Levels Of Behavior Research Articles

Investigating health risk behavior disparities in the United States with finite mixture modeling

Health disparities are ongoing challenges in the United States, with one of the underlying factors being the variation in health risk behaviors across different socioeconomic and demographic communities. In this cross-sectional ecological study, utilizing data from 26,781 US zip codes provided by the Centers for Disease Control and Prevention (CDC), we conducted generalized linear model regressions to explore the associations between race, poverty, education, and urban/rural status in areas. Our analysis indicated that areas with a higher prevalence of Black population and higher poverty levels are associated with a more significant number of unique health risk behaviors. Conversely, other racial groups were associated with fewer unique health risk behaviors, although they may still engage in higher levels of specific behaviors. These insights underscore the need for tailored public health strategies to address the disparities in health risk behaviors across different sub-populations. Additionally, we employed Finite Mixture Modeling (FMM) to identify distinct sub-populations in the United States based on health risk behaviors, specifically binge drinking, smoking, sleep deprivation, and physical inactivity, which are essential risk factors for chronic diseases such as cancer, diabetes, and cardiovascular diseases. We identified four clusters and conducted an in-depth analysis of the demographics and socioeconomic characteristics of the identified clusters. Our findings reveal that one cluster, characterized by the worst health risk behaviors, exhibited the highest poverty rate, the least favorable health insurance profile, and the lowest frequencies of post-secondary education attainment compared to the other three clusters. This cluster, therefore, warrants targeted public health interventions.

Clinical and Cardiometabolic Effects of Reducing Sedentary Behavior in Postmenopausal Women with Rheumatoid Arthritis.

We investigated the effects of a 4-month intervention targeting sedentary behavior on sedentary time and physical activity level, clinical parameters, cardiometabolic risk factors, inflammatory markers, and health-related quality of life in post-menopausal women with rheumatoid arthritis. This was a 4-month, parallel-group, randomized controlled trial (ClinicalTrials.gov identifier: NCT03186924). One-hundred-and-three postmenopausal rheumatoid arthritis patients were randomized (1:1) to either a newly developed intervention targeting sedentary behavior (Take a STAND for Health; TS4H) or standard of care (SOC). Sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition, blood samples and oral glucose tolerance test, blood pressure, muscle function, and health-related quality of life were assessed at baseline (Pre) and after 4 months (Post). Between- and within-group differences were tested using linear mixed models following the intention-to-treat principle. Total sedentary time, time in prolonged sitting bouts, standing, and stepping did not change in either group (all p ≥ 0.337). No significant between- and within-group differences were detected for any of the clinical parameters, markers of cardiometabolic health and inflammation, and health-related quality of life variables (all p ≥ 0.136). Among responders in TS4H group (those who reduced sedentary time by ≥30 min/d), Pre to Post IL-10 concentrations tended to reduce (group*time: p = 0.086; estimated mean difference [EMD]: -12.0 pg/mL [-23.5 to -0.6], p = 0.037), and general health (group*time: p = 0.047; EMD: 10.9 A.U. [-1.1 to 22.9], p = 0.086) and overall physical health tended to improve (group*time: p = 0.067; EMD: 7.9 A.U. [-0.9 to 16.6], p = 0.089). TS4H did not change sedentary behavior, physical activity levels, clinical, cardiometabolic, inflammatory or health-related quality of life outcomes. However, TS4H tended to reduce IL-10 levels and improve health-related quality of life in responders.

Doublecortin-immunoreactive neurons in the piriform cortex are sensitive to the long lasting effects of early life stress.

The olfactory system is a niche of continuous structural plasticity, holding postnatal proliferative neurogenesis in the olfactory bulbs and a population of immature neurons in the piriform cortex. These neurons in the piriform cortex are generated during embryonic development, retain the expression of immaturity markers such as doublecortin, and slowly mature and integrate into the olfactory circuit as the animal ages. To study how early life experiences affect this population of cortical immature neurons, we submitted mice of the C57/Bl6J strain to a protocol of maternal separation for 3 h per day from postnatal day 3 to postnatal day 21. Control mice were continuously with their mothers. After weaning, mice were undisturbed until 6 weeks of age, when they were weighted and tested in the elevated plus-maze, a standard test for anxiety-like behavior, to check for phenotypical effects. Mice were then perfused, and their brains processed for the immunofluorescent detection of doublecortin and the endogenous proliferation marker Ki67. We found that maternal separation induced a significant increase in the body weight of males, but not females. Further, maternally separated mice displayed increased exploratory-like behavior (i.e., head dipping, velocity and total distance traveled in the elevated plus maze), but no significant differences in anxiety-like behavior or corticosterone levels after behavioral testing. Finally, we observed a significant increase in the number of complex doublecortin neurons in the piriform cortex, but not in the olfactory bulbs, of mice submitted to maternal separation. Interestingly, most doublecortin neurons in the piriform cortex, but not the olfactory bulb, express the epigenetic reader MeCP2. In summary, mild early life stress results, during adolescence, in a male-specific increase in body weight, alteration of the exploratory behaviors, and an increase in doublecortin neurons in the piriform cortex, suggesting an alteration in their maturation process.

Building Community-Based Social Capital by Enhancing Individual Social Capital: The Case of Farmers in Turkey’s Konya Region

Social capital refers to the formation of relationships, or working collectively, to achieve a common outcome. The objective of the current study is to determine whether community-based agricultural policy initiatives can succeed in the absence of consistently strong levels of individual farmer social capital behaviors. Targeting farmers from Turkey’s Konya region who also took part in a household survey, we present findings from a hypothetical field experiment of how farmers would allocate wheat endowment during a drought. We found that farmers allocated 48% of wheat endowment to social capital choices. Our results indicate that the more a farmer relies on himself or herself and resources available outside of the community, the less likely it is that the farmer will invest in community efforts.

Differential growth trajectories of behavioral self-regulation from early childhood to adolescence: Implication for youth domain-general and school-specific outcomes

The current study examined the developmental trajectories of behavioral self-regulation from early childhood to adolescence and linked them to adolescent domain-general (i.e., positive functioning and delinquent behavior) and school-specific (i.e., school connectedness and peer victimization) outcomes. Using data from the Future of Families and Child Wellbeing Study (N = 4009), Growth Mixture Models identified four behavioral self-regulation trajectory classes: early developer (n = 2096, 52.3%), moderate stable (n = 1500, 37.4%), lagged developer (n = 212, 5.2%), and regressor (n = 201, 5%). Child and family characteristics were used to distinguish these four trajectories. The early developer trajectory had the strongest protective effect on adolescent outcomes, showing the highest levels of positive functioning and school connectedness and the lowest levels of delinquent behavior and peer victimization. Conversely, the regressor trajectory was linked with highest risky adolescent outcomes. The findings underscore the importance of implementing targeted intervention programs that promote behavioral self-regulation during middle childhood.

PSXIII-5 Behavior and blood urea nitrogen in cattle grazing meadow bromegrass and supplemented with condensed and hydrolizable tannins

Abstract The nutritional value of grasslands declines as the season progresses, negatively impacting cattle nutrition. Protein supplementation may reverse this trend, although high rates of ruminal proteolysis reduce the efficiency of N utilization. Tannins decrease protein degradability in the rumen, although they are also plant defenses with potential to influence animal behavior. The objective of this study was to determine in protein-supplemented cows grazing meadow bromegrass (MB) the influence of tannins on blood urea nitrogen (BUN), and on behavioral levels of activity. Twenty-four Black Angus cow [body weight (BW) = 614 ± 20 kg]-calf (BW = 244 ± 4 Kg) pairs were allotted to six 9-acre paddocks (4 pairs/paddock); animals in the Control (Ctrl; n = 3) and Tannin treatments (TT; n = 3) grazed meadow bromegrass (MB) and had a supplement of dried distillers grains with solubles (DDGS; (1 kgּ cow-1ּ d-1), with the addition of a mix of condensed (2/3): hydrolizable tannins(1/3; SilvaTeam) at 0.4% of the diet for TT. Grazing occurred from July to September 2023 with four experimental periods of 15 d each, the first being the adaptation period (no tannins; Baseline). Data were analyzed as a mixed-effects model with repeated measures and paddock as the experimental unit. Cows were fitted with accelerometers on their left back leg to determine activity, and blood samples were collected from all animals at the end of each period to estimate BUN. Representative samples of grass and supplement were collected from each period and paddock and analyzed for CP and fiber content. Herbage availability (DM basis) in each paddock was assessed before and post-grazing during each period using a rising plate meter and calibration curves. neutral detergent fiber (NDF) (62.9 to 65.1 ± 0.5%) and and acid detergent fiber (ADF) (38.7 to 43.9 ± 0.3%) increased, whereas CP (6.8 to 3.9 ± 0.1%) declined from Period 1 to 4 (P < 0.05). Initial biomass was 5,272 ± 211 Kg/ha and it declined after grazing (Period 4) to 2,319 ± 94 Kg/ha (P < 0.05) with no differences between treatments (P > 0.05). No differences between treatments were observed on motion index, number of steps taken per day, and the proportional percentage of time cows spent standing (9,379 ± 740, 2,611 ± 300, and 54.9 ± 0.02%, respectively; P > 0.05), suggesting that cows in TT did not invest extra time in searching activities or resting relative to Ctrl. It was only detected a greater percentage of transitions from lying to standing in TT than in Ctrl (7 to 3.4 ± 0.003%; P < 0.001). Values for BUN did not differ between treatments (P > 0.05), although they declined from Baseline to Period 4 by 28 % (8.2 to 5.9 ± 0.2mg/dL) in TT and by 2.6 % (5.75 to 5.6 ± 0.01 mg/dL) in Ctrl (P < 0.05). These results suggest that the addition of low levels of tannins to a protein supplement in cows grazing a low-quality grass diet reduces ruminal proteolysis without adversely influencing biomass removal or animals’ levels of activity.

Subordinates' perceptions of the need‐supportive, need‐thwarting, and need‐indifferent behaviors used by their supervisors: A person‐centered investigation

AbstractAdopting a recent tripartite operationalization of subordinates' perceptions of their supervisors' behaviors, anchored in self‐determination theory (SDT), this person‐centered study considers the co‐existence of subordinates' perceptions of their supervisors' need‐supportive, need‐thwarting, and need‐indifferent behaviors. Moreover, we also consider how these various combinations (or profiles) of perceived supervisor behaviors relate to subordinates' levels of work motivation, well‐being, attitudes, behaviors, and work–home functioning. A sample of 596 French employees (Mage = 31.22; 73.5% women) participated in this study. Our results revealed six profiles of subordinates characterized by distinct configurations of perceived need‐related behaviors from supervisors (globally unfavorable, globally favorable and supportive, moderate‐indifferent, moderately favorable and involved, moderately unfavorable, and moderately favorable). Consistent with our expectations, these profiles displayed well‐differentiated patterns of associations with all of the outcomes considered in this study. These findings underscored the key role of subordinates' specific perceptions of need‐supportive, need‐thwarting, and need‐indifferent behaviors, over and above their global perceptions of their supervisors' behaviors, in determining how beneficial or harmful supervisory profiles are. In particular, our results also highlighted the critical role played by need‐indifferent behaviors, which prove to be a very important, and yet typically neglected, component of subordinates' perceptions of their supervisors' behaviors.

Enhancing mental well-being of undergraduates: establishing cut-off values and analyzing substitutive effects of physical activity on depression regulation.

This study aimed to analyze the effects of physical activity (PA), sleep quality, and sedentary behavior on subthreshold depression (StD) among undergraduates. This study included 834 undergraduates and assessed the impact of PA time, sleep quality, and sedentary behavior on depression. The receiver operating characteristic (ROC) analysis was performed to determine cut-off values for StD risk, while the isochronous substitution analysis was performed to evaluate the effects of different activities on depression regulation. Gender, age, and academic grade had no significant influence on depression levels among undergraduates (p > 0.05). However, students engaging in sedentary behavior for more than 12.1 h per day or with a Pittsburgh Sleep Quality Index score above 3.5 were at an increased risk of subclinical depression. Additionally, the isochronous substitution of light-intensity physical activity for other activities (sleep, sedentary behavior, moderate and vigorous intensity physical activity) showed statistically significant effects (p < 0.05) in both 5-min and 10-min substitution models, demonstrating a positive effect on alleviating depression. The findings indicate that specific lifestyle factors, particularly high levels of sedentary behavior and poor sleep quality, are crucial determinants of subclinical depression among undergraduates, independent of demographic variables such as gender, age, and academic grade. Notably, light-intensity PA plays a key role in StD regulation, as substituting it with more intense physical activities or improving sleep quality substantially reduces depression scores. Furthermore, the benefits such substitution became more pronounced with the increase in duration of the activity.

MARKETING RESEARCH OF ENVIRONMENTAL CULTURE POPULATION OF IZHEVSK

The article presents the results of a marketing study of the environmental culture and behavior of the population of the city of Izhevsk in 2023. The goals and objectives, the population under study, the size and structure of the sample, and the analysis tools are defined. An assessment of the actual sample obtained was given, on the basis of which a database was formed and an assessment of environmental culture and behavior was carried out. This study was initiated by the author of the article with the aim of testing a previously developed marketing model for assessing the level of environmental culture and behavior of the population “cognition-feeling-action”. The study became necessary to substantiate a number of provisions in the field of: environmental management and management against the backdrop of growing environmental problems in Russia and its regions; systematization of ideas about corporate social responsibility from the standpoint of justifying the rationality of its application; formation of marketing methodology for studying environmental culture and behavior of the population. Based on the results of a mass sample survey, a general and segment-by-segment assessment of the environmental culture and behavior of the population of Izhevsk in 2023 was given. The survey made it possible to record a number of indicators of the cognitive, affective and behavioral reaction of the population in the environmental sphere in general and by segment: “young” population (18 -44 years old); “middle-aged” population (45-59 years old), “elderly” people (over 60 years old). The structure of knowledge of environmental projects and programs, public and state bodies/institutions responsible for the state of the environment in the city of Izhevsk and Udmurtia has been studied. An assessment of the environmental situation in the city of Izhevsk by segment was recorded, and differentiation of people’s opinions regarding the consequences of environmental deterioration and the relevance of environmental problems was noted. An indirect study of the behavioral attitudes of a “responsible citizen” made it possible to assess the norms of behavior of the population and their readiness to act. Based on people's opinions, a rating of the relevance of measures to improve the environmental situation in the city of Izhevsk and the Urals was formed. As a result, an assessment of ecological culture is given by segments in the “cognition-feeling-action” model and illustrated graphically.

Prevalence of dyslexia related to mental health problems and character strengths among primary school students in northwest China

ABSTRACT Objective This study aimed to examine the prevalence of dyslexia, mental health problems, and character strengths among primary school students in northwest China. Method Primary school students (N = 2,322) were assessed for dyslexia, strengths and difficulties, self-esteem, bullying, depression, anxiety, and character strengths. The Student’s t-test and χ2 test were used to compare continuous and categorical variables between students with and without dyslexia. Results The estimated prevalence of dyslexia ranged from 4.9% to 6.9% and was highly prevalent among boys. Students with dyslexia reported statistically higher mean scores for emotional symptoms, conduct behaviours, internalizing and externalising problems, as well as total difficulties. Conversely, they exhibited lower levels of prosocial behaviour, expressed lower self-esteem, and reported higher instances of being bullied. Additionally, the prevalences of depression and anxiety symptoms were 36.5% and 26.3%, respectively, among dyslexic students. Signature strengths among students with dyslexia included appreciation of beauty and excellence, love, hope, forgiveness, and judgement. Conclusions These findings underscore dyslexia’s impact on mental health and academic performance in China. Implementing character strength-focused interventions could enhance well-being and academic outcomes among dyslexic primary school students.

Responses to prey chemical cues in wild-caught, adult gopher snakes (Pituophis catenifer).

Surface chemical cues from prey elicit elevated levels of tongue-flicking and striking behavior in many species of snakes and lizards. These responses are mediated by the vomeronasal system, and they may even occur in the absence of other sensory cues. How individuals of a species respond to prey chemical cues can reflect developmental, ecological, and evolutionary processes. Our focus in this study was ecologically based, and involved testing whether levels of chemosensory responding reflect the putative relative intake of prey types in nature. We tested 11 wild-caught adult gopher snakes (Pituophis catenifer) for their chemosensory responses, namely tongue flicking, in response to surface chemicals of natural prey items (rodent and bird) and to two control stimuli (distilled water and hexane). On average the snakes had significantly higher rates of tongue flicking toward prey cues than to control stimuli (p = .001). Responses to rodent and bird surface chemicals did not significantly differ from each other (p = .35). Tongue-flick responses to rodent surface chemicals were significantly higher than to both water and hexane (ps < .01), while responses to bird surface chemicals were significantly higher than to water (p < .05) but not to hexane (p = .12). (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Increased forebrain EAAT3 expression confers resilience to chronic stress.

Depression is a disabling and highly prevalent psychiatric illness. Multiple studies have linked glutamatergic dysfunction with the pathophysiology of depression, but the exact alterations in the glutamatergic system that contribute to depressive-like behaviors are not fully understood. Recent evidence suggests that a decreased level in neuronal glutamate transporter (EAAT3), known to control glutamate levels and limit the activation of glutamate receptors at synaptic sites, may contribute to the manifestation of a depressive phenotype. Here, we tested the possibility that increased EAAT3 expression at excitatory synapses could reduce the susceptibility of mice to develop depressive-like behaviors when challenged to a 5-week unpredictable chronic mild stress (UCMS) protocol. Mice overexpressing EAAT3 in the forebrain (EAAT3glo/CMKII) and control littermates (EAAT3glo) were assessed for depressive-like behaviors and long-term memory performance after being subjected to UCMS conditions. We found that, after UCMS, EAAT3glo/CMKII mice did not exhibit depressive-like behaviors or memory alterations observed in control mice. Moreover, we found that EAAT3glo/CMKII mice did not show alterations in phasic dopamine release in the nucleus accumbens neither in long-term synaptic plasticity in the CA1 region of the hippocampus after UCMS, as observed in control littermates. Altogether these results suggest that forebrain EAAT3 overexpression may be related to a resilient phenotype, both at behavioral and functional level, to the deleterious effect of chronic stress, highlighting the importance of neuronal EAAT3 in the pathophysiology of depressive-like behaviors.

Analysis of the influential factors on innovative behaviors among ophthalmic specialty nurses in China: a cross-sectional study

ObjectiveTo investigate the current situation of innovative behavior and organizational structure authorization of ophthalmic specialty nurses in China, and analyze the influencing factors of innovative behavior.MethodsA cross-sectional survey was carried out among 301 ophthalmic specialty nurses in China, representing Representing 82 hospitals in 25 provinces, using a general data questionnaire, Innovative Behavior Scale(IBS), and conditions of work effectiveness questionnaire(CWEQ-II).ResultsThe mean total score for innovative behavior among Chinese ophthalmic specialty nurses was (4.73 ± 1.14), and the mean total score for organizational structure authorization was (61.65 ± 14.69). The logistic regression analysis revealed that organizational structure authorization, hospital grade, and ophthalmic specialty nurses primarily engaged in clinical care and clinical research had statistically significant impacts on the level of innovative behavior (P < 0.05). The higher the organizational structure authorization score, the higher the innovative behavior level of ophthalmic specialty nurses, the level of innovation behavior of grade-B tertiary hospitals is higher than that of grade-A tertiary hospitals. The main positions are low level of innovative behavior in clinical care and high level of innovative behavior in clinical research.ConclusionsThe innovative behavior and organizational structure authorization of Chinese ophthalmic specialty nurses are at a medium level, the innovative behavior of ophthalmic specialty nurses is influenced by factors such as organizational structure empowerment level, hospital grade, and main job position. Nursing managers are advised to develop tailored training programs based on the influencing factors of innovative behavior among Chinese ophthalmic specialty nurses, in order to enhance their level of innovation and improve the quality of nursing services provided by Chinese ophthalmic specialty nurses.

EVALUASI PELAKSANAAN MANDATORY TRAINING ONLINE DENGAN MODEL KIRKPATRICK PADA HOLIDAY INN RESORT NUSA DUA

Abstrak This study aims to obtain an overview of the implementation of Mandatory Online Training based on Kirkpatrick's Evaluation Models at the Holiday Inn Resort Bali Nusa Dua. Data were collected through the distribution of questionnaires and analyzed using quantitative descriptive techniques. The questionnaires were given to permanent and contract employees, excluding daily workers or trainees who participated in this training. The sample in this study was taken using proportionate stratified random sampling techniques. The results of this study at the reaction level showed that the training was conducted well, with an overall average reaction level dimension of 4.10 on a scale of 5.00. At the learning level, the results were very good with an average score of 4.16 on a scale of 5.00. The behavior level of the training participants, measured at the behavior level, showed good results with an overall average behavior level dimension of 4.12 on a scale of 5.00. Overall, the average result level obtained a good criterion with an average score of 4.15 on a scale of 5.00.

The oxytocinergic system and racial ingroup bias in empathic neural activity

Studies have indicated that the human brain exhibits a more robust neural empathic response towards individuals of the same racial ingroup than those of the outgroup. However, the impact of the oxytocinergic system on the dynamic connectivity between brain regions involved in racial ingroup bias in empathy (RIBE) and its implications for real-life social interaction intention remains unclear. To address this gap, we employed functional magnetic resonance imaging (fMRI) to investigate RIBE-modulated neural activities and the influence of the oxytocinergic system at both neural and behavioral levels. Participants homozygous for the A/A and G/G genotypes of the oxytocin receptor gene (OXTR) rs53576 polymorphism underwent scanning while making judgments about painful versus non-painful stimuli in same-race versus other-race scenarios following either oxytocin (OT) or placebo treatment. The results revealed greater activity in the anterior cingulate cortex (ACC) and anterior insula (AI) in response to same-race compared to other-race models in the G/G group but not in the A/A group. RIBE also modulated the connections between bilateral AI and the ACC, and the effect of OT on this modulatory effect was moderated by genotype rs53576 and interpersonal trust. Moreover, more extensive changes in AI-ACC connections were associated with higher levels of revenge intention in the low interpersonal trust group. Overall, our findings suggest a pivotal role of the oxytocinergic system in the RIBE-modulated neural activities and revenge intention in human interactions with the modulatory effect of interpersonal trust.This article is part of the Special Issue on “Empathic Pain”.

Behavioral characteristics of toddlers later identified with an autism diagnosis, ADHD symptoms, or combined autism and ADHD symptoms.

Autism commonly co-occurs with attention-deficit/hyperactivity disorder (ADHD), but less is known regarding how ADHD symptoms impact the early presentation of autism. This study examined early behavioral characteristics of a community sample of toddlers later identified with autism diagnosis, ADHD symptoms, combined autism and ADHD symptoms, or neither condition. Participants were 506 toddlers who were part of a longitudinal study of children's behavioral development. Parents completed questionnaires about their children's behavior at two time points. Four groups were identified based on study measures or medical record: autism diagnosis (n = 45), elevated ADHD symptoms (n = 70), autism and ADHD symptoms (n = 30), or neurotypical development (n = 361). Relationships between early parent report of autism- and ADHD-related behaviors, social-emotional and behavioral functioning, and caregiver experience and subsequent group designation were evaluated with adjusted linear regression models controlling for sex. Significant group differences were found in measures of autism-related behaviors, ADHD-related behaviors, externalizing and internalizing behaviors, and parent support needs (p < .0001). Pairwise comparisons indicated toddlers later identified with combined autism diagnosis and ADHD symptoms had higher levels of autism-related behaviors, externalizing and internalizing behaviors, and autism-related parent support needs compared to the other groups. Toddlers with subsequent elevated ADHD symptoms or combined autism diagnosis and ADHD symptoms exhibited similar levels of ADHD-related behaviors, while both groups displayed more ADHD-related behaviors than toddlers subsequently identified with autism or those with neither condition. In this community sample, toddlers for whomcombined autism diagnosis and ADHD symptoms were subsequently identified showed a distinct presentationcharacterized by higher early autism-related behaviors, broader behavioral concerns, and higherparent support needs. Presence of ADHD symptoms (alone or in combination with autism) was associated with higher parent-reported ADHD-related behaviors during toddlerhood. Results indicate that ADHD-related behaviors are manifest by toddlerhood, supporting screening for both autism and ADHD during early childhood.

Adolescent development of anxiety-related behavior and shifts in behavioral responsiveness to estradiol in female mice.

Early pubertal onset during adolescence is consistently linked with increased risk of anxiety and depression in girls. Although estradiol tends to have anxiolytic effects in adulthood, whether sensitivity to estradiol's anxiolytic actions increases during adolescence is not clear. Using a rodent model, the current study tested the hypothesis that a shift in sensitivity to the anxiolytic effects of estradiol occurs during adolescence. To test this hypothesis, prepubertal and adult C57BL/6 female mice were ovariectomized, implanted with vehicle- or estradiol-filled silastic capsules, and behavioral tested one week later in the open field and elevated zero maze. Our hypothesis predicted that estradiol would decrease anxiety-related behavior to a greater extent in adults than in adolescent females, however, our results did not support this hypothesis. In the open field, estradiol implants significantly decreased anxiety-like behavior in adolescent females (relative to vehicle) and had little to no effect on the behavior of adults. These data suggest that adolescence is associated with a downward shift in sensitivity to the anxiolytic effects of estradiol on behavior in the open field. In contrast, although estradiol treatment did not influence anxiety-like responses in the elevated zero maze in early adolescent or adult females, adolescent females displayed significantly higher levels of anxiety-like behavior than adults. These findings demonstrate that substantial changes in anxiety-related behavior occur during adolescence, including a context-dependent shift in behavioral responsiveness to estradiol.

Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.

The massive use of herbicides, particularly glyphosate-based herbicides (GBHs), raises several worries, notably their neurotoxic effects. Several studies have explored the consequences of developmental exposure. Our work aims to determine the impact of maternal exposure to GBH on behavioral disorders and memory deficits, as well as the involvement of oxidative stress in the hippocampus and prefrontal cortex. In addition, our study explores the neuroprotective properties of melatonin in male and female offspring. Pregnant Wistar rats were injected with GBH 75 mg/kg during gestation and lactation. After weaning, the offspring were treated with melatonin (4mg/kg) from postnatal days 30-58. Our results show that GBH increases anxiety-like behavior levels in offspring, as well as depression-like behavior. GBH also impairs working memory in progeny. While markers of oxidative stress show a disturbance in lipid peroxidation and catalase activity, with a more pronounced effect in females, on the other hand, melatonin considerably attenuated the neurotoxic impact observed in the offspring, with higher efficacy in females. The oxidative stress results confirm the antioxidant power of melatonin to counteract the damaging effects of exposure to environmental contaminants such as glyphosate-based pesticides. It will then be interesting to further our work to fully understand the sex-dependent effect of melatonin.

Pengaruh Budaya Organisasi dan Komitmen Organisasi Terhadap Kinerja Karyawan Melalui Organizational Citizenship Behavior pada Savana Hotel &amp; Convention Malang

This research aims to examine the variables that influence employee performance and their influence on service sector employees at Savana Hotel and Convention Malang. The type of research used is quantitative with an explanatory approach. Primary data in this study used a questionnaire which was distributed using a questionnaire sheet. The population in this study were employees of the Savana Hotel and Convention Malang and a sample of 100 respondents. Using the Partial Least Square (PLS) analysis method 4. Based on the research results, it shows that the variables of organizational culture and organizational commitment have a significant effect on employee performance at the Savana Hotel and Convention. And the organizational citizenship behavior (OCB) variable is able to mediate organizational culture and organizational commitment on employee performance for Savana Hotel and Convention employees. It can be concluded that if organizational culture improves it will support the formation of organizational commitment then these two variables will encourage high levels of organizational citizenship behavior (OCB), this is usually called employee loyalty, this will increase employee performance.

Analisis Perilaku terhadap Niat Berinvestasi

This study aims to determine and analyze the influence of behavior on investor intentions. This study uses primary data. The sample used was 100 respondents, namely people who have invested, have worked and have a fixed income. The sampling technique used nonprobability sampling, precisely the respondent accidental technique by distributing questionnaires. This type of research is quantitative research, then the data was analyzed using research instrument tests (validity and reliability tests), multicollinearity tests, multiple regression analysis (regression models, determination coefficients, F tests, t tests), and classical assumption tests (heteroscedasticity tests, normality, assistance and autocorrelation) with the SPSS software program version 25.0. The results showed that financial behavior has a positive and significant effect on investment intentions. This shows that the better a person's level of financial behavior, the better their investment intentions will be. Investment knowledge has a positive and significant effect on investment intentions. This shows that the better a person's level of investment knowledge, the better their investment intentions will be. Financial literacy has a positive and significant effect on investment intentions. This shows that the better a person's level of financial literacy, the better their investment intentions will be.