Baylis Hillman Type Research Articles

A novel C–C bond formation by Baylis–Hillman type reaction mediated by SmI2: an effective approach to α-hydroxyalkylacrylamide synthesis

α-Bromoacrylamides (1) reacted with aldehydes or ketones, in the presence of SmI2 at −78 °C in THF, within 5 min to produce Baylis–Hillman type reaction products (2) through an anionic process using vinylsamarium Grignard species in good yields (52–89%).