Telehealth-delivered behavioral therapy for chronic pain has been evaluated in the research setting; few data have described real world implementation and outcomes. The purpose of this study was to evaluate characteristics, behavioral health goals, and psychosocial outcomes among participants enrolled in a nationally available standardized 8-week behavioral therapy program for chronic pain provided by both a licensed therapist and a behavior coach via telephone/secure video. This was mixed-methods retrospective cohort analysis among consecutive program graduates (enrollment February-July 2015; N=100; mean age 52y; 23% male). Participant chief complaint, behavioral goals, and mood triggers were abstracted by de-identified clinical record review using structured qualitative research methods. Depression, anxiety, and stress symptoms data were collected at baseline and program graduation by validated survey (DASS-21). Back pain (42%) and hip/leg/knee pain (28%) comprised the most common chief complaints. Pain management (44%) and weight loss (43%) were the most frequently cited goals. At baseline, approximately half of participants had elevated depression (54%), anxiety (50%), and/or stress (45%) scores. Triggers for depressed, anxious or stressed mood included severe pain (47%), health concerns (46%), and interpersonal relationship challenges (45%). At graduation, significant improvement in depression (-48%), anxiety (-44%), and stress (-23%) scores were observed among those with non-normal baseline values (p<.001); degree of improvement did not vary by participant age or sex. In summary, participants in a national behavioral telehealth program for chronic pain shared several common complaints, goals, and mood triggers, and experienced significant improvement in depression, anxiety, and stress symptoms. This work was supported by AbilTo, Inc., New York, NY.