Behavioral Reactions Of Rats Research Articles

Effect of potentiated antibodies to morphine on behavioral reactions in rats with morphine dependence.

We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.

Delayed effects of 1,2-epoxypropyltrimethylammonium chloride on behavioral reactions in rats.

We studied immediate and delayed effects of intraventricular injection of 1,2-epoxypropyltrimethylammonium chloride on behavioral reactions in rats. Apomorphine-induced yawning increased and orientation and exploratory activity was improved 144 h postinjection, which indicates activation of the brain dopaminergic system during this period.

Behavioral reactions of rats in the early postresuscitation period after systemic circulatory arrest of different duration.

Rats were exposed to systemic circulatory arrest for 10, 12, and 15 min. During the first 10 days after resuscitation exploratory activity of animals depended on the duration of systemic circulatory arrest and was determined by two opposite factors: high reactivity of the central nervous system contributing to intensification of exploratory activity, and impaired general state of survivors (inhibition of animal behavior).

Behavioral reactions of rats and the contents of neurospecific proteins in their brain after single X-ray irradiation

We studied the behavior of rats in an open-field test and the contents of neurospecific proteins [neural cell adhesion molecule (NCAM) and glial fibrillary acidic protein (GFAP)] in the brain cortex, hippocampus, striatum, midbrain, cerebellum, andpons Varolii 1, 12, 24, 120, and 168 h after a single X-ray irradiation session (dose of 0.25 Gy). Within the postirradiation period, manifestations of the behavioral activity of the animals were mostly suppressed, and the parameters related to the emotional state of the animals were influenced to a greater extent. The dynamics of the NCAM and GFAP contents were complex and dissimilar in the brain structures under study, but it was possible to observe some general regularities. Within early periods of time, 12 h after irradiation, the NCAM content increased in the cortex, hippocampus, and cerebellum. In these structures, it reached approximately 220, 170, and 150%, respectively, as compared with the control, while it dropped to about 40% in thepons Varolii. Changes in the GFAP content reached their maximum 24 h after irradiation; this index dropped to 29, 44, 34, and 67% in the striatum,pons Varolii, midbrain, and cerebellum, respectively, while it increased to 380% in the hippocampus. Later time intervals were characterized by smoother changes in the contents of the above neurospecific proteins. Seven days after irradiation, the NCAM content did not differ from initial values in the striatum and cerebellum and was higher than the control in the neocortex, hippocampus, and midbrain. Within this period, the GFAP level in the cerebellum and midbrain was relatively normalized, but it increased in the hippocampus and decreased in the pons and striatum. Therefore, the greatest postirradiation shifts in the NCAM and GFAP levels were observed in the structures of the limbic system, and this can be correlated with the data on testing the rats in an open field.

Motivational support of complex behavioral reactions in rats.

The activity of neurons of the medial wall of the frontal cortex (MWFC) of the brain of rats trained to a delayed spatial choice task was investigated. Significant reorganizations of the activity of the neurons were found when the motivational state of the animal was changed. Direct connections were identified between hypothalamic nuclei and the MWFC using the retrograde axonal horseradish peroxidase transport method. The role of hypothalamocortical interactions in providing the motivational-emotional components of behavior is discussed.