Beijing University Of Chinese Medicine Research Articles

Model Analysis of Influencing Factors on Academic Performance of Medical Students

A questionnaire was designed according to the UTAUT model. Students from Beijing University of Chinese Medicine, including undergraduate, graduate, and doctoral students, participated the survey. A total of 221 completed responses were received within one month, and 218 responses were used for quantitative analysis (deletion of 3 invalid responses). This study found that academic performance of medical students was influenced most by learning willingness, followed by facilitating conditions, self-management of learning, etc. The results of this study can be helpful to students and teachers in medical college to adjust their learning and teaching strategies.

Estado de las publicaciones sobre acupuntura en el tratamiento de la dismenorrea primaria indexadas en PubMed (2007-2016): análisis bibliométrico

ObjectiveTo identify the status of publications on acupuncture in the treatment of primary dysmenorrhoea indexed in PubMed (2007-2016). Material and methodsRecords were retrieved using PubMed (2007-2016), and the evaluation of the visibility of the publications made using SCImago Journal Rank. The bibliometric indicators applied were: temporal production, authorship, geographical coverage, collaboration, Bradford's Dispersion Law and formulation of Egghe, visibility, and language coverage. ResultsA total of 78 items were retrieved in 30 international Journals. The main production country was China (69.23%), highlighting the most prolific author Jiang Zhu of the Beijing University of Chinese Medicine, which in turn was the leading institution in terms of volume of publications. The index was 77.77%. Almost all works (97.43%) were in collaboration between authors, of which 28.20% were between national institutions, and 2.56% international. The core journals were: Zhongguo Zhen Jiu [Chinese Acupuncture & Moxibustion], Evidence Based Complementary and Alternative Medicine, and Zhen ci yan jiu [Acupuncture research]. Almost all (98.80%) of publications were present in the SCImago Journal Rank, where 50% of the production is presented in the first quartile. The language coverage of publications focuses on two languages, English (69.23%) and Chinese (30.77%). ConclusionsA comprehensive strategy needs to be implemented in order to continue advancing in this field, with a greater involvement of researchers both at national and international level.

Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition.

PurposeTitanium implant is a widely used method for dental prosthesis restoration. Nevertheless, in patients with systemic diseases, including osteoporosis, diabetes, and cancer, the success rate of the implant is greatly reduced. This study investigates a new implant material loaded with insulin-like growth factor 1 (IGF1), which could potentially improve the implant success rate, accelerate the occurrence of osseointegration, and provide a new strategy for implant treatment in osteoporotic patients.Materials and methodsBiofunctionalized polyelectrolyte multilayers (PEMs) with polyethylenimine as the excitation layer and gelatin/chitosan loaded with IGF1 were prepared on the surface of titanium implant by layer-by-layer self-assembly technique. The physical and chemical properties of the biofunctionalized PEMs, the biological characteristics of bone marrow mesenchymal stem cells (BMMSCs), and bone implant contact correlation test indexes were detected and analyzed in vitro and in vivo using osteoporosis rat model.ResultsPEMs coatings loaded with IGF1 (TNS-PEM-IGF1-100) implant promoted the early stage of BMMSCs adhesion. Under the action of body fluids, the active coating showed sustained release of growth factors, which in turn promoted the proliferation and differentiation of BMMSCs and the extracellular matrix. At 8 weeks from implant surgery, the new bone around the implants was examined using micro-CT and acid fuchsin/methylene blue staining. The new bone formation increased with time in each group, while the TNS-PEM-IGF1-100 group showed the highest thickness and continuity.ConclusionTNS-PEM-IGF1-100 new implants can promote osseointegration in osteoporotic conditions both in vivo and in vitro and provide a new strategy for implant repair in osteoporotic patients.

P.2.f.029 - Functional recovery in patients with major depressive disorder (MDD) – the role of cognitive symptoms in real life clinical practice

To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency (POI) of the kidney deficiency and liver constraint pattern.Ninety patients with POI who consulted with Professor Guo at Dongzimen Hospital, Beijing University of Chinese Medicine from January 2012 to December 2015 were enrolled. Treatment consisted of sequential therapy using traditional Chinese medicine formulae with the actions of nourishing the liver and kidney. Course of treatment was 3 consecutive menstrual cycles for each participant except for those who became pregnant during treatment. Baseline data including age, course of disease, past medical history, lifestyle, pregnancy outcome, menstrual status (cycle length, menstrual flow duration and volume), as well as gonadal hormone levels before and after treatment were recorded and analyzed.During treatment, 18 (20.0%) participants became pregnant. Symptoms including scanty menstrual flow, irritability, low libido, insomnia and excessive dreaming at night, nightsweats, hot flashes, and depression were markedly alleviated. Changes in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels at early follicular stage were observed (P = .009 and P = .002, respectively), and FSH/LH differed significantly pre- and posttreatment (P = .044).Professor Guo's sequential Chinese herbal therapy with the actions of nourishing the liver and kidney to treat POI can enhance ovarian function, promote pregnancy, and improve quality of life.

Practice and discussion on application ability-oriented college English education reform in Beijing university of Chinese medicine

College English education in TCM universities should set up its own unique education system characterized by the TCM characteristics, manipulability and generalizability. Here the Beijing University of Chinese Medicine was taken as an example to discuss the necessity, theoretical basis, specific methods and preliminary achievements of the application ability-oriented college English education reform in the past six years that serves students’ learning needs and career development as well as the university’s talents cultivation. Key words: Traditional Chinese medicine and pharmacy; Eductional reform; College English; Application ability

Yiqi Huoxue prescription can prevent and treat post-MI myocardial remodeling through promoting the expression of AMPK signal pathway

ObjectiveTo investigate how Yiqi Huoxue (YQHX) prescription regulates mitochondrial biosynthesis and ATP synthesis via AMP-activated protein kinase (AMPK) and to reveal its molecular mechanism in preventing and treating post-MI myocardial remodeling. MethodsThe MI animal model of myocardial infarction were established by ligating Sprague Dawley (SD) rats' left anterior descending coronary arteries; the animals were randomly divided into MI group, YQHX prescription group and perindopril group, and a sham operation group was set at the same time. Related drug intervention was administered on the 2nd day after surgery, the YQHX group was given Astragalus, angelica, ginseng, Ligusticum wallichii and pseudoginseng, provided by the Dongzhimen Hospital of Beijing University of Chinese Medicine, once per day, at a dose of 21 g/kg body weight/day (the clinical equivalent dose based on a previous study), and the changes in relevant indicators were observed at 1 week and 4 weeks. Echocardiography (ECG) was used to observe the changes in rat cardiac structure and functions; the morphology-based technique was used to observe the changes in myocardial cells and mitochondria; the expression of AMPK signal pathway-related proteins and mRNA was detected using western blotting and real-time fluorescence quantification respectively, while fluorescence enzyme-labeled method was used for detecting ATP synthesis. ResultsCardiac structure and functions: Compared with the MI group at 1 week, the YQHX prescription group and the perindopril group exhibited increased LVEF and LVFS (Pall < .05); their LVEDs and LVEDd were reduced but suggested no statistically significant differences (F = 2.258, F = 0.3464, Pall > .05). At 4 weeks, both LVEF and LVFS were elevated in the YQHX prescription group (P = .008, .009) and the perindopril group (P = .279, .333), where differences in the later group indicated no statistical significance; the YQHX prescription group and the perindopril group were also featured by reduced LVEDs and LVEDd (Pall < .05). Morphology: Compared with the MI group at two time nodes, the YQHX prescription group and the perindopril group exhibited significant improvement in the pathological changes in myocardial cells and mitochondrial structure. Expression of AMPK signal pathway-related proteins and mRNA: The expression of both pLKB1 and pAMPK proteins followed a rising trend in the YQHX prescription group and the perindopril group at 1 week. The expression of LKB1mRNA and AMPKmRNA was elevated (Pall < .05). The increased expression of PGC-1α, NRF1 and mtTFA proteins demonstrated statistically significant differences (Pall < .05). The expression of mtDNA protein followed an increasing trend. At 4 weeks, the expression of both pLKB1 and pAMPK proteins was elevated (Pall < .05). Heightened expression was also reported in LKB1mRNA and AMPKmRNA (Pall < .05). The increased expression of PGC-1α, NRF1, mtTFA and mtDNA proteins demonstrated statistically significant differences (Pall < .05). ATP synthesis: ATP synthesis was increased in the YQHX prescription group and the perindopril group at both 1 week and 4 weeks (Pall < .001). ConclusionThe possible mechanism of YQHX prescription for preventing and treating post-MI myocardial remodeling may function through strengthening the activation AMPK signal pathway by LKB1, thus further increasing the expression of downstream transcription factor proteins and initiating mitochondrial replication and transcription; as a result, the YQHX prescription can improve the post-MI damage in mitochondrial morphological structure in the tissue at heart marginal zone as well as enhance mitochondrial biosynthesis and ATP synthesis.

Practice and research of "Fundamentals of Nursing" teaching based on the Blackboard platform

Objective To explore the effects of the Blackboard platform in Fundamentals of teaching and students' actual experience after using the Blackboard platform. Methods A historical control study was conducted in College of Nursing of Beijing University of Chinese Medicine from September 2015 to January 2016. In experimental group, 121 undergraduate nursing students of grade 2013 were taught by the combination of traditional classroom teaching and Blackboard platform. In control group, 130 undergraduate nursing students of grade 2012 were applied with traditional classroom teaching. After the course, examinations were performed to assess the theoretical knowledge and operational skills; and the self-made questionnaires and semi-structured interviews were conducted to evaluate the effects of the Blackboard platform in experimental group. Results The theory examination scores of the experimental group was (76.74±8.68) while the control group was (73.09±8.11) , there was a statistically significant difference between two groups (t=-3.44, P 0.05) . Nursing students in experimental group had a high degree of satisfaction with the Blackboard platform. More than 90% nursing students considered that application of the Blackboard platform in Fundamentals of could arouse their enthusiasm of learning (90.68%) , help them to better grasp the classroom learning content (95.76%) and improve the teaching effect (97.46%) . Semi-structured interview results indicated that the nursing students believed that Blackboard platform were helpful to their learning, and made it more convenient to interact with teachers. Conclusions The teaching practice of Fundamentals of based on Blackboard platform can arouse nursing students' learning interest. The teaching model has achieved good effects in both learning and teaching. Nursing students are satisfied with the model. It is necessary to update and improve the Blackboard platform teaching model in time. Key words: Education, nursing; Blackboard network teaching platform; Fundamentals of Nursing; Teaching model

Observation of curative effects of musculoskeletal ultrasound-guided needle-knife on the degenerative meniscus disease

To observe the curative effect of musculoskeletal ultrasound-guided needle-knife on the degenerative meniscus disease, and to provide a new method in the treatment of degenerative meniscus disease. Seventy-seven patients with degenerative meniscus disease treated in the Third Affiliated Hospital of Beijing University of Chinese Medicine from January 2015 to September 2015 were selected, including 30 males and 47 females, aged from 44 to 66 years old, with an average of 57.5 years old. VAS scores, Lysholm scores and distance of meniscal protrusion were analyzed and compared before treatment, 2 weeks and 1 month after treatment. The curative effect was summarized at last. The mean Lysholm scores were 51.63±15.26(before treatment), 77.13±11.82(2 weeks after treatment) and 87.56±8.65(1 month after treatment). The mean VAS scores were 7.080±1.574 (before treatment), 2.630±0.310(2 weeks after treatment) and 0.850±0.177(1 month after treatment). The mean of the distance of meniscal protrusion scores were 0.400±0.156 (before treatment), 0.298±0.140 (2 weeks after treatment) and 0.240±0.110 (1 month after treatment). VAS scores and Lysholm scores were improved significantly compared with preoperative results. The distance of meniscal protrusion showed an obvious improvement after treatment. The treatment of musculoskeletal ultrasound-guided needle-knife has advantages of high accuracy position and excellent effectiveness for degenerative meniscus disease. The treatment provides safety operation and significantly improves quality of life in patients without any complications.

Correlation Between the Revised Brain Symmetry Index, an EEG Feature Index, and Short-term Prognosis in Acute Ischemic Stroke.

The present study aims to investigate the correlation between EEG features and short-term prognosis in patients who have experienced an acute ischemic stroke. The present study included 29 patients who had experienced an acute ischemic stroke and were treated at the Beijing Dongzhimen Hospital affiliated with Beijing University of Chinese Medicine between January 2010 and January 2012. Patients were evaluated using the revised Brain Symmetry Index (r-BSI), National Institutes of Health Stroke Scale, and Glasgow Coma Scale. Functional outcomes were assessed 21 days after admission using the Barthel Index and modified Rankin Scale. Two groups were created based on the Barthel Index (<60 vs. ≥60) and modified Rankin Scale (<3 vs. ≥3). Significant differences were observed in r-BSI, National Institutes of Health Stroke Scale, and Glasgow Coma Scale scores between the two groups. Poor functional outcomes were associated with higher r-BSI and National Institutes of Health Stroke Scale scores as well as lower Glasgow Coma Scale scores in comparison with those obtained for patients with good prognosis. Logistic regression analysis revealed that r-BSI scores at admission exhibited significant negative correlation with Barthel Index scores (-2.070, P = 0.049) and significant positive correlation with modified Rankin Scale scores (2.256, P = 0.033). The r-BSI may be a valuable prognostic tool in the prediction of short-term outcomes for patients who have experienced acute ischemic stroke. The early prediction of functional outcomes after stroke may enhance clinical management and minimize short-term mortality.

Prognostic factors for inability to walk independently in patients with multiple system atrophy

Objective: To explore the prognostic factors for inability to walk independently in patients with multiple system atrophy (MSA). Methods: A total of 123 patients with clinically confirmed MSA admitted to Navy General Hospital and Dongfang Hospital affiliated to the Second Clinical Medical College of Beijing University of Chinese Medicine, from February 2013 to February 2016, were retrospectively reviewed. Clinical data and all records were collected and all subjects were followed up by a telephone call in February 2016. The second milestone of activities of daily living scale (ADL), defined as inability to walk independently, was taken as the primary outcome. Eight possible prognostic factors were investigated and the survival analysis was performed with Cox proportional hazards model regression. Results: Of all the MSA patients, 74 subjects were men and 49 were women with a sex radio of 1.51∶1(M∶F). Seventy cases were diagnosed with MSA-cerebellar type (MSA-C) and 53 with MSA-Parkinson type (MSA-P) (C∶P=1.32∶1). Mean age at the onset of first symptom was (53±8) years old. All patients had severe autonomic nervous dysfunction. At the last follow-up, 56 cases (45.5%) were unable to walk independently. The median survival time from the onset of MSA to inability to walk independently was 73 months. The age of onset ≥ 55 years (HR=1.969, 95%CI 1.095-3.542, P=0.024) and the interval time from disease onset to combined motor and autonomic involvement≤3 years (HR=2.308, 95%CI 1.158-4.600, P=0.017) were independent prognostic factors for inability to walk independently, while gender, MSA clinical subtypes, initial symptoms, alcohol intake, smoking and toxic exposure were not indicators for independent walking (P>0.05). Conclusions: The prognostic factors for inability to walk independently in patients with MSA are the age of onset ≥55 years and the interval time from disease onset to combined motor and autonomic involvement≤3 years. Although factors including gender, MSA clinical subtypes, initial symptoms, alcohol intake, smoking and toxic exposure are not the predictive factors for inability to walk independently in our MSA patients, their roles in the prognosis of MSA still need further investigation.

Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review.

PurposeThe aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis.Materials and methodsSix databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards.ResultsEight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; P<0.00001) and BMD of femoral great trochanter (MD: 0.06 [0.02, 0.10]; I2=59%; P=0.005) compared with caltrate tablets. The other meta-analysis from two trials showed beneficial effects of EXD plus caltrate tablets and calcitriol in improving BMD of femoral neck (MD: 0.04 [0.00, 0.09]; I2=56%; P=0.04), the level of calcium (MD: 0.20 [0.15, 0.24]; I2=0%; P<0.00001), and phosphorus (MD: −0.28 [−0.39, −0.17]; I2=68%; P<0.00001) compared with caltrate tablets and calcitriol alone. The adverse drug reactions of EXD were mainly slight gastrointestinal symptoms.ConclusionThe study provides suggestive evidence of the superiority of EXD monotherapy or combination therapy over basic supplements for treating osteoporosis. However, the evidence remains weak. More rigorously designed and measured, randomized double-blind, placebo-controlled trials with larger sample size are needed to verify the current conclusions.

Establishment of application center of evidence-based nursing best practice guidelines in Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine

Clinical application of practice guideline is the important part in evidence-based nursing. This essay would introduce the foundation of application center of best practice guideline in Dongzhimen Hospital of Beijing University of Chinese Medicine from the background, current status, building of evidence-based team, management and training of organization and propulsion method of guideline project, so as to provide references for the foundation of domestic evidence-based nursing practice center. Key words: Clinical nursing practice guidelines; Registered nurses′ association of Ontario; Best practice organization

Best practice: translate knowledge into action

Nursing College of Beijing University of Chinese Medicine is the first domestic research center of best practice guideline, and the first affiliated hospital-Dongzhimen Hospital is the first domestic application center of best practice guideline. The foundation of two centers sets up a high-end academic platform for better development of practice and research of evidence-based nursing. The evidence-based nursing research receives the academic guidance of international authority, and shares the international evidence-based resources. The research process can enter the NQuIRE® database of international academic organization for unified system management. We also can communicate with international peers. The academic achievements and research achievements can be promoted and published on international platform. This essay would give a specific exposition about the evidence-based nursing and the implementation mode of best evidence. Key words: Evidence-based practice; Knowledge; Practice; Review

The effect of anger on pulse-graph parameters in healthy college students: A pilot study

ObjectiveTo explore the effect of anger on pulse parameters in healthy participants. MethodsThirty healthy college students from Beijing University of Chinese Medicine were selected as volunteers. Each participant was asked to watch an anger-inducing film clip. Their discrete emotional dimensions were assessed by a self-report at three time points: 10 minutes before watching the video (T1), the moment when the video ended (T2) and 15 minutes after the video ended (T3). Meanwhile, pulse-graph parameters (pulse tense, pulse force, pulse fluency, pulse rate and pulse rhythmicity) were recorded by a pulse apparatus at the same three time points. ResultsThe target emotion of anger was successfully elicited, and the participants also reported slight sadness and fear. After emotional elicitation, the participants showed significant changes in pulse tense, pulse force, pulse fluency and pulse rate. There was no significant change in pulse rhythm.

Exploring on nursing educational innovation with best practice guidelines to cultivate evidence-informed practice

The Registered Nurses Association of Ontario (RNAO) is the professional voice of registered nurses, nurse practitioners and nursing students in the province of Ontario, Canada. RNAO’s mandate is to influence and promote public health policy and clinical excellence. RNAO’s best practice guideline (BPG) program established in 1999, focuses on BPG development, implementation and evaluation and has impacted clinical and academic excellence globally. The Best Practice Spotlight Organization (BPSO®) Designation, is RNAO’s unique organizational knowledge exchange strategy that supports health care and academic organizations to implement and integrate multiple best practice guidelines into daily practice and education. Beijing University of Chinese Medicine (BUCM) has recently become the first academic BPSO in China to enable successful implementation of BPGs which must include not only clinical nurses but also nursing educators and students. While relatively new in implementing BPGs into the nursing curricula, BUCM School of Nursing has developed key strategies to support this work. This paper will discuss the nursing educational innovation of integrating BPGs into the curricula to cultivate evidence-based practice (EBP) at the BUCM School of Nursing from the perspectives of undergraduates, graduates and nursing educators.

Study on the relation between tissues pathologies and traditional chinese medicine syndromes in knee osteoarthritis: Medical image diagnostics by preoperative X-ray and surgical arthroscopy.

This study aims to investigate whether integration of traditional Chinese medicine and modern medicine has advantage in achieving the improved diagnosis and treatment of knee osteoarthritis. 90 patients with knee osteoarthritis were selected from The Department of Minimal Invasive Joint of The Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2013 to June 2015. They were divided into 3 groups with 30 cases per group in accordance to the syndrome differentiation of traditional Chinese medicine. The patients underwent arthroscopic surgery, and we categorized the patients having the same characterization in each group, and those having distinct difference into the three groups. Based on the arthroscopic analysis, we performed analysis of statistical data in order to analyze the relation between knee osteoarthritis under arthroscope and traditional Chinese medicine syndromes. There are three syndromes according to traditional Chinese medicine that can be categorized into various different groups. The synovial proliferation can be seen mostly in the syndrome of stagnation of blood stasis. The slight damage of knee joint cartilage can be seen in the syndrome of yang deficiency and cold stagnation, the severe one in the syndrome of kidney-marrow deficiency. We found that there are different pathological expressions with the various degree of the tissues damage at the knee and we categorized the knee according to their syndrome. For knee osteoarthritis, different syndromes of traditional Chinese medicine presents different tissues pathological changes at the knee joint under arthroscopy, which will provide objective basis for the diagnosis of this medical condition.

Efficacy of Qingxin Huatan therapy in regulating cardiac autonomic nerve function in patients with chronic stable angina: study protocol for a randomized controlled trial

Background: Coronary heart disease is a chronic degenerative disease of the coronary arteries characterized by atherosclerosis. Lianxia Ningxin granules, a traditional Chinese medicine, is a representative preparation of Qingxin Huatan therapy, which has been confirmed to be effective in improving autonomic nerve dysfunction in patients with coronary heart disease. Methods/Design: We herein describe a prospective, single-center, randomized, double-blind, placebo-controlled trial to be performed by the Department of Cardiovascular Medicine, Third Affiliated Hospital of Beijing University of Chinese Medicine, China. Eighty patients with chronic stable angina will be randomly assigned to receive 4 weeks of treatment with either Western medicine plus Lianxia Ningxin granules (traditional Chinese medicine group) or Western medicine plus placebo (control group). All patients will be followed up for 8 weeks. The primary outcome is frequency of angina attacks. The secondary outcomes include heart rate variability, plasma catecholamine concentrations, nitroglycerin consumption, duration of angina, severity of angina pain, efficacy of traditional Chinese medicine treatment, and quality of life. Discussion: This study is designed to assess the efficacy of Qingxin Huatan therapy in treating chronic stable angina, and simultaneously investigate the regulatory effects of this therapy on cardiac autonomic nerve function and related neurotransmitter concentrations. The outcomes will provide information concerning the clinical use of Qingxin Huatan therapy to treat chronic stable angina and its ability to regulate cardiac autonomic nervous function. Trial registration : This protocol was registered at the Chinese Clinical Trial Registry (registration number: ChiCTR-TRC-14004699). Ethics: Written approval has been obtained from the Medical Ethical Committee, Third Affiliated Hospital of Beijing University of Chinese Medicine, China (approval number: KTPJ-BZYSY-2003-003). Informed consent: Written informed consent will be obtained from patients or their guardians prior to inclusion in this study.

Formulation, optimization, and pharmacodynamic evaluation of chitosan/phospholipid/β-cyclodextrin microspheres.

Cholinergic neurotransmission loss is the main cause of cognitive impairment in patients with Alzheimer’s disease. Phospholipids (PLs) play an essential role in memory and learning abilities. Moreover, PLs act as a source of choline in acetylcholine synthesis. This study aimed to prepare and optimize the formulation of chitosan/phospholipid/β-cyclodextrin (CTS/PL/β-CD) microspheres that can improve cognitive impairment. The CTS/PL/β-CD microspheres were prepared by spray drying, and optimized with an orthogonal design. These microspheres were also characterized in terms of morphology, structure, thermostability, drug loading, and encapsulation efficiency. The spatial learning and memory of rats were evaluated using the Morris water maze test, and the neuroprotective effects of the CTS/PL/β-CD micro-spheres were investigated by immunohistochemistry. Scanning electron microscopic images showed that the CTS/PL/β-CD microspheres were spherical with slightly wrinkled surfaces. Fourier transform infrared spectroscopy and differential scanning calorimetry proved that PLs formed hydrogen bonds with the amide group of CTS and the hydroxyl group of β-CD. The learning and memory abilities of rats in the treated group significantly improved compared with those in the model group. Immunohistochemical analysis revealed that treatment with the CTS/PL/β-CD microspheres attenuated the expression of protein kinase C-δ and inhibited the activation of microglias. These results suggest that the optimized microspheres have the potential to be used in the treatment of Alzheimer’s disease.

SIMPP analysis on self-study ability of students

According to the theory of microscopic system reform in higher education, a total of 927 college students of different majors from Beijing University of Chinese Medicine were investigated by using SIMPP method. It indicated that through promoting the study of self-prepared, learning state and learning effect, students can enhance their learning ability of the admission acceptance. From the perspective of teachers, the students' self-study ability can be fully mobilized using individual personalized teaching method. Then, the initiative of university education in the teaching and learning can be improved. Ultimately, the efficiency of student learning can be improved. Key words: Higher education; Self-study ability; SIMPP analysis method

WITHDRAWN: Risk of hematologic toxicities and peripheral neuropathy with nab-paclitaxel in treatment of malignancy: an up-to-date metaanalysis

// Yihua Liu 1, 2 , Huiting Fan 1 , Ying Zhang 1 , Yong Yang 3 and Hongsheng Lin 1 1 Department of Oncology, Guang'anmen Hospital, Affiliated to China Academy of Chinese Medical Sciences, Beijing, 100053, China 2 Beijing University of Chinese Medicine, Beijing, 100029, China 3 Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Beijing, 100010, China Correspondence to: Hongsheng Lin, email: drlinhongsheng@126.com Keywords: nab-paclitaxel; taxanes; peripheral neuropathy; hematological toxicities; meta-analysis Received: August 19, 2017 Accepted: November 13, 2017 Published: January 02, 2018 ABSTRACT Background: Nab-paclitaxel represents a promising therapeutic approach being developed. There are concerns about the increased risk of toxicities with nab-paclitaxel. This study performed an up-to-date meta-analysis of all phase II and III prospective clinical trials of nab-paclitaxel to quantify the increased risk of peripheral neuropathy (PN) and hematological toxicities for cancer patients. Materials and Methods: We carried out a systematic literature search of electronic databases and proceedings of oncologic meetings published before May 2017. Eligibility criteria included phase II and III trials of nab-paclitaxel reported adequate safety profiles. Data were extracted from each study and pooled to determine the overall incidence, relative risks (RRs) and 95% confidence intervals (CIs). Results: A total of 7,491 patients with a variety of solid tumors from 30 clinical trials were identified. The results revealed that the incidences of nab-paclitaxel associated all-grade and high-grade hematological toxicities and PN were, neutropenia: 62.5% and 27.2%; leukopenia: 63.9% and 17.2%, anemia: 56.5% and 6.2%, thrombocytopenia: 11.4% and 3.3%, PN: 67.0% and 13.4%, respectively. Compared with taxanes, nab-paclitaxel use did not significantly increase the risk of hematological toxicities and PN. However, this association varied significantly with tumor types and controlled therapies. Conclusions: Nab-paclitaxel associated hematological toxicities are modest and manageable comparable with taxanes, while clinicians should be cautious with PN when adding nab-paclitaxel to the therapies for breast cancer patients.