Behavioral Responses Research Articles

Narrative predicts cardiac synchrony in audiences

Audio-visual media possesses a remarkable ability to synchronise audiences’ neural, behavioural, and physiological responses. This synchronisation is considered to reflect some dimension of collective attention or engagement with the stimulus. But what is it about these stimuli that drives such strong engagement? There are several properties of media stimuli which may lead to synchronous audience response: from low-level audio-visual features, to the story itself. Here, we present a study which separates low-level features from narrative by presenting participants with the same content but in separate modalities. In this way, the presentations shared no low-level features, but participants experienced the same narrative. We show that synchrony in participants’ heart rate can be driven by the narrative information alone. We computed both visual and auditory perceptual saliency for the content and found that narrative was approximately 10 times as predictive of heart rate as low-level saliency, but that low-level audio-visual saliency has a small additive effect towards heart rate. Further, heart rate synchrony was related to a separate cohorts’ continuous ratings of immersion, and that synchrony is likely to be higher at moments of increased narrative importance. Our findings demonstrate that high-level narrative dominates in the alignment of physiology across viewers.

A Comprehensive Investigation of Social Anxiety and Social Evaluative Stress in Autistic Children and Adolescents and Specific Learning Disorders.

The aim was to investigate trait social anxiety and social evaluative stress in autistic children and adolescents and Specific Learning Disorders (SLD). This was done by evaluating behavioral, subjective, and autonomic responses to the Trier Social Stress Test (TSST). Study 1 included 280 children and adolescents: 60 autistic without intellectual disability (ID), 70 SLD, and 150 non-diagnosed (ND) peers. Study 2 involved 55 participants: 15 autistic without ID, 15 SLD, and 20 ND. The sample was predominantly male. In Study 1, behavioral (quality of public speech) and subjective (valence, arousal, perceived competence, and worries) aspects of social stress were examined. Study 2 expands upon the first study, as physiological responses to social stress were also measured. Trait social anxiety was investigated using both parents' and children's reports in the two studies. Parents of autistic participants and with SLD reported higher trait social anxiety in their children than the parents of ND. No differences emerged from the participants' self-reports, though those autistic and with SLD were assigned lower scores in the public speech quality than ND. Autistic children and adolescents reported lower arousal and higher perceived competence than ND, while those with SLD reported a lower perception of competence. Autistic participants had a decreased cardiac reactivity across the TSST when compared to SLD and ND. Our findings show unique patterns of responses within each group, confirming that the combined investigation of trait anxiety and social stress responses could be a valuable insight in research and clinical practice.

Transcutaneous Auricular Vagus Nerve Stimulation for Visually Induced Motion Sickness: An eLORETA Study

Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive form of electrical brain stimulation, has shown potent therapeutic potential for a wide spectrum of conditions. How taVNS influences the characterization of motion sickness – a long mysterious syndrome with a polysymptomatic onset – remains unclear. Here, to examine taVNS-induced effects on brain function in response to motion-induced nausea, 64-channel electroencephalography (EEG) recordings from 42 healthy participants were analyzed; collected during nauseogenic visual stimulation concurrent with taVNS administration, in a crossover randomized sham-controlled study. Cortical neuronal generators were estimated from the obtained EEG using exact low-resolution brain electromagnetic tomography (eLORETA). While both sham and taVNS increased insula activation during electrical stimulation, compared to baseline, taVNS additionally augmented middle frontal gyrus neuronal activity. Following taVNS, brain regions including the supramarginal, parahippocampal, and precentral gyri were activated. Contrasting sham, taVNS markedly increased activity in the middle occipital gyrus during stimulation. A repeated-measures ANOVA showed that taVNS reduced motion sickness symptoms. This reduction in symptoms correlated with taVNS-induced neural activation. Our findings provide new insights into taVNS-induced brain changes, during and after nauseogenic stimuli exposure, including accompanying behavioral response. Together, these findings suggest that taVNS has promise as an effective neurostimulation tool for motion sickness management.

Short-term exposure to okadaic acid induces behavioral and physiological responses in sea urchin (Strongylocentrotus intermedius)

Short-term exposure to okadaic acid induces behavioral and physiological responses in sea urchin (Strongylocentrotus intermedius)

Endogenous Attention Affects Decision-related Neural Activity but Not Afferent Visual Responses.

Endogenous shifts of spatial attention toward an upcoming stimulus are associated with improvements in behavioral responses to the stimulus, preparatory retinotopic shifts in alpha power, and changes in ERPs. Although attentional modulation of several early sensory ERPs is well established, there is still debate about under what circumstances attention affects the earliest cortical visual evoked response-the C1 ERP component-which is putatively generated from afferent input into primary visual cortex. Moreover, the effects of spatial attention on the recently discovered ERP signature of evidence accumulation-the central parietal positivity (CPP)-have not been fully characterized. The present study assessed the effect of spatial attention on the C1 and CPP components through a spatially cued contrast discrimination task using stimuli that were specifically designed to produce large-amplitude C1 responses and that varied in sensory evidence strength to characterize the CPP. Participants responded according to which of two checkerboard stimuli had greater contrast following an 80% valid cue toward the upper or lower visual field. Prestimulus alpha power changed topographically based on the cue, suggesting participants shifted attention to prepare for the upcoming stimuli. Despite these attentional shifts in alpha power and the fact that the stimuli reliably elicited C1 responses several times greater than many prior studies, there was no evidence of an attention effect on the C1. The CPP, however, showed a clear increase in build-up rate on valid trials. Our findings suggest that endogenous attention may not affect the early C1 ERP component but may improve behavior at a decision stage, as reflected in brain signals related to evidence accumulation (the CPP).

Host selection by thrips is affected by the floral volatile profile of sunflower.

Thrips, Frankliniella intonsa, is a highly polyphagous pest with a worldwide distribution. F. intonsa-infested sunflower seeds show marked visual damage. The study findings revealed that significantly more F. intonsa infested confection sunflower compared to oilseed sunflower, via olfactometer bioassay studies, we found that compared with the flower and pollen of oilseed sunflowers, those of confection sunflowers attract F. intonsa. Considering this discrepancy in the preference of F. intonsa on oilseed and confection sunflowers, the volatiles of the flower and pollens of two sunflowers were analysed bygas chromatography-mass spectroscopy. The behavioural responses of F. intonsa were assessed for these compounds using Y-tube bioassays. Geranyl bromide, a unique volatile component of oilseed sunflowers, induced an assertive approach-avoidance behaviour in F. intonsa, whereas the unique component ethyl isovalerate in confection sunflowers attracted F. intonsa. F. intonsa adults demonstrated significant attraction to the blends of confection sunflowers. Furthermore, field verification revealed that intercropping confection and oilseed sunflowers could effectively control F. intonsa. The study provided insights into the chemical cues used by F. intonsa in locating hosts. Therefore, oilseed sunflowers can be used as repellent plants to prevent F. intonsa invasion.

Activation, but not inactivation, of the medial or lateral orbitofrontal cortex impaired context-specific fear encoding

In laboratories, classical fear conditioning and extinction procedures are commonly used to study the behavioral and neural mechanisms underlying fear regulation. Contextual fear conditioning involves the association of an aversive event with the environment where it occurs, which engages the hippocampus and its interactions with the amygdala. The orbitofrontal cortex (OFC), divided into the lateral OFC (lOFC) and medial OFC (mOFC) subregions, plays a crucial role in integrating contextual information from the hippocampus and modulating behavioral responses based on the anticipated outcomes of the context. Because of the extensive anatomical connections of the OFC with the fear circuit, including the hippocampus, the amygdala, and the medial prefrontal cortex, and the reasoning that proper retrieval of fear-related memory is context-dependent, we raised the question to investigate the ability of the animals to discriminate between contexts when they were trained under differential OFC activation levels during the encoding of contextual fear memory. In this study, we conducted a contextual fear conditioning procedure in rats using footshock as an unconditioned stimulus (US), followed by the test of their fear levels in contexts same (dangerous) or different (safe) from the conditioning context. We used a pharmacological approach to modulate the activation levels of the lOFC or the mOFC during conditioning to examine their roles on context-specific fear encoding. Our findings showed that the animals could accurately distinguish between the two contexts in control and OFC hypoactivation groups, but failed to do so if they were trained under OFC hyperactivation. Therefore, OFC hyperactivity disturbed the encoding of contextual information during fear acquisition.

Dental Management of Pedatric Patient with Autism Spectrum Disorder under General Anesthesia: A Case Report

Autism spectrum disorder or autism, corresponds to "a pervasive developmental disorder (PDD), characterized by an abnormal or a deficient development. It is manifested before the age of three, with a characteristic disturbance in the functioning of each of the following three areas: social interaction, verbal and non-verbal communication, and restricted and repetitive behaviors. The combination of these three elements corresponds to the autistic triad. The latter appears in different forms, with varying degrees of severity, and can also vary with age. The oral care of this patient remains delicate, due to the difficulty of communication and the apprehension of his behavioral response. The young female, 13 years old and in good general health, presented to the dental center of Cheikh Khalifa Hospital with spontaneous pain in the right mandibular and left maxillary sectors. She was diagnosed with one of the autistic spectrum disorders: Asperger's syndrome. In our case, the patient was uncooperative and unable to attend the dental treatment in a vigorous state or under conscious sedation. General anaesthesia was the choice option. This last resort allows the patient to lose consciousness, eliminates pain and relaxes the muscles, making dental treatment a pleasant experience. The aim of this poster is to illustrate, through a case study, the protocol for managing a patient with autism spectrum disorder, and to demonstrate the indication for general anesthesia in the treatment of this patient.

Penerapan Inovasi Teknologi dalam Meningkatkan Hasil Tangkapan Ikan bagi Nelayan di KUB Bugel

Service activities were conducted in the Bugel Peni II and III Joint Business Group (KUB) in Bugel Village, Kulonprogo Regency. Fishermen who join this group often do not get maximum catches because they face various obstacles, such as limited technology and unpredictable weather conditions. This community service aims to provide portable FAD innovations and determine the success of using portable FADs in fishermen's catches. Portable FADs are proposed for this service activity to provide a solution to minimize losses due to these obstacles. Portable FADs are an innovation that stimulates fish behavioral responses using sound waves with a specific frequency on an attractor, developing from the concept of conventional FADs. The implementation method begins with outreach to fishermen in the Bugel Peni II and III Joint Business Group (KUB) regarding the concept and benefits of portable FADs. Practical training was carried out on the installation and use of these tools and education regarding their positive impact on fish catches. In addition, data collection was carried out through direct observations in the field to understand fish responses to portable FADs. The positive impact of this service activity is that the application of portable FADs provides in-depth insight into the urgency of using technology to increase fish catches by fishermen. Apart from that, this service activity also provides important insight regarding the natural factors fishermen face in implementing portable FADs, such as weather uncertainty, increasingly scarce fish resources, and natural conditions, namely high waves, which are the main obstacles in achieving the expected results.

Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study.

Elevated youth irritability is characterized by increased proneness to frustration relative to peers when rewards are blocked, and is a transdiagnostic symptom that predicts multiple forms of psychopathology and poorer socioeconomic outcomes in adulthood. Although mechanistic models propose that irritability is the result of aberrant reward-related brain function, youth irritability as it relates to multiple components of reward processes, including reward anticipation, gain, and loss, has yet to be examined in large, population-based samples. Data from the Adolescent Brain and Cognitive Development (ABCD) baseline sample (N = 5923) was used to examine associations between youth irritability (measured by parent-report) and reward-related brain activation and connectivity in a large, preadolescent sample. Preadolescents (M age = 9.96 years, SD = 0.63) performed the Monetary Incentive Delay task during functional MRI acquisition. In the task, during the anticipation period, participants were informed of the upcoming trial type (win money, lose money, no money at stake) and waited to hit a target; during the feedback period, participants were informed of their success. Whole brain and region of interest (ROI) analyses evaluated task conditions in relation to irritability level. Preadolescents with higher compared to lower levels of irritability demonstrated blunted prefrontal cortex activation in the anticipation period and exaggerated striatum-prefrontal connectivity differences among reward conditions during the feedback period. These effects persisted after adjusting for co-occurring anxiety, depression, and attention-deficit/hyperactivity disorder symptoms. These findings provide evidence for the role of reward salience in pathophysiological models of youth irritability, suggesting a mechanism that may contribute to exaggerated behavioral responses.

High-Fructose Diet and Chronic Unpredictable Stress Modify Each Other’s Neurobehavioral Effects in Female Rats

A pervasive exposure to stressors and the consumption of fructose-containing beverages usually go hand-in-hand in everyday life. In contrast to their metabolic outcomes, their impact on the brain and behavior is still understudied. We examined the behavioral response to a novelty (open field test), the expression of biochemical indicators of neuronal activity (Egr1 and FosB/ΔFosB), the synaptic potentiation (CaMKIIα and pCaMKIIThr286), the synaptic plasticity (synaptophysin, PSD95, gephyrin, and drebrin), and the GABAergic system (parvalbumin and GAD67), along with the glucocorticoid receptor (GR) and AMPK, in the medial prefrontal cortex of female Wistar rats subjected to liquid fructose supplementation (F), chronic unpredictable stress (S), or both (SF) over 9 weeks. The only hallmark of the F group was an increased expression of pCaMKIIThr286, which was also observed in the S group, but not in the SF group. The SF group did not show hyperactivity, a decreased expression of FosB, or an increased expression of parvalbumin, as the S group did. The SF group, as with the S group, showed a decreased expression of the GR, although the basal level of corticosterone was unchanged. The SF group showed, as de novo marks, thigmotactic behavior, increased drebrin, and decreased gephyrin expression. These findings suggest that the long-term consumption of fructose, which itself has subtle neurobehavioral consequences, in combination with stress prevents some of its effects, but also contributes to novel outcomes not seen in single treatments.

Asymmetric Synthesis and Biological Activity of Contact Pheromone of Western Flower Thrips, Frankliniella occidentalis

Western flower thrips, Frankliniella occidentalis, is a serious worldwide pest of agriculture and horticulture, and its contact pheromone is 7-methyltricosane. Two enantiomers of 7-methyltricosane were synthesized for the first time. The centra of our strategy were chiral auxiliaries to introduce stereocenter, and Wittig coupling to connect two blocks. The overall yields of our synthesis were 29–30% with seven steps. The electroantennogram (EAG) and the contact behavioral responses revealed that (R)-, (S)- and racemic 7-methyltricosane were separately bioactive, and the racemate was the most bioactive in the male arrestant activity and the female EAG test. This result provides valuable insights, showing that the racemate could be used for the support of the control of western flower thrips, which could be more easily prepared relative to more expensive enantiopure pheromone.

Daily effects of a brief compassion-focused intervention for self-compassion.

Interventions for increasing self-compassion are typically assessed through retrospective reports, which may not accurately capture everyday self-compassionate behaviour. Our study addresses this using experience sampling to evaluate a brief compassion-focused intervention's effects on needs for self-compassion, awareness of opportunities for self-compassion, self-compassionate behaviour and emotional responses to one's distress in daily life. Results indicated that the intervention was associated with less likelihood of reporting needs and opportunities for self-compassion but with no difference in self-compassionate actions or emotional experience. When participants acted self-compassionately, they reported more positive emotional experiences after needing self-compassion. This underscores the disparity between retrospective and ecological assessments, emphasizing the need for interventions to be evaluated in real-life contexts.

The Construction of Analytical Exact Soliton Waves of Kuralay Equation

Abstract The primary objective of this work is to examine the Kuralay equation, which is a complex integrable coupled system, in order to investigate the integrable motion of induced curves. The soliton solutions derived from the Kuralay equation are thought to be the supremacy study of numerous significant phenomena and extensive applications across a wide range of domains, including optical fibres, nonlinear optics and ferromagnetic materials. The inverse scattering transform is unable to resolve the Cauchy problem for this equation, so the analytical method is used to produce exact travelling wave solutions. The modified auxiliary equation and Sardar sub-equation approaches are used to find solitary wave solutions. As a result, singular, mixed singular, periodic, mixed trigonometric, complex combo, trigonometric, mixed hyperbolic, plane and combined bright–dark soliton solution can be obtained. The derived solutions are graphically displayed in 2-D and 3-D glances to demonstrate how the fitting values of the system parameters can be used to predict the behavioural responses to pulse propagation. This study also provides a rich platform for further investigation.

Adiponectin Signaling Modulates Fat Taste Responsiveness in Mice

Background/Objectives: Adiponectin, the most abundant peptide hormone secreted by adipocytes, is a well-known homeostatic factor regulating lipid metabolism and insulin sensitivity. It has been shown that the adiponectin receptor agonist AdipoRon selectively enhances cellular responses to fatty acids in human taste cells, and adiponectin selectively increases taste behavioral responses to intralipid in mice. However, the molecular mechanism underlying the physiological effects of adiponectin on fat taste in mice remains unclear. Conclusions: Here we define AdipoR1 as the mediator responsible for the enhancement role of adiponectin/AdipoRon on fatty acid-induced responses in mouse taste bud cells. Methods and Results: Calcium imaging data demonstrate that AdipoRon enhances linoleic acid-induced calcium responses in a dose-dependent fashion in mouse taste cells isolated from circumvallate and fungiform papillae. Similar to human taste cells, the enhancement role of AdipoRon on fatty acid-induced responses was impaired by co-administration of an AMPK inhibitor (Compound C) or a CD36 inhibitor (SSO). Utilizing Adipor1-deficient animals, we determined that the enhancement role of AdipoRon/adiponectin is dependent on AdipoR1, since AdipoRon/adiponectin failed to increase fatty acid-induced calcium responses in taste bud cells isolated from these mice. Brief-access taste tests were performed to determine whether AdipoRon’s enhancement role was correlated with any differences in taste behavioral responses to fat. Although AdipoRon enhances the cellular responses of taste bud cells to fatty acids, it does not appear to alter fat taste behavior in mice. However, fat-naïve Adipor1−/− animals were indifferent to increasing concentrations of intralipid, suggesting that adiponectin signaling may have profound effects on the ability of mice to detect fatty acids in the absence of previous exposure to fatty acids and fat-containing diets.

Measuring palatability of pet food products: Sensory components, evaluations, challenges, and opportunities.

The pet food industry is a growing business launching a variety of new products in the market. The acceptability or preference of pet food samples has traditionally been measured using either one-bowl or two-bowl tests. Academic researchers and professionals in the pet food industry have explored other methods, including the cognitive palatability assessment protocols and the ranking test, to evaluate more than two samples. A variety of approaches and perspectives were also utilized to predict palatability and key sensory attributes of pet foods, including descriptive sensory analysis by human-trained panelists and pet food caregivers' perceptions of pet food. This review article examined a range of testing methods for evaluating the palatability of pet foods, specifically targeting products for dogs and/or cats. It outlined the advantages and disadvantages of each method. Additionally, the review provided in-depth insights into the key sensory attributes of pet foods and the methodologies for assessing palatability. It also explored pets' behavioral responses and facial expressions in relation to different pet foods. Furthermore, this review discussed current challenges and future opportunities in pet food development, including the use of instrumental analyses and artificial intelligence-based approaches.

PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus

AbstractPituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide widely distributed in the brain including the hypothalamic paraventricular nucleus (PVN) implying a regulatory role in stress function. Recent evidence indicates that one of the main targets of PACAP within the PVN are corticotropin-releasing factor (CRF) neurons, which are key regulators of the hypothalamic-pituitary-adrenal (HPA) axis. However, the neural correlates that mediate PACAP effects on stress function are not fully understood. In the present study, we characterized the neuronal mechanism by which PACAP regulates neuroendocrine and behavioral stress responses in rats. We found that intracerebroventricular administration of PACAP increased the swim stress-induced c-Fos expression in distinct brain areas of the stress and anxiety circuitry including the parvocellular part of the PVN and changed behavioral stress coping during forced swimming to a more passive coping style (i.e., indicated by increased floating and reduced struggling behavior). Subsequently, PACAP administration directly into the PVN mimicked these behavioral effects and potentiated the plasma ACTH response to forced swim stress suggesting an excitatory role of PACAP on HPA stress axis reactivity. In addition, immunohistochemical analysis revealed a considerable portion of stress-activated CRF neurons in the medial parvocellular part of the PVN that co-localized PAC1 receptors suggesting that PACAP-induced effects on stress function are likely mediated directly by activation of CRF neurons in the PVN. Thus, these findings suggest that the PVN may represent one of the key areas where PACAP regulates the neuroendocrine and behavioral stress response.

Connectomics Investigation of Role of Parabrachial Nucleus Aversion using Optogenetics: A Experiment Proposal

In recent decades, there has been a notable increase in research activity focused on the aversive and reward circuits of the brain. The evidence indicates that the parabrachial nucleus (PBn) is a crucial element in the generation of aversion responses in mice. Following successful stimulation of the PBn, mice display increased aversive and stress-related ehaviours. The study employs Fos TRAP2-ChR2 mice, opioids such as oxycodone, and a range of imaging technologies to monitor and manipulate neural pathways. Behavioral tests and optogenetic manipulation are used to assess real-time behavioral responses in mice, with the aim of uncovering the neural pathways and mechanisms involved in PBn-mediated aversion. Nevertheless, the underlying mechanisms of these behaviours remain unclear. The objective of this study is to investigate the connectomics of the parabrachial nucleus (PBn) in order to determine its association with regions involved in motivation, such as the nucleus ambiguus or the amygdala. It is hypothesised that this association may lead to aversion by affecting these regions. An alternative hypothesis is that if the parabrachial nucleus is connected to areas that are not directly related to it, it may be considered a motivational area in its own right. The identification of these connections will elucidate the underlying mechanisms of aversion mediated by PBn, thereby providing a deeper understanding of the neural basis of aversive behaviour and its regulation.

The impact of increasing turbidity on the predator–prey interactions of freshwater fishes

Abstract Human activities are exacerbating environmental change globally. Turbidity in freshwater systems is increasing due to extreme weather events and intensification of activities such as deforestation, urbanisation, agriculture and altering water flow with dams and other structures. Prey species may benefit from turbid habitats as turbidity creates a visual barrier to predators; such predators thus face reduced foraging success as water clarity decreases. However, the literature on the effects of water turbidity on predator–prey interactions in fish is often contrasting. Environmentally driven changes in predator and prey behaviour, foraging and survival ultimately have the potential to affect community structure and ecosystem functioning, thus understanding the impact of changes in turbidity on predator–prey interactions should be a priority. Given the contrasting results in the primary literature, the aim of this review is to provide a broad overview of the current knowledge on the impacts of increased turbidity on predator–prey interactions in freshwater fishes, summarise the published literature and identify knowledge gaps on this topic. We collated 281 studies from the peer‐reviewed literature that tested the impact of water turbidity on the foraging behaviour of predatory fish and anti‐predator behaviour of prey fish. We recorded changes in predator and prey behaviours in response to changes in turbidity levels. Furthermore, we reported whether these behavioural changes were considered to have a positive (e.g. enhanced foraging success) or negative (e.g. higher mortality) impact on the focal species, or whether the impact was unspecified (e.g. changes in anti‐predator behaviour without quantifying actual predation risk). The literature has some strong taxonomic, geographical and environmental biases, where most research focused on commercially important, temperate species. A large proportion of studies (47%) reported a negative (versus a positive or unspecified) impact of turbidity on the focal species (either predator or prey freshwater fish). Negative impacts were reported more often for predators (58%) compared to prey (19%) and while changes in behaviour were frequently reported in prey species, if these changes are adaptive or not is unclear, as actual predation risk was not assessed in the majority of relevant studies (55%). Increases in turbidity have complex effects on predator–prey interactions, with negative impacts more often reported for adult piscivore predators, while prey species may gain a relative advantage compared to visual predators. However, whether prey behavioural responses to increased turbidity are adaptive is generally unclear. We suggest that a more holistic and ecologically relevant experimental approach is needed to disentangle the underlying mechanisms and determine the adaptive nature of prey behavioural responses to increased turbidity. Our review serves as a broad and comprehensive summary of the empirical research conducted on impacts of increasing water turbidity on predator–prey interactions in freshwater fishes. It highlights knowledge gaps and provides a reference point to guide future experimentation and research synthesis in this crucial and growing area of research.

CANNABIDIOL AS A FORM OF TREATMENT FOR PATIENTS WITH POST-TRAUMATIC STRESS DISORDER FROM VICTIMS OF VIOLENCE – INTEGRATIVE REVIEW

Introduction. Violence as a social and public health problem, with a particular focus on its consequences, such as Post-Traumatic Stress Disorder (PTSD). According to the World Health Organization, violence encompasses the intentional use of physical force or power, threatening or harming individuals, groups or communities. Objective: To describe the effects of Cannabidiol on patients with Post-Traumatic Stress due to physical and psychological violence. Methodology: This is an observational and retrospective integrative systematic review, with the exclusion criteria: non-empirical articles, non-indexed publications. A total of 545 articles related to post-traumatic stress and cannabidiol were found and only 13 articles were selected to present the results of this study. Results and discussion: The endogenous endocannabinoid system plays a significant role in the processing and extinction of fear memory. Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, has shown potential in the treatment of anxiety disorders, including PTSD. CBD interacts with the endocannabinoid system indirectly by increasing the availability of endocannabinoids such as anandamide, which act on CB1 receptors in the brain. This activation of the endocannabinoid system may help reduce the behavioral response to aversive memories and improve fear extinction. Final Thoughts: While early research on the effects of CBD on PTSD is promising, more studies are needed to determine its efficacy and safety, particularly in victims of violence. Sources also emphasize the need for greater awareness and accessibility of cannabinoid-based treatments for those who may benefit from them.