The São Francisco delta in eastern Brazil is considered a classical example of a wave-dominated delta constructed in a glacial isostatic adjustment (GIA) far-field region. Although this delta is widely mentioned in the international literature, few details about its sedimentary architecture have been published. In this paper, we use a new dataset consisting of 15 boreholes and 26 radiocarbon datings to discuss the 3D architecture of the delta and the role played by GIA far-field effects in delta construction. The delta plain consists of a 10–12 m thick littoral sand sheet that progrades over a muddy subaqueous clinoform, forming a compound clinoform. Delta construction began between 8.4 and 7.2 ka BP and included a stage of normal regression that lasted until 5.7 ka BP, followed by a stage of forced regression. The transition between these two stages is marked by the highest position of the sand–mud transition in the boreholes. This forced regression is due to a 3–4-m drop in relative sea level since the mid-Holocene, which is characteristic of GIA far-field regions. Additionally, as a consequence of this drop in relative sea level, there is a progressive increase in the altitude of the beach-ridge deposits continentward, which combined with the development of extensive dune fields in the later stages of delta construction, contributes to the increased resilience of the delta to ongoing sea-level rise.The 3D architecture of the delta was strongly influenced by antecedent topography. The delta was built on a bathymetric depression on the shelf that almost entirely traps the sediment load of the São Francisco River. The uneven relief inside this bathymetric depression ultimately controlled lateral variations in the total thickness of the delta edifice.