/min, and experiments repeated 5 to 8 times. Cuff pressure was checked and adjusted every 12 hrs to simulate clinical conditions. Results: Leak rates in 18 mm trachea model (average +/- Standard deviation) Rusch 7.5: 4.37 +/- 2.74 cc/min (p = 0.023) Isis 7.5: 13.93 +/- 6.02 cc/min (p= 0.007) HiLo 7.5: 3.55 +/- 1.65 cc/min (p= 0.009) TaperGuard 7.0: 0.82 +/- 0.52 cc/min (p= 0.025) Novel cuff: 0.01 +/- 0.006 cc/ min Leak rates in 20 mm trachea model (average +/- Standard deviation) Rusch 7.5: 1.99 +/- 1.76 cc/min (p = 0.015) Isis 7.5: 24.94 +/- 8.86 cc/min (p = 0.003) HiLo 7.5: 4.42 +/- 2.23 cc/min (p = 0.011) TaperGuard 7.0: 0.39 +/- 0.72 cc/min (p = 0.30) Novel cuff: 0.006 +/- 0.002 cc/ min Conclusions: The novel endotracheal tube cuff provided statistically significant superior protection against fluid leakage in our bench top model against all standard and improved ETTs in the 18mm tracheal model: 80x to >1000x reduction in leak rate. The results were similar in the 20mm model except for the TaperGuard: while leak rate was on average approximately 65x higher than the novel device, fluid this result failed to reach statistical significance (p=0.3). While clear limitations exist due to the approximative nature of a bench-top setup, the novel device provided significantly better results in reducing leak rate in all but one of 8 comparisons, and non-significantly better results in one. While these results are promising, future studies are required for a more accurate and in-vivo comparison in order to evaluate the real benefit of this novel tool.

An Ultra-Linear Piezo-Floating-Gate Strain-Gauge for Self-Powered Measurement of Quasi-Static-Strain

In this paper we describe a self-powered sensor that can be used for in-vivo measurement of the quasi-static-strain and also for in-vivo measurement of the L1 norm of the strain signal. At the core of the proposed design is a linear floating-gate injector that can achieve more than 13 bits of precision in sensing, signal integration and non-volatile storage. The injectors are self-powered by the piezoelectric transducers that convert mechanical energy from strain-variations into electrical energy. A differential injector topology is used to measure the quasi-static strain by integrating the difference between the L1 norm of the piezoelectric signal generated during the positive and negative strain-cycles. The linear floating-gate injectors are integrated with charge-pumps, digital calibration circuits and digital programming circuits to form a system-on-chip solution that can interface with a standard bio-telemetry platform. We demonstrate the proof-of-concept self-powered measurement of quasi-static strain and L1 norm of the strain signal using sensor prototypes fabricated in a 0.5- μm standard CMOS process and validated using a bench-top biomechanical test setup.