Data of the agrochemical survey of arable soils in Belgorod oblast during the period from 1964 to 2014 have been analyzed. The soil cover mainly consists of typical chernozems (Haplic Chernozems) and leached chernozems (Luvic Chernozems) in the forest-steppe zone and ordinary chernozems (Calcic Chernozems) in the steppe zone. Under long-term agricultural use (from 1964 to 2014), the content of mobile phosphorus in arable soils of the region under study has increased from 55 to 137 mg/kg, and the content of mobile potassium has increased from 105 to 147 mg/kg. During the period of 1976–2014, the share of acid soils has increased from 22.8 to 45.8%, including medium-acid soils from 1.5 to 12.6%. No significant changes in the weighted average content of soil organic matter are revealed for the period from 1985 to 2014. The value of this parameter is within the range of 4.8–5.0%. In the 2010–2014, 95.0% of arable soils belonged to the category of low supplied with mobile sulfur; 99.2, 96.9, 94.1, and 54.4% of soils were poorly supplied with zinc, copper, cobalt, and manganese, respectively. During the same period, the maximum average productivity of the crop area (3710 f. u./ha) was noted at the application of 4.8 t/ha organic fertilizers and 97.9 kg/ha organic fertilizers on the average. The maximum long-term yields of sugar beet (36.8 t/ha) and corn grain (4.97 t/ha) were obtained at the application of relatively low fertilizer rates.