For designing and optimizing the reactor core of modular pebble-bed fluoride salt-cooled high-temperature reactor (PB-FHR), it is of importance to simulate the coupled fluid and particle flow due to strong coolant–pebble interactions. Computational fluid dynamics and discrete element method (DEM) coupling approach can be used to track particles individually while it requires a fluid cell being greater than the pebble diameter. However, the large size of pebbles makes the fluid grid too coarse to capture the complicated flow pattern. To solve this problem, a two-grid approach is proposed to calculate interphase momentum transfer between pebbles and coolant without the constraint on the shape and size of fluid meshes. The solid velocity, fluid velocity, fluid pressure and void fraction are mapped between hexahedral coarse particle grid and fine fluid grid. Then the total interphase force can be calculated independently to speed up computation. To evaluate suitability of this two-grid approach, the pressure drop and minimum fluidization velocity of a fluidized bed were predicted, and movements of the pebbles in complex flow field were studied experimentally and numerically. The spouting fluid through a central inlet pipe of a scaled visible PB-FHR core facility was set up to provide the complex flow field. Water was chosen as liquid to simulate the molten salt coolant, and polypropylene balls were used to simulate the pebble fuels. Results show that the pebble flow pattern captured from experiment agrees well with the simulation from two-grid approach, hence the applicability of the two-grid approach for the later PB-FHR core design.