Beijing Research Articles

Cow Milk Fatty Acid and Protein Composition in Different Breeds and Regions in China

Cow milk is rich in proteins, fats, carbohydrates, and minerals; however, its precise nutrient content varies based on various factors. In the current study, we evaluated the differences in the fatty acid and protein contents of milk and the factors associated with these differences. To achieve this, samples were collected from seven types of cows in different regions. These included samples from three dairy breeds: Chinese Holstein milk from Beijing, China (BH), Chinese Holstein milk (HH) and Jersey milk (JS) from Hebei province, China; and four dairy/meat breeds: Sanhe milk (SH) from Inner Mongolia Autonomous Region, China, Xinjiang brown milk (XH) and Simmental milk (SI) from Xinjiang Uygur Autonomous Region, China, and Shu Xuanhua milk (SX) from Sichuan province, China. Breed significantly affects total fat, fatty acid, and protein contents. Additionally, geographic region significantly affects the contents of different fatty acids, α-lactalbumin, and lactoferrin. JS has the highest total fat and casein contents. XH samples contain significantly higher unsaturated fatty acid content than BH samples and do not differ significantly from JS. Additionally, the low β-lactoglobulin and high lactoferrin contents in XH samples may be favorable for the growth and development of infants. Our results may inform the development of dairy products from different cow breeds and advance the process of accurate breed identification.

The Pragmatic Way: Managing the Streets in Qing Beijing

Drawing upon scholarship from the study of space, social history, and urban history, this article examines the institutional development of street management in Beijing during Qing dynasty (1644-1911). Based on archival sources and private writings about Qing Beijing, this article argues that while the Qing state prescribed a segregated spatial order onto its capital city of Beijing, the practices on the streets were ultimately determined by the constant battle between stagnation and flow. In maintaining the living environment of its imperial capital, Beijing, the Qing state recognized different needs, physically, financially, politically, and administratively, of different people residing and operating in the same urban space. Anchored on an urban history of street management, this article further connects the street concerns to more significant issues about managing the space in the empire and the implications of different priorities for the empire.

Contamination profile and hazards of neonicotinoid insecticides in honey from apiaries in Beijing, China.

The residues of neonicotinoid insecticides in honey have raised global concern for their adverse effects on non-target organisms. However, information on the presence of neonicotinoids in raw honey in China is limited. Our study investigated the distribution profiles of neonicotinoids in raw honey samples collected from apiaries in plain and mountainous areas surrounding Beijing City. At least one of four neonicotinoids, imidacloprid, thiamethoxam, acetamiprid, or clothianidin, was found in 46.9% of samples. Neonicotinoids in multi-floral honey in plain areas exhibited higher concentrations and prevalence than in uni-floral honey collected from mountainous areas. These results indicated that neonicotinoid residues in honey were linked to the agricultural ecosystems influenced by geographies, particularly the intensity of agriculture and nectariferous plant types. The dietary risks to adult and children health from neonicotinoid exposure were deemed de minimis, while risks to honeybees at the maximum concentration level require much attention through refined, higher-tier assessments and possible mitigation measures for the use of these products.

Development of Air Pollution Forecasting Models Applying Artificial Neural Networks in the Greater Area of Beijing City, China

The ever-increasing industrialization of certain areas of the planet combined with the simultaneous degradation of the natural environment are alarming phenomena, especially in the field of human health. The concentration of particulate matter with an aerodynamic diameter of 2.5 μm (PM2.5) and 10 μm (PM10), nitrogen oxides (NOx), carbon monoxide (CO), sulfur dioxide (SO2), and ozone (O3) needs constant monitoring, as they consist of the main cause for many diseases. Based on the existence of statutory limits from the World Health Organization (WHO) for the concentration of each of the aforementioned air pollutants, it is considered necessary to develop forecasting systems that have the ability to correlate the current meteorological data with the concentrations of the above pollutants. In this work, the attempt to predict air pollutant concentrations in the wider area of Beijing, China, is successfully carried out using artificial neural network (ANN) models. In the frame of a specific work, a significant number of ANNs are developed. For this purpose, an open-access meteorological and air pollution database was used. Finally, a statistical evaluation of the developed prognostic models was carried out. The results showed that ANNs present a remarkable prognostic ability in order to forecast air pollution levels in an urban environment.

Event communication of university museums and scientific organizations (based on the experience of the “Night of Museums – 2024” in St. Petersburg)

The article is devoted to the consideration of event communication using the example of participation in the all-Russian event “Night of Museums” by museums of universities and scientific organizations of St. Petersburg in 2024. A sociological survey of St. Petersburg residents showed sufficient awareness of the “Night of Museums” event: every second person knows both about the event and about its holding in 2024 in the Northern capital. However, those wishing to take part in it in 2024 did not exceed 20%, especially to visit museums of universities and scientific institutions (2%). Analyzing the category ‘event communication’ at the intersection of methodological approaches of political science and discourse science, the author considers it promising to study the mutual influence of three discursive constructs: museum discourse – discourse of state memory policy – discourse of national identity, considered in relation to modern political realities of Russia in the context of the implementation of the national security strategy.

Matching analysis between the heating/cooling capacity of PVT heat pumps and the heating/cooling demand of residential buildings across various regions in China

PVT-HP (Photovoltaic-Thermal Heat Pump) is a novel type of energy saving technology. Existing researches on PVT-HP technology focuses only on its operating performance under some specific conditions, ignoring the matching of its energy supply capacity with the energy demand of buildings, which is very important for its engineering design and application. In this paper, the matching relationship between the heating/cooling capacity of the PVT-HP system and the heating/cooling demand of residential buildings in major cities of China has been analyzed. To achieve this goal, a novel prediction model used to calculate the heating/cooling performance of the PVT-HP system has been proposed. And the daily heating guarantee rate and daily cooling guarantee rate have been put forward to evaluate the matching relationship. Based on the evaluation indexes, the applicable matching relationship between the installed capacity of the PVT-HP system and the heating/cooling area of residential buildings has been analyzed. The result of case study shows that for the selected cities of Shenyang, Beijing and Wuhan, the heating/cooling area of residential building for PVT-HP system with installed capacity of 1hp should not exceed 17m2, 31m2 and 25m2, respectively. Further matching analysis of major cities in China shows that the PVT-HP system is more suitable for application in hot summer and cold winter zones of China, in where the suggested heating/cooling area for the PVT-HP system with installed capacity of one horse power is within the range of 30m2 to 37m2.

Selection Process Based on Advancing the Development of a Science and Technology Law System with Chinese Features

The significance of advancing socialist S&T legal system building with Chinese features is examined in this paper, along with the extensive effects it has on S&T innovation and economic growth. Against the backdrop of an increasingly competitive global scientific and technology landscape, China’s ability to innovate and achieve sustainable growth hinges on the establishment of an ideal science and technology legislative framework. This essay first examines the primary obstacles to China’s development of a science, technology, and innovation (S&T) legal system, including inadequate protection for intellectual property rights, a flawed process for transforming scientific and technological advancements, and an insufficient system for encouraging enterprise innovation. Then, this research presents a quantitative analysis model to optimize the path of science and technology legal building by applying the improved particle swarm optimization method (PSO). The model takes into account a wide range of variables, including the degree of intellectual property protection, the strength of legal backing, the pace at which scientific and technological advancements are transformed, etc. Through the analysis of simulation data, the model also confirms the promotion effect of the legal system construction on the quantity of patent applications, the success rate of innovation projects, the enterprise R&D expenditure, and the expansion of the local economy. The study’s findings demonstrate that bolstering the science and technology legal system can effectively encourage businesses to boost R&D investment and foster regional economic development in addition to greatly raising the quantity of patent applications and the success rate of innovation projects. The rigorous intellectual property protection laws and ideal legal framework for the conversion of accomplishments greatly boost the regional innovation vitality and economic efficiency, particularly in the case study of Zhongguancun in Beijing and East China. Moreover, adaptive weighting is used to enhance the PSO algorithm and optimize the development of science and technology legal system’s comprehensive performance index, thereby confirming the model’s viability and efficacy. The study’s findings offer theoretical justification and helpful advice for China’s development of a science and technology legal framework, which is crucial for fostering innovation in these fields and boosting the country’s competitiveness.

MIGRATION IN THE NORTH AND THE SOUTH CAPITALS OF KAZAKHSTAN: THEORY, FACTORS AND ECONOMETRIC ANALYSIS

The article reveals the theoretical positions that influenced the development of migration processes in the Northern and the Southern capitals of Kazakhstan during 2001-2021. The novelty of the work lies in the comparative analysis of the main causes or factors that influenced migration processes in the both capitals of the country. As part of the mathematical formalization of the social attractiveness of the immigration city, the Social Attractiveness Index has been developed and proposed for use. The main tool of research and analysis was econometric data analysis based on Pooled OLS model using the STATA program. As a result, conclusions were drawn that an important factor immigration to the Northern capital was the geographical factor or the close distance of the city of Karaganda. An important factor immigration to the Southern capital was a relatively high index of attractiveness of social infrastructure or the presence of a more numerous and developed educational infrastructure (schools, universities, colleges and healthcare systems (medical institutions, hospitals).

Prevalence and associated factors of diabetic retinopathy among type 2 diabetes in Dongcheng District and Tongzhou District, Beijing City: a cross-sectional study

Objective: Diabetic retinopathy (DR) is the most common cause of adult blindness in China. Screening of DR is important for early detection, prevention, and treatment. However, there is still controversy in the research on the prevalence and risk factors of DR in China. This study was designed to evaluate the prevalence of DR and related risk factors in patients with type 2 diabetes mellitus in Beijing City. Methods: A cross-sectional survey was conducted in in Dongcheng District and Tongzhou District, Beijing City. Patients with type 2 diabetes aged 18-80 years were selected from four communities, and all subjects underwent questionnaires, physical examinations, laboratory examinations and fundus photography. The logistic regression model was used to analyze the associated factors of DR. Results: A total of 1 531 subjects were included, with the median age of 66 years old and the average age of (65.6±7.4) years old, and the glycosylated hemoglobin level in the subjects was 7.2%±1.3%, and the glycosylated hemoglobin compliance rate was 56.0%(857/1 531). A total of 254 patients with diabetic retinopathy were detected, and the prevalence of DR was 16.6%(254/1 531). Among them, there were 218 cases of non-proliferative diabetic retinopathy and 36 cases of proliferative diabetic retinopathy. Compared with the non-DR group, there were statistically significant differences in fasting blood glucose (Z=-3.74, P<0.001), glycosylated hemoglobin(Z=-10.664, P<0.001), urinary microalbumin excretion rate(Z=-7.767,P<0.001), low-density lipoprotein cholesterol(Z=-2.589, P=0.01), and duration of diabetes(Z=-10.189, P<0.001) between the DR group and the non-DR group. Multivariate regression analysis showed that the duration of diabetes (OR=1.08, 95%CI: 1.06-1.10, P<0.001), glycosylated hemoglobin (OR=1.38, 95%CI: 1.23-1.55, P<0.001), and FPG (OR=1.11, 95%CI: 1.03-1.19, P=0.008) were associated factors for DR. Conclusion: In this study, the prevalence of DR in 4 communities of type 2 diabetes in Beijing City was 16.6%. Besides, this study further confirmed that the duration of diabetes, fasting blood glucose levels, and glycosylated hemoglobin are associated factors for DR in patients with type 2 diabetes.

Comparison of Three Influenza Surveillance Data Sources for Timely Detection of Epidemic Onset - Chengdu City, Sichuan Province and Beijing Municipality, China, 2017-2023.

The syndromic surveillance system, exemplified by the influenza-like illness (ILI) surveillance system, has long been crucial in providing early warnings of influenza epidemics. The analysis revealed that employing reported influenza case data from the nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS) enhanced the early detection of influenza epidemics, particularly within the context of multiple respiratory pathogens circulating concurrently. The NIDRIS, characterized by its extensive coverage, obligatory reporting, high specificity, and real-time data transmission, offers a valuable tool for the effective early detection of influenza epidemics. Utilizing this system could enhance preparedness and responses to such health crises, potentially mitigating their impact on public health.

Seasonal biogenic volatile organic compound emission factors in temperate tree species: Implications for emission estimation and ozone formation

Variability in biogenic volatile organic compound (BVOC) emissions across species and seasons poses challenges for accurate regional emission estimates and effective ozone (O3) control policies. To address this issue, we conducted in-situ measurements of emission factors for six dominant tree species in Beijing across four seasons. Subsequently, we developed monthly dynamic standard emission factors (SER-MDs) to model monthly BVOC emissions and their impacts on O3 formation at citywide and district levels. Our observations revealed pronounced seasonal differences in the BVOC composition and emission rates, as well as their responsiveness to monthly average temperature. By introducing the SER-MDs, we estimated BVOC emissions from the dominant tree species in Beijing to be 38.2 Gg yr−1, with monoterpenes and isoprene contributing 49% and 11%, respectively. This calculation reduced the overestimation associated with constant standard emission factors by 31%–38% at district level. The estimates also revealed regional differences in plant compositions rather than simple feedback from regional temperature and photosynthetically active radiation periods. Under these conditions, the maximum monthly BVOC-induced O3 concentration occurred in August and ranged from 4 to 17 μg m−3 across districts, with isoprene being the dominant contributor. Quercus mongolica and Populus tomentosa played significant roles in the formation of BVOC-induced O3 due to their strong isoprene emitting potential in July–August. These results indicate the necessity of introducing species-specific rhythms of BVOC emissions from dominant species in the development of urban BVOC emission inventories. This approach could inform the development of air pollution management policies that are consistent with the local vegetation composition and O3 pollution characteristics. For Beijing and other similar northern cities, reducing the use of tree species emitting substantial amounts of isoprene during periods of regional peak ambient O3 concentrations could constitute an effective nature-based solution for improving urban air quality in the future.

Nasopharyngeal carriage of Streptococcus pneumoniae among children aged 30 days to &lt;60 months in Beijing and Shenzhen, China (2018–2021) during pneumococcal conjugate vaccine introduction and the coronavirus disease (COVID-19) pandemic

ObjectivesTo describe the carriage rate, serotype distribution, and antimicrobial susceptibility patterns of Streptococcus pneumoniae (S. pneumoniae) nasopharyngeal (NP) isolates among healthy children aged 30 days to &amp;lt;60 months in the cities of Beijing and Shenzhen during 2018–2021.MethodsA NP swab sample was collected among four annual cohorts of healthy children at routine well-child visits. S. pneumoniae was identified by culture, optochin sensitivity and bile solubility, serotypes determined by latex agglutination and Quellung, and antimicrobial susceptibility testing performed using E-test strips.ResultsS. pneumoniae NP carriage was 13.1% (645/4,911), with the highest S. pneumoniae carriage prevalence (15.3%) observed in 25 to &amp;lt;60 months. The carriage prevalence was 15.1% in children 13–24 months, 13.2% in children 7–12 months, and 8.2% in children 30 days to 6 months (P &amp;lt; 0.01). Living with siblings [20.0% vs. 9.4%: OR: 2.42 (95% CI: 2.05–2.87)] or attending day-care [31.8% vs. 11.3%: OR: 3.67 (95% CI: 2.94–4.57)] increased the risk (P &amp;lt; 0.01). During the period (January 2020–April 2021) of strict non-pharmaceutical interventions to prevent and control the COVID-19 pandemic, the proportion of children with S. pneumoniae colonization declined from 16.0% (94/587) to 5.8% (108/1,848) in Beijing while increasing from 14.5% (64/443) to 18.6% (379/2,033) in Shenzhen. Among S. pneumoniae isolates, 36.7% (237/645) belonged to 13-valent pneumococcal conjugate vaccine (PCV13) serotypes, 64.3% (408/645) were non-PCV13 serotypes, including 20.8% (134/645) non-serotypeable S. pneumoniae (NST). A total of 158/644 isolates (24.5%) were MDR. For the PCV13 isolates, MDR was detected in 36.3% (86/237) of isolates; in comparison, 17.6% (72/407) of non-PCV13 serotypes, including NST, were MDR (P &amp;lt; 0.01). S. pneumoniae NP carriage was detected in 10.7% of children with previous pneumococcal vaccination (PCV7 or PCV13 only) compared with 14.9% in children without previous pneumococcal vaccination.ConclusionsThe highest S. pneumoniae carriage prevalence were found in the oldest age group (25 to &amp;lt;60 months) and in children living with siblings or attending day-care. Vaccination with PCV7 or PCV13 was associated with lower PCV13-serotype colonization. In Beijing, S. pneumoniae carriage significantly declined during the COVID-19 pandemic.

A deep learning model for personalized intra-arterial therapy planning in unresectable hepatocellular carcinoma: a multicenter retrospective study

Unresectable Hepatocellular Carcinoma (uHCC) poses a substantial global health challenge, demanding innovative prognostic and therapeutic planning tools for improved patient management. The predominant treatment strategies include Transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC). Between January 2014 and November 2021, a total of 1725 uHCC patients [mean age, 52.8±11.5 years; 1529 males] received preoperative CECT scans and were eligible for TACE or HAIC. Patients were assigned to one of the four cohorts according to their treatment, four transformer models (SELECTION) were trained and validated on each cohort; AUC was used to determine the prognostic performance of the trained models. Patients were stratified into high and low-risk groups based on the survival scores computed by SELECTION. The proposed AI-based treatment decision model (ATOM) utilizes survival scores to further inform final therapeutic recommendation. In this study, the training and validation sets included 1448 patients, with an additional 277 patients allocated to the external validation sets. The SELECTION model outperformed both clinical models and the ResNet approach in terms of AUC. Specifically, SELECTION-TACE and SELECTION-HAIC achieved AUCs of 0.761 (95% CI, 0.693-0.820) and 0.805 (95% CI, 0.707-0.881) respectively, in predicting ORR in their external validation cohorts. In predicting OS, SELECTION-TC and SELECTION-HC demonstrated AUCs of 0.736 (95% CI, 0.608-0.841) and 0.748 (95% CI, 0.599-0.865) respectively, in their external validation sets. SELECTION-derived survival scores effectively stratified patients into high and low-risk groups, showing significant differences in survival probabilities (P<0.05 across all four cohorts). Additionally, the concordance between ATOM and clinician recommendations was associated with significantly higher response/survival rates in cases of agreement, particularly within the TACE, HAIC, and TC cohorts in the external validation sets (P<0.05). ATOM was proposed based on SELECTION-derived survival scores, emerges as a promising tool to inform the selection among different intra-arterial interventional therapy techniques. This study received funding from the Beijing Municipal Natural Science Foundation, China (Z190024); the Key Program of the National Natural Science Foundation of China, China (81930119); The Science and Technology Planning Program of Beijing Municipal Science & Technology Commission and Administrative Commission of Zhongguancun Science Park, China (Z231100004823012); Tsinghua University Initiative Scientific Research Program of Precision Medicine, China (10001020108); and Institute for Intelligent Healthcare, Tsinghua University, China (041531001).

The summer warming of Beijing (China) under the Paris Agreement

The summer warming of Beijing (China) under the Paris Agreement

Duration of exposure to compound daytime-nighttime high temperatures and changes in population exposure in China under global warming

Global warming has led to the enhancement of diurnal (daytime-nighttime) compound heat waves, which can severely affect the population’s physical health and productive life; this is particularly the case for vulnerable populations that are more susceptible to psychological and physiological harm with the future normalization of heatwave scenarios. In this study, we attributed the changes in population exposure under diurnal compound high temperatures (HTs) and extremely high temperatures (EHTs) to the influence of climatic (exposure duration) and population factors and their combined influence to determine the relationship between exposure duration and the changes in exposure of vulnerable populations. Diurnal compound HT and EHT covered a land area of 4,016,800 and 1,984,200 km2, respectively. The heat-exposed area spread step-like in all directions, centering on the 24-h high-exposure area with a strong gradient effect. The area of prolonged exposure shifted from the Yellow-Huai-Huai Plain across the geographical boundary between the south and the north to the middle and lower reaches of the Yangtze River Plain. Meanwhile, the average maximum value of vulnerable population exposure reached 186,800 and 93,100 person-h, with high values in Zhengzhou, Chongqing, Wuhan, Chengdu, Beijing, and other cities. Changes in vulnerable population exposure were dominated first by demographic factors and then by climatic factors, with the dominance of climatic factors evident in areas of prolonged exposure. Under prolonged exposure to daytime-nighttime compound EHT, changes in the exposure of child and older populations were dominated by climatic factors with a contribution rate of 87.16% and 87.43%, respectively. Therefore, suitable cooling measures should be proposed for vulnerable populations under prolonged exposure, focusing more on the physical and mental health of children and older adults exposed to compound EHT.

Environmental Perception about Pedestrian Environment on Cultural Visitation Roads

Cultural visitation routes represent an important opportunity for the public display of the famous historical and cultural city of Beijing, and its pedestrian environment, as a linear spatial carrier linking various historical and cultural attractions, is of great significance for the preservation of the famous historical and cultural city of Beijing through analysis of its spatial quality. At present, Beijing’s cultural visitation routes are in the stage of exploration and improvement, and scholars mainly focus on the selection, integration, and construction of cultural visitation routes in their research on cultural visitation routes, while the amount of research on the quality of the pedestrian environment for visitors is relatively small; in particular, the evaluation methods and indicator systems are still in the exploration stage. In this study, from the perspective of environmental behaviour theory, we took the Forbidden City–The Red House of Peking University–Wangfujing cultural visitation route as the research object and constructed a structural equation model to determine the perception of the pedestrian environment quality of the cultural visitation route in Beijing, starting from the visitors’ feelings of the pedestrian environment of the cultural visiting route. This study found that there is a positive correlation between the quality of spatial behaviours, the quality of the pedestrian environment, and the quality of the facilities on the emotional response of the visitors, with the quality of the facilities having the greatest impact on the emotional response of the visitors; among the observational variables, cultural and scientific facilities, spatial landscapes, street furniture, and safety play a more obvious role, and they are the main factors affecting the emotional response of the visitors. Based on the results of this study, an optimisation strategy for enhancing the pedestrian environments of Beijing’s cultural visitation routes is proposed to provide a reference for their design and optimisation.

Risk Factors for Norovirus Outbreaks in Schools and Kindergartens - Beijing Municipality, China, July 2017-June 2022.

Norovirus is the leading cause of global acute gastroenteritis outbreaks. Norovirus outbreaks mainly occur in schools and kindergartens in China, always causing public health issues. Conditional logistic regression method was used to analyze the risk factors for norovirus outbreaks in schools and kindergartens, and found that students vomiting at school or kindergarten, case activity in public areas, and the first case's classroom less than 5 meters from toilets were risk factors. Effective measures to address these factors can help reduce the risk of norovirus outbreaks in schools and kindergartens.

Ranking Model Averaging: Ranking Based on Model Averaging

Ranking problems are commonly encountered in practical applications, including order priority ranking, wine quality ranking, and piston slap noise performance ranking. The responses of these ranking applications are often considered as continuous responses, and there is uncertainty on which scoring function is used to model the responses. In this paper, we address the scoring function uncertainty of continuous response ranking problems by proposing a ranking model averaging (RMA) method. With a set of candidate models varied by scoring functions, RMA assigns weights for each model determined by a K-fold crossvalidation criterion based on pairwise loss. We provide two main theoretical properties for RMA. First, we prove that the averaging ranking predictions of RMA are asymptotically optimal in achieving the lowest possible ranking risk. Second, we provide a bound on the difference between the empirical RMA weights and theoretical optimal ones, and we show that RMA weights are consistent. Simulation results validate RMA superiority over competing methods in reducing ranking risk. Moreover, when applied to empirical examples—order priority, wine quality, and piston slap noise—RMA shows its effectiveness in building accurate ranking systems. History: Accepted by Ram Ramesh, Area Editor for Data Science and Machine Learning. Funding: This research was supported by the Beijing Municipal Natural Science Foundation [Grant 1222002], the National Natural Science Foundation of China [Grants 12071457, 12201018, 12301364, 71925007, 72091212, and 72273120], National Quality Infrastructure [Grant 2022YFF0609903], the Chinese Academy of Sciences Project for Young Scientists in Basic Research [Grant YSBR-008], and the Natural Science Foundation of Anhui Province [Grant 2308085QA09]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://doi.org/10.1287/ijoc.2023.0257 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0257 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .

High-dose hyperfractionated simultaneous integrated boost radiotherapy versus standard-dose radiotherapy for limited-stage small-cell lung cancer in China: a multicentre, open-label, randomised, phase 3 trial

For the past 20 years, twice-daily thoracic radiotherapy with concurrent chemotherapy has been the treatment of choice for limited-stage small-cell lung cancer (LS-SCLC), which has a poor prognosis. We aimed to assess the efficacy and safety of high-dose, accelerated, hyperfractionated, twice-daily thoracic radiotherapy (54 Gy in 30 fractions) versus standard-dose radiotherapy (45 Gy in 30 fractions) as a first-line treatment for LS-SCLC. This open-label, randomised, phase 3 trial was performed at 16 public hospitals in China. The key inclusion criteria were patients aged 18-70 years, with histologically or cytologically confirmed LS-SCLC, who had an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and who were previously untreated or had received one course of cisplatin or carboplatin and etoposide. Eligible patients were randomly assigned (1:1) to receive volumetric-modulated arc radiotherapy (VMAT) of 45 Gy in 30 fractions to the gross tumour volume or VMAT with a simultaneous integrated boost of 54 Gy in 30 fractions to the gross tumour volume starting 0-42 days after the first chemotherapy course. Both groups received 10 fractions of twice-daily thoracic radiotherapy per week. The planning target volume was 45 Gy in 30 fractions in both groups. Patients with responsive disease received prophylactic cranial radiotherapy (25 Gy in 10 fractions). Randomisation was performed using a centralised interactive web response system, stratified by ECOG performance status, disease stage, previous chemotherapy course, and chemotherapy choice. The primary outcome was overall survival in the intention-to-treat population. Safety was analysed in the as-treated population. This study was registered at ClinicalTrials.gov, NCT03214003. From June 30, 2017, to April 6, 2021, 224 patients (102 [46%] females and 122 [54%] males; median age 64 years [IQR 58-68]) were enrolled and randomly assigned to the 54 Gy group (n=108) or 45 Gy (n=116) group. The median follow-up was 46 months (IQR 33-56). The median overall survival was significantly longer in the 54 Gy group (60·7 months [95% CI 49·2-62·0]) than in the 45 Gy group (39·5 months [27·5-51·4]; hazard ratio 0·55 [95% CI 0·37-0·72]; p=0·003). Treatment was tolerable, and the chemotherapy-related and radiotherapy-related toxicities were similar between the groups. The grade 3-4 radiotherapy toxicities were oesophagitis (14 [13%] of 108 patients in the 54 Gy group vs 14 [12%] of 116 patients in the 45 Gy group; p=0·84) and pneumonitis (five [5%] of 108 patients vs seven [6%] of 116 patients; p=0·663). Only one treatment-related death occurred in the 54 Gy group (myocardial infarction). The study was prematurely terminated by an independent data safety monitoring board on April 30, 2021, based on evidence of sufficient clinical benefit. Compared with standard-dose thoracic radiotherapy (45 Gy), high-dose radiotherapy (54 Gy) improved overall survival without increasing toxicity in a cohort of patients aged 18-70 years with LS-SCLC. Our results support the use of twice-daily accelerated thoracic radiotherapy (54 Gy) with concurrent chemotherapy as an alternative first-line LS-SCLC treatment option. Chinese Society of Clinical Oncology-Linghang Cancer Research, the Wu Jieping Medical Foundation, and Clinical Research Fund For Distinguished Young Scholars of Peking University Cancer Hospital and Beijing Municipal Administration of Hospitals Incubating Program.

Genetic Diversity and Population Structural Analysis Reveal the Unique Genetic Composition of Populus tomentosa Elite Trees

Genetic diversity analysis provides the scientific basis for the preservation, evaluation, and utilization of the germplasm resources of tree species. We explored the genetic diversity and structure of Populus tomentosa elite trees in North China using 13 nuclear microsatellite markers. We compared nine groups of accessions including 20 originating from Beijing (BJ), 122 from Hebei (HB), 20 from Shandong (SD), 113 from Henan (HN), 270 from Shanxi (SX), 54 from Shaanxi (SAX), 8 from Gansu (GS), 10 from Anhui (AH), and 6 from Jiangsu (JS). All of the studied primer pairs were polymorphic and generated 125 alleles. Analyses of molecular variance revealed that 79%, 14%, and 8% of the total variation was due to variations within the individual, among individuals, and among populations, respectively. Based on principal coordinate and STRUCTURE cluster analyses, individuals distributed in the southern region (HN, SAX, AH, and JS) were roughly classified into one group, while those distributed in the northeastern region (BJ, HB, and SD) and northwestern regions (SX) were separately divided into one group each. Moreover, the northwestern region included two-thirds of the SX trees, and the remainder were in the northeast region. By analyzing genetic diversity and structure within populations, individuals with different genetic backgrounds were screened for constituent training populations (TRS), including broad allelic variation for related traits. This ensures that the genomic prediction model can accurately capture genetic effects and provide reliable predictions across a broad spectrum of genetic backgrounds. Therefore, our results will benefit genome breeding technology.