This paper presents an experimental study examining the seismic behavior of square reinforced concrete (RC) columns subjected to combined loadings. In this study, nine full-scale square RC columns were made with the same structural properties. Five of them were strengthened with high-performance ferrocement laminate and bonded steel plates in order to investigate the effects of strengthening on the seismic behavior of RC columns under combined loadings. Finally, the failure mode, hysteretic load-displacement response, bearing capacity, energy dissipation, ductility and plastic hinge characteristics were recorded and analyzed. The results show that combined loadings reduced the bearing capacity and changed the failure modes and deformation characteristics. Strengthened RC columns had significantly improved bearing capacity and different failure modes under the same combined loadings in contrast to the non-strengthened RC columns. The vertical eccentricity had little effect on the mechanical properties of columns, while the horizontal eccentricity significantly weakened the mechanical properties of columns. The mechanical properties of uniaxial compression-bending-shear-torsion columns were the worst. The tri-linear model calculation parameters under different failure modes and combined loadings were fixed and validated by experimental results.