Beck Depression Inventory Research Articles

Beyond medications: a multifaceted approach to alleviating comorbid anxiety and depression in clinical settings.

Comorbid anxiety and depression are common and can make the problems more complex and sometimes resistant to pharmacological treatment. In existing research, the diagnoses are often studied separately, and physical activity, healthy nutrition, psychoeducation, and social support have shown good effects. The aim of the present study was to explore the longitudinal effects of a comprehensive treatment on patients with comorbid anxiety and depression in a clinical context. Eighty inpatients (15 men and 65 women) in age range 23-65 years receiving psychiatric treatment in Norwegian clinic participated in the longitudinal study. Treatment was person-centered and was most frequently given for anxiety and depression, e.g., pharmacological treatment and psychotherapy, individually and in groups. In combination with this, physical activity, healthy nutrition, psychoeducation and social support in contacts with authorities and relatives were also a part of treatment. Depression and anxiety were assessed using the Beck Anxiety Inventory and Beck Depression Inventory at three points in time: baseline, at the end of treatment, and 3 months after treatment. The answers were categorized and combined into four groups according to severity of anxiety and depression to measure effects on comorbidity. Mann Whitney U test, Chi-square, Friedmans test, and McNemar test were used to analyze the data. The results showed a significant increase of frequencies in the group with mild anxiety and depression 3 months past treatment compared to baseline. Through the comprehensive, person-centered treatment more patients had low levels of both anxiety and depression 3 months after treatment. We suggest that clinics working with comorbid depression and anxiety patients should add physical activity, nutrition advice, social support, and psychoeducation to the traditional treatment regimes. More research concerning comorbid anxiety and depression are urgent to further expand the treatment possibilities.

Impulse control disorders related cognitive and behavioral features in Parkinson’s disease

Objectives: This study aimed to investigate cognitive and behavioral distinctions in patients with Parkinson's disease (PD) with impulse control disorders (ICDs). Patients and methods: A total of 72 patients (52 males, 20 females; mean age: 60.8±9.2 years; range, 41 to 77 years) with PD (31 with ICD features [PDwIC] and 41 without ICD [PDwoICD]) and 67 healthy controls (35 males, 32 females; mean age: 60.4±10.4 years; range, 36 to 79 years) were included in this prospective cross-sectional study between April 2018 and January 2020. All participants underwent a comprehensive neuropsychometric assessment, including a battery of cognitive and psychiatric tests. Furthermore, the Iowa Gambling Task was employed to evaluate risky decision-making capacities, and the UPPS (Urgency, Premeditation [lack of], Perseverance [lack of], Sensation Seeking) Impulsive Behavior Scale was utilized to assess impulsive personality traits. The Beck Depression Inventory (BDI) was used to assess the presence and severity of depression. Results: The PDwICD, PDwoICD, and healthy control groups showed comparable characteristics in terms of age and education level. Male sex was more prevalent in the PDwICD group than in the control group (p=0.01). The PDwICD group exhibited significantly higher MDS UPDRS I scores and total LEDD compared to the PDwoICD group (p=0.027 and p=0.003, respectively). The PDwICD group also had higher BDI scores and UPPS-Sensation Seeking subscores than the PDwoICD group (p=0.001 and p=0.044, respectively). The multivariate analyses demonstrated an independent association between higher scores of BDI and presence of ICD in PD (p=0.006). Conclusion: In conclusion, comprehensive screening for affective characteristics can help clinicians identify those at higher risk for impulsive behaviors in PD. Prospective studies are needed to better understand the factors leading to ICDs and explore the roles of personality traits, cognitive and behavioral features, and dopaminergic medications.

Originalbeiträge (Originals). High Young schema levels predict manualized confrontation therapy outcome in patients with panic disorder / Der Einfluss von Schemata nach Young auf das Therapieergebnis von Patienten mit Panikstörung

The role of schemas is well established in personality disorders. Their influence on therapy outcome of patients with Axis I disorders remains unclear. Therefore, patients with a panic disorder (PD) with/without agoraphobia varying in their expression of early maladaptive schemas were examined regarding therapy outcomes after exposure therapy. In this study, a sample of 216 patients with panic disorder with/without agoraphobia were recruited in a day clinic. After the initial diagnosis with the Structured Clinical Interview, the patients filled out the Young Schema Questionnaire (YSQ-S2), Beck Depression Inventory and Revised Symptom Checklist. Afterwards, they participated in a five-week manualized exposure therapy by Lang et al. (2011). Subjects with high schema scores showed lower therapeutic success rates than subjects with a weaker pattern score. In addition, it was found that high schema levels, especially of schemas regarding impaired autonomy and achievement (YSQ-S2: domain 2), influenced therapy outcome by either predicting more/severe or less/milder anxiety-, phobicrelated and general symptoms after therapy. The results of this study emphasize the role of schemas not only for personality disorders but also for disorders on Axis I. For PD with/without agoraphobia, schemas regarding impaired autonomy and achievement seem to play the most important role regarding the influence on therapy outcome.

Hand fatigability, self-reported fatigue, and functionality in individuals with multiple sclerosis: A cross-sectional study

BackgroundThe individual experience of fatigue and fatigability in individuals with Multiple Sclerosis (MS) can vary greatly, beyond the high prevalence of fatigue in MS. Although fatigue is known as a common symptom that affects and potentially limits individuals with MS, it has recently been determined that fatigability also causes consequences that limit individuals’ daily lives. The purpose of this study was to compare the associations between self-reported levels of fatigue, measured fatigability, and estimates of functional capacity in people with MS and sex- and age-matched healthy individuals. MethodsTwenty-three individuals with Relapsing-Remitting MS (RRMS) diagnosis and 23 age- and sex-matched healthy individuals were included in the study. To examine the fatigability level Dynamic and Static Fatigue Index were used for gross and pinch-grip, and manual dexterity and functionality levels the Scale for the Assessment and Rating of Ataxia (SARA), Nine Hole Peg Test (NHPT), and Dexterity Questionnaire-24 (DextQ-24) were used. While the Fatigue Severity Scale (FSS) and Fatigue Impact Scale (FIS) were used to examine self-reported fatigue, the Beck Depression Inventory (BDI) was used to assess emotional status. ResultsThere was no difference between RRMS and healthy individuals in terms of fatigability levels (p > 0.05). While the relationship between Static and Dynamic Fatigue Index gross grip fatigability and FSS and FIS was not found to be statistically significant, the relationship between non-dominant side pinch grip Static Fatigue Index and FSS and FIS was significant. In addition, the relationship between the non-dominant side gross grip Static Fatigue Index and the DextQ-24 dressing and daily activities subsections, and the dominant side pinch grip Dynamic Fatigue Index and the television/compact disk/digital video disk subsection of DextQ-24 was significant (p < 0.05). ConclusionFatigability was related to daily life upper limb use for gross grip and self-reported fatigue for pinch grip in individuals with RRMS. It was concluded that future studies focusing on hand fatigability could also consider manual dexterity and self-reported fatigue in individuals with MS from the early-stage. Clarifying the relationship of between fatigability and self-reported fatigue to functioning will allow clinicians to plan more appropriate and directed treatment approaches for individuals with RRMS. Trial registrationClinicalTrials.gov NCT05880745.

Sexual dysfunction, depression, and marital adjustment in diabetic male patients

Background: Type 2 diabetes affects 10.5% of adults globally, with sexual dysfunction being one of the complications, of which erectile dysfunction is the most commonly reported one with the prevalence ranging from 35% to 90%. There are a few studies exploring links between sexual dysfunction, depressive symptoms, and marital satisfaction, which is the reason we undertook the study. Aim: To study the prevalence of sexual dysfunction, depressive symptoms, and marital satisfaction in male patients with diabetes and correlation between the three parameters. Methods: A total of 120 male patients with type 2 diabetes were assessed for sexual dysfunction using ICD-10 criteria and International Index of Erectile Function, depressive symptoms using Beck Depression Inventory, and marital satisfaction using Dyadic Adjustment Scale (DAS). Results: The mean age of patients at diagnosis of diabetes was 42.32 ± 7.48 years, and the mean duration of diabetes was 7.35 ± 3.76 years. Mean HbA1c was 9.05 ± 2.25% with only 22 patients having good glycemic control. Eight-eight patients reported sexual dysfunction with lack of genital response, premature ejaculation, and orgasmic dysfunction being common. Thirty-two patients had depressive symptoms, with borderline clinical depressive symptoms and moderate depressive symptoms in 14 patients each. Marital satisfaction was affected with the total mean DAS score being 93.95 ± 18.34. There was a negative correlation seen between sexual function and depressive symptoms and also between sexual function and increasing age, with a positive correlation seen between sexual function and marital satisfaction. Poor glycemic control was significantly associated with clinically diagnosed erectile and orgasmic dysfunction. Conclusions: Sexual dysfunctions, depressive symptoms, and marital distress are highly prevalent in patients with type 2 diabetes, warranting timely detection and management. The three parameters are significantly correlated with each other, and poor glycemic control is significantly associated with sexual dysfunction. Psychiatric liaison would improve outcomes.

Depressive symptoms-Not apredictor for five-year mortality in patients with subjective cognitive decline, non-amnestic and amnestic mild cognitive impairment.

The main aim of the present study is to evaluate the influence of depressive symptoms on mortality in patients with SCD (subjective cognitive decline), naMCI (non-amnestic mild cognitive impairment), and aMCI (amnestic mild cognitive impairment). Additional factors (age, sex, years of school attendance, and neuropsychological performance) were considered to determine the impact on survival probability. Amonocentric retrospective data analysis based on adjusted patient protocols (n = 1221) from the observation period 1998-2021, using the Cox Proportional Hazards model, assessed whether depressivity had an explanatory value for survival, considering SCD as the reference level in relation to naMCI and aMCI. Covariates were included blockwise. Cox regression revealed that depressiveness (Beck Depression Inventory, Geriatric Depression Scale) did not make asignificant contribution as arisk factor for mortality in all five model blocks, BDI-II with HR 0.997 [0.978; 1.02] and GDS-15 with HR 1.03 [0.98; 1.08]. Increasing age with HR 1.09 [1.07; 1.11] and male sex with HR (inverted) 1.53 [1.17; 2.00] appeared as risk factors for increased mortality across all five model blocks. aMCI (vs. SCD) with HR 1.91 [1.33; 2.76] showed asignificant explanatory value only up to the fourth model block. By adding the six dimensions of the Neuropsychological Test Battery Vienna in the fifth model block, the domains attention and perceptual speed with HR 1.34 [1.18; 1.53], and executive functions with HR 1.24 [1.11; 1.39], showed substantial explanatory values for survival. Accordingly, no tendency can be attributed to depressiveness as arisk factor on the probability of survival, whereas the influence of certain cognitive dimensions, especially attention and perceptual speed, and executive functions, can be seen as protective for survival.

Executive functions and functioning in women with fibromyalgia.

Fibromyalgia (FM) is a chronic condition characterized by widespread pain that is associated with sleep, emotional, and cognitive disturbances, including in executive functions (EFs). To investigate the relationship between EFs and functionality in women with FM. The study included 17 women with FM, aged between 30 and 59 years, with no history of neurological disease. The EFs were assessed using the Digit Span Subtest (DS), Five Digit Test, Trail Making Test (TMT), Corsi Block-Tapping Task, Hayling Test (HT), and Verbal Fluency Task. Functionality was evaluated through the Fibromyalgia Impact Questionnaire. The Beck Depression Inventory, Hamilton Anxiety Rating Scale, and Brief Pain Inventory were used to measure depression, anxiety, and pain, which were controlled in the statistical analyses. The FM patients showed longer response latency on the HT and TMT. They made fewer errors on part B of the HT, and they performed worse on the DS backward and on the Corsi Block-Tapping Task forward and backward. There were moderate correlations in the expected direction between performance on the Corsi Block-Tapping Task backward and interference at work, as well as between the time to complete part B of the Trail Making Test - B (TMT-B) and fatigue. An unexpected relationship was found between errors on part B of the HT and interference at work. The results suggest lower efficiency in processes such as inhibitory control and cognitive flexibility, difficulties in working memory and non-executive processes such as processing speed. Even with pain, anxiety, and depression controlled, some relationships between EFs and functionality were observed, indicating that these symptoms do not fully explain this relationship. We suggest that cognition, particularly EFs, and broader measures of functionality be considered in the evaluation of FM.

Association Between Dry Eye Disease with Anxiety and Depression Among Medical Sciences Students in Qassim Region: Cortisol Levels in Tears as a Stress Biomarker.

This study aimed to investigate the relationships between anxiety, depression, and ocular surface health. Cortisol levels were detected in human tears, and their relationship with anxiety levels was determined using a validated questionnaire. In total, 112 participants were recruited for this study. All participants were healthy medical students at the Qassim University. Each participant signed an informed consent form after receiving detailed information about the study. Visual acuity examination, TBUT, Shirmer1 test were performed. Participants were asked to fill out three questionnaires: Taylor Manifest Anxiety Scale, Beck Depression Inventory, and The Ocular Surface Disease Index. Tear samples were extracted from the Schirmer strips and cortisol level was measured using ELISA kits. A total of 112 college students were included in the study, 58.9% of whom were females. The mean age was 21.9 ± 1.7 years. Subjective reported symptoms of anxiety levels were significantly correlated with depression scores, the OSDI, and reduced Schirmer test measurements. Moreover, cortisol levels detected in tears were positively associated with higher anxiety scores (r=0.328, P<0.05). Ocular surface health is associated with symptoms of anxiety and depression. The use of tears to measure cortisol levels could be an interesting way to serve as an anxiety biomarker.

Factors Associated with Interpersonal Violence and Depression Symptoms in Adolescent Students from Jalisco during the COVID-19 Pandemic

Introduction. Violence is a major public health problem, which increased during the Covid-19 pandemic, affecting the physical and mental development of adolescents. Objective. To analyze factors associated with interpersonal violence and depressive symptoms in adolescent students in the south of Jalisco. Methods. Data were drawn from an online survey of 3,046 adolescents (ages 12-19) conducted between September and December 2021. The Beck Depression Inventory was used to assess depression symptoms. Self-reports of neglect, physical, psychological, sexual, and digital violence in the previous 12 months were analyzed. Bivariate and multivariate logistic regression models explored factors associated with depression and violence. Results. A total of 28.8% of the sample reported depression symptoms, 46.9% physical violence, 42.7% psychological violence, 34.9% neglect, 12.3% digital violence, and 5.2% sexual violence. The odds of depression were higher for those who had experienced physical violence (adjusted odds ratio [aOR] = 1.3 CI 95% [1.1-1.6]), psychological violence (aOR = 4.1 CI 95% [3.4-5.1]), digital violence (aOR = 2.0 CI 95% [1.5-2.5]); and neglect (aOR = 1.6 CI 95% [1.3-1.9]). Girls and adolescents aged 15-19 had higher odds of experiencing sexual, digital, and psychological violence. Poor school performance was associated with lower odds of reporting neglect (aOR = .6 CI 95% [.5-.8]) and sexual violence (aOR = .5 CI 95% [.3-.8]), while being employed was associated with reporting higher odds of physical violence (aOR = 1.5 CI 95% [1.3-1.8]) and neglect (aOR = 1.3 CI 95% [1.1-1.5]). Greater use of social media and videogames was associated with higher odds of physical, psychological, and digital violence. Conclusion. It is necessary to implement comprehensive public programs and policies to address violence and implement intersectoral social intervention strategies in mental health.

Amelioration of suicidal ideation in routine care psychotherapy: Preliminary findings from a large multicenter assessment

BackgroundSuicidal ideation represents a major concern in clinical practice. Yet, little is known about the effects of routine psychotherapy on the amelioration of suicidal ideation. Therefore, the aim of the current study is to assess mental disorder-specific changes of suicidal ideation in a large sample of adult outpatients undergoing routine-care cognitive-behavioural therapy in Germany. MethodsA total of N = 4549 adult outpatients, 64.2% female; age: M(SD) = 36.83 (14.03), range: 18–89 years of age, who completed cognitive-behavioral therapy at one of 26 outpatient clinics in Germany were included in the current study. Amelioration of suicidal ideation was assessed using the Suicide Item (Item 9) of the Beck-Depression Inventory. ResultsSuicidal ideation was reported by 36.7% of the patients pretreatment and by 17.6% posttreatment. Effect sizes were small to moderate (d = 0.25 -0.51) and 4.4% reported an increase in suicidal ideation. Residual suicidal ideation at the posttreatment assessment was more likely in patients diagnosed with recurrent Major Depression, Dystymia, and Borderline Personality Disorder, and older patients. LimitationThe study relies on a naturalistic sample, no waitlist or control conditions were involved. ConclusionAcross primary diagnoses, a significant proportion of patients experience an amelioration of suicidal ideation over the course of routine-care psychotherapy. Still, a substantial proportion of patients report no change or an increase in suicidal ideation during treatment. Thus, continuous monitoring of suicidal ideation appears to be imperative throughout the psychotherapeutic process.

Neurological long-COVID: Associations among fatigue, dysautonomia, depression, and subjective memory complaints

IntroductionLong-COVID is a multisystem disease characterized by a varied presentation of symptoms. According to most recent research, the most common symptom of long-COVID is fatigue, which up to this date lacks a universally accepted definition. This study aimed to investigate neurocognitive and physical manifestations of neurological long-COVID, particularly fatigue and its relation with autonomic disfunction, cognitive impairment (known as, brain fog), and depressive symptoms. Furthermore, the study provided insights into predictors of fatigue in long-COVID. MethodsThe included patients (n=141) were referred to the neuro-long-COVID ambulatory service of Trieste from 30 September 2021–02 March 2022. Patients were given self-reporting questionnaires to screen for fatigue, autonomic dysfunction, cognitive impairment and depressive symptoms. The questionnaires adopted for these conditions to be assessed were Fatigue Severity Scale (FSS), COMPASS-31, Prospective-Retrospective Memory Questionnaire (PRMQ), and Beck Depression Inventory (BDI). Participants were divided into two groups, fatigued and non-fatigued patients, based on FSS scoring (scores > 4.67 indicate fatigued patients). The questionnaire scores of the two groups were then compared. ResultsFatigued patients had significantly higher scores in COMPASS (p<0.001, Cohen’s d=1.077), BDI (p<0.001, Cohen's d=0.862), and PRMQ ( p<0.001, Cohen's d=1.159).Furthermore, the multivariate regression analysis showed that predictors of fatigue in long-COVID were symptomatological burden in acute infection (OR=1.38, 95 % CI 1.020–1.887, p=0.037) and in long-COVID (OR=1.78, 95 % CI 1.133–2.2824, p=0.013), COMPASS-31>16 (OR=3.44, 95 % CI 1240–9.560, p=0.018) and BDI>15 (OR=5.1, 95 % CI 1.715–15.164, p=0.003). ConclusionThis study showed associations between fatigue, dysautonomia and depression, as well as with symptom burden in acute and long-COVID.

Emotional State Evaluation of Retinitis Pigmentosa Patients with the Beck Depression Inventory.

To evaluate the incidence and severity of depression in patients with retinitis pigmentosa (RP). The Beck Depression Inventory (BDI) was administered to 74 patients with RP and 60 healthy controls. Biomicroscopic anterior segment and fundus examination, visual field, optical coherence tomography, and full-field electroretinography tests were performed in all cases. Variables were evaluated with bivariate, multiple linear, and ordinal logistic regression analyses. The RP group included 40 (54%) male and 34 (46%) female patients, while the control group included 23 (38%) male and 37 (62%) female subjects. The patient group had a mean age of 39.20±12.4 years, median best corrected visual acuity (BCVA) of 0.10 decimal (1.0 logarithm of the minimum angle of resolution [logMAR]; range, 1.3-0.7 logMAR), and median visual field mean deviation (MD) score of -28.00 decibels (dB) (range, -1.00 to -34.00 dB). The median BDI score was statistically significantly higher in the patient group (19 points) than in the control group (12 points) (p<0.001). Moderate to severe depression (BDI ≥20) was detected in 61% of patients, while this rate was 25% in healthy controls. BCVA and visual field MD values were identified as predictors of depression score and severity level. The patients' age and gender did not affect total depression score or severity. The prevalence and severity of depression were found to be higher in RP patients than in healthy controls. There was a significant relationship between the patient's functional vision tests and the frequency and severity of depression. Depression reduces the reliability of visual function tests and impairs patients' quality of life. Therefore, assessing mental health as well as functional tests is important in patients with RP.

Web-Based Coping Skills Training and Coach Support for Women Living With a Partner With an Alcohol Use Disorder: Randomized Controlled Trial.

Individuals living with a partner with an alcohol use disorder (AUD) can experience significant psychological distress and use health care more than those without a partner with an AUD. However, the prevailing treatment system's focus on the partner and personal barriers limit these individuals from getting help for themselves. Preliminary work on a self-directed, web-based coping skills training program, Stop Spinning My Wheels (SSMW), shows promise in broadening available treatments for this population. In this study, we conducted a robust evaluation of SSMW primary outcomes. The study aims to test whether women with a partner with an AUD assigned to SSMW experienced a greater reduction in negative affect (depression and anger) (1) than a usual web care (UWC) control and (2) with brief phone coach support (SSMW+coach) rather than without (SSMW only) and (3) whether baseline negative affect moderated treatment effects. Women (mean age 45.7, SD 10.8 years; Black: 17/456, 3.7%; White: 408/456, 89.5%) were randomized to SSMW only, SSMW+coach, or UWC. Depression (Beck Depression Inventory-II) and anger (State-Trait Anger Expression Inventory 2-State Anger) were assessed at baseline, 12-week posttest, and 6- and 12-month follow-ups. Participants in all conditions decreased in depression from baseline to posttest and from baseline to follow-up; SSMW-only and SSMW+coach participants decreased in anger, but UWC participants did not. Compared to UWC participants, SSMW-only participants experienced greater anger reduction (P=.03), and SSMW+coach participants experienced a greater reduction in depression (P<.001) from baseline to posttest. However, from baseline to follow-up, only a greater, but not statistically significant (P=.052), reduction in anger occurred in SSMW+coach compared to UWC. Although the SSMW conditions did not differ from each other in negative affect outcomes (P=.06-.57), SSMW+coach had higher program engagement and satisfaction (all P<.004). Baseline negative affect did not moderate effects, although remission from baseline clinically relevant depressive symptoms (Beck Depression Inventory≥14) was higher in SSMW only (33/67, 49%; odds ratio 2.13, 95% CI 1.05-4.30; P=.03) and SSMW+coach (46/74, 62%; odds ratio 3.60, 95% CI 1.79-7.23; P<.001) than in UWC (21/67, 31%); remission rates did not differ between the SSMW conditions (P=.12). The results partially supported the hypotheses. The SSMW conditions had earlier effects than UWC, but positive change in UWC mitigated the hypothesized long-term SSMW-UWC differences. The results highlight the importance of incorporating active controls in web-based clinical trials. Although SSMW+coach showed benefits over SSMW only on engagement and satisfaction measures and in the number needed to treat (5.6 for SSMW only; 3.2 for SSMW+coach), the SSMW conditions were comparable and superior to UWC on depressive symptom remission levels. Overall, SSMW with or without a coach can reduce clinically meaningful distress and add to available treatment options for this large, underserved group. ClinicalTrials.gov NCT02984241; https://www.clinicaltrials.gov/study/NCT02984241.

Depression Among Fast Food And Traditional Food Users In Adults

This study examines the relationship between fast food consumption, traditional food consumption, and depression among 157 participants from Islamabad and Rawalpindi, Pakistan. Using a convenience sampling method, data were gathered through a cross-sectional study employing the Beck Depression Inventory (BDI) and the Food Frequency Questionnaire (FFQ). The sample predominantly consisted of males (54.1%), unmarried individuals (75.2%), those of middle socioeconomic status (84.7%), and participants living in a joint family system (54.8%). The highest educational level achieved by the participants was a Bachelor’s degree (44.6%), with an average age of 23 years (SD=16.6). Descriptive analysis outlined the demographic characteristics, while independent sample t-tests and one-way ANOVA assessed the associations between the variables. Findings revealed significant mean differences in depression scores between fast food consumers and traditional food consumers, with fast food consumers showing a higher risk of depression (p&lt;0.001). Moreover, married fast food consumers exhibited significantly higher depression scores compared to their unmarried counterparts (p&lt;0.001). No significant gender differences were observed in depression scores. Overall, the study suggests that fast food consumption is linked to an increased risk of depression compared to traditional food consumption, highlighting the potential negative effects of fast food on mental health and the importance of dietary choices in managing depression. These results point to the necessity for further research on dietary habits and mental health, as well as the implementation of public health strategies to encourage healthier eating practices.

The Relationship of Aesthetic Dentistry Practices with Depression and Social Appearance Anxiety in Young Women.

This study aimed to evaluate the relationship between depression and social appearance anxiety in young female patients who applied for aesthetic dental treatment. The study was conducted in a single centre and included 56 female patients aged 18-35 years. The mean age of the participants was 22.27 ± 5.62 years. Participants were informed before treatment, and the Beck Depression Inventory (BDI), Social Appearance Anxiety Scale (SAAS), and Visual Analogue Scale (VAS) were administered. Immediately after the treatment and 1 month later, the SAAS and VAS were administered again. The Kruskal-Wallis test was used for the comparison of the data obtained and the Friedman test was used for temporal comparison. Multiple comparisons were made with Dunn's test. After aesthetic dental treatment, all participants' satisfaction with the appearance of their teeth increased, and social appearance anxiety decreased (p 0.001). The group with the lowest pretreatment satisfaction level was the group with moderate/high-level depressive symptoms. There was no correlation between the severity of depression and the increase in satisfaction after treatment (r &#61; 0.247; p &#61; 0.066). Satisfaction levels were similar in all depression groups after treatment. The group with the highest level of social appearance anxiety before and after treatment was the group with moderate/high-severity depressive symptoms. A moderate positive correlation was found between depression severity and social appearance anxiety (r &#61; 0.4; p &#61; 0.002). The severity of depressive symptoms seen before treatment does not affect the level of satisfaction after treatment. There is a decrease in social appearance anxiety after aesthetic dental treatment. There is a positive relationship between social appearance anxiety and depression severity.

The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis.

Cognitive dysfunction is frequently seen in multiple sclerosis (MS). However, there are conflicting findings regarding the factors it is associated with. To investigate the relationship between aerobic capacity, strength, disability, depression, fatigue, and cognitive reserve and function. The mobile applications Trail Making Test (TMT A-B), Digit Span Test (DST), Visuospatial Memory Test (VSMT), and Tap Fast were used in the cognitive function evaluation. Functional performance was assessed with the 6-minute walk test (6MWT), 5-Time Sit-to-Sand (5STS) test, and grip strength. Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used. A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation. It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health. NCT06084182.

Caregiver burden in informal spousal caregivers predicts psychological and physical health in patients following coronary artery bypass graft surgery: a longitudinal clinical cohort study.

Previous research has shown that informal caregiver burden can have deleterious effects on patient recovery; however, this relationship has yet to be investigated in patients undergoing coronary artery bypass graft (CABG) surgery. This study aimed to examine the impact of the change of caregiver burden from pre- to post-surgery on patients' mental and physical health after CABG surgery. Ninety patient-caregiver dyads were assessed one month before the surgery, two months and one year after the surgery. Caregivers completed the Oberst Burden Scale to measure caregiver burden. Patients completed the Beck Depression Inventory to measure depressive symptoms, a subscale of the Hospital Anxiety and Depression Scale to measure anxiety symptoms, the Short Form-12 health assessment to measure health-related quality of life, and the Coronary Revascularisation Outcomes Questionnaire to measure surgery symptoms. Hierarchical linear regression analyses were conducted to explore the association between change in caregiver burden and post-surgery patient outcomes. A greater increase in caregiver burden from pre- to two-months post-surgery significantly predicted higher patients' depressive symptoms (β = 0.179, p = 0.010), anxiety symptoms (β = 0.114, p = 0.017), reported post-surgery symptoms (β = 0.335, p = 0.008) and reduced physical health-related quality of life (β = -0.358, p = 0.003), after controlling for a wide range of covariates. These findings were not replicated at a one-year follow-up. These results provide insights into the impact of caregiver burden on patient distress following CABG surgery, supporting the idea of psychological support interventions for caregivers to increase patients' short-term recovery outcomes.

Proprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome

Objectives: This study aimed to investigate the potential roles of proprotein convertase subtilisin/ kexin type 9 (PCSK9) and apelin in the etiology of fibromyalgia syndrome (FS). Patients and methods: The retrospective study was conducted between May 2022 and February 2023. Fifty-eight female FS patients (mean age: 45.2±9.9 years; range, 25 to 66 years) and 30 age- and body mass index-matched control subjects (mean age: 43.1±9.9 years; range, 26 to 67 years) were included in the study. Apelin and PCSK9 levels of all individuals were measured using appropriate methods. Results: The levels of PCSK9 (173.2±62.2 vs. 75.1±44.1, p&lt;0.001) and apelin (354.6±195.5 vs. 229.0±83.2, p&lt;0.001) were significantly higher in patients with FS compared to the control group. A positive correlation was found between PCSK9 and apelin levels and various measures, including the Fibromyalgia Impact Questionnaire (FIQ), Symptom Severity Scale (SSS), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI). Additionally, there was a positive correlation between apelin levels and FIQ, SSS, PSQI, Beck Anxiety Inventory, and BDI scores. The optimal cutoff value for PCSK9 in predicting FS was 110.0 ng/mL, with a sensitivity of 84.5% and specificity of 83.9% (area under the curve [AUC]=0.920, 95% confidence interval [CI]: 0.852-0.987, p&lt;0.001). For apelin, the optimal cutoff value for predicting FS was 258.8 ng/L, with a sensitivity of 63.8% and specificity of 64.5% (AUC=0.732, 95% CI: 0.623–0.840, p&lt;0.001). Conclusion: Our findings suggest that PCSK9 may play a role in FS etiology and potentially contribute to oxidative stress. Increased apelin levels may be a compensatory response to high oxidative stress, possibly leading to hyperalgesia. Both PCSK9 and apelin can be predictive markers for FS.

Linking Affect Dynamics and Well-Being: A Novel Methodological Approach for Mental Health.

Emotions are dynamic processes; their variability relates to psychological well-being and psychopathology. Affective alterations have been linked to mental diseases like depression, although little is known about how similar patterns occur in healthy individuals. This study investigates the psychophysiological correlations of emotional processing in healthy subjects, specifically exploring the relationship between depressive traits, cognitive distortions, and facial electromyographic (f-EMG) responses during affective transitions. A cohort of 44 healthy participants underwent f-EMG recording while viewing emotional images from the International Affective Picture System (IAPS). Self-report measures included the Beck Depression Inventory (BDI) and the Cognitive Distortion Scale (CDS). Higher BDI scores were associated with increased EMG activity in the corrugator muscle during transitions between positive and negative emotional states. Cognitive distortions such as Catastrophizing, All-or-Nothing Thinking, and Minimization showed significant positive correlations with EMG activity, indicating that individuals with higher levels of these distortions experienced greater facial muscle activation during emotional transitions. This study's results indicate that there is a bidirectional correlation between depressed features and cognitive distortions and alterations in facial emotional processing, even in healthy subjects. Facial EMG in the context of dynamic affective transitions has the potential to be used as a non-invasive method for detecting abnormal emotional reactions at an early stage. This might help in identifying individuals who are at risk of developing depression and guide therapies to prevent its advancement.

Alternation of psychological resilience may moderate mentalization toward mental health conditions from macro- and microstructure aspects

ObjectiveWe aim to investigate the interplay between mentalization, brain microstructure, and psychological resilience as potential protective factors against mental illness. MethodFour hundred and twenty-six participants (mean age 40.12±16.95; 202 males, 224 females), without psychiatric or neurological history, completed assessments: Dissociative Process Scale (DPS), Peace of Mind (PoM), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Resilience Scale for Adults (RSA), and Magnetic Resonance Imaging (MRI) structures with selected regions of interest, and Diffusion Tensor Imaging (DTI) maps from various tracts in the right hemisphere and connection to the frontal areas, including anterior thalamic radiation (ATR), Cingulum (hippocampus) (CH), Corticospinal tract (CST), Superior longitudinal fasciculus (SLF), Inferior fronto-occipital fasciculus (IFOF), and Uncinate fasciculus (UF) were analyzed. ResultsTwo clusters, representing hypomentalization (HypoM) and hypermentalization (HyperM), were identified based on DPS, CPSS, and RFQ responses. One-way ANOVA showed no significant age or gender differences between clusters. The HypoM group exhibited lower PoM scores, higher BDI and BAI scores, and lower RSA scores (ps< 0.05). Structural brain metric comparison showed significant differences in GMV in the right caudal middle frontal gyrus (rcMFG), right superior frontal gyrus (rsFG), and right frontal pole (rFP) between groups. In addition, the HyperM individuals with a higher risk of depression and a higher ratio of intrapersonal to interpersonal factors of resilience were found with reduced GMV on the rcMFG. Additionally, analyses of DTI metrics revealed significant differences between two groups in rATR and rSLF in terms of fractional anisotropy (FA) values; rATR, rCST, rUF, rSLF, rCH and rIFOF in terms of mean diffusivity (MD) values, and radial diffusivity (RD) (corrected p = 0.05). Moreover, the positive correlation between different domains of resilience and white matter (WM) integrity implied further enhancement of intrapersonal or interpersonal resilience factors that are different for people with different mentalization. ConclusionsThe findings underscore the importance of considering both intrapersonal and interpersonal factors in understanding the interactions between psychological resilience and mental health conditions relevant to brain mechanisms.