Pelvic organ prolapse (POP) is a prevalent condition among senior women, characterized by the descent or herniation of pelvic organs into the vaginal canal. It is a widespread issue, affecting a significant portion of the elderly female population, and yet, effective medical solutions for this condition remain elusive. This can be attributed to the complex nature of POP, where multiple factors, including tissue weakening and structural changes, contribute to its development. Despite the significant impact on women's quality of life, the absence of comprehensive treatment options underscores the urgency for innovative approaches to address this pressing health concern. In this context, 3D printing emerges as a valuable rapid prototyping tool, offering unique capabilities for designing and fabricating smart sensors and actuators. Its precision and versatility enable the creation of intricate devices that can be customized to specific medical applications. Moreover, 3D printing allows for the integration of sensors directly into biomedical devices, facilitating seamless monitoring and feedback mechanisms. Leveraging this technology, the research endeavors to harness the potential of 3D printing to develop advanced thermoelectric devices that can be seamlessly embedded within POP tissue scaffolds. These innovative devices will serve a dual purpose—detecting the health status of the tissue scaffolds and assessing their mechanical durability. In the realm of embedded medical devices, self-powered sensors hold particular significance due to their wireless powering capabilities and in-situ monitoring capabilities of human health. These sensors can operate without the need for external power sources or frequent battery replacements, making them ideal for long-term implantation within the human body. By tapping into the body's own energy sources or ambient environmental factors, self-powered sensors ensure continuous data collection and transmission, enhancing the efficiency and reliability of healthcare monitoring systems. Consequently, this talk aims to demonstrate the feasibility of 3D-printed thermoelectric devices as self-powered sensors, integrated into POP tissue scaffolds. These innovative devices will play a pivotal role in monitoring the tissue scaffold's condition, ensuring its mechanical integrity, and ultimately contributing to improved healthcare outcomes for women affected by POP.