The number of obese people has been steadily rising over one and a half times since recent ten years in Korea. Obesity accompanied by increased body fat could lead to hyperlipidemia, hyperinsulunemia, and hypertension, contributing to metabolic syndrome. The study of metabolic syndrome‐related blood lipids predisposing to atherosclerosis have taken attention more. To know the effects of obesity program on Atherogenic Index(AI) and HOMA Index in the obese middle aged women. Obese middle aged women(age: 46.4±6, BMI: 33.1±2.9, %Fat: 33.5±3.5) had done power walking and jogging on the treadmill for aerobic exercise(50‐60 %VO2max for first 1‐6 weeks, 60‐70 %VO2max for later 7‐12 weeks), weight training for resistant exercise(50‐60 %1RM for first 1‐6 weeks, 60‐80 %1RM for later 7‐12 weeks) for a hour. AI and HOMA Index extrapolated from blood samples were analysed at the beginning of exercise, 6 weeks after beginning exercise, and 12 weeks after beginning exercise. The variables were analyzed using one‐way ANOVA. AI decreased at 12 weeks after beginning exercise(p<.05) and HOMA Index decreased at 12 weeks after beginning exercise(p<.05). Insulin decreased at 12 weeks after beginning exercise but were not statistically significant. Therefore, the maintenance of normal weight and doing exercise is beneficial to preventing the metabolic syndrome and arteriosclerosis.