Regulation Of Behavior Research Articles

Strain and hyaluronic acid interact to regulate ovarian cancer cell proliferation, migration, and drug resistance

The ovarian tumor microenvironment plays a critical yet is poorly understood role in the regulation of cancer cell behaviors including proliferation, migration, and response to chemotherapy treatments. Ovarian cancer is the deadliest gynecological cancer, due to diagnosis at late stages of the disease and increased resistance to chemotherapies for recurrent disease. Understanding how the tumor microenvironment (TME) interacts with biomechanical forces to drive changes to ovarian cancer cell behaviors could elucidate novel treatment strategies for this patient population. Additionally, limitations in current preclinical models of the ovarian TME do not permit investigation of crosstalk between signaling pathways and mechanical forces. Our study focused on uncovering how strains and hyaluronic acid (HA) interact to signal through the CD44 receptor to alter ovarian cancer cell growth, migration, and response to a commonly used chemotherapy, paclitaxel. Using an advanced 3D in vitro model, we were able to identify how interactions of strain and HA as in the TME synergistically drive enhanced proliferation and migration in an ovarian tumor model line, while decreasing response to paclitaxel treatment. This study demonstrates the importance of elucidating how the mechanical forces present in the ovarian TME drive disease progression and response to treatment.

Dopamine D4 receptors in the lateral habenula regulate anxiety-related behaviors in a rat model of Parkinson's disease

Although the output of the lateral habenula (LHb) controls the activity of midbrain dopamine (DA) and 5-hydroxytryptamine (5-HT) containing systems, which are implicated in the pathophysiology of anxiety, it is not clear how activation and blockade of LHb D4 receptors affects anxiety-like behaviors, particularly in Parkinson’s disease related anxiety. In this study, unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta (SNc) in rats induced anxiety-like behaviors, which attribute to hyperactivity of LHb neurons and decrease in the level of DA in the medial prefrontal cortex (mPFC), amygdala and ventral hippocampus (vHip) compared to sham-operated rats. Intra-LHb injection of D4 receptor agonist A412997 induced or increased the expression of anxiety-like behaviors, while injection of D4 receptor antagonist L741742 showed anxiolytic effects in sham-operated and the SNc-lesioned rats. However, the doses producing behavioral effects in the lesioned rats were higher than those of sham-operated rats. Intra-LHb injection of A412997 increased firing rate of LHb neurons, and decreased levels of DA and 5-HT in the mPFC, amygdala and vHip; conversely, L741742 decreased firing rate of LHb neurons, and increased levels of DA and 5-HT in two groups of rats. Compared to sham-operated rats, the duration of A412997 and L741742 action on the firing rate of neurons was markedly shortened in the lesioned rats. Collectively, these findings suggest that D4 receptors in the LHb are involved in the regulation of anxiety-like behaviors, and degeneration of the nigrostriatal pathway down-regulates function and/or expression of these receptors.

Commercial Wearables for the Management of People with Autism Spectrum Disorder: A Review

Autism Spectrum Disorder (ASD) necessitates comprehensive management, addressing complex challenges in social communication, behavioral regulation, and sensory processing, for which wearable technologies offer valuable tools to monitor and support interventions. Therefore, this review explores recent advancements in wearable technology, categorizing devices based on executive function, psychomotor skills, and the behavioral/emotional/sensory domain, highlighting their potential to improve ongoing management and intervention. To ensure rigor and comprehensiveness, the review employs a PRISMA-based methodology. Specifically, literature searches were conducted across diverse databases, focusing on studies published between 2014 and 2024, to identify the most commonly used wearables in ASD research. Notably, 55.45% of the 110 devices analyzed had an undefined FDA status, 23.6% received 510(k) clearance, and only a small percentage were classified as FDA Breakthrough Devices or in the submission process. Additionally, approximately 50% of the devices utilized sensors like ECG, EEG, PPG, and EMG, highlighting their widespread use in real-time physiological monitoring. Our work comprehensively analyzes a wide array of wearable technologies, including emerging and advanced. While these technologies have the potential to transform ASD management through real-time data collection and personalized interventions, improved clinical validation and user-centered design are essential for maximizing their effectiveness and user acceptance.

Self‐Comparing With Virtual Influencers: Effects on Followers' Wellbeing

ABSTRACTWhile there is pervasive research on virtual influencers (VIs) and their impacts on consumer behaviors, there is a lack of understanding of their effects on followers' wellbeing. Drawing on social comparison theory, in this study, we examine how followers self‐compare with VIs and what the effects of this process are on their wellbeing. Based on a qualitative study, involving 31 interviews with followers of VIs on Instagram, we found that they experience both upward and downward comparison. The upward comparison made them feel envious, jealous (i.e., contrastive), or inspired, optimistic, and admired (i.e., assimilative) while the downward assimilative comparison made the followers worry or feel sympathy with the VI they follow. Moreover, we found another set of emotions that can be triggered by the process of social comparison with a VI, such as feelings of shame due to the nature of the influencers not being human. Individuals cope with the negative effects of self‐comparing through emotional and behavioral regulations.

Interface dynamics in electroosmotic flow systems with non-Newtonian fluid frontiers

Abstract Microfluidic applications involving liquid manipulation, selective membranes, and energy harvesting strongly em-phasize the importance of the electrokinetic phenomenon, which is widely used at multiple fluid and electrochemi-cal interfaces. However, critical scientific issues that address multifield coupling and multiscale physics have not been well addressed in non-Newtonian fluids. In this paper, electrical field–fluid flow–ion transport coupling is numerically implemented in two mainstream problems, i.e., induced electroconvection phenomena at ion-selective interfaces and induced charge electroosmosis in polarized cylinders. The effects of different non-Newtonian rheo-logical properties, which are absent in Newtonian fluids, on the interfacial dynamics, instability and ion transport are examined. The results reveal that the non-Newtonian rheology significantly modulates the statistical data and interfacial phenomena. Generalized power-law fluids alter velocity and interfacial charge profiles, with shear thin-ning enhancing ion transport to lower overlimiting current thresholds and shear thickening broadening the limiting current region (with hindered ion transport). In Boger-type Oldroyd-B fluids, the addition of polymer decreases the velocity amplitude and increases the interface resistance. At low voltages, polymer viscoelasticity minimally affects the ohmic and limiting regions, but under convection-dominated flow, different rheological parameters, such as the viscosity ratio, Weissenberg number, anisotropic parameter, and electrohydrodynamic coupling con-stants, enable controllable regulation of ion transport behavior across a wide range. Finally, this paper states that modulated electroosmosis by complex charged polymers is the future cutting edge. The relevant results supple-ment the non-Newtonian physics of electrokinetic systems and provide guidance for the design and operation of microfluidic devices.

Technology-Based Interventions for Autism Spectrum Disorder: A Systematic Review

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviors. Its prevalence has steadily increased, with the CDC reporting a rise from 1 in 100 children in 2006 to 1 in 44 in the United States by 2021. ASD manifests in a spectrum of symptoms, requiring tailored interventions to address each child's unique needs. Recent advancements in technology have shown promise in aiding children with ASD, particularly through robotics and socially assistive robots (SARs). This systematic review explores the impact of technology-based interventions on children with ASD, assessing their efficacy in enhancing social skills, communication, and behavior regulation. Methodology: This review followed PRISMA guidelines, screening 46,580 articles across databases such as PubMed, Cochrane, Science Direct, Google Scholar, and PsychInfo. After applying inclusion and exclusion criteria, 254 studies were selected for in-depth review. The review focused on technology-based interventions, including robotics and socially assistive robots, with MeSH terms such as "Technology," "Artificial Intelligence," "Autism Spectrum Disorder," and "ASD." Results: Technology-based interventions, particularly SARs, demonstrated significant improvements in social interaction, emotional regulation, and communication for children with ASD. Robots such as LEGO Mindstorms and "Kaspar" were effective in enhancing eye contact, cooperation, and emotional recognition. However, results varied depending on the type of technology used, study design, and participant characteristics. Conclusion: While technology-based interventions hold promise for children with ASD, further research is needed to standardize intervention protocols, dosage, and long-term outcomes. These tools offer a non-invasive, scalable solution for enhancing social and cognitive skills, but variability in study designs limits definitive conclusions. Keywords: Autism Spectrum Disorder, Technology, Robotics, Socially Assistive Robots, Communication, Cognitive Skills, Applied Behavioral Analysis

Assessing the effects of cadmium on antioxidant enzymes and histological structures in rainbow trout liver and kidney

Cadmium contamination in aquatic environments poses severe risks to aquatic organisms, particularly fish, where cadmium accumulation in tissues can lead to compromised organ functionality and reproductive issues. The present study aimed to assess the effects of cadmium (Cd) exposure on key biomarkers of oxidative stress, DNA damage, apoptosis, and enzyme activity in the liver and kidney tissues of rainbow trout (Oncorhynchus mykiss). Specifically, the study measured 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, caspase-3 activation, acetylcholinesterase (AChE) activity, and oxidative stress indicators (ONOO−, MDA, GSH, SOD, and CAT) following exposure to three Cd concentrations (1, 3, and 5 mg/L) over three time points (24, 48, and 96 h). Tissue samples were collected post-exposure, and the analysis revealed a significant decrease in MDA levels in both tissues. GSH concentrations declined with prolonged exposure, while SOD activity increased, indicating a response to oxidative stress, contrasted by a reduction in CAT activity. An initial increase in ONOO− levels was observed at 24 h, followed by a subsequent decrease at the 48 and 96 h marks. These results suggest that cadmium induces oxidative stress in the liver and kidney tissues of fish. Cadmium exposure also significantly elevated 8-OHdG levels, signaling DNA damage, and increased caspase-3 activity, indicative of apoptosis, across all doses and time points (p < 0.05). The histological examination of liver and kidney showed tissue injury. Additionally, a negative correlation between AChE activity and exposure duration was noted, with prolonged exposure resulting in substantial AChE inhibition. Given the role of AChE in behavior regulation, these findings underscore the importance of exploring time-dependent, tissue-specific changes in AChE activity to further elucidate the mechanisms underlying cadmium-induced behavioral abnormalities.

Effect of Digital-Based Cognitive Rehabilitation on Executive Functions in Children with Attention Deficit/Hyperactivity Disorder

Background: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by deficits in executive functions. Objectives: This study aimed to evaluate the effect of digital-based cognitive rehabilitation (DBCR) on executive functions, behavioral regulation, and metacognition in children with ADHD. Methods: A total of thirty male participants, aged 6 - 12 years, who met predetermined inclusion criteria, were selected through a random sampling method. Their parents completed the Behavior Rating Inventory of Executive Function (BRIEF) to assess executive functions. The children were divided into experimental and control groups, with the experimental group undergoing 10 DBCR sessions, while the control group participated in generic computer game sessions. Parents completed the BRIEF after the intervention and again five weeks later. The data were analyzed using SPSS 25. Results: Following DBCR, significant improvements were observed in the total score of executive functions and the Metacognition Index (MI) in children with ADHD. The effect sizes for DBCR on the global executive composite (GEC) and MI were 47% and 37%, respectively, while the effect size for the intervention targeting the Behavior Regulation Index (BRI) was approximately 11%. Conclusions: The study suggests that DBCR positively impacts the GEC and MI in children with ADHD, potentially preventing deficits in these areas. Further research is needed to determine the effectiveness of DBCR on the BRI in children with ADHD.

Prosocial Behavior of College Students: A Self-determination Perspective

Students’ prosocial behavior refers to self-determination motivation with the aim of helping others and a caring attitude. The purpose of this research study is to explore the role of college students’ prosocial behavior in terms of self-determination. The age of college students is in the early adulthood category. The research approach in this study is to use a qualitative approach with literature study techniques. The result of this study is that the role of students’ prosocial behavior in terms of self-determination is the existence of students’ autonomous interest and motivation to behave prosocially in real terms. Autonomous prosocial motivation is manifested as the regulation of prosocial behavior determined by the individual himself, the interest and pleasure to help others without coercion from others. However, individuals who are motivated to be prosocial because they want to avoid guilt and shame may cause individuals to experience more negative emotions. This study implies that the role of autonomous motivation as part of self-determination theory becomes strong evidence in individuals achieving desired goals, and specifically also evidence of individuals performing highly prosocial behavior. Keywords: college students, prosocial behavior, self-determination

Sulfonated Penta-Galloyl Glucose (SPGG): The Pharmacological Effects of Promiscuous Glycosaminoglycan Small Molecule Mimetic.

Sulfated glycosaminoglycans (SGAGs), such as heparin, are complex linear polysaccharides attached to core proteins via covalent bonds to form proteoglycans. SGAGs are crucial in assembling extracellular matrix, the regulation of cell signaling and cell behavior, hemostasis, development, and various diseases, including thrombosis, cancer, infectious diseases, and neurodegenerative disorders, through their binding with diverse proteins. Despite the abundant SGAG-protein interactions provided by nature, the development of small SGAG-like molecules remains underexplored. However, sulfonated penta-galloyl glucose (SPGG) represents a promising, easily synthesized, small-molecule mimetic of SGAGs, capable of harnessing these interactions. This minireview discusses the chemical synthesis and characterization of SPGG, along with its pharmacological effects derived from modulating the SGAG-protein interface.

Short-Term Effects of an Outdoor Activities Intervention on Children’s Stress, Socio emotional, Behavioral, and Cognitive Regulation Skills

ABSTRACT Research Findings: In recent years, interest has grown in the potential benefits of outdoor activities (OA) for children’s development, particularly in promoting socioemotional, behavioral, and cognitive regulation skills and reducing stress. However, empirical evidence on the effects of OA programs for children in the first three years of life on these outcomes still needs to be provided. To address this gap, our study involved 95 infants and toddlers (girls = 48, M age = 23.3 months) attending child care centers in north and south Italy and their teachers. Participants were divided into two groups: the Outdoor group (n = 55), actively involved in the OA program for four months, and the Control group (n = 40), who followed the standard curriculum. We assessed the children’s cortisol levels and emotional, behavioral, and cognitive regulation skills before (T1) and after (T2) the implementation of the OA intervention. After the 4-month intervention, improvements in the children’s adaptive behavior (particularly in social interaction) and cognitive-behavioral regulation skills were observed only in the Outdoor group. Children’s stress levels remained stable. Practice or Policy: Our findings show the benefits of daily OA on young children’s self-regulation, suggesting to schools and families that increasing OA from the first years of life may support cognitive and social growth.

Effects of different quorum sensing signal molecules on alleviation of ammonia inhibition during biomethanation

Anaerobic digestion (AD) is a promising technology for achieving both organic wastes treatment and energy recovery. However, challenges such as ammonia inhibition still remain. Quorum sensing (QS) system is relevant with the regulation of microbial community behaviors by releasing and sensing signal molecules, which could improve methane production during AD process. Therefore, the current study explored the effects of different quorum sensing signal molecules on alleviation of ammonia inhibition. The results showed that both secretion of N-butyryl-DL-homoserine lactone (C4-HSL) and N-(β-ketocaproyl)-DL-homoserine lactone (3OC6-HSL) could be inhibited by high ammonia stress while stimulation of N-hexanoyl-L-homoserine lactone (C6-HSL) and N-octanoyl-DL-homoserine lactone (C8-HSL) secretion might be triggered by ammonia toxicity. Moreover, the alleviation of ammonia inhibition could be achieved by both introducing 3OC6-HSL (0.5 μM) and combination of 3OC6-HSL (0.1 μM) and biochar (4 g/L). Exogenous 3OC6-HSL could regulate microbial social behaviors and enhance the secretion of extracellular polymeric substances (EPS) to promote anaerobic digestion. In addition, the mitigation of ammonia inhibition through exogenous 3OC6-HSL and biochar were confirmed by microbial community changes (Methanobacterium, Propionicicella and Petrimonas). Critical enzymes involved in both acidification and methanogenic steps were enhanced after adding the combination of 3OC6-HSL and biochar. The combination of low levels of 3OC6-HSL and biochar could promote both direct interspecies electron transfer (DIET) process and communication between different anaerobic microorganisms to mitigate ammonia inhibition. The current study will provide primary insights for conquering ammonia inhibition during biomethanation.

Genetic Screening Reveals Cone Cell-Specific Factors as Common Genetic Targets Modulating Rival-Induced Prolonged Mating in male Drosophila melanogaster.

Male-male social interactions exert a substantial impact on the transcriptional regulation of genes associated with aggression and mating behavior in male Drosophila melanogaster. Throughout our comprehensive genetic screening of aggression-related genes, we identified that the majority of mutants for these genes are associated with rival-induced and visually-oriented mating behavior, longer-mating-duration (LMD). The majority of mutants with upregulated genes in single-housed males significantly altered LMD behavior but not copulation latency, suggesting a primary regulation of mating duration. Single-cell RNA sequencing revealed that LMD-related genes are predominantly co-expressed with male-specific genes like dsx and Cyp6a20 in specific cell populations, especially in cone cells. Functional validation confirmed the roles of these genes in mediating LMD. Expression of LMD genes like Cyp6a20, Cyp4d21, and CrzR was enriched in cone cells, with disruptions in cone cell-specific expression of CrzR and Cyp4d21 leading to disrupted LMD. We also identified a novel gene, CG10026/Macewindu, that reversed LMD when overexpressed in cone cells. These findings underscore the critical role of cone cells as a pivotal site for the expression of genes involved in the regulation of LMD behavior. This study provides valuable insights into the intricate mechanisms underlying complex sexual behaviors in Drosophila.

NPF and sNPF can regulate the feeding behaviour and affect the growth and antioxidant levels of the rice brown planthopper, Nilaparvata lugens.

Neuropeptide F (NPF) and short neuropeptide F (sNPF) are important neuropeptides and mainly affect feeding behaviour of insects. However, the regulation of insect feeding behaviour by NPF and sNPF appears to differ between species, and it is not clear how NPF and sNPF regulate the food intake of the brown planthopper (Nilaparvata lugens). Therefore, the functions of NPF and sNPF in regulating food intake and affecting the growth and antioxidant levels of N. lugens fed on host rice plants were investigated by knocking down NPF and sNPF respectively and simultaneously knocking down both of them by RNA interference. The results showed that NPF and sNPF were mainly expressed in the head of N. lugens, and N. lugens increased food intake after NPF and sNPF were knocked down, which was reflected in the prolonged duration of N4a and N4b waves in the electrical penetration graph (EPG) experiment after knocking down NPF and sNPF. In addition, knocking down NPF and sNPF led to the increase of body weight and mortality of N. lugens, and also led to the increase of antioxidant level of N. lugens. So it was concluded that NPF and sNPF could regulate food intake, maintain body weight stability and oxidative balance in N. lugens. Our study clarified the molecular mechanism of NPF and sNPF regulating feeding behaviour and affect the growth and antioxidant level of N. lugens.

Engineering Electrolytes with Transition Metal Ions for the Rapid Sulfur Redox and In Situ Solidification of Polysulfides in Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries have been pursued due to their high theoretical energy density and superb cost-effectiveness. However, the dissolution-conversion mechanism of sulfur inevitably leads to shuttle effects and interface passivation issues, which impede Li-S battery practical application. Herein, the approach of adopting transition metal salts (CoI2) to engineering the electrolyte is proposed. Different from anchored transition metal catalysts in the cathode, soluble cobalt ions can chemically reduce and solidify polysulfides, alleviating the dependence of sulfur conversion on the conductive interface while suppressing the shuttle effect. Importantly, all elements in CoI2 are in the lowest valence state and solid complexes are formed after the redox reaction, which prevents the migration of high valent Co3+ to the anode, thus overcoming the poor compatibility between redox mediator and Li anode. Notably, I3- has the function of eliminating dead sulfur and dead lithium, which we apply to Li-S batteries. After activating I3- at a certain frequency, Li-S batteries indeed achieve a longer and more stable cycle life. By combining the regulatory behavior of anions and cations, the electrolyte is engineered for Li-S batteries with high capacity, long lifespan, and excellent rate performance.

Ethanolamine and Vinyl–Ether Moieties in Brain Phospholipids Modulate Behavior in Rats

Plasmalogens are brain-enriched phospholipids with a vinyl–ether bond at the sn-1 position between the glycerol backbone and the alkyl chain. Previous studies have suggested that plasmalogens modulate locomotor activity, anxiety-like behavior, and cognitive functions in rodents; however, the specific moieties contributing to behavioral regulation are unknown. In this study, we examined the behavioral modulation induced by specific phospholipid moieties. To confirm the permeability of phospholipids in injected liposomes, we measured the fluorescence intensity following intravenous injection of liposomes containing ATTO 740-labeled dioleoylphosphatidylethanolamine. Then, we compared the behavioral effects following injection of liposomes composed of egg phosphatidylcholine (PC) and 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (PE 18:0/22:6), PC 18:0/22:6, 1-(1Z-octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (PE P-18:0/22:6), or PC P-18:0/22:6, into the tail vein of male rats. The time spent in the central region of the open field was significantly reduced after injection of PE 18:0/22:6, harboring an ester bond at sn-1 compared to controls. Furthermore, the discrimination ratio in the novel object recognition test was significantly higher in PC 18:0/22:6 compared to PE 18:0/22:6, suggesting that the substitution of ethanolamine with choline can enhance recognition memory. We demonstrate that the structures of the sn-1 bond and the hydrophilic moiety in the phospholipids can modulate exploratory behaviors and recognition memory in rodents.

Role of Peripheral and Central Insulin Resistance in Neuropsychiatric Disorders.

Insulin acts on different organs, including the brain, which helps it regulate energy metabolism. Insulin signaling plays an important role in the function of different cell types. In this review, we have summarized the key roles of insulin and insulin receptors in healthy brains and in different brain disorders. Insulin signaling, as well as insulin resistance (IR), is a major contributor in the regulation of mood, behavior, and cognition. Recent evidence showed that both peripheral and central insulin resistance play a role in the pathophysiology, clinical presentation, and management of neuropsychiatric disorders like Cognitive Impairment/Dementia, Depression, and Schizophrenia. Many human studies point out Insulin Resistance/Metabolic Syndrome can increase the risk of dementia especially Alzheimer's dementia (AD). IR has been shown to play a role in AD development but also in its progression. This review article discusses the pathophysiological pathways and mechanisms of insulin resistance in major neuropsychiatric disorders. The extent of insulin resistance can be quantified using IR biomarkers like insulin levels, HOMA-IR index, and Triglyceride glucose-body mass index (TyG-BMI) levels. IR has been shown to precede neurodegeneration. Human trials showed current treatment with certain antidiabetic drugs, as well as life style management, like weight loss and exercise for IR, have shown promise in the management of cognitive/neuropsychiatric disorders. This may pave the pathway to the development of new therapeutic approaches to these challenging disorders of dementia and psychiatric diseases. Recent clinical trials are showing some encouraging evidence for these pharmacological and nonpharmacological approaches for IR in psychiatric and cognitive disorders, even though more research is needed to apply this evidence into clinical practice. Early identification and management of IR may help as a strategy to potentially alter neuropsychiatric disorders onset as well as its progression.

Moderating Role of Self-Regulation Difficulties in the Momentary Associations Between Depressive Symptoms and Participation Poststroke.

Because depressive symptoms are momentarily associated with lower levels of participation poststroke, it is crucial to investigate what moderates such associations to identify a potential intervention target to reduce the momentary links between depressive symptoms and participation poststroke. Self-regulation seems to be a potential moderator of such associations. To investigate the extent to which difficulties in self-regulation moderate the momentary associations between depressive symptoms and participation poststroke. This study uses a real-time, repeated-measures design using smartphone-based ecological momentary assessment surveys five times a day for 10 days. We performed multilevel modeling to uncover the momentary associations among the study variables. Community. 39 people with stroke. We obtained real-time data for difficulties in self-regulation (total, cognitive, behavioral, and emotion regulation), depressive symptoms, and participation in daily activities (performance in daily activities and satisfaction with performing daily activities). We included 1,612 survey responses in the analysis. Higher depressive symptoms were momentarily associated with lower levels of performance (β = -0.05 to -0.07, p < .001) and satisfaction (β = -0.04 to -0.06, p < .05), regardless of adjusting for self-regulation variables and other covariates. Difficulties in total self-regulation (β = -0.01, p < .001) and emotion regulation (β = -0.02, p < .001) magnified the negative associations between depressive symptoms and satisfaction with performing daily activities. Using self-regulation and emotion regulation strategies may be a target for just-in-time intervention for reducing the momentary associations between depressive symptoms and satisfaction with performing daily activities poststroke. Plain-Language Summary: Depressive symptoms have immediate and real-time associations with lower levels of participation in daily activities in people with stroke. Self-regulation, including cognitive regulation (e.g., goal setting, planning strategies), behavioral regulation (e.g., controlling impulsive behaviors), and emotion regulation (e.g., managing negative feelings), may be an intervention target for reducing the immediate associations between depressive symptoms and lower levels of participation poststroke. Thus, we investigated whether difficulties in self-regulation variables magnify the negative real-time associations between depressive symptoms and participation poststroke. To obtain real-time data on difficulties in self-regulation variables, depressive symptoms, and participation (i.e., performance and satisfaction), we asked 39 community-dwelling people with stroke to answer smartphone surveys. The results showed that difficulties in total self-regulation and emotion regulation magnified the negative associations between depressive symptoms and satisfaction with performing daily activities. Our findings suggest that self-regulation and emotion regulation strategies may be a target for real-time intervention for reducing the momentary associations between depressive symptoms and satisfaction with performing daily activities poststroke.

Magnesium (Mg2+): Essential Mineral for Neuronal Health: From Cellular Biochemistry to Cognitive Health and Behavior Regulation.

Magnesium (Mg2+) is a crucial mineral involved in numerous cellular processes critical for neuronal health and function. This review explores the multifaceted roles of Mg2+, from its biochemical interactions at the cellular level to its impact on cognitive health and behavioral regulation. Mg2+ acts as a cofactor for over 300 enzymatic reactions, including those involved in ATP synthesis, nucleic acid stability, and neurotransmitter release. It regulates ion channels, modulates synaptic plasticity, and maintains the structural integrity of cell membranes, which are essential for proper neuronal signaling and synaptic transmission. Recent studies have highlighted the significance of Mg2+ in neuroprotection, showing its ability to attenuate oxidative stress, reduce inflammation, and mitigate excitotoxicity, thereby safeguarding neuronal health. Furthermore, Mg2+ deficiency has been linked to a range of neuropsychiatric disorders, including depression, anxiety, and cognitive decline. Supplementation with Mg2+, particularly in the form of bioavailable compounds such as Magnesium-L-Threonate (MgLT), Magnesium-Acetyl-Taurate (MgAT), and other Magnesium salts, has shown some promising results in enhancing synaptic density, improving memory function, and alleviating symptoms of mental health disorders. This review highlights significant current findings on the cellular mechanisms by which Mg2+ exerts its neuroprotective effects and evaluates clinical and preclinical evidence supporting its therapeutic potential. By elucidating the comprehensive role of Mg2+ in neuronal health, this review aims to underscore the importance of maintaining optimal Mg2+ levels for cognitive function and behavioral regulation, advocating for further research into Mg2+ supplementation as a viable intervention for neuropsychiatric and neurodegenerative conditions.

Emotional and behavioral problems are associated with hypothalamic development from childhood to adolescence: Findings from a longitudinal cohort study

BackgroundDespite the pivotal role of the hypothalamus in regulating various physiological processes, our understanding of its developmental trajectory and subregional organization during childhood and adolescence remains limited, as well as how emotional and behavioral problems can impact hypothalamic development, potentially leading to neurodevelopmental disorders. MethodsThis population-based longitudinal cohort study utilized data from a representative sample of 702 children, who were followed two to five times. Emotional and behavioral problems were assessed using the Strengths and Difficulties Questionnaire (SDQ). Linear mixed models were employed to delineate developmental trajectories and behavioral regulation. ResultsUsing an automated segmentation technique, we quantified the volumes and asymmetries of the hypothalamus and its subregions in a large longitudinal sample of 702 subjects aged 6–15 years with 1371 MRI scans, and mapped their developmental trajectories. Our findings indicate that while the anterior and posterior regions of the hypothalamus exhibit a tendency toward decline, the tubular region demonstrates a linear increase which is influenced by lateralization, sex, and intracranial volume. Furthermore, emotional and behavioral problems - particularly emotional symptoms and peer relationship problems - are related to faster development in superior tubular and anterior-superior regions. ConclusionsIn this study, we initially delineated the developmental trajectories of the hypothalamus and its subregions from childhood to adolescence based on a longitudinal cohort study. Our findings revealed that the development of hypothalamus followed the pattern of “lateral early to medial late, and dorsomedial early to ventromedial late”, and the emotional and behavioral problems are associated with faster hypothalamic development. This study provides preliminary evidence regarding the impact of emotional and behavioral problems on the dynamic development of the hypothalamus, offering a crucial foundation for future prevention and intervention strategies targeting cognitive and emotional behavioral problems.