Purpose: This study aims to address concerns about the ability of Chinese social workers to collaborate with multiple systems and effectively implement multisystemic therapy (MST), given their low professional status. Based on the first MST practice in Mainland China, the study evaluates the effectiveness of MST in addressing disruptive behaviors in a child in difficult circumstances (CDCs), assesses its fitness within the Chinese context, and explores strategies for social workers to collaborate within the contexts of the specialized protection system for CDCs and the establishment of social work service stations. Method: A single-case AB research design with repeated measures across multiple contexts was adopted. Results: The study suggests MST's potential effectiveness and cultural and political compatibility in China, and identifies three strategies for social workers to intervene across multiple systems. Conclusion: MST could be a valuable tool in social work practice with proper integration into local systems in China.