The axial flow along the thimbles of the in core instrumentation induces vibration and shocks against their guides in the vessel, producing wear and even leakage, either on the thimbles, or on the instrumentation tube of the fuel assemblies. The new 1300 MW reactors were mainly concerned by this problem. In order to characterize the phenomenon and help to reduce or suppress vibration of the thimbles, two methods have been developed and applied to French and Belgian reactors. The first one consists of an analysis of the shocks perceived on the thimbles tubes by accelerometers; this analysis, based on the study of statistical distribution (amplitude, impulse rate of shocks.) has allowed to choose among the different solutions proposed to solve the problem ; this choice has been confirmed by direct wear measurements made later. The second method is based on spectral and time analysis of the fluctuating signals from in core neutron chambers. The correlation appears clearly between shocks and fluctuations. An estimation of the thimble modal shape in the instrumentation tube of the assembly, has been made. These two analysis methods have been widely applied during starp-up of the first eight 1300 MW reactors : they have contributed to solve the problem and to increase the availability of these plants. On the 900 MW reactors, where the problem is less severe, the approach has been to study the mechanical behaviour of one new plant, Chinon B3 : all in core guide tubes have been equipped with accelerometers and an on line monitoring system directly transmits to Chatou the parameters of shocks, in order to define an acoustic parameter able to characterize wear, and so, to define a new type of maintenance for the thimbles. The first results are presented.