CANNABIDIOL AS A FORM OF TREATMENT FOR PATIENTS WITH POST-TRAUMATIC STRESS DISORDER FROM VICTIMS OF VIOLENCE – INTEGRATIVE REVIEW

Abstract

Introduction. Violence as a social and public health problem, with a particular focus on its consequences, such as Post-Traumatic Stress Disorder (PTSD). According to the World Health Organization, violence encompasses the intentional use of physical force or power, threatening or harming individuals, groups or communities. Objective: To describe the effects of Cannabidiol on patients with Post-Traumatic Stress due to physical and psychological violence. Methodology: This is an observational and retrospective integrative systematic review, with the exclusion criteria: non-empirical articles, non-indexed publications. A total of 545 articles related to post-traumatic stress and cannabidiol were found and only 13 articles were selected to present the results of this study. Results and discussion: The endogenous endocannabinoid system plays a significant role in the processing and extinction of fear memory. Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, has shown potential in the treatment of anxiety disorders, including PTSD. CBD interacts with the endocannabinoid system indirectly by increasing the availability of endocannabinoids such as anandamide, which act on CB1 receptors in the brain. This activation of the endocannabinoid system may help reduce the behavioral response to aversive memories and improve fear extinction. Final Thoughts: While early research on the effects of CBD on PTSD is promising, more studies are needed to determine its efficacy and safety, particularly in victims of violence. Sources also emphasize the need for greater awareness and accessibility of cannabinoid-based treatments for those who may benefit from them.