Several single-column pier girder bridges have been involved in overturning accidents, resulting in significant economic losses and casualties, thus necessitating a risk assessment of the overturning stability. To date, the effect of structural degradation due to concrete creep on the long-term stability of bridges has not been demonstrated. In this study, a full-scale nonlinear analysis of the lateral overturning process of a collapsed concrete box girder based on the explicit dynamic finite element method (EFEM) was conducted to verify the reliability of the numerical method. An EFEM model incorporating concrete creep was developed to demonstrate the effect of structural degradation on the long-term stability of bridges. The synthesis overturning axis method (SOAM) was proposed to evaluate the long-term overturning stability of concrete continuous bridges, aiming to address the deficiencies in existing methods, particularly for curved bridges, and was compared with conventional methods. The results show that the variations in bearing reaction forces between curved and straight bridges under creep and self-weight are minimal, staying within 2%. An increase in the creep terminal coefficient results in the opposite trend in the ultimate vehicle weight of curved bridges and straight bridges, but fluctuations remain within 2%, indicating that long-term creep has a limited effect on the overall overturning stability. A failure analysis of 20 single-column pier bridges reveals significant differences in the ultimate vehicle weight between the rigid overturning axis method (ROAM) and folded overturning axis method (FOAM), with error ranges of −14.2% to 567.4% and −99.1% to −32.1%, respectively. The SOAM results have the smallest error range compared to those of the EFEM, with an error range of −38.8% to 33.9%. Despite these errors, the SOAM demonstrates a significant improvement in characterizing the trend and assessment accuracy of the overall overturning stability of single-column pier bridges.